ライフサイエンスコーパス: Src family

1 sites, including those that are dependent on Src family and FGFR kinase activity.

2 ent study, we show that CLEC-2 signaling via Src family and Syk tyrosine kinases promotes platelet ad

3 d, proximal cysteine (Cys277) found in three Src-family and six unrelated kinases.

4 Src-family and Syk kinases determine the structure of th

5 hanced neutrophil integrin signaling through Src-family and Syk kinases, whereas autoimmunity resulte

6 bosutinib, and saracatinib that target ABL, SRC-family, and numerous other kinases.

7 Nonreceptor tyrosine kinases of the Src family are large multidomain allosteric proteins tha

8 uding the p160 steroid receptor coactivator (SRC) family composed of SRC-1 (NCOA1), SRC-2 (TIF2/GRIP1

9 tion via ANT proteins and leads to transient src family-dependent tyrosine phosphorylation of L1, ANT

10 oved multikinase inhibitor that also targets Src family, dramatically attenuated the spontaneous and

11 By using an MT1-MMP Y573A mutant or the Src family inhibitor PP2, we observed that the previousl

12 rs successfully predicted TERT repression by Src-family inhibitor SU6656 and lack of repression by ER

13 g the tyrosine phosphorylation of C-Raf with Src family inhibitors blocks growth, basal dimerization,

14 izing cellular dynamics, we demonstrate that Src family isoforms produce very different phenotypes, e

15 Finally, we demonstrated that JAM-C controls Src family kinase (SFK) activation in LSC and that LIC w

16 Ls) to open the paracellular pathway through Src family kinase (SFK) activation.

17 Moreover, we present in vivo evidence that Src family kinase (SFK) activity is critical for PCP reg

18 the autophosphorylation site tyrosine in the SRC family kinase (SFK) FYN as well as Tyr142 in beta-ca

19 ro model of dormancy to evaluate the role of Src family kinase (SFK) in regulating this dormant-to-pr

20 Accordingly, inhibitors such as the SRC family kinase (SFK) inhibitor dasatinib reduced pPLC

21 s study, we show that the pyrrolo-pyrimidine Src family kinase (SFK) inhibitor PP2 effectively promot

22 tivation was completely abolished by the pan-Src family kinase (SFK) inhibitor, PP2, or when Syk is i

23 was inhibited in the presence of PP2, a pan-src family kinase (SFK) inhibitor, suggesting that c-Cbl

24 e AR by an alpha7 agonist was inhibited by a Src family kinase (SFK) inhibitor.

25 Previously, we found that the Src family kinase (SFK) Lyn functions as a redox sensor

26 uced H2O2 is detected by the redox-sensitive Src family kinase (SFK) Lyn within the responding blood

27 mutation in the inhibitory SH2 domain of the SRC family kinase (SFK) LYN.

28 lar permeability attributable to loss of the Src family kinase (SFK) Lyn.

29 tment of neutrophils through redox-regulated Src family kinase (SFK) signaling in neutrophils.

30 alternative signaling activation mechanisms, Src family kinase (SFK) signaling is sufficient to trans

31 ined that CRKL signaling was associated with SRC family kinase (SFK) signaling, specifically with YES

32 resulted in increased phosphorylation of the SRC family kinase (SFK) YES, increased expression of WNT

33 domain triggered PEAR1 phosphorylation in a src family kinase (SFK)-dependent manner.

34 crophages is, in addition, contributed to by Src family kinase (SFK)-dependent pathways.

35 glioblastoma, promotes tumorigenesis through Src family kinase (SFK)-dependent phosphorylation of Doc

36 educed GPVI expression and signaling via the Src family kinase (SFK)-Syk-PLCgamma2 pathway, and fibri

37 ne lipid rafts, leading to the activation of Src Family Kinase (SFK)/hemopoietic cell kinase (Hck) an

38 demonstrate the activation of PLCgamma by a Src family kinase (SFK1) during NE assembly.

39 e carcinoma is associated with activation of SRC family kinase (SRC, YES, FYN) activity and loss of c

40 We identified Src family kinase activation mediated by mu-receptors as

41 These effects require Src family kinase activation, a classic LRP1-mediated Tr

42 cription and secretion through inhibition of Src family kinase activation, particularly Lck, downstre

43 The second-stage binding requires Src family kinase activity to initiate CD8 binding to th

44 induces CaM phosphorylation at Tyr(99) by a Src family kinase and that phosphorylated CaM activates

45 or tyrosine kinases and EGF receptor, with a Src family kinase as a required intermediate.

46 signals through an evolutionarily conserved Src family kinase cascade to drive cytoskeletal rearrang

47 of Eps8 aimed to identify specific FGFR and Src family kinase dependent phosphosites and co-associat

48 ess (0.1-0.4 kPa), and such ILP formation is Src family kinase dependent.

49 tion increased receptor association with the Src family kinase Fgr and shifted signals from the adapt

50 In this study, the participation of the Src family kinase Fyn in the production of TNF after sti

51 he slit diaphragm and transduce signals in a Src family kinase Fyn-mediated tyrosine phosphorylation-

52 gh formation of a signaling complex with the Src family kinase Fyn.

53 motif of ADAP, a known docking site for the Src family kinase Fyn.

54 cells, and these genes include seven of nine Src family kinase genes, FGFR1, FGFR2, ITK, NTRK1, NTRK2

55 r 3 uses templated catalysis to redirect the Src family kinase Hck to phosphorylate hDM2, a negative

56 The Src family kinase Hck, Wiskott-Aldrich-syndrome protein,

57 Aberrant activation of the SRC family kinase hematopoietic cell kinase (HCK) trigge

58 thermore, MCR-independent phosphorylation of Src family kinase induces IgF1 receptor phosphorylation,

59 rylation is compromised in the presence of a Src family kinase inhibitor and when the SH3 domains of

60 igh levels of pY128Cas are more sensitive to SRC family kinase inhibitor Dasatinib.

61 Here, we sought to repurpose the Src family kinase inhibitor oncology compound, AZD0530,

62 The Src family kinase inhibitor PP2 blocked injury-induced t

63 regulated kinase (ERK1/2) was blocked by the Src family kinase inhibitor PP2, indicating that the act

64 , and cerebrospinal fluid penetration of the Src family kinase inhibitor saracatinib in patients with

65 ng to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulate al

66 The Src Family kinase Lck sets a critical threshold for T ce

67 fts function in the phosphoregulation of the Src family kinase Lck.

68 cancer cells feature high expression of the Src family kinase Lyn that has been implicated in the pa

69 g, they did so by opposite regulation of the Src family kinase Lyn.

70 onocytes and that inhibition of the MAPK and Src family kinase pathways blocked the ability of CD4 li

71 The latter event is mediated by Lyn, a Src family kinase previously found to be overexpressed,

72 lly, phospho-specific staining for Zap70 and Src family kinase proteins suggests that sensing of subs

73 ng the underlying actin cytoskeleton through Src family kinase signaling and m-Tor-dependent protein

74 cones responses involve the potentiation of Src family kinase signaling, a common effector of both p

75 moattraction, or by pharmacological block of Src family kinase signaling, consistent with receptor re

76 quitination of Ag.BCR complexes occurs by an Src family kinase signaling-dependent mechanism that is

77 n-like growth factor receptor signaling, and SRC family kinase signaling.

78 We have previously demonstrated that the Src family kinase Yes, the Yes-associated protein (YAP)

79 c studies showed that these TKIs inhibit the Src family kinase Yes1, which was found to be essential

80 er kinetics of Erk1/2 activation through the src family kinase(s)-Syk signaling pathway.

81 orylation of Syk, Akt, and ERK, but not SFK (Src family kinase), was significantly reduced in RhoG-de

82 leading to integrin activation via the SFK (Src family kinase)-Syk (spleen tyrosine kinase)-PLCgamma

83 5beta1 integrin and the acylated form of the Src family kinase, Fyn, to lipid rafts.

84 siRNA-mediated suppression of Fyn, a Src family kinase, inhibited VSM cell motility.

85 Delta;Y567F/Y567F) knock-in mice lacking the SRC family kinase-binding site on KIT (pY567) exhibited

86 endogenous ROS activate TrkB signaling by a Src family kinase-dependent but brain-derived neurotroph

87 estricts TGF-beta1 secretion in a Cdc42- and Src family kinase-dependent manner and independently of

88 In stiff matrices, prolactin increased SRC family kinase-dependent phosphorylation of focal adh

89 presence of epidermal growth factor (EGF) by Src family kinase-mediated phosphorylation on c-Abl-Tyr4

90 Blockade of Src family kinase-mediated WASp Tyr-291/Tyr-293 phosphor

91 ptor type-protein tyrosine phosphatase alpha-Src family kinase-Rap1 pathway as responsible for recrui

92 gulated proliferative response by activating Src family kinase.

93 been shown to confer enhanced sensitivity to SRC-family kinase (SFK) inhibitors in other malignancies

94 CD8 associates with the Src-family kinase (SFK) Lck, which, in turn, initiates t

95 Here we report that the Src-family kinase (SFK) regulator CD148 has a unique and

96 ation through receptor tyrosine kinase (RTK)/SRC-family kinase (SFK) signaling or mutant NRAS, which

97 Together, these findings suggest that Src-family kinase activation, NMDAR stimulation, and lik

98 These results support a model in which Src-family kinase binding induces conformational changes

99 arget peptide from an unrelated protein, the Src-family kinase Fyn.

100 s with the SH3 or the SH3-SH2 domains of the Src-family kinase Hck.

101 We further hypothesized that src-family kinase inhibition would improve barrier funct

102 sed the effect of TNF-alpha, with or without src-family kinase inhibitor SU6656, on barrier propertie

103 imulated with antigen in the presence of the src-family kinase inhibitor, PP2.

104 t; 0.25 or 2.5 mug/0.5 mul/hemisphere), PP2 (Src-family kinase inhibitor; 6.25 or 62.5 ng/0.5 mul/hem

105 Our previous work showed that the src-family kinase Lck is a targetable mediator of BCR si

106 In this article, we show that the Src-family kinase LCK, but not FYN, associates with NTB-

107 e tyrosine-phosphorylated by Pyk2, bound the Src-family kinase Lyn and linked TLR9 to a Src-kinase Sy

108 Upon Fc receptor activation, Src-family kinase signaling leads to segregation of Fcga

109 trated by independent association of the Lyn Src-family kinase with an intracellular immunoreceptor t

110 orthologue of Syk, and Src42A, a Drosophila Src-family kinase, and is dependent on Nox activity.

111 PPARgamma by inhibiting the activity of the Src-family kinase, Fyn.

112 Thus, extracellular actin detection via a Src-family kinase-dependent cascade is an ancient means

113 nduced CLEC-2 immunodepletion occurs through Src-family kinase-dependent receptor internalization in

114 se activation, NMDAR stimulation, and likely Src-family kinase-mediated NR2B subunit-containing NMDAR

115 hermore, the trophic factor S100beta induces Src-family kinase-mediated tyrosine phosphorylation of h

116 d DC activation occurred within minutes in a Src-family-kinase- and CD18-integrin-dependent manner.

117 Here we report that Src family kinases (SFK) and focal adhesion kinase (FAK)

118 The Src family kinases (SFK) and insulin-like growth factor-

119 tion of type-1 TNF receptors, recruitment of Src family kinases (SFK) and SFK-dependent phosphorylati

120 Focal adhesion kinase (FAK) and Src family kinases (SFK) are known to play critical role

121 Here we show the role of Src family kinases (SFK) in mouse and human pDCs.

122 Src family kinases (SFK) integrate signal transduction f

123 ORF4 protein (E4orf4) subverts signaling by Src family kinases (SFK) to perturb cellular morphology,

124 ER2 are activated through phosphorylation by Src family kinases (SFK).

125 d by PDGF, reactive oxygen species (ROS) and Src family kinases (SFKs) act downstream of PDGFRs to en

126 Src family kinases (SFKs) activation is required for int

127 hese receptors lacking the binding sites for Src family kinases (SFKs) and phosphatidylinositol-3-kin

128 engagement of LFA-1 led to the activation of SRC family kinases (SFKs) and SFK inhibition blocked cyt

129 e, we report that RUNX1 is phosphorylated by Src family kinases (SFKs) and that this occurs on multip

130 The SRC family kinases (SFKs) and the receptor tyrosine kina

131 Src family kinases (SFKs) are involved in both NMDA-medi

132 both fibroblast growth factor receptors and SRC family kinases (SFKs) but does not affect the abilit

133 The Src family kinases (SFKs) c-Src and Yes mediate vascular

134 oblastoma (GBM), the EGF receptor (EGFR) and Src family kinases (SFKs) contribute to an aggressive ph

135 The Src family kinases (SFKs) Lck, Hck, and Fgr directly pho

136 Src family kinases (SFKs) play a central role in mediati

137 The Src family kinases (SFKs) play essential roles in collag

138 tyrosine phosphorylation indicated that, the Src family kinases (SFKs) were found to phosphorylate CD

139 The interactions of Src family kinases (SFKs) with the plasma membrane are c

140 This process was mediated by Src family kinases (SFKs), and nuclear EGFR had a role i

141 Anoxia or exogenous NMDA activated Src family kinases (SFKs), as measured by increased phos

142 d this, we identified the involvement of the Src family kinases (SFKs), based upon the ability of SFK

143 ion of the C-terminal inhibitory tyrosine of SRC family kinases (SFKs), implicating CD148 as a critic

144 induced by IGF-1 can occur in cells lacking Src family kinases (SFKs), indicating that an unknown ki

145 r of the group of tyrosine kinases named the Src family kinases (SFKs), is overexpressed, associated

146 , and subsequent TSAd-mediated activation of Src family kinases (SFKs), SFKs engage the receptor tyro

147 telet activation signals in conjunction with Src family kinases (SFKs), spleen tyrosine kinase (Syk),

148 PECAM-1 transduces forces to activate src family kinases (SFKs), which phosphorylate and trans

149 ition and substrate recognition of the eight Src family kinases (SFKs).

150 downregulated the expression and activity of Src family kinases (SFKs).

151 ctivation of kinases, Syk acts downstream of Src family kinases (SFKs).

152 phorylation of the tyrosines in the ITAMs by Src family kinases (SFKs).

153 urn is required to activate VEGFR2-recruited SRC family kinases (SFKs).

154 CD38, via Src family kinases and adapters, interacts with a MAPK s

155 lusive interaction between SRC but not other Src family kinases and FLT3-ITD, which is mediated by th

156 sites depends on the direct interaction with Src family kinases and is upstream of the activation by

157 e co- or posttranslational myristoylation of Src family kinases and other oncogenic proteins, thereby

158 ls through a signaling pathway that involves Src family kinases and p38 MAPK.

159 resulted in the following: 1) activation of Src family kinases and Syk revealed by their recruitment

160 activation was dependent on PKA and required Src family kinases and the Rap1 exchanger C3G.

161 etwork revealed decreased phosphorylation of Src family kinases and their targets.

162 e function of Csk as a negative regulator of Src family kinases appears to have arisen with the emerg

163 Src family kinases are required for normal PEAK1 localiz

164 Src family kinases are required for the generation of th

165 Src family kinases are thought to be major signaling eff

166 e not accompanied by the expected decline of Src family kinases but were accompanied by Akt-mammalian

167 Pharmacological inhibition of Src family kinases by SKI-606 (bosutinib) induces C/EBPd

168 ylation of a neighboring tyrosine residue by Src family kinases disrupts COP1 binding, thereby stabil

169 Inhibition of Src family kinases efficiently reduces the interaction o

170 Three major Src family kinases found in T cells (Lck, Fyn, and Lyn)

171 splaying high potency and selectivity toward SRC family kinases have been developed by combining liga

172 Mice lacking the Src family kinases Hck, Fgr, and Lyn in the hematopoieti

173 on neutrophils, P-selectin on platelets, and Src family kinases in both cell types.

174 THrP elevated Y418 phosphorylation levels in Src family kinases in CD11b(+)Gr1(+) cells via osteoblas

175 Interestingly, it also positively regulates Src family kinases in hematopoietic and endothelial cell

176 CDCP1 is phosphorylated by Src family kinases in its full-length and cleaved states

177 morphology changes, which are independent of SRC family kinases in Src-/-, Yes-/-, Fyn-/- (SYF) mouse

178 The possible roles of Src family kinases in the enhanced malignant properties

179 osignaling and control of RhoA and implicate Src family kinases in the regulation of p115 RhoGEF.

180 demonstrate that YY1 is a target of multiple Src family kinases in vitro and in vivo.

181 leles exhibited a greater sensitivity to the Src family kinases inhibitor dasatinib in response to co

182 Among Src family kinases only Yes, not Fyn or Src, was functio

183 tein that can function by the recruitment of Src family kinases or by competition with phosphatases.

184 nd is therefore capable of signaling without SRC family kinases or stimulation of the T cell receptor

185 Although Src family kinases participate in leukocyte function in

186 urs via a novel, sequential process in which Src family kinases phosphorylate the C-terminal ITIM, th

187 In the second phase, Src family kinases phosphorylate tyrosyl residues within

188 We show that Src family kinases play a critical role in myeloid cell-

189 Increased activity of SRC family kinases promotes tumor invasion and metastasi

190 er, the identification of YY1 as a target of Src family kinases provide key insights into the inhibit

191 In addition, phosphorylation of Src family kinases significantly increased after stimula

192 -alphavbeta3 coupling altered recruitment of Src family kinases to adhesion complexes and impaired me

193 Moreover, the activatory phosphorylation of Src family kinases was considerably delayed as well as t

194 Instead, Src family kinases were required for the generation of t

195 Saracatinib, a specific inhibitor of Src family kinases, administered at low doses during the

196 nd treatment with dasatinib, an inhibitor of Src family kinases, also mimics the effects of versican.

197 ultimerization of DCC, activation of FAK and Src family kinases, and increases in exocytic vesicle fu

198 required for TGFbeta1-mediated activation of Src family kinases, and Src inhibition blocked both pY65

199 at the tyrosine residue is phosphorylated by Src family kinases, and that Src-activation limits surfa

200 Furthermore, TNFalpha, via SRC family kinases, increases pro-proliferative NOTCH2 s

201 he PSGL-1-L-selectin complex signals through Src family kinases, ITAM domain-containing adaptor prote

202 Specifically, Src family kinases, NCK1 and Vav1, bound to the Tyr(P)(1

203 e with ActApo, including p38, JNK, PI3K-Akt, Src family kinases, NFkappaB p65, and AP1 transcription

204 he signaling through spleen tyrosine kinase, Src family kinases, phosphatidylinositol-3-kinase, and p

205 signaling pathways mediated by RhoA/ROCK and Src Family Kinases, respectively.

206 wo GEFs are further regulated by FAK/ERK and Src family kinases, respectively.

207 Nef binds to the Src homology 3 domains of Src family kinases, resulting in kinase activation impor

208 3BP2 is required for optimal activation of Src family kinases, small GTPase Rac2, neutrophil supero

209 This in turn activates the Src family kinases, spleen tyrosine kinase and PLCgamma2

210 fic contribution of c-Src, one member of the Src family kinases, was demonstrated using c-Src-deficie

211 gnificant homology with other members of the Src family kinases, which may lead to unintended off-tar

212 Phosphorylation of paxillin by Src family kinases, which regulates adhesion turnover, i

213 ivating components in the network, including Src family kinases, whose inhibition affects only a subs

214 and provide insights into transformation by Src family kinases.

215 ells phosphorylates SLP-76 in the absence of SRC family kinases.

216 g Abl localization and Abl/Arg activation by Src family kinases.

217 yrosine phosphorylation on FcRgamma chain or Src family kinases.

218 osphorylating the inhibitory tyrosine of the Src family kinases.

219 inding region of M2 and its interaction with Src family kinases.

220 osphorylating the inhibitory tyrosine of the src family kinases.

221 d cortactin were identified as substrates of Src family kinases.

222 s suggest a role of GD3 in the regulation of Src family kinases.

223 ested that this occurs through inhibition of Src family kinases.

224 ed production of ROS that was independent of Src family kinases.

225 le phosphorylation and activation of PI3K by Src family kinases.

226 ng the C-terminal inhibitory tyrosine of the src family kinases.

227 erimentally observed association of BCR with Src-family kinases (10-20 s).

228 ase (Csk), the primary negative regulator of Src-family kinases (SFK), plays a crucial role in contro

229 Multiple SRC-family kinases (SFKs) are commonly activated in carc

230 le of phosphoinositide 3-kinases (PI3Ks) and Src-family kinases (SFKs) in these responses using human

231 increased expression of c-Cbl, Vav1, and the Src-family kinases (SFKs) Lyn and Fgr.

232 haride-induced cell migration, activation of Src-family kinases (SFKs), and phosphorylation of focal

233 cell antigen receptor (TCR) is initiated by Src-family kinases (SFKs).

234 tering of receptors, which in turn activates Src-family kinases (SFKs).

235 factor-beta (TGF-beta), RhoA/Rho-kinase and Src-family kinases (SrcFK) have independently been impli

236 Amongst these are the Src-family kinases (SrcFKs), a multi-functional group of

237 analysis showed that SHP2 activates several SRC-family kinases and downstream targets, most of which

238 ion of integrins and involves stimulation of Src-family kinases and focal adhesion kinase, as well as

239 The synthesis of ROS by oxLDL/CD36 required Src-family kinases and protein kinase C (PKC)-dependent

240 DNGR-1 is phosphorylated by Src-family kinases and recruits the tyrosine kinase Syk

241 the specific requirement of HCK p59 and FGR src-family kinases for FCRL4-mediated immunomodulatory a

242 -based cells express increased levels of the src-family kinases HCK and FGR.

243 his study, we investigate the roles of these src-family kinases in FCRL4-mediated immunoregulation of

244 Thus, Src-family kinases in the DH may similarly control conte

245 encodes a tyrosine phosphatase that inhibits Src-family kinases responsible for Ag receptor signaling

246 either the SH3 or tandem SH3-SH2 domains of Src-family kinases reveal distinct dimer conformations o

247 ithin RECs by elevating ROS, which activated Src-family kinases that stimulated the extracellular sig

248 activation and intracellular localization of SRC-family kinases, especially FYN and LYN.

249 c-Src is a tyrosine kinase belonging to the Src-family kinases.

250 r for C-terminal SRC kinase, an inhibitor of SRC-family kinases.

251 host cell effectors, including Hck and other Src-family kinases.

252 inding affinities of Gleevec between the two Src-family kinases.

253 s activity does not appear to be mediated by Src-family kinases.

254 gage cytoplasmic signaling molecules such as Src-family kinases.

255 tinib, a clinical Bcr-Abl inhibitor, targets Src-family kinases.

256 models, mainly because of the redundancy of Src family members and the importance of BCR signaling f

257 Recently, we found that activation of the Src family nonreceptor tyrosine kinase Fyn in oligodendr

258 aracterize the molecular associations of the SRC family of coactivators with other protein complexes

259 ecent experiments have demonstrated that the Src family of kinases plays an important role in the reg

260 ade of phosphorylated proteins including the SRC family of kinases.

261 late neurogenesis.SIGNIFICANCE STATEMENT The Src family of nonreceptor tyrosine kinases acts in signa

262 nt procedure to test the hypothesis that the Src family of tyrosine kinases (SFK) in the dorsal hippo

263 The Src family of tyrosine kinases (SFKs) regulate numerous

264 rthermore, in vitro studies suggest that the Src family of tyrosine kinases critically regulates glut

265 In addition, we found that members of the Src family of tyrosine kinases were required for CVB ent

266 al Src kinase (CSK), a negative regulator of Src family of tyrosine kinases.

267 mic adaptor protein Dab1, Src and Fyn of the Src-family of non-receptor protein tyrosine kinases, and

268 Fyn is a member of the Src-family of nonreceptor protein-tyrosine kinases.

269 , including several oncogenes of the Ras and Src families, palmitoylation is indispensable for protei

270 was blocked in cultured microglia by PP2, a Src family protein tyrosine kinase inhibitor.

271 loops emanating from Lyn and Fyn, which are Src family protein tyrosine kinases (SFKs).

272 1), and this inhibition is attenuated by the Src-family protein tyrosine kinase (SFK).

273 -3'-kinase, protein tyrosine kinases (PTKs), Src family PTK, focal adhesion kinase, Rho GTPase Rac1,

274 addition, it highlights a potential role for Src family signaling in this progenitor subtype of HCC.

275 erential downstream kinase signaling through SRC family-TNK2 or JAK kinases and differential sensitiv

276 We identified an IL-2-JAK-independent SRC family Tyr-kinase-controlled signaling network that

277 face expression of TrkB that is inhibited by Src family tyrosine kinase and A2A receptor antagonists.

278 The protein Lck (p56(Lck)) is a Src family tyrosine kinase expressed at all stages of th

279 we show that Tim-3 can directly bind to the Src family tyrosine kinase Fyn and the p85 phosphatidyli

280 In this study, we show evidence that the Src family tyrosine kinase Fyn helps regulate this Th17/

281 rization and invasion were blocked by PP2, a Src family tyrosine kinase inhibitor.

282 a TCR-associated complex, which includes the Src family tyrosine kinase Lck.

283 hrough the phosphorylation and activation of Src family tyrosine kinase members, such as Fyn, that ph

284 rough its downstream, intracellular Dab1 and Src family tyrosine kinase signaling cascade, is essenti

285 We identified an Src family tyrosine kinase, hematopoietic cell kinase (H

286 Here, we determined that FYN, a Src family tyrosine kinase, interacts with the C-termina

287 phosphorylated forms of BCR-signaling nodes (Src family tyrosine kinase, spleen tyrosine kinase [SYK]

288 In addition to Abl and Src family tyrosine kinases, a number of previously unkn

289 Protein phosphatase 2A (PP2A), YAP, Src family tyrosine kinases, Shc, phosphatidylinositol 3

290 ponses can be mimicked through inhibition of Src family tyrosine kinases.

291 0) and Tyr(129), which are phosphorylated by Src family tyrosine kinases.

292 tivation motif (ITAM), which signals through Src family tyrosine kinases.

293 tase inhibition, and negatively regulated by Src-family tyrosine kinase activity, which restricts the

294 Deletion of lyn, a Src-family tyrosine kinase expressed by B, myeloid, and

295 Src-family tyrosine kinase Fyn and serine-threonine prot

296 ITAM receptors engage Src-family tyrosine kinases (SFKs) to initiate phagocyto

297 reported that mice deficient in the myeloid Src-family tyrosine kinases Hck, Fgr, and Lyn (Src tripl

298 Activation of Src-family tyrosine kinases on the Golgi is essential fo

299 Src-family tyrosine kinases play pivotal roles in human

300 Inhibiting the kinases of the SRC family, which are downstream of PGRMC1, blocked the