ライフサイエンスコーパス: Src-family tyrosine kinase

1 of Itk via coordinate action of PI 3-K and a src family tyrosine kinase.

2 th factor (EGF) receptor and activation of a Src family tyrosine kinase.

3 lls and specifically activated Lyn kinase, a src family tyrosine kinase.

4 ant c-Src tyrosine kinase and Fyn, a related Src family tyrosine kinase.

5 ponses can be mimicked through inhibition of Src family tyrosine kinases.

6 ned from mouse embryos carrying mutations in Src family tyrosine kinases.

7 interaction with Fc Rgamma, calmodulin, and Src family tyrosine kinases.

8 many different signaling molecules including src family tyrosine kinases.

9 Unc119, that associates with IL-5Ralpha and Src family tyrosine kinases.

10 s the first receptor-associated activator of Src family tyrosine kinases.

11 abrogated by PP2, a selective inhibitor for Src family tyrosine kinases.

12 hibited by PP1, a selective inhibitor of the Src family tyrosine kinases.

13 0) and Tyr(129), which are phosphorylated by Src family tyrosine kinases.

14 on of Dok was mediated, at least in part, by Src family tyrosine kinases.

15 eins (G proteins) requires the activation of Src family tyrosine kinases.

16 e found that E6AP can bind to several of the Src family tyrosine kinases.

17 tivation motif (ITAM), which signals through Src family tyrosine kinases.

18 1 (SH1) domain is transphosphorylated by the Src family tyrosine kinases.

19 its well-established role as an activator of src family tyrosine kinases.

20 ide ligand specific to the SH3 domain of the Src family tyrosine kinases.

21 ha subunits, H-Ras, c-Src, and other related Src family tyrosine kinases.

22 x with normal cellular Src (c-Src) and other Src family tyrosine kinases.

23 and functional interaction of caveolin with Src family tyrosine kinases.

24 receptor complex and various members of the src family tyrosine kinases.

25 veolin interacts directly or indirectly with Src family tyrosine kinases.

26 emblance to the known recognition motifs for Src family tyrosine kinases.

27 ated enveloped virions (CEV) require Abl and Src family tyrosine kinases.

28 reversal is dependent upon the activation of Src family tyrosine kinases.

29 nt by signaling through the Dab1 adaptor and Src family tyrosine kinases.

30 ion to tubulin, including the SH3 domains of Src family tyrosine kinases.

31 ells and are dependent on CD36 activation of Src family tyrosine kinases.

32 sly implicated in the activation of Cdk2 and Src family tyrosine kinases.

33 nels are physiologically relevant targets of Src family tyrosine kinases.

34 nase (Csk) phosphorylates and down-regulates Src family tyrosine kinases.

35 osine phosphorylation, but not activation of Src-family tyrosine kinases.

36 ai similarly modulate Hck, another member of Src-family tyrosine kinases.

37 in situ prevents the oncogenic actions of a SRC: family tyrosine kinase.

38 In addition to Abl and Src family tyrosine kinases, a number of previously unkn

39 Inhibition of Src family tyrosine kinase activation with [4-Amino-5-(4

40 uggesting that GIRK channels are upstream of Src family tyrosine kinase activation.

41 e have shown that this event is dependent on Src family tyrosine kinase activity and the subsequent a

42 Here, we report how Src family tyrosine kinase activity controls apCAM-media

43 AM-1 cytoplasmic domain antibodies, required Src family tyrosine kinase activity, was independent of

44 udies indicated that leflunomide can inhibit src-family tyrosine kinase activity, more recent studies

45 tase inhibition, and negatively regulated by Src-family tyrosine kinase activity, which restricts the

46 the catalytic site, can be phosphorylated by Src family tyrosine kinases, although endogenous phospho

47 monstrated that soluble E-selectin activated Src family tyrosine kinases, an effect that was upstream

48 face expression of TrkB that is inhibited by Src family tyrosine kinase and A2A receptor antagonists.

49 on of focal adhesion kinase (FAK) and Lyn, a Src family tyrosine kinase and substrate of FAK, was up-

50 e transphosphorylation of Y551 by endogenous Src family tyrosine kinases and autophosphorylation at t

51 y, but they differ in that invasion requires Src family tyrosine kinases and calcium-calmodulin activ

52 ated SS RBC adhesion absolutely requires the Src family tyrosine kinases and is also enhanced by trea

53 se of CEV from the cell requires Abl but not Src family tyrosine kinases and is blocked by imatinib m

54 en produces a rapid, transient activation of src-family tyrosine kinases and tyrosine phosphorylation

55 f GDNF are inhibited by PP2, an inhibitor of Src family tyrosine kinases, and by LY29003, an inhibito

56 epends on GTPase RhoA, the RhoA ROCK kinase, Src family tyrosine kinases, and NADPH, and is modulated

57 calization requires phosphotyrosine, Abl and Src family tyrosine kinases, and neural Wiskott-Aldrich

58 the core dimer of protein phosphatase 2A, an src-family tyrosine kinase, and via phosphotyrosines, Sh

59 e of CEV from the cell requires Abl- but not Src-family tyrosine kinases, and is blocked by STI-571 (

60 These data demonstrate that the Src family tyrosine kinases are direct effectors of G pr

61 Src family tyrosine kinases are down-regulated through p

62 Src family tyrosine kinases are important signaling enzy

63 Src family tyrosine kinases are involved in modulating v

64 Although most Src family tyrosine kinases are modified by palmitoylati

65 this study, we show for the first time that Src family tyrosine kinases are physically and functiona

66 In vitro studies indicate that activities of Src family tyrosine kinases are regulated by tyrosine ph

67 Furthermore, Src-family tyrosine kinases are required in the early st

68 These data identify an egg Src family tyrosine kinase as a potential upstream regul

69 in hemopoietic cells leads to activation of Src family tyrosine kinases as well as Syk or ZAP-70.

70 s recognized by an antibody directed against Src family tyrosine kinases associate with PLC-gamma SH2

71 to study the phosphorylation of caveolin by Src family tyrosine kinases both in vitro and in vivo.

72 sensitive to the pharmacologic inhibition of Src family tyrosine kinases but was not affected by inhi

73 which was dependent on activation of a p60c-Src family tyrosine kinase, but not the epidermal growth

74 signaling requires activation of Zap-70 and Src family tyrosine kinases, but requirements for other

75 Conversely, inhibition of Src family tyrosine kinases by the pyrazolopyrimidine PP

76 Further, the recent recognition that Src family tyrosine kinases contribute to signaling by a

77 We further demonstrate that these events are Src family tyrosine kinase-dependent and specifically id

78 ta indicate that hypotonic stress results in Src family tyrosine kinase-dependent tyrosine phosphoryl

79 he endogenous PDGFbeta-R tyrosine kinase and Src family tyrosine kinases, differing results when the

80 c transmembrane proteins bearing syk but not src family tyrosine kinase domains are capable of autono

81 ) begins to address how one such pathway, an Src family tyrosine kinase, enhances cytoskeletal linkag

82 The protein Lck (p56(Lck)) is a Src family tyrosine kinase expressed at all stages of th

83 Deletion of lyn, a Src-family tyrosine kinase expressed by B, myeloid, and

84 Lck is a Src-family tyrosine kinase expressed in T lymphocytes, w

85 in rat brain interact with Fyn, one of four Src-family tyrosine kinases expressed in the brain.

86 and 1 (PSGL1), alpha(L)beta(2) integrin, the Src family tyrosine kinase FGR and spleen tyrosine kinas

87 ociated enveloped virions (CEV) use Abl- and Src-family tyrosine kinases for actin motility, and that

88 st growth factor receptor (FGFR), Flk-1, and src family tyrosine kinases from 1996 through mid-1997.

89 we show that Tim-3 can directly bind to the Src family tyrosine kinase Fyn and the p85 phosphatidyli

90 In this study, we show evidence that the Src family tyrosine kinase Fyn helps regulate this Th17/

91 This study addresses the effects of the Src family tyrosine kinase Fyn on Na(V)1.5 cardiac sodiu

92 trafficking caused by downregulation of the Src family tyrosine kinase Fyn was confirmed in more-det

93 at human tau tyr18 was phosphorylated by the src family tyrosine kinase fyn.

94 Src-family tyrosine kinase Fyn and serine-threonine prot

95 The Src family tyrosine kinase, Fyn, can facilitate regulati

96 tion with the adaptor protein, Grb2, and the Src-family tyrosine kinase, Fyn.

97 Inhibitors of Src family tyrosine kinases, G(i) proteins, phosphatidyl

98 ndothelial isoform of nitric-oxide synthase, Src-family tyrosine kinases, Galphaq and the insulin rec

99 shown that Cbl forms in vivo complexes with Src family tyrosine kinases, Grb2 adaptor protein, and t

100 Src family tyrosine kinases have been identified as pote

101 The Src family tyrosine kinase Hck possesses two phosphoryla

102 reported that mice deficient in the myeloid Src-family tyrosine kinases Hck, Fgr, and Lyn (Src tripl

103 We identified an Src family tyrosine kinase, hematopoietic cell kinase (H

104 ses suggest the involvement of c-Met and the Src family tyrosine kinases in mediating UV-induced Gab1

105 Here we investigate the requirement of Src-family tyrosine kinases in adipogenesis.

106 osphorylation was blocked by addition of the Src family tyrosine kinase inhibitor 4-amino-5-(4-chloro

107 The Src family tyrosine kinase inhibitor PP2 significantly b

108 The Src family tyrosine kinase inhibitor, PP1, was shown to

109 First, the specific Src family tyrosine kinase inhibitor, PP2, inhibited JNK

110 rization and invasion were blocked by PP2, a Src family tyrosine kinase inhibitor.

111 ide-in signaling and was inhibited by PP2, a Src family tyrosine kinase inhibitor.

112 istein, a tyrosine kinase inhibitor; PP2, an Src family tyrosine kinase inhibitor; AIDA, a group I me

113 yl)pyrazolo[3,4-D]pyrimidine (10 microm), an Src-family tyrosine kinase inhibitor.

114 Second, specific Src family tyrosine kinase inhibitors (herbimycin A and

115 Src family tyrosine kinase inhibitors also inhibited pla

116 f Fyn activation on differentiation, we used Src family tyrosine kinase inhibitors, PP1 and PP2, in c

117 Here, we determined that FYN, a Src family tyrosine kinase, interacts with the C-termina

118 n of tyrosine 876 on the GluR2 C terminus by Src family tyrosine kinases is important for the regulat

119 ur residues are present in p56lyn, the other src family tyrosine kinase known to bind to the ITAM, su

120 nd apoEr2, we examined the effect of Fyn, an Src family-tyrosine kinase known to interact with and ph

121 phosphorylation was dependent upon both the Src family tyrosine kinase Lck and the tyrosine phosphat

122 The Src family tyrosine kinase Lck appears to play a key rol

123 Although the Src family tyrosine kinase Lck is essential for T cell r

124 In this report, the crystal structure of the Src family tyrosine kinase Lck was used to guide the cre

125 a TCR-associated complex, which includes the Src family tyrosine kinase Lck.

126 This alternative pathway involves Src family tyrosine kinase Lck.

127 R) results in the proximal activation of the Src family tyrosine kinase Lck.

128 The Src family tyrosine kinases Lck and Fyn are critical for

129 hosphatase has been reported to activate the src family tyrosine kinases Lck and Fyn by dephosphoryla

130 how that KIR CYT, once phosphorylated by the src-family tyrosine kinase LCK, additionally bind the p8

131 , whereas consistent with work done with the Src-family tyrosine kinase Lck, the presence of helix al

132 cytoplasmic tails with the N-terminus of the Src-family tyrosine kinase Lck.

133 tyrosine kinase, EMT/ITK/TSK (EMT), and the SRC family tyrosine kinase, LCK.

134 to guide the dissection of two kinases [the Src-family tyrosine kinase, Lck, and the heme-regulated

135 usly demonstrated that mice deficient in the Src family tyrosine kinase Lyn developed a mild lupus-li

136 We report here that the Src family tyrosine kinase Lyn negatively regulates the

137 (IgE), FcepsilonRI, is phosphorylated by the Src family tyrosine kinase Lyn to initiate mast cell sig

138 study, we provide the first evidence that a Src family tyrosine kinase, Lyn, plays a key role in inh

139 lation of its beta and gamma subunits by the Src family tyrosine kinase, Lyn.

140 rafts, where they are phosphorylated by the Src family tyrosine kinase, Lyn.

141 Src-family tyrosine kinases mediate many receptor signal

142 vating the E-cadherin/PI3K pathway through a Src family tyrosine kinase-mediated signaling.

143 hrough the phosphorylation and activation of Src family tyrosine kinase members, such as Fyn, that ph

144 osine phosphorylated in vitro and in vivo by Src family tyrosine kinases on tyrosine 876 near its C t

145 Activation of Src-family tyrosine kinases on the Golgi is essential fo

146 Inhibition of src family tyrosine kinase or PI3K activity blocked pMHC

147 be blocked by pharmacological inhibitors of Src family tyrosine kinases or the epidermal growth fact

148 T cell antigen receptor (TCR) activates the Src family tyrosine kinase p56 Lck, which, in turn, phos

149 , Syk, and phospholipase Cgammal but not the Src family tyrosine kinase p56(lck).

150 Furthermore, we find that activation of the src-family tyrosine kinase, p56lck is an upstream mediat

151 l cell adhesion molecule (NCAM) requires the src family tyrosine kinase p59(fyn) in nerve growth cone

152 The src family tyrosine kinase p59fyn binds to a signaling m

153 Sodium channels are regulated by a Src-family tyrosine kinase pathway, and this modulation

154 ) that specifically inhibits the activity of Src family tyrosine kinases, PDGF did not activate Stat3

155 Src family tyrosine kinases play a key role in T-cell an

156 Src-family tyrosine kinases play pivotal roles in human

157 The Lck protein, a Src family tyrosine kinase, plays a critical role in T c

158 Many in vivo substrates of Src family tyrosine kinases possess sequences conforming

159 horylation was sensitive to the inhibitor of Src family tyrosine kinases, PP1, in a dose-dependent fa

160 Gp60 activation also phosphorylated the Src family tyrosine kinases pp60(c-Src) and Fyn.

161 the hippocampus, the combined activation of SRC family tyrosine kinases, protein kinase A, protein k

162 ced PKD activation was mediated primarily by Src family tyrosine kinases rather than protein kinase C

163 or Btk (Bruton's tyrosine kinase) family and Src family tyrosine kinases, respectively, PDGF can stim

164 Src family tyrosine kinases respond to a variety of sign

165 Src family tyrosine kinases resulted in CADTK tyrosine p

166 ies suggest that TCR signaling downstream of Src family tyrosine kinase(s) but upstream of calcineuri

167 c-Src family tyrosine kinase(s) was found to be upstream o

168 nd biochemical data clearly demonstrate that Src-family tyrosine kinases serve as a critical signal r

169 ) and Caveolin-1 (Cav-1) in the mechanism of Src family tyrosine kinase (SFK) inhibition by Csk.

170 The Src family tyrosine kinase (SFK) Lyn is activated by the

171 Src family tyrosine kinases (SFK) regulate cell prolifer

172 an oral small molecule inhibitor of Abl and Src family tyrosine kinases (SFK), including p56(Lck) (L

173 Src family tyrosine kinases (SFKs) are important regulat

174 Src family tyrosine kinases (SFKs) are involved in a div

175 Src family tyrosine kinases (SFKs) phosphorylate immunot

176 Src family tyrosine kinases (SFKs) play an important rol

177 (Csk) phosphorylates and down-regulates the Src family tyrosine kinases (SFKs).

178 ITAM receptors engage Src-family tyrosine kinases (SFKs) to initiate phagocyto

179 ecently described activator and substrate of Src-family tyrosine kinases (SFKs).

180 Protein phosphatase 2A (PP2A), YAP, Src family tyrosine kinases, Shc, phosphatidylinositol 3

181 gh EGF receptor was abolished by blockade of Src family tyrosine kinase signaling but not inhibition

182 rough its downstream, intracellular Dab1 and Src family tyrosine kinase signaling cascade, is essenti

183 Pyrazolopyrimidine, a selective inhibitor of Src family tyrosine kinases, significantly blocked the V

184 n of p130Cas was also dependent on an active Src family tyrosine kinase, since it could be blocked by

185 phosphorylated forms of BCR-signaling nodes (Src family tyrosine kinase, spleen tyrosine kinase [SYK]

186 It has been shown that Src-family tyrosine kinases such as Lyn could be a poten

187 rations (50-250 microM) markedly inactivated Src family tyrosine kinases temporally and spatially in

188 p56lck (Lck) is a lymphoid-specific Src family tyrosine kinase that is critical for T-cell d

189 Fyn is a Src-family tyrosine kinase that affects long term potent

190 Fyn is a prototype Src-family tyrosine kinase that plays specific roles in

191 mbryonic fibroblast (MEF) cells deficient in Src family tyrosine kinases to examine the role of Src i

192 y kinases (Fyn, Src, and Lck) and Fes, a non-Src-family tyrosine kinase, to alter Na,K-ATPase activit

193 te binds only the active conformation of the Src family tyrosine kinase, unlike the ATP cofactor, whi

194 autophosphorylation and activity of Fyn, an Src family tyrosine kinase, was observed in LAR(-/-) cel

195 dence that IL-13 induces the activation of a Src family tyrosine kinase, which is required for IL-13

196 osine phosphorylation of Cas proteins; then, Src family tyrosine kinases, which are recruited to phos

197 uated ERK1/2 activation, while inhibition of Src family tyrosine kinases with PP2 abolished the respo