ライフサイエンスコーパス: Syk kinase

1 evels of the cytoskeleton-associated phospho-Syk kinase.

2 ar regulation was also noted for the related Syk kinase.

3 in the cytoplasmic domain and recruitment of Syk kinase.

4 l lipid rafts include FcRgamma and activated Syk kinase.

5 osphorylation is induced in cells expressing Syk kinase.

6 phylum Cnidaria, contains a gene encoding a Syk kinase.

7 y discrete tyrosine-phosphoproteins, but not Syk kinase.

8 osphorylation of Fc gamma RII independent of Syk kinase.

9 ent association between Vav and both Lyn and Syk kinases.

10 exogenous substrate specific for ZAP-70 and Syk kinases.

11 t low concentrations of antigen that induced Syk kinase activation and near-maximal secretion.

12 -mediated phagocytosis that leads to Src and Syk kinase activation, Ca(2+) mobilization, and calcineu

13 he CD47-SIRPalpha axis to the pro-phagocytic Syk kinase activation.

14 e R406, has been shown to be an inhibitor of Syk kinase, active in a variety of in vitro and in vivo

15 gnaling by directly binding to and enhancing Syk kinase activity and activation of its downstream eff

16 e that gamma phosphorylation is dependent on Syk kinase activity and is independent of endogenous COS

17 ced phosphorylation of Cbl was downstream of Syk kinase activity and was unchanged by expression of t

18 se activation are therefore not dependent on Syk kinase activity in this system.

19 ls decline and phospho-Syk levels as well as Syk kinase activity increase.

20 Blocking Syk kinase activity prevented relative post-HSCT BCR hyp

21 ons in the interdomain-B region affected ITK-SYK kinase activity, they only modestly altered downstre

22 In a COS7 cell system, the expression of Syk kinase alone is sufficient to convert the alpha4beta

23 apidly, resulting in enhanced recruitment of Syk kinase and calcium fluxes.

24 in phosphorylation of Src family kinases and Syk kinase and induced a calcium influx in freshly isola

25 duction, as judged by impaired activation of Syk kinase and phospholipase C-gamma2 as well as by dimi

26 d a novel innate signaling pathway involving Syk kinase and the adaptor CARD9, which is critical for

27 SYK kinase and the adaptor protein CARD9 were essential

28 ine-based activation motif that can activate Syk kinase and the phosphatidylinositol 3-kinase (PI3K)/

29 pid inhibition of phosphorylation of Src and Syk kinases and downstream production of reactive oxygen

30 h PDTC reduced and delayed the activation of Syk kinases and erk2.

31 echanisms that include activation of Src and Syk kinases and protein kinase C.

32 , including the activation of Src family and Syk kinases and the production of reactive oxygen specie

33 n the KO cells leads to the dysregulation of Syk kinases and/or phosphatases, possibly SHP-1.

34 riggered the phosphorylation of FcgammaRIIa, Syk kinase, and phospholipase Cgamma2 in granulocytic HL

35 on receptor for beta-glucans and signals via Syk kinase but independently of the Toll-like receptor (

36 eatment of Jurkat T cells with TNF activated Syk kinase but not ZAP70, another member of Syk kinase f

37 osine residues in the activation loop of the Syk kinase catalytic domain is necessary for signaling,

38 Notably, pharmacologic inhibitors of SYK kinase currently in phase I-II trials for other indi

39 ysis of kinase dependence using antisense to Syk kinase demonstrated that TNF, but not IL-1 beta, sti

40 phagosomes required spleen tyrosine kinase (Syk) kinase-dependent production of reactive oxygen spec

41 Src-family and Syk kinases determine the structure of the actin cytoske

42 acterizing the steady state kinetics using a Syk kinase domain construct [Syk(360-635)] revealed that

43 ctivity of mammalian target of rapamycin and Syk kinases, enhanced receptor recycling and Ca2+ flux h

44 Syk kinase but not ZAP70, another member of Syk kinase family, and the optimum activation occurred a

45 ting a functional difference between these 2 Syk-kinase family members in primary NK cells.

46 beta 2 but not beta 1 integrin signaling and Syk kinase function via a direct association between the

47 The role of Syk kinase in Fc gamma receptor (Fc gamma R) IIA-mediate

48 g Syk mRNA and protein and the importance of Syk kinase in Fc gamma receptor-mediated phagocytosis.

49 eceptor is capable of inducing signaling via Syk kinase in myeloid cells and that it can induce phago

50 integrin-directed migration suggesting that Syk kinase in part encodes myeloid Rac2 specificity in v

51 ype lectins and suggest a potential role for Syk kinase in regulation of innate immunity.

52 In contrast, phosphorylation of syk kinase, in response to a non-cross-reacting stimulus

53 -70) and Src- (Fyn/Lck) family kinases, with Syk kinase inducing the most prominent effect.

54 Phosphorylation of c-Cbl was inhibited by a Syk kinase inhibitor but with an IC(50) that was not con

55 D-transfected cells were pretreated with the Syk kinase inhibitor Piceatannol before ligation, which

56 by the Src family kinases inhibitor PP1, the Syk kinase inhibitor R406 and the integrin alphaIIbbeta3

57 Syk kinase inhibitors blocked Syk signaling and exhibite

58 We demonstrate here that multiple Syk kinase inhibitors both prevent parasite-induced band

59 safety in human clinical trials, we suggest Syk kinase inhibitors constitute a promising class of an

60 offer a mechanistic rationale to reposition SYK kinase inhibitors for evaluation in patients with me

61 We also show that the same Syk kinase inhibitors suppress merozoite egress near the

62 ed pDCs, which was blocked by Src family and Syk kinases inhibitors, thus indicating the activation o

63 Using a yeast two-hybrid screen to identify Syk kinases-interacting proteins (SKIPs), we isolated 3B

64 The C-terminal SH2 domain of SYK kinase is essential for its ability to activate PLC-

65 These results indicate that Syk kinase is required for Fc gamma RIIA-mediated phagoc

66 that loss of early signaling components like syk kinase may account for some of the effects of nonspe

67 Syk kinase may be an important new therapeutic target in

68 These results indicate that loss of Syk kinase-mediated integrin signaling impairs leukocyte

69 TCIPS were the pharmacologic antagonists of Syk kinase, phospholipase C and protein kinase C, all do

70 ated with a higher induction in the level of Syk kinase phosphorylation following stimulation with an

71 These results indicate that an inhibitor of Syk kinase produces significant clinical benefits at 12

72 of mast cells is thought to involve Lyn and Syk kinases proximal to the receptor and the signaling c

73 ogy domains of 3BP2, and required functional Syk kinases, Ras, and calcineurin.

74 tion and BCR microcluster growth, leading to Syk kinase recruitment and calcium responses.

75 ivation of Syk kinase, whereas both TLR2 and Syk kinase regulate COX2 expression.

76 phorylation of Gab2 and its association with Syk kinase, SHP-2 phosphatase, and the p85 subunit of ph

77 Our studies link Dectin-1/Syk kinase signaling with autophagy-dependent maturation

78 for binding of the tandem SH2 domain of the Syk kinase (Syk-tSH2) to doubly phosphorylated peptides

79 ules with overlapping functions, such as the Syk kinases, SYK, and ZAP-70, and adaptor molecules, SH2

80 ctivation of the antigen receptor-associated Syk kinase that accumulates in adhesion-promoting podoso

81 Surprisingly, Syk kinase, the reported target of MNS, did not mediate

82 enous B-cell receptors (BCR) coupled through Syk kinase to phospholipase C-gamma (PLC-gamma) activate

83 ntegrin signaling via Src family kinases and Syk kinase to PLCgamma2 is required for MK spreading, mi

84 Thus, the direct binding of Syk kinase to the integrin beta3 cytoplasmic tail is a n

85 K) links the B cell receptor (BCR)-activated Syk kinase to the phosphoinositide and mitogen-activated

86 de evidence suggesting that UA activates the Syk kinase via membrane cholesterol.

87 two adjacent Src homology 2 domains) of the Syk kinase, we report a method combining calorimetric an

88 if-like domain of dectin-1 and activation of Syk kinase, whereas both TLR2 and Syk kinase regulate CO

89 il integrin signaling through Src-family and Syk kinases, whereas autoimmunity resulted from exaggera

90 l receptor signalling by phosphorylating Lyn/Syk kinases, which in turn activate multiple integrins (

91 associated with increased phosphorylation of Syk kinase, while the endogenous TCR zeta-chain is down-