ライフサイエンスコーパス: Smad4 protein

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1 rCP1 suppression increases the expression of Smad4 protein.

2 l determinant for the protein degradation of Smad4 protein.

3 480 cells, which express mutant K-Ras but no smad4 protein.

4 e R-Smad1, R-Smad5, I-Smad6, I-Smad7, and Co-Smad4 proteins.

5 aled a correlation between downregulation of Smad4 protein and downregulation of the Brca1 and Rad51

6 vide the first linkage between the Smad3 and Smad4 proteins and TGFbeta stimulation of type I collage

7 Smad2, Smad3, and Smad4 proteins are important mediators of the antiprolif

8 The mutant SMAD4 proteins are predicted to be truncated at the carb

9 ion of uPA levels was lost upon depletion of Smad4 protein by RNA interference.

10 Here we show that Smad3 and Smad4 proteins can bind to two distinct sites within the

11 lytical ultracentrifuge studies on Smad3 and Smad4 protein constructs are presented to clarify the mo

12 oring Smad4 point mutations, exhibited rapid Smad4 protein degradation due to the effect of SCF(beta-

13 n (E3) ligase, is a critical determinant for Smad4 protein degradation in pancreatic cancer cells.

14 d4 mutants, we found that most point-mutated Smad4 proteins, except those within or very close to a m

15 Loss of Smad4 protein expression is correlated with poor prognos

16 SMAD3 and SMAD4 protein expression were also upregulated suggestin

17 d a series of polyps from these patients for SMAD4 protein expression.

18 en of thirty-two MSI(-) lines showed loss of SMAD4 protein expression; usually, one allele was lost a

19 ines that stably express wild-type or mutant Smad4 proteins fused to a murine estrogen receptor domai

20 anced interaction with the MH1 region of the Smad4 protein, indicating that an increased intramolecul

21 We explored an inducible system in which Smad4 protein is activated by translocation to the nucle

22 immunostaining revealed that the presence of Smad4 protein is associated with the presence of Snail a

23 Very low Smad4 protein levels in human pancreatic ductal adenocar

24 igonucleotides (MOs) to knockdown endogenous Smad4 protein levels, we discovered that Smad4beta was r

25 The candidate prognostic biomarkers, SMAD4 protein loss (P=.01) in tumor cells and microRNA-2

26 deling of HP and prognostic biomarkers, only SMAD4 protein loss was significant (hazard ratio, 9.3; P

27 No MSI(+) cancer showed loss of SMAD4 protein or SMAD4 mutation, and very few had alleli

28 g sequences were also able to bind Smad3 and Smad4 proteins purified in vitro.

29 ated degradation, yet the precise control of Smad4 protein stability is unclear.

30 Two tumor-derived mutant Smad4 proteins that fail to mediate TGF-beta responses w

31 Loss of smad4 protein was confirmed by functional studies.

32 Very little smad4 protein was detected in these cells.

33 sequence of the conserved MH1/MH2 domains of Smad4 proteins, which were used in PCR to amplify a 137-

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