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1 ested, with the most notable exception being Streptomyces.
2 been widely reported in bacteria but none in Streptomyces.
3 and B, indolosesquiterpenoids isolated from Streptomyces.
4 level for the proper cell differentiation in Streptomyces.
5 thesis is a requirement for morphogenesis in Streptomyces.
6 ted availability of the biochemical tools in Streptomyces.
7 influenced the contemporary biogeography of Streptomyces.
10 oelicolor is a model system for the study of Streptomyces, a genus of bacteria responsible for the pr
11 draft genome sequence of the plant pathogen Streptomyces acidiscabies 84-104, an emergent plant path
12 me, hydroxyethylphosphonate dioxygenase from Streptomyces albus (SaHEPD), and find that it displays t
13 s isolated from the culture-broth extract of Streptomyces albus cultures cotransformed with an enviro
15 gene cluster was heterologously expressed in Streptomyces albus J1074 setting the stage for convenien
17 ologous expression of these gene clusters in Streptomyces albus led to the isolation of three new PPs
18 -membered metagenomic library constructed in Streptomyces albus, the species that exhibited the highe
20 in filamentous bacteria, including the genus Streptomyces, although here our mechanistic understandin
24 s in the prolific antibiotic-producing genus Streptomyces and provide strong evidence that antibiotic
25 biosynthetic genes in two "clean" strains of Streptomyces and showed the production of HSAF analogues
26 growth is found in the filamentous bacteria Streptomyces, and is directed by a polarisome-like compl
27 h that coats the aerial hyphae and spores in Streptomyces, and mutants lacking the chaplins are unabl
28 thetic gene cluster and its pathway-specific Streptomyces antibiotic regulatory protein (SARP) cloned
31 t only to bacterial PNPases from E. coli and Streptomyces antibioticus, but also PNPase from human mi
34 in that patterns of genetic diversity within Streptomyces are consistent with genome surfing, and we
40 ramycin is an antitumor compound produced by Streptomyces argillaceus that has been used for the trea
42 is a potent antitumor antibiotic produced by Streptomyces atroolivaceus S-140, featuring an unusual 1
44 ) annotated to perform housekeeping roles in Streptomyces avermitilis Biochemical experiments define
45 ed in the transcriptome of a pure culture of Streptomyces avermitilis, suggesting for the first time
49 has long been thought that the life cycle of Streptomyces bacteria encompasses three developmental st
50 Philanthinus) cultivate a distinct clade of Streptomyces bacteria for protection against pathogenic
53 ning of an 11-gene berninamycin cluster from Streptomyces bernensis UC 5144, its heterologous express
55 mber of dps per genome among closely related Streptomyces can be explained by gene duplication or lat
59 ine biosynthetic pathway first discovered in Streptomyces cattleya While fluoroacetate has long been
60 D, X2 and X0beta, produced by the bacterium Streptomyces CBR38; and the macrolides elaiophylin, efom
61 A and efomycin G, produced by the bacterium Streptomyces CBR53.These metabolites were found at the i
63 red as a previously unreported metabolite of Streptomyces chromofuscus ATCC49982, and the gene cluste
64 gna unguiculata PLD, as well as the PLD from Streptomyces chromofuscus, cabbage, or peanuts, and no P
66 pentalenene synthase (Uniprot: B5GLM7) from Streptomyces clavuligerus was used in an automated compu
69 d 9 inhibited both Mtb GlgE and a variant of Streptomyces coelicolor (Sco) GlgEI with Ki = 237 +/- 27
70 produced from different microbes, including Streptomyces coelicolor , Bacillus subtilis , and Pseudo
71 member of the prodiginine group produced by Streptomyces coelicolor A3(2) and other actinobacteria.
72 oneidensis MR-1, Bacillus subtilis 3610, and Streptomyces coelicolor A3(2) as well as a mixed biofilm
73 e of 2-methylisoborneol synthase (MIBS) from Streptomyces coelicolor A3(2) has been determined in com
74 synthesis of this cofactor was discovered in Streptomyces coelicolor A3(2) in which chorismate is con
76 diphosphate C-methyltransferase (GPPMT) from Streptomyces coelicolor A3(2) is the first methyltransfe
78 ning RpfA function using the model bacterium Streptomyces coelicolor and have uncovered unprecedented
79 s transcription in actinobacteria, including Streptomyces coelicolor and Mycobacterium tuberculosis.
80 C-terminal HNH nuclease domain, Sco5333 from Streptomyces coelicolor and Tbis1 from Thermobispora bis
81 the copper centers of the small laccase from Streptomyces coelicolor at room temperature and pH 7.4,
82 netically refactored in a heterologous host, Streptomyces coelicolor CH999, to produce 3 mg/L A-74528
86 non-covalent inhibitors and GlgE, a variant Streptomyces coelicolor GlgEI (Sco GlgEI-V279S) was made
87 ucture resembles that of M. tuberculosis and Streptomyces coelicolor GlgEs, reported before, with eac
88 ructure, based on the cocrystal structure of Streptomyces coelicolor IHF duplex DNA, a bona fide rela
94 on with RNA from an RNase III null mutant of Streptomyces coelicolor M145 and a primer complementary
95 nd native mass spectrometry demonstrate that Streptomyces coelicolor NsrR (ScNsrR), previously report
96 ulating the nitrosative stress response like Streptomyces coelicolor NsrR, Sven6563 binds to a conser
97 ggests that, following phosphate limitation, Streptomyces coelicolor PhoP functions as a 'master' reg
98 s in the genome-minimized model actinomycete Streptomyces coelicolor provided the 57.6 kb merochlorin
100 his work, we show that the Rieske protein of Streptomyces coelicolor requires both the Sec and the Ta
101 e lipoprotein signal peptidase (lsp) gene in Streptomyces coelicolor results in growth and developmen
103 d produced simocyclinone heterologously in a Streptomyces coelicolor strain engineered for improved a
104 a MarR family transcriptional regulator from Streptomyces coelicolor that is well represented in sequ
105 onally, the macrodomain protein SCO6735 from Streptomyces coelicolor This protein is a member of an u
106 m of the multicopper oxidase (MCO) SLAC from Streptomyces coelicolor was investigated by structural (
107 orthologues from Mycobacterium smegmatis and Streptomyces coelicolor were phosphorylated by the corre
109 we confirmed that both aerobic prokaryotic (Streptomyces coelicolor) and eukaryotic (Homo sapiens) F
110 he distantly related Pgl system described in Streptomyces coelicolor, are widely distributed in ~10%
111 escribe how PcaV, a MarR family regulator in Streptomyces coelicolor, controls transcription of genes
112 ransferase regulator), a MarR homologue from Streptomyces coelicolor, functions in oxidative stress r
113 entous high-GC Gram-positive actinobacterium Streptomyces coelicolor, involved in controlling colony
114 cterial genera, including Bacillus subtilis, Streptomyces coelicolor, Mycobacterium smegmatis, and Ps
116 tures were obtained for the enzyme pair from Streptomyces coelicolor, solved at 1.3 A (ScLPMO10B) and
117 -enteric bacteria Pseudomonas aeruginosa and Streptomyces coelicolor, SoxR is activated by endogenous
118 erine-based desferroxiamine E siderophore in Streptomyces coelicolor, the corresponding biosynthetic
119 ents of the transcriptome and translatome of Streptomyces coelicolor, the model antibiotic-producing
129 iosynthesis of the pacidamycin nucleoside in Streptomyces coeruleorubidus proceeds through three step
131 and confirm two of its main components: Scy (Streptomyces cytoskeletal element), a unique bacterial c
132 we show that new optimized derivatives from Streptomyces-derived griselimycin are highly active agai
135 ll biological approach, we show that the two Streptomyces dynamins specifically localize to sporulati
136 ntalenolactone biosynthetic gene clusters of Streptomyces exfoliatus UC5319 and S. arenae TU469, resp
138 ng the composition of the growth medium, and Streptomyces explorer cells can communicate this explora
141 sociated niches have selected some symbiotic Streptomyces for increased cellulose degrading activity
142 For instance, in the antibiotic producer Streptomyces fradiae, a layered network of TetRs regulat
144 omain searches for TA pairs in the sequenced Streptomyces genomes, we identified two putative relBE l
147 f most steps of this biosynthetic pathway in Streptomyces ghanaensis (ATCC14672), except for the ulti
148 ), a clinically relevant antitumor agent, by Streptomyces globisporus that negative feedback can exte
149 nucleoside blasticidin S (BS) isolated from Streptomyces griseochromogenes was the first non-mercuri
151 surprisingly, the eukaryote-like enzyme from Streptomyces griseus IleRS lacks this capacity; at the s
152 By contrast, in the closely related protease Streptomyces griseus Protease B (SGPB), the equivalent P
153 ense of NADPH, similar to its counterpart in Streptomyces griseus We obtained the crystal structure o
159 d the dimeric geometry from its hypothesized Streptomyces homologue CprB, which is a gamma-butyrolact
162 However, it is structurally more similar to Streptomyces hygroscopicus VldE, a GDP-valienol-dependen
163 amide synthase of the geldanamycin producer, Streptomyces hygroscopicus, shows a broader chemoselecti
166 s that drive plant biomass deconstruction in Streptomyces, including acquisition and selective retent
167 Pectobacterium, Pseudomonas, Ralstonia, and Streptomyces, involvement of prophage in disease symptom
168 understanding of the cellulolytic ability of Streptomyces is currently limited to a few soil-isolates
169 ass degrading genes (CAZy) are widespread in Streptomyces, key enzyme families are enriched in highly
171 ressor protein (CsoR) has been identified in Streptomyces lividans (CsoR(Sl)) and found to regulate c
172 e use a structurally characterized CsoR from Streptomyces lividans (CsoR(Sl)) together with three spe
176 nsis UC 5144, its heterologous expression in Streptomyces lividans TK24 and Streptomyces venezuelae A
177 nd PepN2, two neighboring PepN homologs from Streptomyces lividans were purified in E. coli but displ
180 o use KcsA (a K(+) channel from the bacteria Streptomyces lividans) as a surrogate because it lacks a
181 ent Actinobacteria (Mycobacterium smegmatis, Streptomyces lividans, and Rhodococcus jostii) each exhi
182 ion that induced prodiginine production from Streptomyces lividans, suggesting differential regulatio
184 biotic, is a phosphonotripeptide produced by Streptomyces luridus, in which glycine and leucine are l
185 e desertomycin amidinohydrolase gene dstH in Streptomyces macronensis led to the accumulation of dese
186 tigation of another family member, EncP from Streptomyces maritimus, thereby expanding the biocatalyt
190 ates were treated with transglutaminase from Streptomyces mobaraensis and tyrosinase from Trichoderma
191 tion of microbial transglutaminase (TG) from Streptomyces mobaraensis in different types of restructu
192 second step with the less specific MTG from Streptomyces mobaraensis, a successful bio-orthogonal la
193 tion of microbial transglutaminase (TG) from Streptomyces mobaraensis, and bovine and porcine fibrino
195 4-hydroxy-3-nitrosobenzamide biosynthesis in Streptomyces murayamaensis is performed by NspF, a mono-
196 for the nogalamycin monooxygenase (NMO) from Streptomyces nogalater As with flavin, dithranol oxidati
200 cally abundant and geographically widespread Streptomyces phylogroups from our culture collection.
201 igate the key roles of type II TA systems in Streptomyces physiology and environmental stress respons
203 tin (iso-MGS) biosynthetic gene cluster from Streptomyces platensis NRRL 18993 consists of 11 genes,
204 anipulation in the PTM-PTN dual overproducer Streptomyces platensis SB12029, revealing two genes, ptm
206 n FilP and DivIVA, the main component of the Streptomyces polarisome complex, leads to formation of a
210 se-binding lectin (SL2-1) from the bacterium Streptomyces rapamycinicus was identified by analysis of
211 ory network that controls differentiation in Streptomyces, repressing a large regulon of developmenta
213 consisting of orthogonal promoter sequences, Streptomyces ribosome binding sites, and yeast selectabl
214 inically approved antibiotic daptomycin from Streptomyces roseosporus, but has notable structural dif
215 Here we report the crystal structure of Streptomyces sahachiroi AlkZ (previously Orf1), a bacter
217 zyme from the plant pathogen 87.22 strain of Streptomyces scabies Scabin shares nearly 40% sequence i
221 the marginolactone azalomycin F in mangrove Streptomyces sp. 211726 has shown that only nineteen ext
222 gates), were characterized as metabolites of Streptomyces sp. AD-23-14 isolated from the Rock Creek u
223 ), and tetranactin (3) in a crude extract of Streptomyces sp. AMC 23 in the precursor ion scan mode.
225 inamide construction in the marine bacterium Streptomyces sp. CNB-091, which involves a novel intermo
226 biosynthetic logic of their construction in Streptomyces sp. CNH-287 based on the identification of
227 xplored its atropo-selective biosynthesis in Streptomyces sp. CNQ-418 in order to elucidate the N,C-b
229 tinomycetes Salinispora pacifica CNS-143 and Streptomyces sp. CNT-179, highlighted by the unprecedent
230 to identify nigericin in a crude extract of Streptomyces sp. Eucal-26 by means of precursor ion scan
231 mily of anti-infective compounds produced by Streptomyces sp. K01-0509 with a novel mode of action.
232 ene cluster for herbicidin A biosynthesis in Streptomyces sp. L-9-10 as well as its verification by h
233 s units to surfactin in the agar proximal to Streptomyces sp. Mg1 but not other streptomycetes tested
237 thway arising from an orphan gene cluster in Streptomyces sp. NRRL-F6652, a close relative of Strepto
238 been isolated from laboratory cultures of a Streptomyces sp. obtained from a tropical marine sedimen
239 ate the biomass-deconstructing capability of Streptomyces sp. SirexAA-E (ActE), an aerobic bacterium
241 luding the anticancer agent cinerubin B from Streptomyces sp. SPB74 and an antibiotic, arenimycin B,
242 d the close relationship between CLI2509 and Streptomyces sp. SPB78, which was previously implicated
244 lorins A-D, produced by the marine bacterium Streptomyces sp. strain CNH-189, which possess novel che
246 been isolated from laboratory cultures of a Streptomyces sp. Svetamycins A-D, F, and G are cyclic de
248 expression studies indicate that in several Streptomyces species at least one Dps is significantly o
249 s study, we examined a collection of diverse Streptomyces species for the best innate ability to hete
250 ted with primary metabolism in nonpathogenic Streptomyces species have been recruited as basic elemen
253 Phenotypic tests identified the isolate as a Streptomyces species, but 16S rRNA sequence analysis pro
254 a class of polyether ionophores produced by Streptomyces species, was investigated by accurate-mass
260 h-throughput transcriptional assay format in Streptomyces spp. by leveraging eGFP, inserted both at a
263 l species, and that at least for the case of Streptomyces, strain de-replication based on SSU gene se
266 in (ACM) isolated from cultures of different Streptomyces strains is a potent mechanism-based inhibit
269 those governing sporulation of Bacillus and Streptomyces, suggesting that Myxococcus evolved a highl
273 rD3 genes from the apramycin gene cluster in Streptomyces tenebrarius were expressed in E. coli and t
276 mental behaviours in bacteria, here, causing Streptomyces to deviate from its classically-defined lif
278 During sporulation, the filamentous bacteria Streptomyces undergo a massive cell division event in wh
279 expression in Streptomyces lividans TK24 and Streptomyces venezuelae ATCC 10712, and detection of var
281 th PKS module from the pikromycin pathway of Streptomyces venezuelae creates a reaction chamber for t
284 tion of this site, which is conserved in the Streptomyces venezuelae GlgE enzyme, did not affect the
286 al S-adenosyl-L-methionine enzyme DesII from Streptomyces venezuelae is able to oxidize the C3 hydrox
288 n the jadomycin biosynthetic gene cluster of Streptomyces venezuelae ISP5230, affects both chloramphe
291 a full-length PKS module from the bacterium Streptomyces venezuelae that revealed an unexpectedly di
292 n (MTM) and pikromycin (PKM), co-produced by Streptomyces venezuelae, represent minimalist macrolide
293 application of genome-wide approaches using Streptomyces venezuelae, which is capable of fairly sync
294 dl) genes by exploiting a new model species, Streptomyces venezuelae, which sporulates in liquid cult
296 the biosynthetic gene clusters for BLMs from Streptomyces verticillus ATCC15003, tallysomycins from S
299 aenorhabditis elegans and the bacterial prey Streptomyces, which have evolved a powerful defense: the
300 ed the feasibility of these affinity tags in Streptomyces, which will be widely employed to explore t
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