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1 Sertoli cells (SCs) regulate testicular fate in the diff
2 Sertoli cells are considered the "supporting cells" of t
3 Sertoli cells produce GDNF and other growth factors and
4 Sertoli cells, can function as non-professional toleroge
5 Sertoli cells, the epithelial cell type within testis co
13 led to a dis-organization of F-actin across Sertoli cell cytosol, causing truncation of actin microf
14 ed by specialized junctions between adjacent Sertoli cells in the seminiferous epithelium near the ba
15 estis barrier (BTB), formed between adjacent Sertoli cells, undergoes extensive remodeling to facilit
16 lood-testis barrier (BTB) formed by adjacent Sertoli cells is composed of coexisting tight junction (
17 mary pre-pubertal Sertoli cells and in adult Sertoli line, TLR4\NOD1 and NOD2 crosstalk converged in
19 of potential feminizing genes, DMRT1 allows Sertoli cells to participate in RA signaling, which is e
24 , we observed progressive germ cell loss and Sertoli cell only tubules in Lkb1(cko) testes from mice
25 is-to-ovary genetic reprogramming occurs and Sertoli cells transdifferentiate into granulosa-like cel
26 germ cell (Dazl), proliferating (PCNA), and Sertoli cell populations, and quantitated levels of apop
27 s in protein distribution at the Sertoli and Sertoli-germ-cell cell interface and by phosphorylation
28 ted spermatogonia, primary spermatocytes and Sertoli cells in the testis, resulting in cell death and
30 cell-cell adhesion between spermatogenic and Sertoli cells through its interaction with NECL4 on Sert
33 tor cells acquire SOX9 expression and become Sertoli cells that form testis cords, whereas the remain
34 Although these changes are usually benign, Sertoli adenomas can sometimes harbor premalignant lesio
36 ier created by specialized junctions between Sertoli cells near the basement membrane confers an immu
37 ages revealed a normal BTB structure between Sertoli cells in the BT-IgSF-KO mice, we conclude that i
39 quired for the lineage specification of both Sertoli and granulosa cells by repressing Sf1 expression
42 gocytic clearance of apoptotic germ cells by Sertoli cells is essential for spermatogenesis, little o
43 gocytic clearance of apoptotic germ cells by Sertoli cells is vital for germ cell development and dif
45 ficient clearance of apoptotic germ cells by Sertoli cells using LAP.Although phagocytic clearance of
47 s3, CRB3) is a polarity protein expressed by Sertoli and germ cells at the basal compartment in the s
48 t testis, Rai14 was found to be expressed by Sertoli and germ cells, structurally associated with act
49 cycle (i) RALDH-dependent synthesis of RA by Sertoli cells (SC), the supporting cells of the germ cel
54 e spermatocyte stage, BSG-mediated germ cell-Sertoli cell interactions appear to be necessary for int
56 s exert deleterious effects on Leydig cells, Sertoli cells, and germ cells via very different mechani
58 alpha) since germ cells are known to control Sertoli cell production of this cytokine, and if yes, ho
64 mium because its knockdown would desensitize Sertoli cells to cadmium-induced TJ barrier disruption.
66 cal role in mammalian gonads is to determine Sertoli cells, we correlated this genomic signature with
69 dysgenesis (Leydig cell aggregation, ectopic Sertoli cells, malformed seminiferous cords) is not evid
71 re, and cooperated with endogenous embryonic Sertoli and primordial germ cells in the generation of t
73 onstrate the generation of induced embryonic Sertoli-like cells (ieSCs) by ectopic expression of five
74 codes a core NMD factor, in murine embryonic Sertoli cells (SCs) leads to severe testicular atrophy a
76 al-time polymerase chain reaction to examine Sertoli and germ cell markers on rat testes and human fe
77 ycans on glycoproteins, thereby facilitating Sertoli-germ cell attachment at a particular stage of sp
78 substance (MIS), which is produced by fetal Sertoli cells shortly after commitment of the bipotentia
83 , receptors, and integrins required for germ-Sertoli cell adhesion and dynamic junctional restructuri
87 rovide evidence that ZIKV infection of human Sertoli cells, which are an important component of the s
88 f P-glycoprotein by RNAi was found to impede Sertoli cell BTB function, making the tight junction (TJ
89 r knockdown by RNAi was also found to impede Sertoli cell-cell GJ communication, disrupting protein d
92 Transgenic mice expressing miR-471-5p in Sertoli cells show increased germ cell apoptosis and com
94 we found that Notch signaling was active in Sertoli cells at various fetal, neonatal, and adult stag
95 astly, the BEST1 promoter was also active in Sertoli cells of the testis in transgenic mice where SOX
96 emonstrate that Notch signaling is active in Sertoli cells throughout development and that proper reg
97 importance, a knockdown of laminin alpha2 in Sertoli cells was shown to induce the Sertoli cell tight
99 of proliferating cellular nuclear antigen in Sertoli cells were observed in Ppard(+/+) mice as compar
101 xt investigated if overexpression of Cx43 in Sertoli cells could rescue the PFOS-induced cell injury.
103 der than 10 weeks, accompanied by defects in Sertoli cell polarity and testicular junctional complexe
104 testes and found that an RDH10 deficiency in Sertoli cells, but not in germ cells, results in a mild
106 naling components have long been detected in Sertoli and germ cells in the developing and mature test
108 uncover a selective requirement for ELMO1 in Sertoli-cell-mediated removal of apoptotic germ cells an
109 ve regulatory sites around genes enriched in Sertoli and pregranulosa cells; however, active enhancer
110 led several potential modifiers expressed in Sertoli cells at the time of testis determination in mic
111 e found that WT1 and KDR are co-expressed in Sertoli cells of the testes and somatic cells of embryon
113 in the re-organization of actin filaments in Sertoli cells during the epithelial cycle, participating
114 perturbed organization of actin filaments in Sertoli cells, disruption of the blood-testis barrier an
118 uration, and formation of tight junctions in Sertoli cells, thus confirming a requirement for PPARD i
119 concomitant activation of CTNNB1 and KRAS in Sertoli cells also caused testicular granulosa cell tumo
121 permatogenesis, its specific localization in Sertoli cells makes Zbtb20 a useful marker for the ident
123 Arid4a and Arid4b are expressed mainly in Sertoli cells of testes, which implies that their roles
124 tions in the organization of microtubules in Sertoli cells and a loss of barrier integrity despite a
125 ing actin microfilaments and microtubules in Sertoli cells so that they failed to support cell adhesi
128 orphology and the position of the nucleus in Sertoli cells were normal, however, in the nesprin-3-kno
130 in, or the use of a synthetic F5 peptide, in Sertoli cells with an established functional blood-testi
131 elial ovarian tumors (29%), predominantly in Sertoli-Leydig cell tumors (26 of 43, or 60%), including
134 SHR ablation also caused small reductions in Sertoli cell numbers up to day 20 with more marked effec
136 ate that Ins2 is a direct target of Rhox5 in Sertoli cells, and we show that this regulation is physi
138 of testes, which implies that their roles in Sertoli cell function are to support spermatogenesis and
141 e mechanisms controlled by LKB1 signaling in Sertoli cell functions and testicular biology have not b
144 that proper regulation of Notch signaling in Sertoli cells is required for the maintenance of gonocyt
145 constitutively activating NOTCH signaling in Sertoli cells leads to premature differentiation of all
146 central component of TGF-beta signaling, in Sertoli cells led to testis cord dysgenesis and prolifer
148 of the transcription factors SRY and SOX9 in Sertoli cells lead to human sex reversal diseases with a
149 Here we show that after ablation of Sox9 in Sertoli cells of adult, fertile Sox8(-/-) mice, testis-t
150 ressing its dominant-negative mutant T17N in Sertoli cell epithelium was shown to block the TGF-beta3
151 c deletion of transcription factor Zbtb20 in Sertoli cells has no apparent influence on spermatogenes
152 stis barrier (BTB), PFOS was found to induce Sertoli cell injury by perturbing actin cytoskeleton thr
155 rected], was found to block the PFOS-induced Sertoli cell injury by rescuing the PFOS-induced F-actin
159 mmed juvenile and adult granulosa cells into Sertoli-like cells, triggering formation of structures r
161 leads to malfunction of the somatic (Leydig, Sertoli) cells and consequent downstream TDS disorders.
162 gnaling protein that is required to maintain Sertoli cell function and could serve as a novel target
164 sexual cell-fate reprogramming in which male Sertoli cells transdifferentiate into their female equiv
166 of PPARD inhibited proliferation of a mouse Sertoli cell line, TM4, and an inverse agonist of PPARD
168 s of the DMRT1 transcription factor in mouse Sertoli cells, even in adults, activates Foxl2 and repro
169 Changes in PGD2 secretion in juvenile mouse Sertoli cells (SC5 cells) were measured using an ELISA.
170 staglandin D2 (PGD2) inhibition in SC5 mouse Sertoli cells, evidence of binding at the COX-2 active s
173 tion of this approach, we identified a novel Sertoli cell enhancer upstream of Wt1, and used it to dr
175 erstitial progenitors, through the action of Sertoli cell-derived Hedgehog signals, become positive f
176 s development is solely under the control of Sertoli cells, by uncovering an active and essential rol
177 unction restructuring in primary cultures of Sertoli cells isolated from rat testes that formed a TJ-
178 cells, with likely secondary degeneration of Sertoli cells, including the blood-testis barrier, which
179 s, SOX9 is required for the determination of Sertoli cells that orchestrate testis morphogenesis.
180 nsequently, this prevented the disruption of Sertoli cell TJ permeability barrier and redistribution
181 fects are correlated with a dysregulation of Sertoli-expressed genes that are required for germ cell
187 tion and MNG induction appears to be loss of Sertoli cell-germ cell membrane adhesion, probably due t
188 I of meiosis but does inhibit maturation of Sertoli cells, which continue to express the immaturity
191 ation of plectin to the nuclear perimeter of Sertoli cells, the resulting link between the nuclear en
192 BTB in the rat testis and the phenotypes of Sertoli cell-conditional Cx43 knockout mice share many o
193 nockout mice (SCSKO), a normal population of Sertoli cells was observed, but the blood-testis barrier
195 ysis revealed that the expression program of Sertoli cells is altered upon inactivation of Sin3A in g
203 ating step for 1 month were transferred onto Sertoli feeder cells, they differentiated into functiona
204 an testes, the blood-testis barrier (BTB) or Sertoli cell barrier created by specialized junctions be
208 (GODZ; also known as DHHC3) and its paralog Sertoli cell gene with a zinc finger domain-beta (SERZ-b
209 ired phagocytosis by specialized phagocytes: Sertoli cells and the retinal pigmented epithelium (RPE)
211 re the basal membranes of adjacent polarized Sertoli cells form a niche for the proliferating spermat
213 provide evidence, based on an embryonic pre-Sertoli cell line, that this domain functions at a thres
214 ending are unaffected in a rat embryonic pre-Sertoli cell line, the variants exhibited selective defe
215 pe A, Int, B spermatogonia as well as in pre-Sertoli cells and Leydig cells but was undetectable in s
216 s is initiated when expression of Sry in pre-Sertoli cells directs the gonad toward a male-specific f
218 ific siRNA duplexes was performed in primary Sertoli cell cultures with an established TJ permeabilit
219 n impaired the cell junctions of the primary Sertoli cells and failed to support the clonal formation
225 -testis barrier (BTB) involved in regulating Sertoli cell adhesion via its effects on the occludin-zo
226 n reducing occupancy of DNA sites regulating Sertoli-cell differentiation [the testis-specific SRY-bo
230 s strands of tight junctions between somatic Sertoli cells that restricts solutes from crossing the p
232 sites during sex determination, we subjected Sertoli cells from mouse fetal testes to DNaseI-seq and
233 a without direct contact with the supporting Sertoli cells, we show that haploid spermatids express t
241 rmatid (apical ES) interface, as well as the Sertoli cell-cell (basal ES) interface at the blood-test
242 d via changes in protein distribution at the Sertoli and Sertoli-germ-cell cell interface and by phos
244 ed by changes in F-actin organization at the Sertoli cell BTB in vitro and in vivo, associated with a
249 pecific, actin-rich adherens junction at the Sertoli cell-spermatid interface) to coordinate cellular
250 n led to a redistribution of occludin at the Sertoli-Sertoli cell interface, moving from cell membran
252 (ii) anchoring junction restructuring at the Sertoli-spermatid interface induced by adjudin which mim
253 testes, most notably at the apical ES at the Sertoli-spermatid interface, and expressed stage-specifi
256 rmer promoting and the latter disrupting the Sertoli cell tight junction-permeability barrier functio
257 ecise organization of binding motifs for the Sertoli cell reprogramming factors SOX9, GATA4 and DMRT1
258 rier, recapitulated the defects found in the Sertoli cell-specific androgen receptor (AR) knockout mi
261 ha2 in Sertoli cells was shown to induce the Sertoli cell tight junction permeability barrier disrupt
264 e (FSH) acts through receptors (FSHR) on the Sertoli cell to stimulate spermatogenesis while androgen
266 testis growth through receptors (AR) on the Sertoli cells, Leydig cells and peritubular myoid cells.
267 L-1alpha (100 pg/ml) was shown to "open" the Sertoli cell barrier when its integrity was assessed by
269 ed in vitro by RNAi was found to perturb the Sertoli cell tight junction-permeability function in vit
270 n of rictor by RNAi was found to perturb the Sertoli cell TJ-barrier function in vitro and the BTB in
272 The removal of calcium by EGTA perturbed the Sertoli cell tight junction barrier, but calcium repleti
273 a transient loss of plastin 3 perturbed the Sertoli cell tight junction-permeability barrier, mediat
274 ter the knockdown of both Cx43 and PKP2, the Sertoli cell TJ barrier function was perturbed transient
275 which is known as apical ES and possibly the Sertoli-Sertoli cell interface, known as basal ES, at th
276 t overexpression of Cx43 indeed resealed the Sertoli cell tight junction-permeability barrier based o
278 icrofilament, thereby failing to support the Sertoli cell morphology and adhesion protein complexes (
281 on than androgen action mediated through the Sertoli cells although androgen action through other cel
284 ecruitment of actin-related protein 3 to the Sertoli cell-cell interface, where it became more tightl
285 nd GATA4, whereas SOX9 was restricted to the Sertoli precursors and LHX9 to the coelomic epithelium a
289 ntation in the epithelium, and a "tightened" Sertoli cell TJ permeability barrier, supporting the rol
291 l-cell adhesions of developing germ cells to Sertoli nurse cells, with likely secondary degeneration
292 e caused, at least partly, by disruptions to Sertoli cell function and increased germ cell apoptosis,
294 s, there is evidence of pregranulosa cell-to-Sertoli cell transdifferentiation near birth, following
295 e fetal Leydig cells that acts directly upon Sertoli cells to promote their proliferation during late
300 interactions of other testicular cells with Sertoli cells and to test novel antivirals for clearing
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