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1 ions of adhesion proteins from the bacterium Streptococcus pyogenes.
2 urface of invasive M3-type strain MGAS315 of Streptococcus pyogenes.
3 treptolysin O (SLO), a virulence factor from Streptococcus pyogenes.
4 e 8 charged residues in YtgP, a homolog from Streptococcus pyogenes.
5 lycoside-hydrolase secreted by the bacterium Streptococcus pyogenes.
6 plays an important role in the virulence of Streptococcus pyogenes.
7 occus pneumoniae, Staphylococcus aureus, and Streptococcus pyogenes.
8 using two rapid antigen detection assays for Streptococcus pyogenes.
9 ins are critical for the in vivo survival of Streptococcus pyogenes.
10 , including the clinically relevant pathogen Streptococcus pyogenes.
11 d to effectively identify DNA signatures for Streptococcus pyogenes.
12 phil peptide (HNP-1) with the human pathogen Streptococcus pyogenes.
13 AgI/II-family proteins are also expressed by Streptococcus pyogenes.
14 gous to the myosin cross-reactive antigen of Streptococcus pyogenes.
15 share homology with the mitogenic toxins of Streptococcus pyogenes.
16 with PJI, namely, Staphylococcus aureus and Streptococcus pyogenes.
17 hat mimics that of many virulence factors of Streptococcus pyogenes.
18 tia marcescens and, to a lesser extent, with Streptococcus pyogenes.
19 lence factor secretion in the human pathogen Streptococcus pyogenes.
20 a heme ABC transporter in the Gram positive Streptococcus pyogenes.
21 ogens including Streptococcus pneumoniae and Streptococcus pyogenes.
22 to make up the machinery for heme uptake in Streptococcus pyogenes.
23 t of the heme acquisition machinery found in Streptococcus pyogenes.
24 functional upstream domain of protein F1 of Streptococcus pyogenes.
25 Cas9 enzymes from Staphylococcus aureus and Streptococcus pyogenes.
26 ting infection with the riboflavin auxotroph Streptococcus pyogenes.
27 can enter human cells and kill intracellular Streptococcus pyogenes.
28 toxins secreted by Staphylococcus aureus and Streptococcus pyogenes.
29 yte activation in response to infection with Streptococcus pyogenes.
30 s II-bound peptide from the mucosal pathogen Streptococcus pyogenes.
31 s aureus (10 [43.5%] vs 4 [12.9%]; P = .02), Streptococcus pyogenes (2 [8.7%] vs 19 [61.3%]; P < .001
32 mutagenesis approach, we have identified in Streptococcus pyogenes a gene that exhibits a receptor-l
33 r, pharyngitis resulting from infection with Streptococcus pyogenes (a group A Streptococcus [GAS]) c
34 Having no known environmental reservoir, Streptococcus pyogenes, a bacterium responsible for a wi
41 ing a positive result for samples containing Streptococcus pyogenes and a negative result for those w
42 p protein (Cpa) of the T3 pilus derived from Streptococcus pyogenes and expressed this fusion protein
45 tudy, we created an RNase III null mutant of Streptococcus pyogenes and its RNA sequencing (RNA-Seq)
47 ce against lethal soft tissue infection with Streptococcus pyogenes and prevented bacterial dissemina
48 al effects against Staphylococcus aureus and Streptococcus pyogenes and protected against staphylococ
49 ive clinical diagnose include Staphylococci, Streptococcus pyogenes and Pseudomonas aeruginosa in ble
50 has never, or rarely, been reported for the Streptococcus pyogenes and S. bovis groups of species, e
52 which includes common human pathogens, e.g., Streptococcus pyogenes and Streptococcus pneumoniae.
55 ular elements of patients with GP respond to Streptococcus pyogenes and whether this initial immune r
57 utagenesis of EndoS (an endoglycosidase from Streptococcus pyogenes ) and were found to be capable of
58 ccus epidermidis, Staphylococcus aureus, and Streptococcus pyogenes) and Gram-negative (Klebsiella pn
59 oth gram-positive (Staphylococcus aureus and Streptococcus pyogenes) and gram-negative bacteria (Pseu
60 m Staphylococcus aureus, streptolysin O from Streptococcus pyogenes, and anthrolysin O from Bacillus
64 ease onset in children and associations with Streptococcus Pyogenes, and influenza A H1N1-infection a
65 tein 9 (Cas9) from Staphylococcus aureus and Streptococcus pyogenes, and recombinant Cas9 and develop
66 in 8 patients, and Streptococcus agalactiae, Streptococcus pyogenes, and Streptococcus salivarius in
68 eus, methicillin-resistant S. aureus (MRSA), Streptococcus pyogenes, and vancomycin-resistant Enteroc
70 li of the nasty gram-positive human pathogen Streptococcus pyogenes are assembled as single, micromet
71 The heme-binding proteins Shp and HtsA of Streptococcus pyogenes are part of the heme acquisition
73 organisms, such as Staphylococcus aureus and Streptococcus pyogenes, are the dominant organisms isola
74 HIV-1 Gag-p24 on the tip of the T3 pilus of Streptococcus pyogenes as a fusion to the Cpa protein (L
75 inhibits growth of the pathogenic bacterium Streptococcus pyogenes as effectively as melittin create
76 e success of the group A streptococcus (GAS, Streptococcus pyogenes) as an important human pathogen.
77 i, Klebsiella pneumoniae, Proteus mirabilis, Streptococcus pyogenes, Bacillus subtilis, Staphylococcu
79 (FUD), a polypeptide based on F1 adhesin of Streptococcus pyogenes, binds by anti-parallel beta-stra
81 ustom DNA-binding modules, the nuclease-dead Streptococcus pyogenes Cas9 (dCas9) protein, which recog
82 e-wide off-target effects of the widely used Streptococcus pyogenes Cas9 (SpCas9) are imperfect, poss
87 SaCas9), which is significantly smaller than Streptococcus pyogenes Cas9 (SpCas9), to facilitate effi
91 o 70 degrees C, compared to 45 degrees C for Streptococcus pyogenes Cas9 (SpyCas9), which expands the
92 icity, selectivity, and reaction kinetics of Streptococcus pyogenes Cas9 activity, we challenged libr
96 DNA vectors expressing maize codon-optimized Streptococcus pyogenes Cas9 endonuclease and single guid
97 Here, we report the crystal structure of Streptococcus pyogenes Cas9 in complex with sgRNA and it
98 g guide RNA (stgRNA) that repeatedly directs Streptococcus pyogenes Cas9 nuclease activity toward the
99 also compared the cleavage efficiency of the Streptococcus pyogenes Cas9 protein based on expression
100 cular structures of the catalytically active Streptococcus pyogenes Cas9 R-loop that show the displac
101 hese inhibitors also blocked the widely used Streptococcus pyogenes Cas9 when assayed in Escherichia
102 protein containing a catalytically defective Streptococcus pyogenes Cas9, a cytidine deaminase, and a
103 ing method using only the well-characterized Streptococcus pyogenes Cas9, by incorporating MS2 or PP7
104 However, in M. tuberculosis, the existing Streptococcus pyogenes Cas9-based CRISPRi system is of l
110 d expression and activity of SLO, DNase, and Streptococcus pyogenes cell envelope protease in vitro.
113 etween sequence, stability, and folding, the Streptococcus pyogenes collagenous domain CL (Gly-Xaa-Ya
117 Type-II CRISPR-Cas systems, such as the Streptococcus pyogenes CRISPR-Cas9 system, can be adapte
121 reveal that a bacterial endoglycosidase from Streptococcus pyogenes , EndoS, is complementary to othe
122 ant bacterial pathogens in humans, including Streptococcus pyogenes, express surface proteins that bi
123 -residue functional upstream domain (FUD) of Streptococcus pyogenes F1 adhesin interacts with fibrone
125 to the surface of the human pathogen group A Streptococcus pyogenes (GAS) and subsequent hPg activati
127 ow that PS increased the severity of group A Streptococcus pyogenes (GAS) cutaneous skin infection in
134 -mediated opsonophagocytosis enables group A Streptococcus pyogenes (GAS) to establish infection.
135 rt a population genomic study of the group A Streptococcus pyogenes (GAS), a human pathogen with high
136 The normalized fluorescence intensity of the Streptococcus pyogenes gave a signal that is up to 16.4
139 Rgg2 and Rgg3 (Rgg2/3) regulatory circuit of Streptococcus pyogenes (group A streptococcus [GAS]) is
144 e role of zinc efflux in the pathogenesis of Streptococcus pyogenes (group A Streptococcus [GAS]), a
145 15,783-bp genome of a serotype M49 strain of Streptococcus pyogenes (group A streptococcus [GAS]), st
146 d an RNase Y ortholog has been identified in Streptococcus pyogenes (group A streptococcus [GAS]).
147 a, including one (stk) in the human pathogen Streptococcus pyogenes (group A streptococcus [GAS]).
148 major surface feature of the human pathogen Streptococcus pyogenes (group A streptococcus [GAS]).
149 t to which glucose alters gene expression in Streptococcus pyogenes (group A streptococcus) and the c
151 the Gram-positive human-restricted pathogen Streptococcus pyogenes (Group A Streptococcus, GAS) has
154 genes that are crucial for the virulence of Streptococcus pyogenes (group A Streptococcus, GAS).
158 rammed genome editing using CRISPR/Cas9 from Streptococcus pyogenes has enabled rapid and accessible
159 , formed autocatalytically, in the pili from Streptococcus pyogenes has highlighted the role that suc
160 mbinant immunoglobulin G-degrading enzyme of Streptococcus pyogenes (IdeS) followed by chemical reduc
162 A bacterial enzyme, IgG-degrading enzyme of Streptococcus pyogenes (IdeS), was shown to specifically
163 use of immunoglobulin G-degrading enzyme of Streptococcus pyogenes (IdeS), which is capable of diges
164 A reactivity against IgG-degrading enzyme of Streptococcus pyogenes (IdeS)- or pepsin-generated F(ab'
168 pha2 exhibited considerable activity against Streptococcus pyogenes, indicating a role of PSMs in the
169 rate that type I interferons produced during Streptococcus pyogenes infection are required to prevent
170 ated as an adjunctive treatment for clinical Streptococcus pyogenes infection however, the protein ta
171 ontrast to infection of superficial tissues, Streptococcus pyogenes infection of deeper tissue can be
174 (CMT) pathway of the Gram-positive pathogen Streptococcus pyogenes injects effector proteins into th
176 owed that the adhesive is capable of killing Streptococcus pyogenes introduced subcutaneously at the
182 The ExPortal protein secretion organelle in Streptococcus pyogenes is an anionic phospholipid-contai
187 epeats (CRISPR)-associated protein Cas9 from Streptococcus pyogenes is an RNA-guided DNA endonuclease
188 ession of many virulence-associated genes in Streptococcus pyogenes is controlled in a growth phase-d
190 e factors by the group A streptococcus (GAS) Streptococcus pyogenes is important in this pathogen's a
193 cription of several key virulence factors of Streptococcus pyogenes is under the control of Mga and N
197 egulator of the group A streptococcus (GAS) (Streptococcus pyogenes), is a transcriptional regulator
200 m Staphylococcus aureus and SrtA(strep) from Streptococcus pyogenes, is exploited for site-specific l
202 C-reactive protein (CRP), and M protein from Streptococcus pyogenes, it has been hypothesized that th
204 h year, millions of people are infected with Streptococcus pyogenes, leading to an estimated 500,000
205 ombined with focused experimental testing in Streptococcus pyogenes, led to a better understanding of
206 f a catalytically inactive Cas9 (dCas9) from Streptococcus pyogenes loaded with single guide RNAs (sg
207 r Staphylococcus aureus (</=0.12 microg/mL), Streptococcus pyogenes (</=0.12 microg/mL), Streptococcu
212 ected mutagenesis of an endoglycosidase from Streptococcus pyogenes of serotype M49 (Endo-S2) and the
224 nstrate that the group A Streptococcus (GAS; Streptococcus pyogenes) protease SpyCEP (S. pyogenes cel
225 and several bacterial ligands: M6 protein of Streptococcus pyogenes, PspC of Streptococcus pneumoniea
228 tudy of the two lactose metabolic operons of Streptococcus pyogenes, reported in this issue of Molecu
229 ar analysis conducted on streptolysin O from Streptococcus pyogenes revealed that this CDC also has g
232 en was used to identify mutations in rgg2 of Streptococcus pyogenes (rgg2Sp ) that conferred pheromon
235 The AF, but not the meconium SALSA, bound to Streptococcus pyogenes, S. agalactiae, S. gordonii, and
236 resent in pathogenic streptococci, including Streptococcus pyogenes, S. agalactiae, S. pneumoniae, an
240 human pathogens Streptococcus pneumoniae and Streptococcus pyogenes, SEER identifies relevant previou
241 cluding that in group A Streptococcus (GAS) (Streptococcus pyogenes Ser/Thr kinase (SP-STK)), regulat
242 the eukaryote-type serine/threonine kinase (Streptococcus pyogenes serine/threonine kinase; SP-STK)
245 The CRISPR-associated endonuclease Cas9 from Streptococcus pyogenes (spCas9) along with a single guid
246 (CRISPR)-associated endonuclease (Cas)9 from Streptococcus pyogenes (SpCas9) can be used to edit sing
247 The RNA-guided CRISPR-Cas9 nuclease from Streptococcus pyogenes (SpCas9) has been widely repurpos
248 In vitro assays demonstrate that Cas9 from Streptococcus pyogenes (SpCas9) is more active in creati
249 (CRISPR)-associated endonuclease (Cas)9 from Streptococcus pyogenes (SpCas9) is used to deplete VEGFR
250 ver, the size of the commonly used Cas9 from Streptococcus pyogenes (SpCas9) limits its utility for b
252 for entry of other virulent pathogens (e.g., Streptococcus pyogenes, Staphylococcus aureus, and poten
253 arisons of the 1.84-Mb genome of serotype M5 Streptococcus pyogenes strain Manfredo with previously s
254 We identified a unique genetic element in Streptococcus pyogenes strain SF370 that controls MMR vi
256 identifying variation, we pooled DNA of 100 Streptococcus pyogenes strains of different emm types in
257 eruginosa, S. aureus, Enterococcus faecalis, Streptococcus pyogenes, Streptococcus agalactiae, and vi
258 ria monocytogenes, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Escher
259 pathogens, including Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Helico
260 against local and/or systemic infections by Streptococcus pyogenes, Streptococcus pneumoniae, Lister
261 rsA homologues encoded by Bacillus subtilis, Streptococcus pyogenes, Streptococcus pneumoniae, Strept
262 reproduce the canonical PAM preferences for Streptococcus pyogenes, Streptococcus thermophilus CRISP
264 of superantigens and superantigen-containing Streptococcus pyogenes supernatants, although not by iso
266 -ribulose 5-phosphate 3-epimerase (RPE) from Streptococcus pyogenes that catalyzes the equilibration
267 pacity factor (SOF), a substance produced by Streptococcus pyogenes that turns mammalian serum cloudy
269 /SpyCatcher), based on a protein domain from Streptococcus pyogenes, that locks itself together via s
270 toxin production and increased virulence in Streptococcus pyogenes The nature of the polymorphism is
271 type M1 and M3 strains of the human pathogen Streptococcus pyogenes (the group A Streptococcus [GAS])
274 ortant in regulation of virulence factors of Streptococcus pyogenes (the group A streptococcus, GAS),
275 l streptococci, including the human pathogen Streptococcus pyogenes(the group A Streptococcus[GAS]),
276 r model organisms, Staphylococcus aureus and Streptococcus pyogenes, the activity is dependent on pri
277 toxins produced by Staphylococcus aureus and Streptococcus pyogenes, the superantigens (SAgs) are the
279 protein against the Gram-positive bacterium Streptococcus pyogenes This protein is composed of two d
280 lysin PlyC to permeabilize the cell wall of Streptococcus pyogenes to antibodies, thereby allowing t
282 We previously used crystal coordinates for Streptococcus pyogenes UGDH to generate a model of the h
284 n-mediated translocation (CMT), performed by Streptococcus pyogenes, utilizes the cholesterol-depende
285 nature-tagged mutagenesis (STM), to identify Streptococcus pyogenes virulence genes important for pat
287 ermore, utilization of supplied 5-CHO-THF by Streptococcus pyogenes was shown to require expression o
288 ion of streptococcal pyrogenic exotoxin A by Streptococcus pyogenes was unaffected by alpha and beta
289 synthetase proteins from the human pathogen Streptococcus pyogenes, we demonstrate the in vitro reco
290 Studying the pilus tip adhesin Spy0125 of Streptococcus pyogenes, we developed a single molecule a
291 elical peptide epitope from the M protein of Streptococcus pyogenes, were designed by exchanging one
292 h a fluorescent antibody complex specific to Streptococcus pyogenes, were volumetrically normalized a
293 cterial enzyme IdeS (IgG-degrading enzyme of Streptococcus pyogenes), which selectively cleaves IgG a
294 betabetaalpha/metal-dependent nuclease from Streptococcus pyogenes, which is encoded by the SF370.1
295 e also analyzed promiscuity of epitopes from Streptococcus pyogenes, which is known to exhibit epitop
296 tting a pilin subunit from a human pathogen, Streptococcus pyogenes, which usually undergoes intramol
297 lence of many bacterial pathogens, including Streptococcus pyogenes, which utilizes the cholesterol-d
298 e interactions of the group A streptococcus, Streptococcus pyogenes, with the extracellular matrix pr
299 ine development and mucosal immunity against Streptococcus pyogenes would benefit from the availabili
300 e immune response against the human pathogen Streptococcus pyogenes, yet the innate immune response a
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