ライフサイエンスコーパス: Schiff

1 Schiff base formation between Lys99 and the imine of the

2 Schiff base ligands have long been successfully employed

3 Schiff-base condensation between an amine and an aldehyd

4 Schiff-base formation between Abeta and the aldehyde-bea

5 Schiff-base formation between DOB and histone proteins i

6 study, including a reaction intermediate, 2 Schiff bases, and 28 bis- or tris(pyrazol-3(4)-yl)methan

7 muli using a visual analog scale (VAS) and a Schiff scale.

8 romophore covalently linked to Lys(296) by a Schiff base is subsequently hydrolyzed, but little is kn

9 f the SRI-HtrI attractant conformer causes a Schiff base connectivity switch from inwardly connected

10 Asparagine reacted with fructose to form a Schiff base before decarboxylation to produce acrylamide

11 e in ADC nor norspermidine in CANSDC, form a Schiff base to pyridoxal 5'-phosphate, suggesting that t

12 VitB antigens reach this location and form a Schiff base with MR1, triggering a 'molecular switch' th

13 proline as the nucleophile, MmuNeil3 forms a Schiff base intermediate via its N-terminal valine.

14 PLP forms a Schiff base with the -amino group of a lysine residue of

15 rupture of the C1'-O4' bond, resulting in a Schiff base intermediate at the N-glycosidic bond.

16 of an abasic site by a mechanism involving a Schiff-base covalent intermediate with the abasic site.

17 methyl-4-carboxy-2,2'-bipyridine, and L is a Schiff base macrocycle derived from 2,6-diformyl-4-methy

18 in the product the enzyme no longer makes a Schiff base linkage to the pyridoxal 5'-phosphate (PLP)

19 the bound product reveals the presence of a Schiff base between C-4' of the PLP cofactor and the ami

20 which is consistent with the formation of a Schiff base between Top1 and the ring open aldehyde form

21 The influence of a Schiff base namely N,N'-(pyridine-2,6-diyl)bis(1-(4-meth

22 r molecule, would trigger the formation of a Schiff base that can undergo further dehydration reactio

23 It involves the formation of a Schiff base through a reaction between the ketone and th

24 mining step of the process is formation of a Schiff base, which is followed by rapid intramolecular r

25 lision-induced dissociation (CID) produces a Schiff base product anion.

26 n the retinal binding pocket of rhodopsin, a Schiff base links the retinal ligand covalently to the L

27 Such a Schiff base intermediate was trapped and characterized b

28 )N NMR chemical shift measurements of such a Schiff base linkage in the resting holoenzyme form, the

29 forms a covalent bond with retinal through a Schiff base linkage.

30 Strand scission proceeds via a Schiff base intermediate, but the DNA-protein cross-link

31 dently of divalent cation and proceeds via a Schiff base intermediate, indicating that it occurs via

32 derivative, bound to a protein (opsin) via a Schiff base.

33 embly of paramagnetic Cu(2) complexes with a Schiff base scaffold possessing extended electron deloca

34 trategically located -COOH which accelerates Schiff base formation.

35 Accelerating Schiff base hydrolysis and subsequent ATR dissociation,

36 he equilibrium back toward the CP-accessible Schiff base form, restoring the wild-type phenotype.

37 he equilibrium in favor of the EC-accessible Schiff base form, and suppressor mutations shift the equ

38 t(W/Wv) mice were stained with periodic acid Schiff (PAS) to detect glycogen.

39 Periodic Acid Schiff and alkaline phosphatase staining revealed subapi

40 e stained with hematoxylin and periodic acid Schiff to determine pericyte loss (PL) and acellular cap

41 cell density was evaluated in periodic acid Schiff-stained conjunctival sections.

42 with hematoxylin and eosin and periodic acid Schiff.

43 cell density was counted after Periodic-acid Schiff staining.

44 roxide (KOH) stain followed by periodic acid-Schiff (PAS) evaluation if KOH testing is negative, and

45 Cassava samples stained with Periodic Acid-Schiff (PAS) highlighted the presence of starch and cell

46 tained with hematoxylin-eosin, periodic acid-Schiff (PAS) reaction, and Masson trichrome method.

47 x specimens were reexamined by periodic acid-Schiff (PAS) staining and PCR to identify undiagnosed am

48 elated with hematoxylin-eosin, periodic acid-Schiff (PAS), and mucicarmine-stained preparations.

49 itive for CK7, CEA, as well as periodic acid-Schiff (PAS), whereas negative for CK5/6, CK34betaE12, C

50 e observed significantly fewer periodic acid-Schiff (PAS)-stained intestinal goblet cells and less mu

51 Periodic acid-Schiff and immunohistochemical staining revealed mucous

52 tandard hematoxylin and eosin, periodic acid-Schiff and silver methenamine, and picrosirius red stain

53 th L. interrogans Histological periodic acid-Schiff D staining of infected kidney showed interstitial

54 epitheliopathy and Alcian blue/periodic acid-Schiff histochemical analysis to characterize goblet cel

55 Periodic acid-Schiff loops and CD11b(+) macrophages within the tumor s

56 reous biopsy with cytospin and periodic acid-Schiff stain for hyphae was the most sensitive method fo

57 samples were stained with H&E, periodic acid-Schiff stain, and antibody to MUC5AC, the predominant mu

58 njunctiva of the right eye for periodic acid-Schiff staining and from the left eye for MUC5AC mucin i

59 rmed in this category included Periodic Acid-Schiff staining for fungi, PCR analysis for toxoplasmosi

60 ocyte markers gene expression, Periodic Acid-Schiff staining for glycogen storage, ELISA for albumin

61 ion was determined by means of periodic acid-Schiff staining of lung sections, Western blot analysis

62 blet cell hyperplasia by using periodic acid-Schiff staining, and cytokine and chemokine levels by pe

63 were undetectable on standard periodic acid-Schiff staining, even though only a single histologic se

64 and hematoxylin and eosin and periodic acid-Schiff staining, respectively.

65 dients in glycogen storage via periodic acid-Schiff staining, urea production via carbamoyl phosphata

66 ed using hematoxylin-eosin and periodic acid-Schiff stains.

67 technique using trichrome and periodic acid-Schiff subtraction morphometry; the other two methods in

68 al cells staining positive for periodic acid-Schiff was observed in MCMV/AAD airways.

69 lungs contain few alcian blue/periodic acid-Schiff's (AB/PAS)+ staining 'goblet' cells in the absenc

70 n perfusates was quantified by periodic acid-Schiff's base dot-blot assay, using purified pig gastric

71 aining with hematoxylin-eosin, periodic acid-Schiff, and Gram stain.

72 oscopy, hematoxylin and eosin, periodic acid-Schiff, Congo red, and light microscopy.

73 amined with hematoxylin-eosin, periodic acid-Schiff, Masson trichrome, or reticulin stains.

74 with hematoxylin and eosin and periodic acid-Schiff, visualized by means of electron microscopy, and

75 Occlusion of sweat ducts with periodic acid-Schiff-positive and Congo red-positive material was note

76 y were reflected by changes in periodic acid-Schiff-positive material and expression of MUC5AC over t

77 Ab modestly reduced levels of periodic acid-Schiff-positive mucus cells and the thickness of the smo

78 cy, 7 had BAL fluid containing periodic acid-Schiff-positive surfactant-like material with macrophage

79 elying solely on visualizing a periodic acid-Schiff-positive vacuolar myopathy to identify late-onset

80 Hyalinized periodic acid-Schiff-positive vessels were widely separated.

81 e of being densely loaded with periodic acid-Schiff-positive, diastase-resistant granules, resembling

82 he ducts that was positive for periodic acid-Schiff.

83 , however our results suggest an alternative Schiff base mechanism which may be responsible for the r

84 by employing the solvothermal aldehyde-amine Schiff base condensation reaction.

85 nfirmed the formations of Michael adduct and Schiff base of HMF with amino acids.

86 tent of protein oxidation (carbonylation and Schiff base formation) and their sensory profile (quanti

87 imple model where backbone modifications and Schiff base substituents control barrier heights on the

88 adipic and gamma-glutamic semialdehydes) and Schiff base cross-links.

89 r the synthesis of a library of 442 Ru-arene Schiff-base (RAS) complexes.

90 The formation of cross-links (assessed as Schiff bases) during freezing and the subsequent process

91 we detected the presence of emixustat-atRAL Schiff base conjugates, indicating that emixustat also a

92 The unusual charge neutrality of both Schiff base counterions in the P2 (380) conducting state

93 Replacing the n-butylamine Schiff base normally chosen to mimic the saturated linka

94 idues is poised to activate the substrate by Schiff base formation, promote mechanistically important

95 that occupy the positions of the chromophore Schiff base proton acceptor and donor, a hallmark of rho

96 ied interaction network between chromophore, Schiff base, and counterion complex explaining the alter

97 protease through the formation of a covalent Schiff base adduct of the pBzF residue with the epsilon-

98 avage of beta-hydroxy-ketones via a covalent Schiff base intermediate.

99 t the ability of substrates to form covalent Schiff base catalytic intermediates and to initiate chem

100 arbonyl of TPQ, forming a series of covalent Schiff base intermediates.

101 became trapped by MR1 as reversible covalent Schiff base complexes.

102 for the formation/hydrolysis of the covalent Schiff base intermediates, whereas the other conformatio

103 The results show that the BF-CS Schiff base Ag (I) complexes are embedded into MCNT netw

104 etization), and Hc (coercivity) of the BF-CS Schiff base composites reach 1.908 S cm(-1), 28.20 emu g

105 When the mass ratio of MCNTs and BF-CS Schiff base is 0.95:1, the conductivity, Ms (saturation

106 n nanotubes/BaFe12O19-chitosan (MCNTs/BF-CS) Schiff base Ag (I) complex composites were synthesized s

107 as an internal aldimine with a deprotonated Schiff base.

108 UV-absorbing photoreceptor with deprotonated Schiff base and allowed reconstitution into native-like

109 tion of an isocyanide to a hydrazine derived Schiff base affords unique six-membered pyridotriazine s

110 anic frameworks (COFs), formed by the direct Schiff reaction between 1,3,5-tris(4-aminophenyl)benzene

111 the hydroxyimine form of the PLP(H+)-L-dopa Schiff base is predicted to be the major isomer with a r

112 r proton transfer in the external PLP-L-dopa Schiff base.

113 e nanodisc environment leading to an earlier Schiff base deprotonation.

114 the mutation of which to Glu produced early Schiff base proton transfer and strongly inhibited chann

115 e visual pigments is necessary for efficient Schiff base hydrolysis.

116 ons were stained with hematoxylin and eosin, Schiff reagent, and fluorescein, to assess morphologic c

117 actions with His910 and Phe889, an essential Schiff base with Lys907 and a hydrogen bond with Tyr892.

118 )methane derivatives instead of the expected Schiff base products.

119 yme showed L-methionine bound in an external Schiff base (ESB) linkage to PLP as the enzyme was isola

120 polarized in a manner that would facilitate Schiff base hydrolysis.

121 te lysine residue that is initially used for Schiff base formation in the internal aldimine and later

122 oxidised to alpha-aminoadipic acid and form Schiff bases structures.

123 , we show that 5fC bases in DNA readily form Schiff-base conjugates with Lys side chains of nuclear p

124 scent molecular rotors of boron derived from Schiff bases: (2,4,8,10-tetra-tert-butyl-6-phenyldibenzo

125 -Iodophenyl)imines A are readily formed from Schiff's base condensation of 2-iodoanilines with carbon

126 Furthermore, Schiff-base-modified peptides exhibit on average a 20% i

127 ct asymmetric aldol reaction between glycine Schiff bases and aldehydes is reported.

128 In a Perspective, Gordon Schiff discusses the importance of appropriately analyzi

129 ed pyrolysis of a series of heterobimetallic Schiff base complexes ensures a rigorous control of the

130 Discovered by Hugo Schiff, condensation between amine and aldehyde represen

131 lished by replacing the rapidly hydrolyzable Schiff-base moiety of first-generation members with a cy

132 ation of bithiophene-substituted cadmium(II) Schiff base complexes forms thin conducting metallopolym

133 itory action of a biologically inert Co(III) Schiff base (Co(III)-sb) complex.

134 e activation of a biologically inert Co(III) Schiff base [Co(III)-SB] complex to its protein inhibito

135 trate that neither the oligo, or the Co(III) Schiff base complex alone, are sufficient for inactivati

136 A Co(III) Schiff base complex modified with a 17-bp DNA sequence i

137 Heterobis imine Schiff base probe L is able to discriminate geometrical

138 ise to water loss in conjunction with imine (Schiff base) formation.

139 ly conjugated oligomers of secondary imines (Schiff bases) present at relatively low concentrations.

140 and amino acid side chains in the immediate Schiff base vicinity are very well conserved.

141 midoxime acts as an internal general acid in Schiff-base formation.

142 Acid catalysis, which is often employed in Schiff base synthesis, radically changes the course of r

143 ation of the ion/ion intermediate results in Schiff base formation generated via reaction between a p

144 ccumulation of excess 11-cis-retinal and its Schiff-base conjugate and the formation of toxic bisreti

145 Here we show that by localizing manganese-Schiff base catalysts at the oil droplet-water interface

146 factors and does not form a protein-mediated Schiff base with the substrate, unlike most aldolases.

147 c scheme, the human rhodopsin exhibited more Schiff base deprotonation than bovine rhodopsin, which c

148 The N-alkylated indanylidenepyrroline (NAIP) Schiff base 3 is an unnatural alpha-amino acid precursor

149 for all steps of the mechanism, most notably Schiff base formation and hydrolysis.

150 lar surface coverage confirm the efficacy of Schiff base chemistry, at least with the terephthalaldeh

151 the protein sequence controls the extent of Schiff base deprotonation and accumulation of intermedia

152 wever, the rapid and reversible formation of Schiff base prohibits formation of alternative products,

153 the amyloid fibril through the formation of Schiff bases, cross-linking the fibrils, which may preve

154 hat DOPAL interacts with aS via formation of Schiff-base and Michael-addition adducts with Lys residu

155 of 11-cis-retinal followed by hydrolysis of Schiff base (SB) and 2) hydrolysis of SB in dark state r

156 Specifically, interconversion of Schiff base and enamine intermediates, formed covalently

157 ohydride reduction confirmed the presence of Schiff base complexes.

158 not from inherent differences in the rate of Schiff base hydrolysis but rather from differences in th

159 etic strategy that regulates the sequence of Schiff base reaction via weak secondary interactions.

160 m chemical models of three distinct types of Schiff base rotary motors.

161 nd synthetic strategies toward COFs based on Schiff-base chemistry, collects and rationalizes their p

162 n screening using either disulfide bridge or Schiff base imine immobilization chemistries on plasmach

163 nes), forming either hemiaminal (+148 Da) or Schiff base (imine, +130 Da) products.

164 the complex [(UO2 )(THF)(H2 L)] (L="Pacman" Schiff-base polypyrrolic macrocycle), is found and expla

165 erived from a new water-soluble pentadentate Schiff base backbone ligand has been prepared and charac

166 ses strain in the Lys pyridoxal 5'-phosphate Schiff base and increases the pK(a), resulting in proton

167 arth trication in a binucleating polypyrrole Schiff-base macrocycle (Pacman) and bridged through a ur

168 inuclear magnesium complex of a polypyrrolic Schiff base macrocycle results in the formation of a new

169 I-Lumi II process that immediately precedes Schiff base deprotonation in the activation of rhodopsin

170 Mutation of the primary Schiff base counterion (VCOP(D108A)) produced a pigment

171 been exploited for over 150 years to produce Schiff bases, one of the most popular classes of compoun

172 s binding to 8-oxoG-containing DNA, promotes Schiff base formation, and stimulates its glycosylase an

173 re model compound 11-cis-retinyl-propylamine Schiff base demonstrate the direct isomerization of visu

174 rption spectrum consistent with a protonated Schiff base (lambda(max) = 420 nm).

175 talytic cycle is facilitated by a protonated Schiff base form of the holoenzyme in which the linking

176 rs to be capable of stabilizing a protonated Schiff base in Meta III, but not of constraining the rec

177 e capable of binding retinal as a protonated Schiff base is described.

178 ly bound to the protein through a protonated Schiff base linkage.

179 0) energy surfaces (Phi(CI)) of a protonated Schiff base of all-trans retinal in protic and aprotic s

180 nal and form a covalent bond as a protonated Schiff base.

181 11-cis retinyl chromophore with a protonated Schiff-base (PSB11), UV pigments uniquely contain an unp

182 ilibrium between the phenolic and protonated Schiff base tautomeric forms of this intermediate.

183 is-retinal (11CR), by a covalent, protonated Schiff base linkage.

184 g the intermediate Opsin-derived, protonated Schiff base in the visual cycle with simple polarized al

185 to approximately 40 kcal/mol for protonated Schiff base (PSB) chromophore in rhodopsin.

186 nd H6, while deprotonation of its protonated Schiff's base triggers the rearrangement of the hydrogen

187 e conclude that Lumi II (the last protonated Schiff base photointermediate under physiological condit

188 photoisomerization of the retinal protonated Schiff base (RPSB) chromophore.

189 neC backbone of all-trans retinal protonated Schiff base accelerates the electronic decay in solution

190 l salt bridge between the retinal protonated Schiff base linked to H7 and Glu113 on H3 is one of the

191 photoisomerization of the retinal protonated Schiff-base in bacteriorhodopsin, isorhodopsin and rhodo

192 hysical properties of the retinal-protonated Schiff base chromophore in solution.

193 cally isomerizes the retinylidene protonated Schiff base both thermally and photochemically.

194 The pKa of the retinylidene protonated Schiff base was modulated from 2.4 to 8.1, giving rise t

195 connection of their retinylidene protonated Schiff bases to the outwardly located periplasmic side a

196 favor of the oxoenamine tautomer (protonated Schiff base).

197 es E90, E123, D253, N258, and the protonated Schiff base (SBH), as well as nearby residues K93, T127,

198 n involves both hydrolysis of the protonated Schiff base and thermal isomerization of 11-cis to all-t

199 the proton dissociation from the protonated Schiff base is not affected, the rate of its reprotonati

200 cis-retinal and hydrolysis of the protonated Schiff base linkage between the 11-cis-retinal chromopho

201 ed bond-length alternation of the protonated Schiff base of 11-cis-retinal chromophore, induced by N8

202 e in opsin visual pigments is the protonated Schiff base of 11-cis-retinaldehyde (11cRAL).

203 t Arch variants, the pK(a) of the protonated Schiff-base linkage to retinal is near neutral pH, a use

204 transfer between the zwitterionic protonated Schiff base configuration and the neutral hydroxyimine t

205 ted at the edge of PLP opposite the reactive Schiff base.

206 the late M- (M2) with a deprotonated retinal Schiff base and the consecutive green-absorbing N-state

207 rt cycle includes protonation of the retinal Schiff base by Asp96 (M-->N reaction) and reprotonation

208 ncluding the D121-H87 cluster of the retinal Schiff base counterion and a glutamate at position 132 t

209 of the internal proton donor to the retinal Schiff base in the light-driven proton pump of Exiguobac

210 3) (Asp(253) in CrChR2) receives the retinal Schiff base proton during M-state formation.

211 rtate residue, the counterion to the retinal Schiff base, to a histidine.

212 as the internal proton donor to the retinal Schiff base.

213 plex has an outwardly connected retinylidene Schiff base like the repellent signaling forms of the SR

214 ex counterion to the protonated retinylidene Schiff base, and neutralization of the negatively charge

215 ecedes the deprotonation of the retinylidene Schiff base (i.e., formation of an M intermediate).

216 nts of proton transfer from the retinylidene Schiff base in several channelrhodopsin variants express

217 stable 1,3-thiazines, whereas the reversible Schiff base formation between aldehydes and amino groups

218 nd cone visual pigments undergoes reversible Schiff base hydrolysis and dissociation following photob

219 See Schiff for a scientific commentary on this article.

220 adily available halogen sources and a simple Schiff base as the chiral catalyst.

221 ly immobilized to the host IL through simple Schiff base reaction.

222 donor, respectively, of the photoactive site Schiff base (SB) proton.

223 ns in the HtrI subunit of the complex on SRI Schiff base connectivity indicate that the two proteins

224 s selectivity by forming an unusually stable Schiff base with lysine 907 in the IRE1 endonuclease dom

225 ium(II) and tin(II) by using the substituted Schiff base 2,6-diacetylpyridinebis(2,6-diisopropylanil)

226 es (MWCNT), chitosan and a novel synthesized Schiff base (SB) (TiO2/MWCNT/CHIT/SB) on the surface of

227 certain cases, however, compounds other than Schiff bases have been reported to result from such reac

228 aracteristics and they were more stable than Schiff base adducts at 60 degrees C.

229 The Schiff base becomes protonated in the transition to Meta

230 edominance of intermediate MRPs, such as the Schiff base compounds.

231 between positions C10 and C15 as well as the Schiff base nitrogen in the ground state in comparison t

232 by formation of a direct H-bond between the Schiff base and Asn87.

233 observe a deuterium equidistant between the Schiff base and the C-terminal carboxylate of the substr

234 rtate 253 accepts the proton released by the Schiff base (t(1/2) = 10 mus), with the latter being rep

235 HDL was immobilized by the Schiff base method onto silica and gave HPAC columns wit

236 Syntheses of these COFs were done by the Schiff base reactions of 1,3,5-triformylphloroglucinol (

237 For pi-conjugated COFs, the Schiff base condensation of aldehydes and amines is the

238 ing sugars react with asparagine to form the Schiff base before decarboxylation, to generate acrylami

239 ges in the K-state propagating away from the Schiff base along the polyene chain.

240 and its ability to accept a proton from the Schiff base during the photocycle.

241 ing the primary phototransition and from the Schiff base to Glu-169 during P2 (380) formation.

242 s the light-induced proton transfer from the Schiff base to its counterion Asp-97 during the photocyc

243 oplasmic half-channel, located 15 A from the Schiff base.

244 f the carbinolamine intermediate to give the Schiff base and to function as a general acid/base.

245 ctions of TCNQF (-) radicals (H2valpn is the Schiff base from the condensation of o-vanillin with 1,3

246 lidene-pyrroline chromophore that mimics the Schiff base of rhodopsin and can be used to introduce li

247 d from hydroxyl-bearing amino acids near the Schiff base in different visual pigments: at site 292 (A

248 K reveals the appearance of strain near the Schiff's base once the 13-cis configuration is fully for

249 or other residues slows reprotonation of the Schiff base (decay of the M intermediate) by more than 2

250 kes place shortly after deprotonation of the Schiff base (L-to-M transition) and results in an increa

251 he retinyl chromophore and hydrolysis of the Schiff base (SB) through which the retinyl chromophore i

252 omerization and dark state hydrolysis of the Schiff base by 1-2 orders of magnitude.

253 lier observations that neutralization of the Schiff base counterion, Asp97, does not block the format

254 embrane voltage modulates protonation of the Schiff base in a 13-cis photocycle intermediate (M right

255 refore suggest that the reprotonation of the Schiff base in ESR is preceded by transient protonation

256 energetics and the protonation state of the Schiff base in retinal, the covalently bound ligand resp

257 eins was confirmed by NaBH4 reduction of the Schiff base intermediate and kinetics studies.

258 occurs before a conformational change of the Schiff base intermediate toward a cyclic structure.

259 omophore and the (15)N chemical shift of the Schiff base nitrogen in the active metarhodopsin II inte

260 ce experiments confirm the assignment of the Schiff base nitrogen, and additional (13)C, (15)N, and (

261 fluctuations in the protonation state of the Schiff base occur prior to forming the activated MII sta

262 ) photoisomerization-induced transfer of the Schiff base proton to the Asp-97 counterion disrupts its

263 carboxylate anion on the alpha-carbon of the Schiff base stabilizes the zwitterions and shifts the eq

264 achieved by preventing reprotonation of the Schiff base through a mutation of the primary proton don

265 s the pK(a), resulting in protonation of the Schiff base to initiate transaldimination.

266 n and the deprotonation/reprotonation of the Schiff base, are coupled to the channel-opening mechanis

267 gen of the PLP and the imino nitrogen of the Schiff base, respectively.

268 changes dramatically with protonation of the Schiff base.

269 side chain of Tyr57 and with the C15H of the Schiff base.

270 channel occurs prior to deprotonation of the Schiff base.

271 hodopsin acts as the primary acceptor of the Schiff-base proton in low-efficiency channelrhodopsins.

272 h the internal aldimine is protonated on the Schiff base N.

273 the connectivity of the active site once the Schiff base and its counterion are neutralized by proton

274 absorbance spectrum at earlier times or the Schiff base deprotonation-reprotonation which occurs dur

275 inylidene-phosphatidylethanolamine (PE), the Schiff-base conjugate of 11-cis-retinal and PE, from the

276 Recently, the Schiff-base chemistry or dynamic imine-chemistry has bee

277 t M-states have been observed reflecting the Schiff base reorientation after the deprotonation step.

278 of retinal model compounds reveals that the Schiff base environment is polar.

279 proton-conduction pathway from Asp96 to the Schiff base.

280 p-Azo and Tp-Stb) were synthesized using the Schiff base reaction between triformylphloroglucinol (Tp

281 the pyrimidine ring is maintained, while the Schiff base intermediate is preferred if the C5 horizont

282 ide pH range and interacts directly with the Schiff base counterion Asp-97; and (ii) photoisomerizati

283 ter-mediated H-bonding interactions with the Schiff base linkage.

284 crements of 54 and 134 amu, corresponding to Schiff base and dihydropyridine (DHP)-type adducts, resp

285 est results were obtained using a tridentate Schiff base aluminum(III) Lewis acidic complex, 1H-1,2,3

286 When combined with amino acids they undergo Schiff base formation, decarboxylation and alpha-aminoke

287 UV pigments uniquely contain an unprotonated Schiff-base (USB11).

288 ostatic effects surrounding the unprotonated Schiff base (USB) retinyl chromophore in the UV pigment.

289 ly converted to an agonist, the unprotonated Schiff base of all-trans retinal, upon light activation.

290 on of Phe-86 that converted the unprotonated Schiff base-linked 11-cis-retinal to a protonated form.

291 hemoglobin amino groups to produce unstable Schiff base complexes that can dissociate or rearrange t

292 active site does not appreciably change upon Schiff base formation.

293 One of the most widely used Schiff base ligands, the "salen" ligand, has been extens

294 ied with monoclonal anti-cTnI antibodies via Schiff reaction based chemistry.

295 mpounds that transiently sequester atRAL via Schiff base formation ameliorate retinal degeneration.

296 The reductive half-reaction proceeds via Schiff base chemistry, in which the primary amine substr

297 We suggest a mechanism where Schiff base-mediated deimination forms DMQ(6) quinone, t

298 rimary alkoxides and diaminopyrimidines with Schiff base formation and subsequent annulation in the p

299 ox-mediated coupling of benzylic ethers with Schiff bases has been accomplished.

300 and is described by a multisquare model with Schiff base deprotonation at the lumirhodopsin I interme