ライフサイエンスコーパス: T antigen

1 ernatively spliced 57kT forms of MCPyV large T antigen.

2 genome has undergone mutations in the large T antigen.

3 D patients were transformed using SV40 large T antigen.

4 of the role of simian virus 40 (SV40) small t antigen.

5 sion in mice that express the Polyoma middle T antigen.

6 MCC tumors that fail to express MCPyV large T antigen.

7 xpresses small T antigen and truncated large T antigen.

8 nd in only 1 of 56 tumors positive for large T antigen.

9 arrying the gene encoding the polyoma middle T antigen.

10 methylation, and John Cunningham (JC) virus T antigen.

11 an essential step in unwinding origin DNA by T antigen.

12 cificity for conserved epitopes of JCV large T antigen.

13 mune response to peptides encoding BKV large T antigen.

14 immortalized with telomerase and SV40 large T antigen.

15 Golgi, resulting in the formation of sialyl-T antigen.

16 n small T antigen (sTAg) and truncated large T antigen.

17 origin-binding domain of virus-encoded large T antigen.

18 ncy was the principal carcinogenic effect of T-antigen.

19 ost tumors express the MCPyV large and small T antigens.

20 mian virus 40 (SV40) large (T) and small (t) T antigens.

21 y test both tumor-derived and wild type (WT) T antigens.

22 r MUC1 carrying one or more Tn, T, or sialyl-T antigens.

23 y of MCCs, may drive tumorigenesis via viral T antigens.

24 the use of WbiP for the facile synthesis of T-antigens.

25 spect to the early gene products, the tumor (T) antigens.

26 imeric reporters containing the entire BPCV1 T antigen 3' UTR undergo negative regulation when coexpr

27 or virus promoter-driven polyomavirus middle T antigen, a tumor in which beta1-integrin function is i

28 eased in proportion to the reduction in p68N-T antigen affinity, confirming that p68-T antigen intera

29 SV40 T antigen also induces H3K18 hypoacetylation.

30 Other polyomavirus-encoded large T antigens also increase the levels of CBP/p300 and sust

31 cript between a previously undescribed virus T antigen and a human receptor tyrosine phosphatase.

32 HPV E7 proteins, as well as simian virus 40 T antigen and adenovirus E1A, can associate with and ina

33 subunits as well as for the localization of T antigen and damage-signaling proteins to viral replica

34 nd viral oncogenes, including the SV40 large T antigen and human papilloma virus 16 E6-antigen.

35 mmortalized with temperature-sensitive large T antigen and human telomerase reverse transcriptase (OS

36 ing partner of the mouse polyoma virus large T antigen and later shown to possess tumor suppressor-li

37 l body numbers, and expression of SV40 large T antigen and oncogenic Ras.

38 AX, and Mre11-Rad50-Nbs1 (MRN) assemble with T antigen and other viral DNA replication proteins in la

39 of a kinase activity associated with middle T antigen and our serendipitous discovery that this acti

40 On the other hand, SVST complements large T antigen and Ras for the transformation of human mammar

41 It is predicted to encode the large T antigen and small T antigen early proteins and the VP1

42 es previously immortalized by the SV40 large T antigen and telomerase.

43 The fraction of cells expressing SV40 large T antigen and the levels of T antigen mRNA were reduced

44 helicases, such as the simian virus 40 large T antigen and the papillomavirus E1 protein, are active

45 hromosomes of MCC tumors and expresses small T antigen and truncated large T antigen.

46 rocytes, which instead expressed early viral T antigens and exhibited apoptotic death.

47 les, specifically the simian virus 40 (SV40) T antigens and oncogenic Ras(12V), affect fatty acid met

48 only recognizes Gal beta1,3GalNAc alpha-OR (T-antigen and derivatives) as the acceptor to generate t

49 cin origin, with terminal fucose, the sialyl T-antigen, and N-linked oligosaccharides identified as p

50 me or all of the functions of the SV40 small T antigen, another well-characterized oncoprotein, in tw

51 cture of the hexameric helicase of JCV large T antigen (apo) and its use to drive the structure-based

52 tly focused on a few epitopes within variant TS antigens appear to neither contribute to, nor detract

53 ons of full-length and truncated MCPyV large T antigen are unknown.

54 criptase (hTERT) plus SV40 large T and small T antigens are transformed by either oncogenic Ras (H-Ra

55 These results indicate that MCPyV T antigens are tumorigenic in vivo, consistent with thei

56 We further show that the BKPyV large T antigen, as well as large T antigens from related poly

57 ecule and ensemble assays to show that large T antigen assembled on the SV40 origin unwinds DNA effic

58 This enzyme binds to SV40 large T antigen at two places, close to the N-terminal end and

59 s long-terminal region-driven polyoma middle T antigen breast cancer model.

60 By binding YAP, small t antigen brings it together with protein phosphatase 2A

61 JCV large T antigen, but not VP1 capsid protein, was expressed in

62 ere positive for early SV40 transcript large T antigen, but only 4 of the 14 cases exhibited late vir

63 uch as retinoblastoma (RB1) by mutated viral T antigens, but the molecular pathogenesis of MCPyV-nega

64 loping antibodies capable of detecting large T antigen by immunohistochemistry.

65 In contrast, expression of the MCPyV large T antigen C-terminal 100 residues could inhibit the grow

66 how that the oncogenes simian virus 40 large T antigen, c-Myc, and cyclin E induce spatial reorganiza

67 However, we have observed that SV40 large T antigen can induce cell proliferation and transformati

68 The two small T antigens can target different proteins for dephosphory

69 ated a novel mouse hepatocellular SV40 large T-antigen carcinoma cell line, MHT that maintains the ab

70 The analysis of the mechanisms by which T antigen carries out its many functions has proved to b

71 erse transcriptase (hTERT) and/or SV40 large T antigen cDNA vectors, and antibiotic-resistant cells w

72 d anthracyclines were studied in CEA424/SV40 T-antigen (CEA/Tag) transgenic mice, which develop gastr

73 tion of p53 and Rb proteins using SV40 large T antigen completely rescued necrotic cell death.

74 he hexameric replicative helicase SV40 large T antigen, constituting a simple primosome that is activ

75 On its own, small t antigen controls cell survival and differentiation.

76 ecovery of cellular immune response to large T antigen corresponds with resolution of active BKV infe

77 Our results suggest that the SV40 T antigen could be a valuable tool to dissect cellular a

78 MCPyV large T antigen could bind to Rb but was unable to bind to p53

79 arious models are proposed to illustrate how T antigen could separate the central origin.

80 progeny than the wild type, suggesting that T antigen-CUL7-directed proteolysis facilitates virus pr

81 standards sequenced in this study with large T antigen deletions were cultured in cell lines immortal

82 1) Despite their common T-antigen-derived origins, MIN6 and BTC3 cells display m

83 Mice expressing MCPyV T antigens developed hyperplasia, hyperkeratosis, and ac

84 Enzymatic synthesis of T-antigen disaccharides have relied on the use of beta-1

85 ogenesis using an orthotopic, polyoma middle-T antigen-driven model in Foxp3(DTR) knockin mice.

86 form core 1 Galbeta1-3GalNAcalpha1-Ser/Thr (T antigen) during mucin type O-glycan biosynthesis.

87 cted to encode the large T antigen and small T antigen early proteins and the VP1, VP2, and VP3 struc

88 untranslated region (UTR) of the BPCV1 large T antigen early transcript and identified a functional m

89 The large tumor antigen (T antigen) encoded by simian virus 40 is an amazing mole

90 in combination with wild-type or SV40 large T antigen expressing epithelia resulted in prostates tha

91 Verhaegen et al. report MCPyV small T-antigen-expressing transgenic mice that now provide in

92 3 in the two MCC specimens that lacked large T antigen expression and in only 1 of 56 tumors positive

93 nvestigated any potential link between MCPyV T antigen expression and the highly metastatic nature of

94 rnative mechanisms of negative regulation of T antigen expression between the BPCVs and the polyomavi

95 Small t antigen expression blocked both stimulus-induced and c

96 agic acid and spiperone also inhibited large T antigen expression by BK virus and JC virus, two impor

97 These miRNAs negatively regulate T antigen expression by directing small interfering RNA

98 vel monoclonal antibody detected MCPyV large T antigen expression in 56 of 58 (97%) unique MCC tumors

99 Ectopic T antigen expression results in the immortalization and

100 As a consequence of T antigen expression, B cells develop normally but, upon

101 rcentage of BKV infected cells and the large T-antigen expression were significantly decreased in HRP

102 BKV by immunofluorescent analysis and large T-antigen expression which suggested BKV infection by We

103 ols, which was not due to the suppression of T-antigen expression.

104 sX abundance, (b) the fibronectin, collagen, T-antigen (FCT) region of the genome, which contains the

105 he deletion of the C terminus of MCPyV large T antigen found in MCC serves not only to disrupt viral

106 the BKPyV large T antigen, as well as large T antigens from related polyomaviruses, is alone capable

107 These residues are well conserved in the T antigens from the polyomaviruses, indicating that the

108 T-Antigen (Gal-beta1,3-GalNAc-alpha-O-Ser/Thr) is an imp

109 major capsid protein gene VP1, and the large T antigen gene.

110 acid reading frame of opposing-strand large T antigen gene.

111 utations were detected in both VP1 and large T antigen genes.

112 These data indicate that T antigen has a mechanism to specifically unwind the cen

113 68 (p68N) that physically interacts with the T antigen helicase domain.

114 cture of p68N and map its interface with the T antigen helicase domain.

115 due pairs, R498/D499 and R540/D502, in large-T-antigen helicase are critically involved in the transf

116 on structural data for simian virus 40 large-T-antigen helicase revealed a set of nine residues bound

117 ise molecular interactions between the viral T antigen, host replication proteins, including DNA poly

118 xP-flanked stop cassette, and the SV40 large T-antigen (iAST).

119 T-antigen immortalization of cells allowed cell growth.

120 Comparisons of polyoma and SV40 small T antigens implicate Abeta in the control of differentia

121 gland tumors induced by polyomavirus middle T antigen in JNK2(-/-) mice were more sensitive to CDDP

122 the results of their efforts to express SV40 T antigen in mature B cells of mice.

123 viral DNA, implicating CUL7 association with T antigen in MRN proteolysis.

124 re effective than full-length and 57kT large T antigen in promoting the growth of human and mouse fib

125 e novo by overprinting of the second exon of T antigen in the common ancestor of a large clade of mam

126 e used transgenic mice expressing SV40 large T antigen in their prostatic neuroendocrine cells, under

127 a viral oncogene that cooperates with middle T antigen in transformation.

128 inase expression induced expression of MCPyV T antigens in stratified squamous epithelial cells and M

129 the oncogenic activity of MCC tumor-derived T antigens in vivo, a conditional, tissue-specific mouse

130 growth factor alpha, but not simian virus 40 T-antigen, increase the rate of hepatocyte growth under

131 cell lines with the expression of SV40 large T antigen increased the levels of Ras activation and per

132 PP2A Abeta/Akt interaction by polyoma small T antigen increased turnover of Akt Ser-473 phosphorylat

133 sformation of many cell types in culture and T antigen induces neoplasia when expressed in rodents.

134 p68N-T antigen affinity, confirming that p68-T antigen interaction is vital for primosome function.

135 For small T antigens, interaction with PP2A is needed for each of

136 Polyomavirus small t antigen is a viral oncogene that cooperates with middl

137 genic mice in which expression of SV40 large T antigen is driven by UPK II promoter.

138 Although SV40 large T antigen is essential, it is not sufficient for cellula

139 f topo I with the C-terminal binding site on T antigen is required for these activities.

140 T antigen is required for viral DNA replication, transcr

141 l cell polyomavirus (MCPyV) expressing viral T antigens is a common feature of most Merkel cell carci

142 T-Antigen is found to be closely associated with cancer

143 ce that express a fragment of the SV40 small t antigen known to inhibit protein phosphatase 2A (PP2A)

144 large probasin promoter directed SV40-large T-antigen (LPB-Tag) expressing mouse prostate, mPIN form

145 protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53.

146 monstrated that simian virus 40 (SV40) large T antigen (LT) binds to the Bub1 kinase, a key regulator

147 t the co-crystal structure of the SV40 Large-T Antigen (LT) hexameric helicase bound to its origin ds

148 pended on the coexpression of the SV40 large T antigen (LT) in the cells.

149 Simian virus 40 (SV40) large T antigen (LT) is a multifunctional protein that is impo

150 Simian virus 40 (SV40) large T antigen (LT), for example, targets p53 directly, but m

151 inding and helicase domains of the MCV large T antigen (LT), suggesting a selective pressure to remov

152 t expression of simian virus 40 (SV40) large T antigen (LT), without a viral origin, is sufficient to

153 iated DDR pathways accumulate in MCPyV large T antigen (LT)-positive nuclear foci in cells infected w

154 t-antigen (ST) collaborates with SV40 large T-antigen (LT) and activated rasv12 to promote transform

155 ens, pharmacologic interference of the large T antigen (LTA) may represent an effective therapeutic a

156 Phylogenetic trees based on large T-antigen (LTA) allow separation of subtype I into subgr

157 e prostate model that is driven, in part, by T antigen-mediated functional inactivation of p53.

158 Here we found that SV40 T antigen-mediated transformation inhibits HCMV infectio

159 enesis in ovariectomized polyomavirus middle T-antigen mice.

160 rom Escherichia coli O127, which expresses a T-antigen mimic in the lipopolysaccharide (LPS) structur

161 use mammary tumor virus-polyoma virus middle T antigen (MMTV-PyMT)-induced breast cancer to conduct s

162 the mouse mammary tumor virus-polyoma middle T-antigen model.

163 the Mouse Mammary Tumor Virus-Polyoma Middle T-Antigen mouse.

164 ssing SV40 large T antigen and the levels of T antigen mRNA were reduced in infected human and monkey

165 locks tumor formation in both polyoma middle T antigen (MT) and HER2/Neu transgenic models of breast

166 re we characterize YAP as a target of middle T antigen (MT) important for transformation.

167 The gene coding for middle T antigen (MT) is the murine polyomavirus oncogene most

168 Middle T antigen (MT) is the primary polyomavirus oncogene resp

169 Middle T antigen (MT) is the principal oncoprotein of murine po

170 reast cancer driven by either polyoma middle T antigen (MT) or HER2 is p110alpha dependent.

171 d differentiation and cooperates with middle T antigen (MT) to transform primary cells in vitro and i

172 Middle T antigen (MT), the oncogene of polyomavirus, can drive

173 Middle T antigen (MT), the principal oncoprotein of murine poly

174 ialyl Lewis-X (sLe(X)) and the di-sialylated T-antigen (NeuAcalpha2,3Galbeta1,3(NeuAcalpha2,6)GalNAc)

175 cal monopartite NLSs, such as c-myc and SV40 T-antigen NLSs.

176 at the addition of the simian virus 40 large-T-antigen nuclear localization signal (NLS) results in t

177 H was independently associated with JC virus T antigen (odds ratio [OR] = 1.93; P = .0077), body mass

178 ALTO is evolutionarily related to the middle T antigen of murine polyomavirus despite almost no seque

179 e and a cell line transformed with the large T antigen of simian virus 40, were developed, and both w

180 ic C subunit, in a manner similar to that of T antigens of the small DNA tumor viruses.

181 As in other polyomaviruses, the large T-antigen of MCV recognizes the viral origin of replicat

182 e studies uncover the action of polyomavirus T antigens on cellular CBP/p300 and suggest that additio

183 While the impact of MCV and viral T-antigens on MCC development has been extensively inves

184 in HER2/neu mice, but not in polyoma middle T-antigen oncomice.

185 PP2A) activity by either expression of small t antigen or depletion of PP2A/C by RNA interference enh

186 cells on activation of either polyoma middle T antigen or ErbB2 signaling.

187 d in cells immortalized by either SV40 large T antigen or p53-null mutation, whereas alpha3beta1-depe

188 vity because of the expression of SV40 large T-antigen or because of a mutation in the TP53 gene.

189 of PP2A with okadaic acid, fostriecin, small T antigen, or PP2A knockdown abrogated rapamycin-induced

190 two highly constrained regions of the large T antigen ORF provided a start codon and C-terminal hydr

191 the 2.9 A crystal structure of the MCV large T-antigen origin binding domain (OBD) in complex with a

192 1 and minimal intrarenal expression of SV40-T antigen (P < 0.001).

193 ntigen, suggesting a functional link between T antigen-p68 interaction and primosome activity.

194 of p68 residues in the interface diminished T antigen-p68 interaction, confirming the interaction si

195 Here, we report the detailed large T antigen-p68 interface, as revealed in a co-crystal str

196 ell lines show oncogene addiction to the MCV T antigens, pharmacologic interference of the large T an

197 case domains of simian virus 40 (SV40) large T antigen play a critical role in DNA replication.

198 motility of cells transformed by SV40 large T antigen plus activated ras.

199 ferences between SVST and polyomavirus small T antigen (POLST) in their effects on differentiation, t

200 prototypical NLS from simian virus 40 large T-antigen preferentially at the major NLS binding site.

201 sis on the cell-cell modules that complement T-antigen-presenting cell interaction, provides a fundam

202 ns with the unique T. cruzi trans-sialidase (TS) antigen protect against gastric and systemic T. cruz

203 isms were detected in the VP1, VP2 and Large T Antigen proteins, suggesting potential functional effe

204 that the binding of topo I to this region of T antigen provides the proper unwound DNA substrate for

205 Using the MMTV-Polyoma Middle T antigen (PyMT) mouse model of human ductal carcinoma,

206 The polyomavirus middle T antigen (PyMT) oncogene activates the cellular nonrece

207 mary tumor virus (MMTV)-Polyoma virus middle T antigen (PyMT) or MMTV-c-Neu transgenic mice.

208 mmary tumorigenesis using the polyoma middle T antigen (PyMT) transgenic mouse model.

209 metastatic breast cancer, the polyoma middle T antigen (PyMT) transgenic mouse.

210 In the polyoma middle T-antigen (PyMT) transgenic mouse model of breast cancer

211 Murine polyomavirus small t antigen (PyST) regulates cell cycle, cell survival, ap

212 Polyoma small T antigen (PyST), an early gene product of the polyoma v

213 Like all polyomavirus T antigens, PyST functions largely via its interactions

214 c mice that express the polyoma virus middle T antigen (PyV-MT) in the mammary gland and that are wil

215 Polyoma virus middle T antigen (PyVmT) is a powerful viral oncogene; however,

216 ncluding the widely used polyomavirus middle-T antigen (PyVmT) model, which provides an opportunity t

217 ctively, due to large deletions in the large T antigen region.

218 of miRNA-mediated negative regulation of the T antigens remains uncertain.

219 suppressor p53 and pRb in urothelium by SV40 T antigen resulted in urothelial carcinoma, resembling h

220 nslocation strand, suggesting that the large T antigen ring can open to bypass bulky adducts.

221 s from nontumor sources did not possess this T antigen signature mutation.

222 Fabpi-TAg mice expressing large T-antigen solely in villi had ectopic enterocyte prolife

223 The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and

224 ecently demonstrated that polyomavirus small T antigen (ST) binds YAP, a major effector of Hippo sign

225 We have previously shown that SV40 small t antigen (st) cooperates with deregulated cyclin E to a

226 SV40 small t antigen (ST) has been reported to be necessary and suf

227 Coexpression of SV40 small t antigen (st), but not other tested oncogenes, efficien

228 e of the functions of the polyomavirus small T antigens (ST) are shared by the E6 and E7 oncoproteins

229 SV40 small t-antigen (ST) collaborates with SV40 large T-antigen (L

230 ress putative polyomavirus oncoprotein small T antigen (sTAg) and truncated large T antigen.

231 nds directly to the hexameric viral helicase T antigen, suggesting a functional link between T antige

232 es immortalized using simian virus 40 (SV40) T antigen, suggesting the possibility of transcomplement

233 hereas immortalization induced by SV40 large T antigen supported fibroblast proliferation in the abse

234 SV40 small T antigen (SVST) has received considerable attention bec

235 Simian virus 40 (SV40) large T antigen (SVT) interferes with normal cell regulation a

236 promoter to target expression of SV40 large T-antigen (T-Ag) in the undifferentiated murine embryoni

237 domain (OBD) of simian virus 40 (SV40) large T-antigen (T-Ag) is essential for many of T-Ag's interac

238 rototypical replicative helicase, SV40 large T-antigen (T-ag), was investigated.

239 nity binding element for the viral initiator T-antigen (T-ag).

240 o address this question, we knocked down MCV T-antigen (TA) expression in MCV-positive MCC cell lines

241 r suppressor p53 (fused to Gal4BD) and large T antigen (TAg) (fused to VP16) was visualized in vivo b

242 the input virus nor the expression of large T antigen (TAg) alone is sufficient to trigger the activ

243 lleles, including the simian virus 40 (SV40) T antigen (TAg) and oncogenic H-Ras, inhibit HCMV infect

244 Simian virus 40 large T antigen (TAg) contributes to cell transformation, in p

245 and emphasized the importance of functional T antigen (Tag) for efficient replication.

246 wild-type (WT) simian virus 40 (SV40) large T antigen (TAg) inhibits apoptosis via the activation of

247 Simian virus 40 large T antigen (TAg) transforms cells in culture and induces

248 seeding of tumorigenic hepatocytes from SV40 T antigen (Tag) transgenic MTD2 mice into the livers of

249 origin and flanking sequences, to which BKV T antigen (Tag), cellular proteins, and small regulatory

250 duced activation of the oncogenic SV40 large T antigen (TAg).

251 In agreement, expression of large tumor T antigens (TAg) encoded by polyomaviruses in mammalian

252 The rat insulin promoter (RIP)-T-antigen (Tag) is a well characterized transgenic mouse

253 feron gamma (IFNgamma) induction of the SV40 T-antigen (TAg) was assayed by immunohistochemistry and

254 In addition, T antigen targets multiple cellular pathways, including

255 ns result in expression of a truncated large T antigen that retains the Rb binding or LXCXE motif but

256 Mutant T antigens that fail to bind topo I normally do not part

257 ng discovered provides a collection of novel T antigens that, like simian virus 40, can be used to di

258 sis of the common core 1 O-glycan structure (T-antigen), the precursor structure for most mucin-type

259 ormation assay that also includes SV40 large T antigen, the catalytic subunit of cellular telomerase,

260 By contrast, large T antigen, the replicative DNA helicase of the simian vi

261 K may have potential applications in masking T-antigen, the tumor antigen, in vivo.

262 lization via genetic influences such as SV40 T-antigen, thus limiting our knowledge of the events tha

263 evels of SnoN cooperated with polyoma middle T antigen to accelerate the formation of aggressive mult

264 uses encoding the mouse polyoma virus middle T antigen to elastase-tv-a transgenic mice with a pancre

265 te (TRAMP) model of PCa that uses SV40 large T antigen to induce PCa, loss of Foxm1 decreased tumor g

266 ggest that additional mechanisms are used by T antigens to induce cell immortalization and transforma

267 defined oncogenic driver antigen (SV40 large T-antigen) to follow the activation and differentiation

268 BPCV1 miRNA is not encoded antisense to the T antigen transcripts but rather lies in a separate, pro

269 preserving the reading frame of the opposing T antigen transcripts.

270 , but were the cell line 661W, a mouse SV-40 T antigen transformed photoreceptor cell line.

271 selectively induces apoptosis of SV40 large T-antigen transformed cells and significantly reduces co

272 contrast to the half-life of simian virus 40 T antigen-transformed cells.

273 In contrast, T-antigen-transformed REF52 and p53+/+ HCT116 tumor cell

274 hrelinomas induced by a tissue-specific SV40 T-antigen transgene.

275 MATERIALS AND C3(1) Sv-40 large T antigen transgenic mice (n = 23) were studied with ins

276 eighted (DW)-MRI in the polyoma virus middle T antigen transgenic mouse model of breast cancer.

277 by using mammary tumour virus-polyoma middle T-antigen transgenic (PyMT) mice as a model of inherited

278 ination is a secondary occurrence, following T antigen-triggered oligodendroglial apoptosis.

279 Mice expressing Polyoma middle T antigen under the mouse mammary tumor virus promoter w

280 mouse prostate (TRAMP) mice express the SV40 T-antigen under the control of the probasin promoter, an

281 Stimulation with TD antigens under inflammatory conditions induces plasma

282 e, and Tregs are produced in the presence of TD antigens under tolerance conditions.

283 genic expression of the polyoma virus middle T antigen, under control of the mouse mammary tumor viru

284 Unexpectedly, large T antigen unwinds DNA past a DNA-protein crosslink on th

285 died these mutants to gain insights into how T antigen unwinds the origin.

286 these controversies, we detected MCPyV large T antigen using immunohistochemistry with two distinct a

287 The occurrence of T- and sialyl T-antigen varied in bovine and ovine reproductive tract

288 on induced by Merkel cell polyomavirus small T antigen viral oncoprotein.

289 In support of this, wild-type T antigen was able to specifically unwind a 31-bp DNA co

290 While large T antigen was expressed to higher levels in adar1(-/-) c

291 Furthermore, MCPyV-truncated large T antigen was more effective than full-length and 57kT l

292 ombination, transforming growth factor alpha/T-antigen, was sufficient to direct cell autonomous grow

293 However, JCV proteins (VP1 or T antigen) were detected mainly in the brains of 23/24 H

294 al oncoprotein, simian virus 40 (SV40) large T-antigen, which is frequently used to immortalize cells

295 his work shows how this association of small t antigen with YAP is important for its effects on cell

296 Analysis of mutant T antigens with disrupted binding to the ubiquitin ligas

297 MWPyV is a widespread human virus expressing T antigens with low transforming potential.

298 roteins, by replacing SV40 large T and small T antigens with sh-p53, mutant CDK4 (CDK4(R24C)), and sh

299 to plasma cells in response to T-dependent (TD) antigens within germinal centers (GCs).

300 In contrast, tolerance induction by TD antigens without costimulation triggers the developme