ライフサイエンスコーパス: Src tyrosine kinase

1 kinase A, calcium calmodulin, caesin kinase, src tyrosine kinase).

2 nt on kinase activity and is not shared by c-Src tyrosine kinase.

3 Sam68 is a target of the c-Src tyrosine kinase.

4 dent of mitogen-activated protein kinase and Src tyrosine kinase.

5 is required for coupling caveolin-1 to the c-Src tyrosine kinase.

6 demonstrate that MUC1 associates with the c-Src tyrosine kinase.

7 r loading on the conformational landscape of Src tyrosine kinase.

8 k can inhibit cellular transformation by the Src tyrosine kinase.

9 nteract endogenously and form a complex with Src tyrosine kinase.

10 fect on the catalytic activity of purified c-src tyrosine kinase.

11 hat thapsigargin also rapidly stimulates the Src tyrosine kinase.

12 n implicated in the formation of active p60v-src tyrosine kinase.

13 to ligand or because of the activity of the Src tyrosine kinase.

14 tonin and vitronectin receptors and of pp60c-src tyrosine kinase.

15 or mapping the conformational landscape of c-src tyrosine kinase.

16 for invadosome formation or activity, nor is Src tyrosine kinase.

17 n is not direct but requires the presence of Src tyrosine kinase.

18 lation of GRIP by protein kinase C (PKC) and Src tyrosine kinase.

19 olecular target for sarcoma treatment is the Src tyrosine kinase.

20 l as Galphai proteins, and was controlled by Src tyrosine kinase.

21 nd ERK2 activation through CD44 required the Src tyrosine kinase.

22 ptor (EGFR), and SKP1 loss also to increased SRC tyrosine kinase.

23 orylation of AR and its interaction with the Src tyrosine kinase.

24 d ECs induced an increase in the activity of SRC tyrosine kinases.

25 G1 through a pathway involving activation of Src tyrosine kinases.

26 cytoplasmic signaling molecules, including c-Src tyrosine kinases.

27 , a protein shown recently to be a target of Src tyrosine kinases.

28 g protein acting as a prominent substrate of Src tyrosine kinases.

29 CaR regulates cell-cell adhesion through Fyn/Src tyrosine kinases.

30 rylation of Disabled-1 (Dab1) by the Fyn and Src tyrosine kinases.

31 e important family of signaling enzymes, the Src tyrosine kinases.

32 alcium signaling pathways involving Pyk2 and Src tyrosine kinases.

33 sphate production, or activation of Pyk2 and Src tyrosine kinases.

34 Inhibition of c-Src tyrosine kinase (4-amino-5-[4-chlorophenyl]-7-[t-but

35 In the case of the Src tyrosine kinase, a prototypical kinase due to its ro

36 permeability downstream of VEGF receptor or Src tyrosine kinase activation in vivo.

37 f the phosphopeptides also revealed ABL1 and SRC tyrosine kinase activation.

38 Inhibition of Src tyrosine kinase activity abrogated EGF-stimulated Er

39 Inhibition of C-SRC tyrosine kinase activity also blocks PGE(2)-induced

40 Src tyrosine kinase activity and tyrosine phosphorylatio

41 min with Cbl in osteoclasts was decreased by Src tyrosine kinase activity and we found that destabili

42 Inhibition of Src tyrosine kinase activity eliminated oxidative stress

43 ostate cancer demonstrated the enrichment of Src tyrosine kinase activity in approximately 90% of pat

44 ng that the SH1(KD) mutant did not inhibit c-SRC tyrosine kinase activity in general.

45 remodeling of Kv4.3 channel and increased c-Src tyrosine kinase activity, a stretch-responsive kinas

46 Blocking Src tyrosine kinase activity, but not EGF receptor or JA

47 Targeted inhibition of Src tyrosine kinase activity, mutational inactivation of

48 n showed a rapid and transient decrease in c-Src tyrosine kinase activity.

49 t cell populations exhibit a FGF-1-dependent Src tyrosine kinase activity.

50 e in tyrosine phosphorylation is governed by Src tyrosine kinase activity.

51 and/or ROCE, was recently shown to depend on src tyrosine kinase activity.

52 shown previously to cause up-regulation of c-Src tyrosine kinase activity.

53 v-Src is an activated Src tyrosine kinase and a potent oncogene known to phosp

54 Inhibition of raft-associating c-Src tyrosine kinase and downstream JNK kinase by pharmac

55 he auto-activation of purified recombinant c-Src tyrosine kinase and Fyn, a related Src family tyrosi

56 we showed that RACK1 inhibits the oncogenic Src tyrosine kinase and NIH 3T3 cell growth.

57 t a model in which the reciprocal actions of Src tyrosine kinase and Shp-1 tyrosine phosphatase dynam

58 r protein that is required for activation of SRC tyrosine kinase and simultaneously coordinates the a

59 rosine phosphorylation is necessary for both Src tyrosine kinase and STAT activation by the betaPDGF

60 Thus, estrogen, by activating an src tyrosine kinase and the extracellular signal-related

61 Here we report that non-receptor Src tyrosine kinase and the membrane protein caveolin-1

62 MUC1 cytoplasmic domain interacts with the c-Src tyrosine kinase and thereby increases binding of MUC

63 te that norepinephrine stimulation activates Src tyrosine kinase and this activation is required for

64 ate that dSlo can bind simultaneously to the Src tyrosine kinase and to the catalytic subunit of the

65 n regulates VEGF-induced activation of the c-Src tyrosine kinase and vascular permeability.

66 Cortactin is a substrate of Src tyrosine kinases and a regulator of cytoskeletal dyn

67 Cortactin is a target for phosphorylation by Src tyrosine kinases and by serine/threonine kinases tha

68 cell adhesion results from reggie effects on Src tyrosine kinases and epidermal growth factor recepto

69 This was mediated through Src tyrosine kinases and protein phosphatase-1/2A.

70 n of G-protein-independent DRD1 coupled to c-Src tyrosine kinases and required local release of neuro

71 a demonstrate that ICAM-1 ligation activates SRC tyrosine kinases and that this activation requires S

72 ed a time-dependent activation of Src (pp60c-src) tyrosine kinase and Src tyrosine kinase inhibitors

73 we showed that RACK1 also interacts with the Src tyrosine kinase, and is an inhibitor of Src activity

74 asion by derepressing upstream EGF receptor, SRC tyrosine kinase, and phosphoinositide 3-kinase signa

75 increases were (i) blocked by inhibitors of Src tyrosine kinase, antagonists of N-methyl-d-aspartate

76 Previously, we showed that Src tyrosine kinases are activated early in the developm

77 endothelial nitric-oxide synthase and the c-Src tyrosine kinase, are also potently inhibited by each

78 These findings introduce the Src tyrosine kinase as a regulator of SCF(beta-TrCP).

79 is dependent on its ability to activate the Src tyrosine kinase as an outcome of a complex formed be

80 Src tyrosine kinase associated and co-localized with the

81 caspase-8 was shown to co-localize with the Src tyrosine kinase at the cellular periphery.

82 tivation of PKC, RACK1 co-localizes with the Src tyrosine kinase at the plasma membrane and functions

83 tment with PP2, a selective inhibitor of the Src tyrosine kinase, attenuated both ISO-mediated EGFR p

84 alpha7 nicotinic receptors (nAChRs) through src tyrosine kinases because eliminating lck kinase expr

85 omain and appears to be mediated through the Src tyrosine kinase, because both the expression of a do

86 We now demonstrate that HBx activation of Src tyrosine kinases, but not Ras, promotes a high level

87 Shp-2 tyrosine phosphatase can regulate the Src tyrosine kinase by a non-enzymatic mechanism.

88 ral decrease in inhibition of the EGFr and v-src tyrosine kinases by both the diselenium and disulfur

89 The ubiquitously expressed Src tyrosine kinases (c-Src, c-Yes, and c-Fyn) regulate

90 erived growth factor receptor (PDGFr), and v-src tyrosine kinases, compounds in this series displayed

91 The structure of a large fragment of the c-Src tyrosine kinase, comprising the regulatory and kinas

92 The c-Src tyrosine kinase, Csk, physically interacts with the

93 These results define a Src tyrosine kinases-dependent mechanism whereby BCR/ABL

94 Aberrant activation of the Src tyrosine kinase disrupts cell-cell contacts through

95 The activity of the other 5 members of the Src tyrosine kinases expressed in the rabbit heart (Fyn,

96 Src tyrosine kinase expression and activity are elevated

97 Grb10 is a new substrate for members of the Src tyrosine kinase family and that the tyrosine phospho

98 Identification of members of the Src tyrosine kinase family as substrates of the E6AP ubi

99 ss spectroscopy-based studies, we identified Src tyrosine kinase family members Src and Fyn as upstre

100 Recent work shows that Hck, a member of the Src tyrosine kinase family with myeloid-restricted expre

101 tively specific inhibitor for members of the Src tyrosine kinase family, and by the expression of dom

102 including p60fyn and p56lck, members of the src tyrosine kinase family.

103 was sensitive to inhibitors of the Pyk2 and Src tyrosine kinase family.

104 constriction could be c-Src, a member of the Src tyrosine kinase family.

105 calization to neuronal membrane rafts, NMDAR/Src tyrosine kinase family/ERK signaling, and protection

106 ons showed that GluN2A, 5HT2C receptors, and Src tyrosine kinase form protein associations in synapto

107 Src tyrosine kinase has been found to be overexpressed i

108 The Src tyrosine kinase has been implicated in a wide variet

109 Src tyrosine kinase has long been implicated in colon ca

110 The Src-tyrosine kinase has been implicated in modulating ne

111 Src tyrosine kinases have been implicated in axonal grow

112 Src tyrosine kinases have been shown to mediate cellular

113 the principal site for recognition by the c-Src tyrosine kinase; however, little is known about the

114 tly co-expressing full-length caveolin and c-Src tyrosine kinase in 293T cells.

115 BMS-354825 also inhibited Src tyrosine kinase in A10 cells.

116 or activation of the temperature-sensitive v-Src tyrosine kinase in MDCK cells can be blocked by inhi

117 Sam68, a specific target of the Src tyrosine kinase in mitosis, possesses features commo

118 binding protein, is a major substrate of the Src tyrosine kinase in mitotic cells.

119 MUC1 has been shown to bind to c-Src tyrosine kinase in vitro, whereby c-Src phosphorylat

120 ory factors for coupling caveolin-1 to the c-Src tyrosine kinase in vivo.

121 An important role for non-Src tyrosine kinases in flow-mediated BMK1 activation wa

122 This study examined the role of SRC tyrosine kinases in ICAM-1-initiated signaling withi

123 ibited p38 activation, suggesting a role for SRC tyrosine kinases in p38 activation.

124 We detected the FYN and c-SRC tyrosine kinases in the flagellar mid-piece region.

125 Activation of SRC tyrosine kinases in turn leads to tyrosine phosphory

126 Although the Src tyrosine kinase induces constitutive Stat3 phosphory

127 chemical inhibitor PP2 and dominant-negative Src tyrosine kinase inhibited single-cell motility in PG

128 Most interestingly, both the general Src tyrosine kinase inhibitor genistein (25 microm) and

129 Furthermore, Src tyrosine kinase inhibitor or dominant negative Src i

130 we observed that the pyrido[2,3-d]pyrimidine src tyrosine kinase inhibitor PD173955 inhibited Bcr-Abl

131 Treatment with the Src tyrosine kinase inhibitor PP2 completely attenuated

132 Src tyrosine kinase inhibitor PP2, a protein kinase A in

133 inhibitor gefitinib, a quinolinecarbonitrile Src tyrosine kinase inhibitor, and the antimalarial hydr

134 Dasatinib, a potent and specific Src tyrosine kinase inhibitor, was found to decrease the

135 n at Tyr-146, which was inhibited by PP2, an SRC tyrosine kinase inhibitor.

136 labeled SERT was found in rat platelets, and Src-tyrosine kinase inhibitor 4-amino-5-(4-chlorophenyl)

137 ation of Src (pp60c-src) tyrosine kinase and Src tyrosine kinase inhibitors completely blocked the ty

138 -dependent; it is mimicked by application of Src tyrosine kinase inside the cell via the whole-cell p

139 for activated betaIIPKC, binds for example, Src tyrosine kinase, integrin, and phosphodiesterase.

140 Previously, we demonstrated that the Src tyrosine kinase interacts with the Shp-2 tyrosine ph

141 the pathogenesis of melanoma, we show that c-Src tyrosine kinase is activated in melanoma cell lines.

142 onal-specific N1-Src splice variant of the C-Src tyrosine kinase is conserved through vertebrate evol

143 The Src tyrosine kinase is necessary for activation of extra

144 owever, the effect of myocardial ischemia on Src tyrosine kinases is unknown.

145 Tks4, a substrate of Src tyrosine kinase, is implicated in the regulation of

146 Since the PDGF receptor also activates the Src tyrosine kinase, it is possible that Src mediates ty

147 Dominant-negative Src tyrosine kinase, Jak2, and protein kinase A partiall

148 T lymphocytes express two Src tyrosine kinases, Lck and Fyn.

149 tion between TRPV4, alpha2 integrin, and the Src tyrosine kinase Lyn in sensory neurons.

150 a and gamma subunits of Fc epsilon RI by the Src tyrosine kinase Lyn, which is anchored to the inner

151 ine phosphorylation of NMDA receptors via an src tyrosine kinase/MAPK pathway.

152 Src tyrosine kinase may provide a viable target for ther

153 Further, we found that Src tyrosine kinase-mediated activation of p38 MAPK is r

154 in vitro through FcgammaRIIA-dependent, Abl/Src tyrosine kinase-mediated F-actin polymerization.

155 cetylcholine receptor (M1R), and opposes the Src tyrosine kinase-mediated increase in the function of

156 rmacological studies indicate involvement of Src tyrosine kinase mediates 5HT2C facilitation of NMDA.

157 The aim of this study was to test whether c-Src tyrosine kinase mediates connexin-43 (Cx43) reductio

158 Because activation of Src tyrosine kinase occurs in malignant and premalignant

159 ed to ask whether heat shock activates p60 c-Src tyrosine kinase or phosphatidylinositol 3-kinase (PI

160 ent to HUVEC demonstrated that inhibition of Src tyrosine kinases or pretreatment with cortactin smal

161 1 and 4, cytosolic phospholipase A2 (cPLA2), Src tyrosine kinases, p38 MAPK, phospholipase C, and int

162 ated SLAP-130/FYB with the SH2 domain of the src tyrosine kinase p59fyn.

163 ampal slices is mediated by activation of an src tyrosine kinase pathway.

164 The Src tyrosine kinase phosphorylates Cas (Crk-associated s

165 The Src tyrosine kinase phosphorylates specific sites on the

166 n, BAPTA/AM, EGTA, and L-655238, implicating src-tyrosine kinases, PI3-kinase, Ca2+ mobilization, and

167 enesis and vascular permeability, in which c-Src tyrosine kinase plays an essential role.

168 Inhibition of tyrosine kinase, Src tyrosine kinase, protein kinase C, and mitogen-activ

169 ctivities of HBx is the ability to stimulate Src tyrosine kinases, Ras-GTPases and transcriptional ac

170 t govern the coupling of caveolin-1 to the c-Src tyrosine kinase remain largely unknown.

171 In CFTR-defective cholangiocytes, Src tyrosine kinase self-activates and phosphorylates to

172 a 1.5-A-resolution x-ray structure of the V-Src tyrosine kinase SH2 domain complexed with a five-res

173 V suppresses apoptosis through ITAM-mediated Src tyrosine kinase signaling.

174 tured nociceptors were dependent on integrin/Src tyrosine kinase signaling.

175 Rapid digestion of pp60c-src tyrosine kinase (src TK) in combination with electro

176 Src tyrosine kinase (Src) is implicated in the developme

177 We studied regulation by c-Src tyrosine kinase (Src) of KCNQ1-5 channels heterologo

178 Transformation by the Src tyrosine kinase (Src) promotes nonanchored cell grow

179 etic mechanisms for the inhibition of pp60(c-src) tyrosine kinase (Src TK) by 4-anilinoquinazolines,

180 hibits beta4 integrin-mediated activation of SRC tyrosine kinase.SRCis the first discovered oncogene,

181 sine kinase subfamily and Arg-Ala-Ala in the Src tyrosine kinase subfamily.

182 Src tyrosine kinase suppresses KCNQ (M-type) K(+) channe

183 to the catalytic domain of the prototypical Src tyrosine kinase that retains full catalytic ability.

184 roblast growth factor receptor (FGFr), and c-src tyrosine kinases (TKs).

185 luorescent protein (RFP) mCherry and a human Src tyrosine kinase to create inactive chimeric proteins

186 hich has been found to involve activation of Src tyrosine kinase to stimulate phospholipase C-gamma (

187 nase acts downstream of the EGF receptor and Src tyrosine kinases to promote invadopodium function in

188 provide a molecular link that connects the c-Src tyrosine kinase transduction pathway to ER stress-in

189 Src tyrosine kinases transmit integrin-dependent signals

190 Oncogenic forms of the Abl and Src tyrosine kinases trigger the destruction of the Abi

191 Activation of SRC tyrosine kinases was accompanied by tyrosine phospho

192 nd Drug Administration-approved inhibitor of Src tyrosine kinases, was used to impinge on the proapop

193 eptide derived from the SH2 region of pp60(v-src) tyrosine kinase, was also microinjected.

194 motifs and given that Sin is a substrate for Src tyrosine kinases, we examined the involvement of the

195 We also show that alpha2beta1 integrin and Src tyrosine kinase, which have been implicated in mecha

196 Direct association of the Src tyrosine kinase with cloned hKv1.5 and native hKv1.5

197 eriments to characterize the associations of Src tyrosine kinase with PKCepsilon in a conscious rabbi

198 nd 4b inhibited the PDGFr, FGFr, EGFr, and c-src tyrosine kinases with IC50 values of 1.11, 0.13, 0.4