ライフサイエンスコーパス: Src homology domain

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1 Src homology domains [i.e., Src homology domain 2 (SH2) and Src homology domain 3 (S

2 LC-gamma2-deficient cells reconstituted with Src homology domain 2 (SH2) domain mutant PLC-gamma2 did

3 ontaining a functional point mutation in the Src homology domain 2 (SH2) led to more rapid dephosphor

4 resulted in the tyrosine phosphorylation of Src homology domain 2 (SH2)-containing phosphatase-2 (SH

5 of BCR-mediated signaling via recruitment of Src homology domain 2 (SH2)-containing phosphatases.

6 ine phosphorylation and association with the Src homology domain 2 (SH2)-containing protein tyrosine

7 By contrast, SOCS-2 and cytokine-inducible Src homology domain 2 (SH2)-containing protein up-regula

8 er in a pathway downstream of EGL-15 and the Src homology domain 2 (SH2)/SH3-adaptor protein SEM-5/GR

9 factor receptor binding protein 2 (Grb2) and Src homology domain 2 containing (Shc) TbetaR-II, thereb

10 tory function of CEACAM1, was dependent upon src homology domain 2 containing phosphatase 1 activity,

11 lasmid or a small interference RNA targeting src homology domain 2 containing phosphatase 1.

12 the protein kinase A (PKA) pathway activates Src homology domain 2 containing protein tyrosine phosph

13 The two SH2 (Src homology domain 2) domains present in phospholipase

14 ion and VEGFR-2 deactivation, the latter via Src homology domain 2-containing (SH2-containing) tyrosi

15 B cells require the inositol 5-phosphatase, Src homology domain 2-containing inositol 5-phosphatase

16 ing protein tyrosine phosphatase (SHP) 2 and Src homology domain 2-containing inositol phosphatase 1

17 n of SIRP-alpha and downstream activation of Src homology domain 2-containing phosphatase-1.

18 We observed that ICAM-1 interacts with Src homology domain 2-containing phosphatase-2 (SHP-2),

19 ion of both the receptor and the phosphatase Src homology domain 2-containing protein tyrosine phosph

20 rosine-phosphorylated CTLA-4, and associated Src homology domain 2-containing protein tyrosine phosph

21 g binding to DCIR induced phosphorylation of Src homology domain 2-containing protein tyrosine phosph

22 is the binding site for both SOCS-3 and for Src homology domain 2-containing tyrosine phosphatase 2

23 endent on protein tyrosine phosphatase SHP2 (Src homology domain 2-containing tyrosine phosphatase 2)

24 Additionally, when immobilized Src homology domains 2 and 3 (SH2 and SH3, respectively)

25 The Src-homology domain 2 (SH2)-containing cytoplasmic tyros

26 r(P)(19)) may function as a docking site for Src homology domain-2 (SH2) domain containing proteins d

27 ar sequence of FGFRL1 consists of a putative Src homology domain-2 (SH2)-binding motif adjacent to a

28 ressing both heme oxygenase-1 (HO-1) and the Src homology domain-2 containing tyrosine phosphatase-1

29 Here we demonstrate noncanonical Src homology domain 3 (SH3) binding site motifs in the i

30 is mediated by an interaction of the second src homology domain 3 (SH3) domain of ponsin with the pr

31 proline rich, the hypothesis that it targets Src homology domain 3 (SH3) domains was tested, but muta

32 In eukaryotes, the Src homology domain 3 (SH3) is a very important motif in

33 An extensive search and analysis for Src homology domain 3 (SH3) ligand motifs revealed a myr

34 g mutant Myo5 proteins with deletions of the src homology domain 3 (SH3) or both TH2 and SH3 domains

35 Antennapedia-mediated delivery of Hck Src homology domain 3 (SH3), a domain that binds to the

36 e (GST) fusion proteins encoding the unique, Src homology domain 3 (SH3), and SH2 domains of Fyn, Hck

37 following either the loss or mutation of its Src homology domain 3 (SH3), resulting in both increased

38 mains [i.e., Src homology domain 2 (SH2) and Src homology domain 3 (SH3)] play a critical role in lin

39 evalence of modular protein domains, such as Src homology domain 3 and 2 (SH3 and SH2), among importa

40 l interfering RNA or myristoylated cortactin Src homology domain 3 blocking peptide attenuated ROS pr

41 cruitment of IRSp53 effector proteins to its Src homology domain 3 by promoting 14-3-3 binding in the

42 One class I ligand for Src homology domain 3 docking, found in the N terminus (

43 in Kalirin-9, with its Sec14p, spectrin, and Src homology domain 3 motifs, is essential for regulatin

44 -terminal and central regions of WRN and the Src homology domain 3 of c-Abl.

45 a potential interaction motif for the Noxa1 Src homology domain 3, caused up-regulation of basal and

46 nvolved in protein-protein interactions with Src homology domain 3-containing proteins.

47 This domain is one of the rare examples of Src homology domain 3-like folds in bacterial proteins,

48 Clear, unbiased electron density for the Src homology domain 3-like third domain, which is often

49 otyrosine-binding (PTB) domain and potential Src-homology domain 3 (SH3) binding sites.

50 the native state ensemble of the C-terminal src homology domain-3 (C-SH3) from Caenorhabditis elegan

51 ntramolecular interactions of the PLC-gamma1 Src homology domains and/or by positioning it for phosph

52 toylation consensus sequence and SH3 and SH2 Src homology domains, but lacks a tyrosine kinase domain

53 The Src homology domain containing phosphatase 2 (SHP2) and

54 at the cytoplasmic tail of CEACAM1 bound the src homology domain-containing phosphatase 1 and adaptor

55 development, whereas a tyrosine phosphatase Src homology domain-containing tyrosine phosphatase (Shp

56 In this study, we provide evidence that the Src-homology domain-containing adaptor Nck1 negatively r

57 terization of protein modules exemplified by Src Homology domains has revolutionized our understandin

58 Src homology domains [i.e., Src homology domain 2 (SH2)

59 se results fit a model which postulates that Src homology domain interactions are a molecular determi

60 Tyrosine kinase activity, a determinant of Src homology domain interactions, has a prominent effect

61 sented here suggest that, although cbl lacks src homology domains, it represents a novel intermediate

62 line-phenylalanine repeats, and proline-rich Src homology domain ligand sites.

63 minal catalytic domain (cGAP), or N-terminal Src homology domains (nGAP).

64 involve phosphotyrosine adapter molecules or src-homology domains of p85alpha, and extend to other st

65 The first 10 residues within the Src homology domain (SH)-4 domain of the Src family kina

66 intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displ

67 Intramolecular interactions between the Src homology domains (SH2 and SH3) and the catalytic dom

68 PI-3 kinase activation required a putative Src-homology domain (SH2) binding motif in the MyD88 Tol

69 etween the PH (pleckstrin homology) and SH2 (Src homology) domains that binds to IRbeta.

70 Tyr-783 in the beta1 tail, and that the Arg Src homology domain then engages this phosphorylated reg

71 tion of two C-terminal Grb10 motifs (BPS and Src homology domains) with receptor phosphotyrosine resi

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