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1 veness to treatment with levodopa-carbidopa (
Sinemet).
2 ecrease in adverse responses seen at the mid-
Sinemet (
250 mg levodopa-25 mg carbidopa) dose level.
3 The response to
Sinemet did not change after intracerebroventricular veh
4 The present study has evaluated GDNF-
Sinemet interactions in parkinsonian rhesus monkeys.
5 Sinemet is currently the most widely used drug for treat
6 nation with a suprathreshold dose of L-DOPA (
Sinemet(
R)) in 22 patients with Parkinson's disease (16
7 Adverse responses to
Sinemet treatment alone in parkinsonian animals included
8 Thus, combined GDNF-
Sinemet treatment could be of therapeutic value in treat
9 Combined GDNF-
Sinemet treatment significantly reduced the occurrence o
10 ponse and by mitigating adverse responses to
Sinemet treatment.
11 Both GDNF and
Sinemet,
when given alone, significantly improved total
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