ライフサイエンスコーパス: Src-family kinase

1 gulated proliferative response by activating Src family kinase.

2 ells phosphorylates SLP-76 in the absence of SRC family kinases.

3 g Abl localization and Abl/Arg activation by Src family kinases.

4 yrosine phosphorylation on FcRgamma chain or Src family kinases.

5 osphorylating the inhibitory tyrosine of the Src family kinases.

6 inding region of M2 and its interaction with Src family kinases.

7 osphorylating the inhibitory tyrosine of the src family kinases.

8 d cortactin were identified as substrates of Src family kinases.

9 s suggest a role of GD3 in the regulation of Src family kinases.

10 asma membrane, where it can be acted upon by Src family kinases.

11 ique to Cbl and is phosphorylated by Syk and Src family kinases.

12 mbrane and Golgi in that it is controlled by Src family kinases.

13 ested that this occurs through inhibition of Src family kinases.

14 ed production of ROS that was independent of Src family kinases.

15 le phosphorylation and activation of PI3K by Src family kinases.

16 ng the C-terminal inhibitory tyrosine of the src family kinases.

17 and provide insights into transformation by Src family kinases.

18 r for C-terminal SRC kinase, an inhibitor of SRC-family kinases.

19 host cell effectors, including Hck and other Src-family kinases.

20 inding affinities of Gleevec between the two Src-family kinases.

21 s activity does not appear to be mediated by Src-family kinases.

22 gage cytoplasmic signaling molecules such as Src-family kinases.

23 tinib, a clinical Bcr-Abl inhibitor, targets Src-family kinases.

24 c-Src is a tyrosine kinase belonging to the Src-family kinases.

25 erimentally observed association of BCR with Src-family kinases (10-20 s).

26 atment with heme; however, inhibition of the Src family kinases abolished the rescue effect of heme o

27 Pharmacologic inhibition of src family kinases abolished Vav1 phosphorylation by oxL

28 We identified Src family kinase activation mediated by mu-receptors as

29 These effects require Src family kinase activation, a classic LRP1-mediated Tr

30 cal reagents, PP2 and Dasatinib, which block Src family kinase activation, blocked scattered growth o

31 cription and secretion through inhibition of Src family kinase activation, particularly Lck, downstre

32 Together, these findings suggest that Src-family kinase activation, NMDAR stimulation, and lik

33 The second-stage binding requires Src family kinase activity to initiate CD8 binding to th

34 Src family kinase activity was required for IGF-IR assoc

35 of this inhibitory circuit was dependent on Src-family kinase activity and consequent to biased BCR

36 hosphatase CD45 is an important regulator of Src-family kinase activity.

37 Saracatinib, a specific inhibitor of Src family kinases, administered at low doses during the

38 nd treatment with dasatinib, an inhibitor of Src family kinases, also mimics the effects of versican.

39 Dasatinib, a dual Src family kinase and Abl inhibitor, is being tested cli

40 induces CaM phosphorylation at Tyr(99) by a Src family kinase and that phosphorylated CaM activates

41 CD38, via Src family kinases and adapters, interacts with a MAPK s

42 myristic acid analog known to interact with Src family kinases and an inhibitor of cyclin dependent

43 lusive interaction between SRC but not other Src family kinases and FLT3-ITD, which is mediated by th

44 sites depends on the direct interaction with Src family kinases and is upstream of the activation by

45 e co- or posttranslational myristoylation of Src family kinases and other oncogenic proteins, thereby

46 ls through a signaling pathway that involves Src family kinases and p38 MAPK.

47 fies a model in which integrin signaling via Src family kinases and Syk kinase to PLCgamma2 is requir

48 resulted in the following: 1) activation of Src family kinases and Syk revealed by their recruitment

49 activation was dependent on PKA and required Src family kinases and the Rap1 exchanger C3G.

50 etwork revealed decreased phosphorylation of Src family kinases and their targets.

51 analysis showed that SHP2 activates several SRC-family kinases and downstream targets, most of which

52 ion of integrins and involves stimulation of Src-family kinases and focal adhesion kinase, as well as

53 The synthesis of ROS by oxLDL/CD36 required Src-family kinases and protein kinase C (PKC)-dependent

54 DNGR-1 is phosphorylated by Src-family kinases and recruits the tyrosine kinase Syk

55 ultimerization of DCC, activation of FAK and Src family kinases, and increases in exocytic vesicle fu

56 required for TGFbeta1-mediated activation of Src family kinases, and Src inhibition blocked both pY65

57 at the tyrosine residue is phosphorylated by Src family kinases, and that Src-activation limits surfa

58 orthologue of Syk, and Src42A, a Drosophila Src-family kinase, and is dependent on Nox activity.

59 d DC activation occurred within minutes in a Src-family-kinase- and CD18-integrin-dependent manner.

60 e function of Csk as a negative regulator of Src family kinases appears to have arisen with the emerg

61 Src family kinases are required for normal PEAK1 localiz

62 Src family kinases are required for the generation of th

63 Src family kinases are thought to be major signaling eff

64 or tyrosine kinases and EGF receptor, with a Src family kinase as a required intermediate.

65 nhibitor with low nanomolar activity against SRC family kinases, BCR-ABL, c-KIT, EPHA2, and the PDGF-

66 These results support a model in which Src-family kinase binding induces conformational changes

67 Delta;Y567F/Y567F) knock-in mice lacking the SRC family kinase-binding site on KIT (pY567) exhibited

68 e not accompanied by the expected decline of Src family kinases but were accompanied by Akt-mammalian

69 Pharmacological inhibition of Src family kinases by SKI-606 (bosutinib) induces C/EBPd

70 signals through an evolutionarily conserved Src family kinase cascade to drive cytoskeletal rearrang

71 velop myeloproliferative neoplasm, like Lyn (Src family kinase)- deficient mice.

72 of Tyr-845 in the EGFR, which is mediated by Src family kinases, depended on uPAR in EGFRvIII-express

73 of Eps8 aimed to identify specific FGFR and Src family kinase dependent phosphosites and co-associat

74 ess (0.1-0.4 kPa), and such ILP formation is Src family kinase dependent.

75 endogenous ROS activate TrkB signaling by a Src family kinase-dependent but brain-derived neurotroph

76 estricts TGF-beta1 secretion in a Cdc42- and Src family kinase-dependent manner and independently of

77 ion of macrophage Vav in vitro in a CD36 and Src family kinase-dependent manner.

78 In stiff matrices, prolactin increased SRC family kinase-dependent phosphorylation of focal adh

79 that PACAP-mediated Rit activation involves Src family kinase-dependent TrkA receptor transactivatio

80 Thus, extracellular actin detection via a Src-family kinase-dependent cascade is an ancient means

81 nduced CLEC-2 immunodepletion occurs through Src-family kinase-dependent receptor internalization in

82 ylation of a neighboring tyrosine residue by Src family kinases disrupts COP1 binding, thereby stabil

83 Inhibition of Src family kinases efficiently reduces the interaction o

84 activation and intracellular localization of SRC-family kinases, especially FYN and LYN.

85 ly, we found that B lymphoid kinase (Blk), a Src family kinase expressed primarily in B cells, is exp

86 permeability by activating small GTPases and Src family kinases/FAK, and down-regulating tight juncti

87 tion increased receptor association with the Src family kinase Fgr and shifted signals from the adapt

88 the specific requirement of HCK p59 and FGR src-family kinases for FCRL4-mediated immunomodulatory a

89 Three major Src family kinases found in T cells (Lck, Fyn, and Lyn)

90 In this study, the participation of the Src family kinase Fyn in the production of TNF after sti

91 he slit diaphragm and transduce signals in a Src family kinase Fyn-mediated tyrosine phosphorylation-

92 gh formation of a signaling complex with the Src family kinase Fyn.

93 motif of ADAP, a known docking site for the Src family kinase Fyn.

94 arget peptide from an unrelated protein, the Src-family kinase Fyn.

95 5beta1 integrin and the acylated form of the Src family kinase, Fyn, to lipid rafts.

96 PPARgamma by inhibiting the activity of the Src-family kinase, Fyn.

97 cells, and these genes include seven of nine Src family kinase genes, FGFR1, FGFR2, ITK, NTRK1, NTRK2

98 splaying high potency and selectivity toward SRC family kinases have been developed by combining liga

99 r 3 uses templated catalysis to redirect the Src family kinase Hck to phosphorylate hDM2, a negative

100 The Src family kinase Hck, Wiskott-Aldrich-syndrome protein,

101 Mice lacking the Src family kinases Hck, Fgr, and Lyn in the hematopoieti

102 s with the SH3 or the SH3-SH2 domains of the Src-family kinase Hck.

103 -based cells express increased levels of the src-family kinases HCK and FGR.

104 Aberrant activation of the SRC family kinase hematopoietic cell kinase (HCK) trigge

105 on neutrophils, P-selectin on platelets, and Src family kinases in both cell types.

106 THrP elevated Y418 phosphorylation levels in Src family kinases in CD11b(+)Gr1(+) cells via osteoblas

107 Interestingly, it also positively regulates Src family kinases in hematopoietic and endothelial cell

108 CDCP1 is phosphorylated by Src family kinases in its full-length and cleaved states

109 morphology changes, which are independent of SRC family kinases in Src-/-, Yes-/-, Fyn-/- (SYF) mouse

110 The possible roles of Src family kinases in the enhanced malignant properties

111 osignaling and control of RhoA and implicate Src family kinases in the regulation of p115 RhoGEF.

112 demonstrate that YY1 is a target of multiple Src family kinases in vitro and in vivo.

113 his study, we investigate the roles of these src-family kinases in FCRL4-mediated immunoregulation of

114 Thus, Src-family kinases in the DH may similarly control conte

115 Furthermore, TNFalpha, via SRC family kinases, increases pro-proliferative NOTCH2 s

116 ), we show that PTK6 phosphorylates AKT in a Src family kinase-independent manner.

117 thermore, MCR-independent phosphorylation of Src family kinase induces IgF1 receptor phosphorylation,

118 siRNA-mediated suppression of Fyn, a Src family kinase, inhibited VSM cell motility.

119 We further hypothesized that src-family kinase inhibition would improve barrier funct

120 Administration of nonspecific Src family kinase inhibitor (PP2) immediately after thro

121 rylation is compromised in the presence of a Src family kinase inhibitor and when the SH3 domains of

122 igh levels of pY128Cas are more sensitive to SRC family kinase inhibitor Dasatinib.

123 Here, we sought to repurpose the Src family kinase inhibitor oncology compound, AZD0530,

124 The Src family kinase inhibitor PP2 blocked injury-induced t

125 regulated kinase (ERK1/2) was blocked by the Src family kinase inhibitor PP2, indicating that the act

126 , and cerebrospinal fluid penetration of the Src family kinase inhibitor saracatinib in patients with

127 leles exhibited a greater sensitivity to the Src family kinases inhibitor dasatinib in response to co

128 on a fibronectin matrix are abolished by the Src family kinases inhibitor PP1, the Syk kinase inhibit

129 sed the effect of TNF-alpha, with or without src-family kinase inhibitor SU6656, on barrier propertie

130 rosine kinase inhibitor, and PP2, a specific Src-family kinase inhibitor, diminish reovirus infectivi

131 imulated with antigen in the presence of the src-family kinase inhibitor, PP2.

132 t; 0.25 or 2.5 mug/0.5 mul/hemisphere), PP2 (Src-family kinase inhibitor; 6.25 or 62.5 ng/0.5 mul/hem

133 Pretreatment with pan-Src family kinase inhibitors, PP2 and dasatinib, abolish

134 e membrane phosphatase CD45, which activates Src family kinases, is excluded, and this is necessary t

135 he PSGL-1-L-selectin complex signals through Src family kinases, ITAM domain-containing adaptor prote

136 ng to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulate al

137 The Src family kinase Lck has been shown to be crucial in T

138 The Src Family kinase Lck sets a critical threshold for T ce

139 The activated Src family kinase Lck stimulates the activity of Itk and

140 fts function in the phosphoregulation of the Src family kinase Lck.

141 Enriched in the IS is the Src family kinase Lck.

142 Our previous work showed that the src-family kinase Lck is a targetable mediator of BCR si

143 In this article, we show that the Src-family kinase LCK, but not FYN, associates with NTB-

144 ncreased activity of the negative regulatory Src family kinase Lyn and reduced activities of the posi

145 l cell adhesion molecule-1 (PECAM-1) and the Src family kinase Lyn inhibit platelet activation by the

146 cancer cells feature high expression of the Src family kinase Lyn that has been implicated in the pa

147 g, they did so by opposite regulation of the Src family kinase Lyn.

148 e tyrosine-phosphorylated by Pyk2, bound the Src-family kinase Lyn and linked TLR9 to a Src-kinase Sy

149 presence of epidermal growth factor (EGF) by Src family kinase-mediated phosphorylation on c-Abl-Tyr4

150 Blockade of Src family kinase-mediated WASp Tyr-291/Tyr-293 phosphor

151 se activation, NMDAR stimulation, and likely Src-family kinase-mediated NR2B subunit-containing NMDAR

152 hermore, the trophic factor S100beta induces Src-family kinase-mediated tyrosine phosphorylation of h

153 Specifically, Src family kinases, NCK1 and Vav1, bound to the Tyr(P)(1

154 e with ActApo, including p38, JNK, PI3K-Akt, Src family kinases, NFkappaB p65, and AP1 transcription

155 Among Src family kinases only Yes, not Fyn or Src, was functio

156 tein that can function by the recruitment of Src family kinases or by competition with phosphatases.

157 nd is therefore capable of signaling without SRC family kinases or stimulation of the T cell receptor

158 Although Src family kinases participate in leukocyte function in

159 onocytes and that inhibition of the MAPK and Src family kinase pathways blocked the ability of CD4 li

160 he signaling through spleen tyrosine kinase, Src family kinases, phosphatidylinositol-3-kinase, and p

161 urs via a novel, sequential process in which Src family kinases phosphorylate the C-terminal ITIM, th

162 In the second phase, Src family kinases phosphorylate tyrosyl residues within

163 We show that Src family kinases play a critical role in myeloid cell-

164 The latter event is mediated by Lyn, a Src family kinase previously found to be overexpressed,

165 Increased activity of SRC family kinases promotes tumor invasion and metastasi

166 lly, phospho-specific staining for Zap70 and Src family kinase proteins suggests that sensing of subs

167 er, the identification of YY1 as a target of Src family kinases provide key insights into the inhibit

168 ptor type-protein tyrosine phosphatase alpha-Src family kinase-Rap1 pathway as responsible for recrui

169 wo GEFs are further regulated by FAK/ERK and Src family kinases, respectively.

170 signaling pathways mediated by RhoA/ROCK and Src Family Kinases, respectively.

171 encodes a tyrosine phosphatase that inhibits Src-family kinases responsible for Ag receptor signaling

172 Additionally, inhibition of Src family kinases resulted in increased cellular retent

173 Nef binds to the Src homology 3 domains of Src family kinases, resulting in kinase activation impor

174 either the SH3 or tandem SH3-SH2 domains of Src-family kinases reveal distinct dimer conformations o

175 er kinetics of Erk1/2 activation through the src family kinase(s)-Syk signaling pathway.

176 Finally, we demonstrated that JAM-C controls Src family kinase (SFK) activation in LSC and that LIC w

177 Ls) to open the paracellular pathway through Src family kinase (SFK) activation.

178 Elevated Src family kinase (SFK) activity is associated with tumo

179 Moreover, we present in vivo evidence that Src family kinase (SFK) activity is critical for PCP reg

180 Src family kinase (SFK) activity is elevated in many can

181 the autophosphorylation site tyrosine in the SRC family kinase (SFK) FYN as well as Tyr142 in beta-ca

182 ro model of dormancy to evaluate the role of Src family kinase (SFK) in regulating this dormant-to-pr

183 Accordingly, inhibitors such as the SRC family kinase (SFK) inhibitor dasatinib reduced pPLC

184 s study, we show that the pyrrolo-pyrimidine Src family kinase (SFK) inhibitor PP2 effectively promot

185 tivation was completely abolished by the pan-Src family kinase (SFK) inhibitor, PP2, or when Syk is i

186 was inhibited in the presence of PP2, a pan-src family kinase (SFK) inhibitor, suggesting that c-Cbl

187 e AR by an alpha7 agonist was inhibited by a Src family kinase (SFK) inhibitor.

188 Here we identify the Src family kinase (SFK) Lyn as a redox sensor that media

189 Previously, we found that the Src family kinase (SFK) Lyn functions as a redox sensor

190 uced H2O2 is detected by the redox-sensitive Src family kinase (SFK) Lyn within the responding blood

191 mutation in the inhibitory SH2 domain of the SRC family kinase (SFK) LYN.

192 lar permeability attributable to loss of the Src family kinase (SFK) Lyn.

193 Src family kinase (SFK) proteins are frequently activate

194 tment of neutrophils through redox-regulated Src family kinase (SFK) signaling in neutrophils.

195 alternative signaling activation mechanisms, Src family kinase (SFK) signaling is sufficient to trans

196 ined that CRKL signaling was associated with SRC family kinase (SFK) signaling, specifically with YES

197 resulted in increased phosphorylation of the SRC family kinase (SFK) YES, increased expression of WNT

198 domain triggered PEAR1 phosphorylation in a src family kinase (SFK)-dependent manner.

199 crophages is, in addition, contributed to by Src family kinase (SFK)-dependent pathways.

200 glioblastoma, promotes tumorigenesis through Src family kinase (SFK)-dependent phosphorylation of Doc

201 educed GPVI expression and signaling via the Src family kinase (SFK)-Syk-PLCgamma2 pathway, and fibri

202 lation of cell-surface MHC-I by assembling a Src family kinase (SFK)-ZAP-70/Syk-PI3K cascade.

203 ne lipid rafts, leading to the activation of Src Family Kinase (SFK)/hemopoietic cell kinase (Hck) an

204 Here we report that Src family kinases (SFK) and focal adhesion kinase (FAK)

205 The Src family kinases (SFK) and insulin-like growth factor-

206 tion of type-1 TNF receptors, recruitment of Src family kinases (SFK) and SFK-dependent phosphorylati

207 Activation of Src family kinases (SFK) and the subsequent phosphorylat

208 Focal adhesion kinase (FAK) and Src family kinases (SFK) are known to play critical role

209 Here we show the role of Src family kinases (SFK) in mouse and human pDCs.

210 Src family kinases (SFK) integrate signal transduction f

211 ORF4 protein (E4orf4) subverts signaling by Src family kinases (SFK) to perturb cellular morphology,

212 ed the reorganization of actin filaments and Src family kinases (SFK), respectively.

213 ER2 are activated through phosphorylation by Src family kinases (SFK).

214 onRI, which depends on its interactions with Src family kinases (SFK).

215 been shown to confer enhanced sensitivity to SRC-family kinase (SFK) inhibitors in other malignancies

216 CD8 associates with the Src-family kinase (SFK) Lck, which, in turn, initiates t

217 Here we report that the Src-family kinase (SFK) regulator CD148 has a unique and

218 ation through receptor tyrosine kinase (RTK)/SRC-family kinase (SFK) signaling or mutant NRAS, which

219 ase (Csk), the primary negative regulator of Src-family kinases (SFK), plays a crucial role in contro

220 demonstrate the activation of PLCgamma by a Src family kinase (SFK1) during NE assembly.

221 d by PDGF, reactive oxygen species (ROS) and Src family kinases (SFKs) act downstream of PDGFRs to en

222 Src family kinases (SFKs) activation is required for int

223 hese receptors lacking the binding sites for Src family kinases (SFKs) and phosphatidylinositol-3-kin

224 We found increased phosphorylation of Src family kinases (SFKs) and putative Src substrates in

225 engagement of LFA-1 led to the activation of SRC family kinases (SFKs) and SFK inhibition blocked cyt

226 e, we report that RUNX1 is phosphorylated by Src family kinases (SFKs) and that this occurs on multip

227 The SRC family kinases (SFKs) and the receptor tyrosine kina

228 We investigated the interplay of Src family kinases (SFKs) and TrkB to better understand

229 Src family kinases (SFKs) are involved in both NMDA-medi

230 Src family kinases (SFKs) are pleiotropic activators tha

231 that inhibiting pathway-specific VEGFR2 and Src family kinases (SFKs) blocks ANDV-induced endothelia

232 both fibroblast growth factor receptors and SRC family kinases (SFKs) but does not affect the abilit

233 The Src family kinases (SFKs) c-Src and Yes mediate vascular

234 oblastoma (GBM), the EGF receptor (EGFR) and Src family kinases (SFKs) contribute to an aggressive ph

235 The Src family kinases (SFKs) have been proposed to play sti

236 are redundant roles in positively regulating Src family kinases (SFKs) in immunoreceptor signaling pa

237 The Src family kinases (SFKs) Lck, Hck, and Fgr directly pho

238 Src family kinases (SFKs) play a central role in mediati

239 The Src family kinases (SFKs) play essential roles in collag

240 Src family kinases (SFKs) promote cancer progression and

241 Most mammalian cell types depend on multiple Src family kinases (SFKs) to regulate diverse signaling

242 tyrosine phosphorylation indicated that, the Src family kinases (SFKs) were found to phosphorylate CD

243 The interactions of Src family kinases (SFKs) with the plasma membrane are c

244 This process was mediated by Src family kinases (SFKs), and nuclear EGFR had a role i

245 Anoxia or exogenous NMDA activated Src family kinases (SFKs), as measured by increased phos

246 d this, we identified the involvement of the Src family kinases (SFKs), based upon the ability of SFK

247 Platelets contain high levels of Src family kinases (SFKs), but their functional role dow

248 ercellular adhesion molecule-1 by activating Src family kinases (SFKs), DAP12 and Fc receptor-gamma (

249 ion of the C-terminal inhibitory tyrosine of SRC family kinases (SFKs), implicating CD148 as a critic

250 induced by IGF-1 can occur in cells lacking Src family kinases (SFKs), indicating that an unknown ki

251 r of the group of tyrosine kinases named the Src family kinases (SFKs), is overexpressed, associated

252 , and subsequent TSAd-mediated activation of Src family kinases (SFKs), SFKs engage the receptor tyro

253 telet activation signals in conjunction with Src family kinases (SFKs), spleen tyrosine kinase (Syk),

254 CSF-1R Tyr-559, required for the binding of Src family kinases (SFKs), was both necessary and suffic

255 activates the EGFR through activation of the Src family kinases (SFKs), which induce proteolytic shed

256 PECAM-1 transduces forces to activate src family kinases (SFKs), which phosphorylate and trans

257 ER stress coincided with the inhibition of Src family kinases (SFKs), which was exacerbated by PTP1

258 ition and substrate recognition of the eight Src family kinases (SFKs).

259 downregulated the expression and activity of Src family kinases (SFKs).

260 ctivation of kinases, Syk acts downstream of Src family kinases (SFKs).

261 phorylation of the tyrosines in the ITAMs by Src family kinases (SFKs).

262 urn is required to activate VEGFR2-recruited SRC family kinases (SFKs).

263 tion is inhibited by inhibitors of P2Y12 and Src family kinases (SFKs).

264 r of several tyrosine kinases, including the Src family kinases (SFKs).

265 Multiple SRC-family kinases (SFKs) are commonly activated in carc

266 le of phosphoinositide 3-kinases (PI3Ks) and Src-family kinases (SFKs) in these responses using human

267 increased expression of c-Cbl, Vav1, and the Src-family kinases (SFKs) Lyn and Fgr.

268 haride-induced cell migration, activation of Src-family kinases (SFKs), and phosphorylation of focal

269 cell antigen receptor (TCR) is initiated by Src-family kinases (SFKs).

270 CP1 might function through the activation of Src-family kinases (SFKs).

271 tering of receptors, which in turn activates Src-family kinases (SFKs).

272 ng the underlying actin cytoskeleton through Src family kinase signaling and m-Tor-dependent protein

273 cones responses involve the potentiation of Src family kinase signaling, a common effector of both p

274 moattraction, or by pharmacological block of Src family kinase signaling, consistent with receptor re

275 quitination of Ag.BCR complexes occurs by an Src family kinase signaling-dependent mechanism that is

276 n-like growth factor receptor signaling, and SRC family kinase signaling.

277 Upon Fc receptor activation, Src-family kinase signaling leads to segregation of Fcga

278 In addition, phosphorylation of Src family kinases significantly increased after stimula

279 3BP2 is required for optimal activation of Src family kinases, small GTPase Rac2, neutrophil supero

280 region of beta-actin was attenuated with the Src family kinase-specific inhibitor PP2 [4-amino-5-(4-c

281 This in turn activates the Src family kinases, spleen tyrosine kinase and PLCgamma2

282 e carcinoma is associated with activation of SRC family kinase (SRC, YES, FYN) activity and loss of c

283 factor-beta (TGF-beta), RhoA/Rho-kinase and Src-family kinases (SrcFK) have independently been impli

284 Amongst these are the Src-family kinases (SrcFKs), a multi-functional group of

285 leading to integrin activation via the SFK (Src family kinase)-Syk (spleen tyrosine kinase)-PLCgamma

286 -competitive inhibitor of Bcr-Abl, cKIT, and Src family kinases that exhibits efficacy in patients wi

287 ithin RECs by elevating ROS, which activated Src-family kinases that stimulated the extracellular sig

288 -alphavbeta3 coupling altered recruitment of Src family kinases to adhesion complexes and impaired me

289 the assembly states of Hck, a member of the Src-family kinases, under various conditions in solution

290 Moreover, the activatory phosphorylation of Src family kinases was considerably delayed as well as t

291 orylation of Syk, Akt, and ERK, but not SFK (Src family kinase), was significantly reduced in RhoG-de

292 fic contribution of c-Src, one member of the Src family kinases, was demonstrated using c-Src-deficie

293 Rac1/WAVE2 and Cdc42/WASP pathways, whereas Src family kinases were required for proper WASP tyrosin

294 Instead, Src family kinases were required for the generation of t

295 gnificant homology with other members of the Src family kinases, which may lead to unintended off-tar

296 Phosphorylation of paxillin by Src family kinases, which regulates adhesion turnover, i

297 ivating components in the network, including Src family kinases, whose inhibition affects only a subs

298 trated by independent association of the Lyn Src-family kinase with an intracellular immunoreceptor t

299 We have previously demonstrated that the Src family kinase Yes, the Yes-associated protein (YAP)

300 c studies showed that these TKIs inhibit the Src family kinase Yes1, which was found to be essential