ライフサイエンスコーパス: Src homology 2 domain

1 PI3K by interaction with the p85 C-terminal Src homology 2 domain.

2 entral proline-rich domain, and a C-terminal Src homology 2 domain.

3 s a docking site for proteins that contain a Src homology 2 domain.

4 ound that SHIP-1 bound to Lyn via the SHIP-1 Src homology 2 domain.

5 ed with SHP-1 phosphatase via its C-terminal Src homology 2 domain.

6 ne-phosphorylated TCR zeta-chain through its Src homology 2 domain.

7 to tyrosine-phosphorylated hLnk through its Src homology 2 domain.

8 region, a pleckstrin homology domain, and a Src homology 2 domain.

9 ement requires a functional Dbl homology and Src homology 2 domain.

10 plexes with ZAP-70, Syk, and LAT through its Src homology 2 domain.

11 to tyrosine phosphorylated JAM-A through its Src homology 2 domain.

12 ion loop of the insulin receptor via the APS Src homology 2 domain.

13 ducer and activator of transcription (Stat)3 Src homology 2 domain.

14 were found in exons 21 and 20, encoding the Src homology 2 domain.

15 by a Fes-R483K mutant that incapacitates its Src homology 2 domain.

16 yrosine motifs, a proline-rich region, and a Src homology 2 domain.

17 placed by lysine, abolishing function of the Src homology 2 domain.

18 lcium-binding domain, and a non-conventional Src homology-2 domain.

19 yrosine 380 is critical for interaction with Src homology 2 domains.

20 tations affecting the pleckstrin homology or Src homology 2 domains.

21 AP) or Syk (Z/Syk) molecules lacking the two Src homology 2 domains.

22 ut are absent in other proteins that contain Src homology 2 domains.

23 h TRAF6 is mediated by SHP-1 lacking the two Src homology 2 domains.

24 catalytic domain from the N-terminal tandem Src homology 2 domains.

25 s with RAFTK through a region other than its Src homology 2 domains.

26 module, with properties similar to those of SRC homology 2 domains.

27 intracellular effector proteins that contain Src homology 2 domains.

28 gh both its collagen homologous region 2 and Src homology 2 domains.

29 nd phospholipase C (PLC)-gamma1 bind LAT via Src homology-2 domains.

30 toplasmic tyrosine phosphatase that contains Src homology 2 domains), a negative regulator of JAK2 si

31 Introduction of an Src homology 2 domain, a PH domain, or a kinase domain m

32 tein is a novel protein that contains only a Src homology 2 domain and a pleckstrin homology domain;

33 chain, which requires its functional variant Src homology 2 domain and an intact RING finger.

34 to the binding of p85 through its N-terminal Src homology 2 domain and the generation of PI-3,4,5-P(3

35 n, whereas Fyn binds to STEP(61) through its Src homology 2 domain and the unique N-terminal domain.

36 strategy we describe here is not limited to Src homology 2 domains and could be used to profile the

37 APS, which contains pleckstrin homology and Src homology 2 domains and several potential tyrosine ph

38 y) domain, SH3 (Src homology 3) domain, SH2 (Src homology 2) domain and kinase (Src homology 1) domai

39 ylation, receptor tyrosine engagement by its Src homology 2 domain, and membrane recruitment of SHIP

40 tk can directly interact with AR through its Src homology 2 domain, and such interaction may prevent

41 p65, whereas the N-terminal, linker domain, Src homology 2 domain, and transcriptional activation do

42 5, Grb2, SHP-2, Nck, or phospholipase Cgamma Src homology 2 domains, and activates MAPK in cells.

43 ion was found to be independent of PLCgamma1 Src homology 2 domains, and instead required the pleckst

44 , including antibodies, protein domains such Src homology 2 domains, and protein kinases.

45 ins: an SH3 (Src homology 3) domain, an SH2 (Src homology 2) domain, and a catalytic domain.

46 In this antiparallel structure, the Src homology 2 domains are at opposite ends of the dimer

47 Src-homology-2 domains are small, 100 amino acid protein

48 gest that tyrosine 1139 may be important for Src homology 2 domain association because a mutant lacki

49 creating docking sites for nontransmembrane, Src homology 2 domain-bearing protein tyrosine phosphata

50 ement leads to recruitment and activation of src homology 2 domain-bearing tyrosine phosphatase 1.

51 e tyrosine are not ordinarily found in other Src homology 2 domain binding motifs.

52 ously shown that a potent antagonist of Grb2 Src homology-2 domain-binding, C90, blocks growth factor

53 , and GST-pulldown studies showed that Itk's Src homology 2 domain binds directly to two phosphotyros

54 SOCS1, via its Src homology 2 domain, binds to phosphotyrosine residues

55 ivation of a reporter gene, whereas a SHIP-1 Src homology 2 domain construct resulted in an increase

56 An inhibitory peptide, which binds to the Src homology 2 domains contained in PLC-gamma without in

57 on, the chromosome 8p tumor suppressor genes Src homology 2 domain containing 4A (SH2D4A) and Sorbin

58 protein expression of the lipid phosphatases Src homology 2 domain containing inositol polyphosphate

59 Mature Tregs deficient in Src homology 2 domain containing leukocyte protein of 76

60 also exhibited intracellularly dislocalized Src homology 2 domain containing phosphatase 1 (SHP-1) a

61 Src homology 2 domain containing phosphatase 2 (SHP-2) a

62 We previously identified SHP-2 (Src homology 2 domain containing phosphatase 2) as an im

63 dly distributed pleckstrin homology (PH) and Src homology 2 domain containing protein that can bind p

64 ooth muscle cells, the transmembrane protein Src homology 2 domain containing protein tyrosine phosph

65 The Src homology 2 domain containing protein tyrosine phosph

66 Src homology 2 domain containing transforming protein (S

67 ubstrate 2 (IRS2), docking protein 1 (DOK1), Src homology 2 domain containing transforming protein 1

68 th factor receptor bound protein 2-ErbB1 and Src homology 2 domain containing transforming protein 1-

69 he tyrosine phosphatase, SHP-1, and for SHC (Src homology 2 domain containing transfroming protein 1)

70 Phosphorylation of the adaptor protein Shc (Src homology 2 domain containing) transforming protein 1

71 ustering, and signaling by means of p66 Shc (Src homology 2 domain containing), regulates the product

72 ciated with linker for activated T cells and Src homology 2-domain containing leukocyte protein of 76

73 in, we demonstrate an important role for the Src homology 2-domain containing tyrosine phosphatase (S

74 Shp2 (the Src homology-2 domain containing protein tyrosine phosph

75 show NLRP3 inflammasome stimulators trigger Src homology-2 domain containing protein tyrosine phosph

76 The Src homology-2 domain containing protein tyrosine phosph

77 nsin homologue deleted from chromosome 10 or src homology 2 domain-containing 5' inositol phosphatase

78 Although the Src homology 2 domain-containing 5' inositol phosphatase

79 3BP2 is a pleckstrin homology and Src homology 2 domain-containing adapter protein mutated

80 protein (HRF/TCTP) and protein levels of the Src homology 2 domain-containing inositol 5' phosphatase

81 B function can also be achieved by enhancing Src homology 2 domain-containing inositol 5' phosphatase

82 The Src homology 2 domain-containing inositol 5'-phosphatase

83 The Src homology 2 domain-containing inositol 5'-phosphatase

84 re, we find that endothelium express SHIP-1 (Src homology 2 domain-containing inositol 5'-phosphatase

85 Animals lacking Src homology 2 domain-containing inositol 5-phosphatase

86 Molecular mechanisms by which the Src homology 2 domain-containing inositol 5-phosphatase

87 The negative regulatory role of the Src homology 2 domain-containing inositol 5-phosphatase

88 Src homology 2 domain-containing inositol 5-phosphatase

89 phosphatase and tensin homologue (PTEN) and Src homology 2 domain-containing inositol phosphatase (S

90 phosphatase and tensin homologue (PTEN) and Src homology 2 domain-containing inositol phosphatase (S

91 oid cells causes tyrosine phosphorylation of Src homology 2 domain-containing inositol polyphosphate

92 n 1 Receptor Associated Kinase (IRAK) M, and Src homology 2 domain-containing inositol polyphosphate

93 Inpp5d (Src homology 2 domain-containing inositol-5-phosphatase

94 We determine that Src homology 2 domain-containing inositol-5-phosphatase

95 arcoma-associated transcript 2 (EAT-2) is an Src homology 2 domain-containing intracellular adaptor r

96 vation molecule-associated protein (SAP), an src homology 2 domain-containing intracellular signaling

97 Src homology 2 domain-containing leukocyte phosphoprotei

98 The Src homology 2 domain-containing leukocyte phosphoprotei

99 The adaptor protein Src homology 2 domain-containing leukocyte phosphoprotei

100 SLP-76 (Src homology 2 domain-containing leukocyte phosphoprotei

101 Mice deficient in the adaptor Src homology 2 domain-containing leukocyte phosphoprotei

102 Two hematopoietic-specific adapters, src homology 2 domain-containing leukocyte phosphoprotei

103 The adaptor protein Src homology 2 domain-containing leukocyte phosphoprotei

104 SLP-76 (Src homology 2 domain-containing leukocyte phosphoprotei

105 The Src homology 2 domain-containing leukocyte phosphoprotei

106 The Src homology 2 domain-containing leukocyte protein of 76

107 different phosphorylation kinetics and that Src homology 2 domain-containing leukocyte protein of 76

108 ignaling mediated by the cytoplasmic adaptor Src homology 2 domain-containing leukocyte protein of 76

109 P are coordinated by tyrosine-phosphorylated Src homology 2 domain-containing leukocyte protein of 76

110 ires both the ZAP-70 tyrosine kinase and the Src homology 2 domain-containing leukocyte protein of 76

111 interactions, where protein kinase C-theta;, Src homology 2 domain-containing leukocyte protein of 76

112 70-dependent tyrosine phosphorylation of the Src homology 2 domain-containing leukocyte protein of 76

113 ns of the gene encoding the scaffold protein Src homology 2 domain-containing leukocyte protein of 76

114 The SLP-76 (Src homology 2 domain-containing leukocyte protein of 76

115 icant reduction of HIV-1 virus production in Src homology 2 domain-containing leukocyte protein of 76

116 impediments to the phosphorylation of SLP76 (SRC homology 2 domain-containing leukocyte protein of 76

117 henylalanine mutation in the adaptor protein Src homology 2 domain-containing leukocyte protein of 76

118 roteins linker for activation of T cells and Src homology 2 domain-containing leukocyte protein-76 ar

119 ase-1 (SHP-1) and SHP-2, and not the adaptor Src homology 2 domain-containing molecule 1A, to the ITS

120 n of the N-terminal ITIM of PECAM-1 by other Src homology 2 domain-containing nonreceptor tyrosine ki

121 Src homology 2 domain-containing phosphatase (Shp2) is c

122 and phosphatase-deficient mice indicate that Src homology 2 domain-containing phosphatase 1 (SHP)-1,

123 The protein tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 (SHP-1) h

124 s, in which the protein tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 (SHP-1) i

125 tion dependent upon the ITIMs of CEACAM1 and Src homology 2 domain-containing phosphatase 1 (SHP-1).

126 In contrast, upregulation of the Src homology 2 domain-containing phosphatase 1 (SHP-1/PT

127 g to HVEM, recruits the tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 and reduc

128 onstitutive activity of protein kinase C and Src homology 2 domain-containing phosphatase 1.

129 identify low molecular weight inhibitors for Src homology 2 domain-containing phosphatase 2 (SHP-2) t

130 TCR signal through the tyrosine phosphatase Src homology 2 domain-containing phosphatase 2 (SHP-2).

131 Src homology 2 domain-containing phosphatase 2 (Shp2), e

132 cells through the regulation of SCF-mediated Src homology 2 domain-containing phosphatase 2 and ERK a

133 reduction in SCF-mediated phosphorylation of Src homology 2 domain-containing phosphatase 2 and ERK1/

134 In addition, DJ-1 reduced Src homology 2 domain-containing phosphatase 2 phosphata

135 and association of the tyrosine phosphatases src homology 2 domain-containing phosphatase-1 (SHP-1) a

136 n of RAW264.7 cells with a dominant negative Src homology 2 domain-containing phosphatase-1 (SHP-1)(C

137 tion in DCs by Lyn involves the phosphatases Src homology 2 domain-containing phosphatase-1 and SHIP-

138 hosphorylation and subsequent binding of the Src homology 2 domain-containing phosphatase-2, SHP-2.

139 Here we show that SHIP2 (Src homology 2 domain-containing phosphoinositide 5-phos

140 letion of the TCR-signaling adaptor molecule Src homology 2 domain-containing phosphoprotein of 76 kD

141 The Src homology 2 domain-containing phosphotyrosine phospha

142 The 66-kDa Src homology 2 domain-containing protein (p66Shc) is a m

143 eases the docking and activation of adaptors Src homology 2 domain-containing protein and Gab1 on the

144 he cytoplasmic domain of 2B4 associates with src homology 2 domain-containing protein or signaling ly

145 nase is recruited to the contact site, while Src homology 2 domain-containing protein phosphatase 2 i

146 ed lymphoproliferative syndrome (XLP) is the Src homology 2 domain-containing protein SAP.

147 Grb10 is a pleckstrin homology and Src homology 2 domain-containing protein that interacts

148 Inhibitory activity against Src homology 2 domain-containing protein tyrosine phosph

149 ulate NK cell cytotoxicity by activating the Src homology 2 domain-containing protein tyrosine phosph

150 contrast, the negative regulators, SHIP and Src homology 2 domain-containing protein tyrosine phosph

151 Mice deficient in the tyrosine phosphatase Src homology 2 domain-containing protein tyrosine phosph

152 (SHP-2) to the membrane scaffolding protein Src homology 2 domain-containing protein tyrosine phosph

153 Src homology 2 domain-containing protein tyrosine phosph

154 ed the expression of and association between Src homology 2 domain-containing protein tyrosine phosph

155 BCR-induced CD22 phosphorylation and Src homology 2 domain-containing protein tyrosine phosph

156 Mice deficient in Src homology 2 domain-containing protein tyrosine phosph

157 The PTPN11 gene encodes SHP-2 (Src homology 2 domain-containing protein tyrosine Phosph

158 Src homology 2 domain-containing protein tyrosine phosph

159 ad reduced CD22 tyrosine phosphorylation and Src homology 2 domain-containing protein tyrosine phosph

160 th only residual activity of the phosphatase Src homology 2 domain-containing protein tyrosine phosph

161 e phosphorylation of PECAM-1, recruitment of Src homology 2 domain-containing protein tyrosine phosph

162 The Src homology 2 domain-containing protein tyrosine phosph

163 nal-regulatory protein family, also known as Src homology 2 domain-containing protein tyrosine phosph

164 hesized that CD36-TSP-1 interaction recruits Src homology 2 domain-containing protein tyrosine phosph

165 demonstrated by the sustained activation of Src homology 2 domain-containing protein tyrosine phosph

166 dergoes phosphorylation and is recognized by Src homology 2 domain-containing protein tyrosine phosph

167 in the cytoplasmic domain of CEACAM1 and the Src homology 2 domain-containing protein tyrosine-phosph

168 herin was also accompanied by a reduction of Src homology 2 domain-containing protein-tyrosine phosph

169 r signal regulatory protein (SIRP) alpha and Src homology 2 domain-containing protein-tyrosine phosph

170 s and shared binding partners, including the Src homology 2 domain-containing protein-tyrosine phosph

171 igen-related tyrosine phosphatase [LAR], and src homology 2 domain-containing protein-tyrosine phosph

172 e sulfenic acid state, we visualize oxidized Src homology 2 domain-containing protein-tyrosine phosph

173 The Src homology 2 domain-containing protein-tyrosine phosph

174 rbB1 and ErbB2 homodimers and recruitment of Src homology 2 domain-containing proteins (Shc and Grb2)

175 ted upon ligand binding and recruit specific Src homology 2 domain-containing proteins that link to d

176 depletion, but there was less recruitment of Src homology 2 domain-containing proteins to the EGFR.

177 e 201, which is a potential binding site for Src homology 2 domain-containing proteins, in JAK2V617F-

178 kinases and its subsequent association with Src homology 2 domain-containing proteins.

179 ing and creates a potential binding site for Src homology 2 domain-containing proteins.

180 The tandem Src homology 2 domain-containing PTPs (SHPs) belong to t

181 ctivated Flk-1/KDR has been shown to recruit Src homology 2 domain-containing signaling molecules tha

182 sites on ERK1/2, p38, phospholipase C-gamma, Src homology 2 domain-containing transforming protein 1,

183 ced phosphorylation of phospholipase C-gamma/Src homology 2 domain-containing transforming protein 1/

184 of beta(c) is necessary for cooperation, the Src homology 2 domain-containing transforming protein bi

185 ing sites for the principal effectors of MT--Src homology 2 domain-containing transforming protein, p

186 nhibitor AG1478, a dominant-negative RAS, an Src homology 2 domain-containing Tyr phosphatase inhibit

187 TLT1 recruited Src homology 2 domain-containing tyrosine phosphatase (S

188 In Jurkat T cells, approximately 5--10% of Src homology 2 domain-containing tyrosine phosphatase (S

189 Active Src homology 2 domain-containing tyrosine phosphatase 2

190 The src homology 2 domain-containing tyrosine phosphatase 2

191 the target T cells and stimulates docking of Src homology 2 domain-containing tyrosine phosphatase 2

192 Inhibitors of AT2R or Src homology 2 domain-containing tyrosine phosphatase ha

193 lators of the Janus kinase-STAT pathway SHP, Src homology 2 domain-containing tyrosine phosphatase-1

194 SHP-1 and SHP-2 are two Src homology 2 domain-containing tyrosine phosphatases w

195 tor tyrosine-based inhibition motifs recruit Src homology 2 domain-containing tyrosine phosphatases.

196 rowth factor receptor binding protein 2, and Src homology 2 domain-containing) were fused to NH(2) te

197 tyrosine phosphorylation associates with the src homology 2-domain-containing protein tyrosine phosph

198 receptor tyrosine kinases, as noted for the Src homology 2-domain-containing PTPs, SHP-1 and -2.

199 high-level miR-155 expressed lower levels of Src homology-2 domain-containing inositol 5-phosphatase

200 In the present study, we identify Src homology-2 domain-containing inositol 5-phosphatase

201 Src homology-2 domain-containing inositol polyphosphate-

202 on of MCs positive for the signaling adaptor Src homology-2 domain-containing leukocyte protein of 76

203 n the C-terminal tyrosine phosphorylation of Src homology-2 domain-containing phosphatase (SHP) 2.

204 (CagA) and CagA-signaling molecules (phospho-Src homology-2 domain-containing phosphatase [p-SHP2] an

205 tion of protein kinase Cdelta (PKCdelta) and Src homology-2 domain-containing phosphatase-1 (SHP-1) e

206 ously unknown target of PKC-delta signaling, Src homology-2 domain-containing phosphatase-1 (SHP-1),

207 pharmacological inhibitors for non-receptor Src homology-2 domain-containing protein tyrosine phosph

208 dependent on activation of STAT3 but not the Src homology-2 domain-containing tyrosine phosphatase (S

209 ory function derived from recruitment of the Src homology-2 domain-containing tyrosine phosphatase 1

210 ted the effects of the tyrosine phosphatase, SRC-homology 2 domain-containing phosphatase 2 (SHP2), o

211 ly inactivate the tyrosine phosphatase SHP2 (Src-homology 2 domain-containing phosphatase 2).

212 s, KIR2DL1 that included R245 recruited more Src-homology-2 domain-containing protein tyrosine phosph

213 ude the protein tyrosine phosphatases SHP-1 (Src-homology-2-domain-containing protein tyrosine phosph

214 either recombinase deficient (Rag-2(-/)-) or Src homology 2 domain--containing leukocyte protein of 7

215 sine sites and the recruitment of 25 or more Src homology 2 domain-encoding proteins and associated f

216 ptor-based scaffold via its binding site for Src homology 2 domains, facilitating signaling of the mi

217 (i) a C-terminal structure consisting of two Src homology 2 domains flanking the p110 catalytic subun

218 spliced forms of CRK, possess an N-terminal Src homology 2 domain, followed by a Src homology 3 (SH3

219 Furthermore, we show that microinjected Src homology 2 domains from either Grb2 or SHP-2 blocked

220 By using the model system of the tandem Src homology 2 domain (i.e., two adjacent Src homology 2

221 hosphorylation at the 536 site engages the N-Src homology 2 domain in an intramolecular fashion relie

222 Deletion of the C-terminal Src homology 2 domain in p66(shc) reduced its ability to

223 a cytoplasmic tyrosine phosphatase with two Src homology 2 domains, in signaling pathways downstream

224 The E76K mutation in the N-terminal Src homology 2 domain increased interactions of mutant S

225 e 564 site has the potential to engage the C-Src homology 2 domain intramolecularly, which can modest

226 ced GFP fusion protein reveals that the SHIP-Src homology 2 domain is essential in both cases whereas

227 ession of a wild-type SHIP, but not the SHIP Src homology 2 domain-lacking catalytic activity, up-reg

228 ) p110 catalytic subunits are activated upon Src homology 2 domain-mediated binding of their p85 regu

229 atic activity of PLCgamma2 is triggered upon Src homology 2 domain-mediated binding to the tyrosine-p

230 umors and establish a critical role for Grb2 Src homology-2 domain-mediated interactions in this proc

231 33, 230, and 237, corresponding to the hBVR Src homology-2 domain motif (Ser(230) and Ser(237)), fla

232 s by expressing either wild-type SHIP2 or an Src homology 2 domain mutant of SHIP2 reduced Akt activa

233 of Itk, or in T cells overexpressing an Itk Src homology 2 domain mutant, HS1 failed to localize to

234 protein tyrosine phosphatase containing two Src homology 2 domains near its N terminus, and has been

235 IRS6/DOK5 neither associates with these Src homology 2 domains nor activates MAPK.

236 tyrosine and provides a docking site for the src homology 2 domain of CrkL, which also undergoes IFN-

237 The Src homology 2 domain of CTEN is not only required for b

238 of the phosphotyrosine peptide pYEEI to the Src homology 2 domain of human Lck has been calculated.

239 Furthermore, the Src homology 2 domain of Lnk is essential for Lnk's inhi

240 ith glutathione S-transferase fused to the N-Src homology 2 domain of p85, the regulatory subunit of

241 tes a direct interaction with the C-terminal Src homology 2 domain of phospholipase C (PLC)-gamma1 an

242 ry-PLCgamma interaction was dependent on the Src homology 2 domain of PLCgamma and a conserved N-term

243 The Src homology 2 domain of protein SH2-Bbeta (SH2-Bbeta (5

244 ring the proline-rich domain, but not on the Src homology 2 domain of SHIP2.

245 81 constitutes the major binding site of the Src homology 2 domain of Src and therefore the primary r

246 The Src homology 2 domain of src was found to interact with

247 bstitution of proline 630 located within the Src homology 2 domain of Stat2 to leucine (P630L).

248 In addition, the Src homology 2 domain of STAT5 was required for the effe

249 Tyr(930) enables differential binding to the Src homology 2 domain of the adaptor protein Grb7, which

250 creates a high-affinity binding site for the src homology 2 domain of the Src family of tyrosine kina

251 the pTyr residue of the pYEEI ligand for the Src Homology 2 domain of the Src kinase (Src SH2 domain)

252 bition motif (ITIM), binds to the C-terminal Src homology 2 domain of the tyrosine phosphatase SHP-1.

253 Overlay blots with recombinant Src homology 2 domains of IRS-1 adaptor proteins showed

254 yr-380 is essential for interaction with the Src homology 2 domains of p85alpha, a multifunctional ad

255 trisphosphate-PI3K interactions based on the Src homology 2 domains of PI3K.

256 Furthermore, both Src homology 2 domains of SHP-1 are necessary for effici

257 lasmic domain of CD22 that interact with the Src homology 2 domains of SHP-1.

258 of sea urchin eggs with dominant-interfering Src homology 2 domains of SpSFK1 delays and reduces the

259 osphorylation at tyrosine 397, FAK binds the Src homology 2 domains of Src and phosphoinositide 3-kin

260 cruited to focal adhesions by binding to the Src homology 2 domains of tensins and the focal adhesion

261 d with PV for binding to the C-terminal SH2 (Src homology 2) domain of p85alpha, the regulatory subun

262 The SH3 (Src homology 3) and SH2 (Src homology 2) domains of dSrc were fully dispensable w

263 hat the phosphotyrosine-binding, but not the Src homology 2, domain of ShcA is required for TGFbeta-i

264 ding Y340 of CD33 was primarily to the amino Src homology-2 domain of SHP-1.

265 Although the crystal structure of the tandem Src homology-2 domains of human ZAP-70 in complex with a

266 tates binding of VEGFR2 to the Rous sarcoma (Src) homology 2-domain of T cell-specific adaptor (TSAd)

267 e two proteins were mapped to the C-terminal Src-homology 2 domain of p85alpha and N terminus of AR.

268 an Ciona intestinalis were injected with the Src-homology 2 domains of phospholipase C gamma or of th

269 hosphotyrosine residues that engage the SH2 (Src-homology 2) domains of phospholipase C-g (PLC-g) and

270 em Src homology 2 domain (i.e., two adjacent Src homology 2 domains) of the Syk kinase, we report a m

271 tion molecule-associated protein (SAP) is an Src homology 2 domain-only adaptor involved in multiple

272 inhibited by overexpressing either the SHIP Src homology 2 domain or a dominant negative mutant of S

273 c-Src antibody and peptide inhibitors of the Src homology-2 domain or a putative Src tyrosine phospho

274 y a single negative feedback mediated by the Src homology 2 domain phosphatase-1 (SHP-1) accounts qua

275 viated allele symbol me(v)) are deficient in Src-homology 2-domain phosphatase (SHP)-1, a critical ne

276 estern blot technique, in which a battery of Src homology 2 domain probes is used to detect patterns

277 osine phosphorylation and the recruitment of Src homology 2 domain proteins have been widely describe

278 C-terminal regulatory tyrosine or the entire Src homology 2 domain, respectively, required Hsp90 acti

279 modular domain architecture consisting of an Src homology 2 domain (SH2) followed by two Src homology

280 l adapter protein known to associate via its Src homology 2 domain (SH2) with the MET C-terminus, was

281 ins several structured domains including the Src homology 2 domain (SH2), linker domain (LD), DNA-bin

282 forms a functional dimer through reciprocal Src homology 2 domain (SH2)-phosphotyrosyl peptide inter

283 of Dok1, promoting its association with the Src homology 2 domain (SH2)/SH3 adaptor protein Nck.

284 SHEP1 contains an Src homology 2 domain that binds to a conserved tyrosine

285 hosphatase-2 has a binding motif for the Lnk Src Homology 2 domain that is phosphorylated in response

286 SHP-1 possesses two Src homology 2 domains that serve as docking elements to

287 55, which creates a docking site for the Crk Src homology 2 domain, thereby promoting LPA-induced mor

288 RasGAP used its N-terminal Src homology 2 domain to bind FGFR once stimulated by FG

289 ing this tyrosine reduces the ability of the Src homology 2 domain to bind to ErbB-2 and significantl

290 either the phosphotyrosine binding (PTB) or Src homology 2 domain to determine that phosphorylation

291 H2-Bbeta has been shown to bind via its SH2 (Src homology 2) domain to tyrosyl-phosphorylated JAK2 an

292 prior studies have shown that recruitment of Src homology 2 domain tyrosine phosphatase (SHP-2) to th

293 Recruitment of the Src homology 2 domain tyrosine phosphatase (SHP-2) to th

294 response to IGF-I, leading to recruitment of Src homology 2 domain tyrosine phosphatase (SHP-2).

295 SHP-1 (Src homology 2 domain tyrosine phosphatase 1), a phospho

296 LC-beta; the PH domain [PtdIns(3,4,5)P3] and Src homology 2 domain [tyrosine-phosphorylated proteins,

297 SH2-Bbeta(R555E) with a defective Src homology 2 domain was unable to stimulate JAK2 and J

298 er protein containing a Src homology 3 and a Src homology 2 domain, was isolated from a yeast interac

299 selectively to Janus kinase 2 and the STAT3 Src homology-2 domain, which serve crucial roles in STAT

300 -kinase, specifically associates through its Src homology 2 domains with tyrosine-phosphorylated Ikap