ライフサイエンスコーパス: T-cell clone

1 l receptor interaction with a tumor-specific T-cell clone.

2 a6 receptor of the G9C8 insulin-reactive CD8 T-cell clone.

3 (TCR) isolated from a hemophilia A subject's T-cell clone.

4 rophil autoantibodies, and 6 of 47 (12.8%) a T-cell clone.

5 amma production and proliferation by the CD4 T-cell clone.

6 f both CD244 and TIM-3, but not PD-1, on CD8 T cell clones.

7 pare iNOS-dependent and iNOS-independent CD4 T cell clones.

8 d expansion of alloreactive and autoreactive T cell clones.

9 d their ability to stimulate CD1b-restricted T cell clones.

10 on of PKCtheta mutants in antigen-stimulated T cell clones.

11 X peptide-stimulated PBMCs, and IFX-specific T cell clones.

12 mer staining and confirmed by isolating CD4+ T cell clones.

13 s the antigen for highly diabetogenic CD4(+) T cell clones.

14 +) population was distinct from the leukemic T cell clones.

15 n and IFN-gamma expression in plaque-derived T cell clones.

16 s and stimulation of the specific autoimmune T cell clones.

17 aged animals by the appearance of large CD8 T cell clones.

18 ed in Ca(2+) signaling in some lymphomas and T cell clones.

19 gorithm that detected significantly expanded T cell clones.

20 ertoire but does not eliminate self-reactive T cell clones.

21 with either indirect or direct alloreactive T-cell clones.

22 ficity, thereby avoiding the need to isolate T-cell clones.

23 , in combination with either direct/indirect T-cell clones.

24 o compared with virus-specific cytotoxic CD8 T-cell clones.

25 hemokine secretion than "ineffective" CD8(+) T-cell clones.

26 the selection of weakly self-reactive, naive T-cell clones.

27 and evade lysis by HLA-restricted cytotoxic T-cell clones.

28 tly higher activation of HIV-specific CD8(+) T-cell clones.

29 ) DCs in elicitation of HCMV-specific CD8(+) T-cell clones.

30 s a large number of distinct HTLV-1-infected T-cell clones.

31 igen-driven expansion of a limited number of T-cell clones.

32 to assess the functional capacity of derived T-cell clones.

33 well as by adoptive transfer of diabetogenic T-cell clones.

34 ed during adoptive transfer experiments with T-cell clones.

35 he more prolonged expansion of high-affinity T-cell clones.

36 transfer compared with that of monospecific T-cell clones.

37 tiviral capacity of some HIV-specific CD8(+) T-cell clones.

38 m the preferential loss of high-avidity CD8+ T-cell clones.

39 resistance to infection present in some CD4 T-cell clones.

40 cal T cell, BDC-2.5, and other ChgA-specific T-cell clones.

41 Here we used 15 mouse or human CD8+ T cell clones (11 antiviral, 4 anti-self) in conjunction

42 nsulin reactive, MHC class-I-restricted CD8+ T cell clone (1E6) that can recognize over 1 million dif

43 n an individual clone basis, 14 of 53 CD4(+) T-cell clones (26%) recognized 6 distinct but overlappin

44 Mouse T cell clone 2C recognizes two different major histocomp

45 en specificity, we have studied the TCR from T cell clone 2C.

46 ence of proteasomal processing and immediate T cell clone activation upon stimulation with FLUX in so

47 his potential promiscuity, reactivity of the T cell clones against 400 randomly selected HLA-A*0201-b

48 Wherever tested, all CD8(+) T cell clones against these novel lytic cycle epitopes r

49 ptide, recognized by the diabetogenic CD8(+) T cell clone AI4, to DCs in NOD mice via the endocytic r

50 Twenty-four of the valve-infiltrating T cell clones also had the same clone identified in bloo

51 drug-specific responses from in vitro primed T cell clones and clones from hypersensitive patients we

52 f T1D patient-derived beta cell-autoreactive T cell clones and lines, but, when screening for pathoge

53 We isolated the corresponding T-cell clone and characterized the recognized epitope as

54 cinoma cell line stimulates a tumor-specific T-cell clone and elicits antigen-specific cells in vivo,

55 7)-RLGL-WE14 tetramers bind to ChgA-specific T-cell clones and easily detect ChgA-specific T cells in

56 expression was detected in IL-17-expressing T-cell clones and in CD161(+) T helper type 17 cells ex

57 Mechanistic experiments using human T-cell clones and lines are providing a clinically relev

58 Multiple T-cell clones and polyclonal lines having different avid

59 s at earlier time-points in Bet v 1-specific T-cell clones and promoted less IL-5 production in T cel

60 ty by the adoptive transfer of mHAg-specific T-cell clones and the challenges for the broad applicati

61 e kinetics of activation of Bet v 1-specific T-cell clones and the polarization of naive T cells.

62 apies has required the isolation of specific T-cell clones and their clonotypic TCRs.

63 Although high- and low-affinity CD8(+) T cell clones are recruited into the primary response, t

64 We show that PPI-specific CD8 T-cell clones are mainly reliant upon cytotoxic degranul

65 uggest that high-avidity HIV-1-specific CD8+ T-cell clones are recruited during early infection but a

66 However, none of the 75 expanded T cell clones assayed contained intact virus.

67 so confirmed the presence of GVHD-associated T-cell clones at the site of the disease.

68 after adoptive transfer by the diabetogenic T cell clone BDC-2.5 indicates that large numbers of cel

69 the target Ag for a highly diabetogenic CD4 T cell clone BDC-5.2.9.

70 stance to transfer of diabetes by the CD4(+) T-cell clone BDC 2.5 as well as the CD8(+) AI4 T-cell cl

71 e target antigen for the highly diabetogenic T-cell clone BDC-5.2.9.

72 the target antigen for the diabetogenic CD4 T-cell clone BDC-5.2.9.

73 ontributed to the activation of a pathogenic T-cell clone, BDC2.5.

74 All remaining T cell clones belong to two additional sets expressing B

75 Insulin epitopes recognized by diabetogenic T cell clones bind poorly to the class II I-A(g7) molecu

76 y expressed GATA3, nonetheless, a portion of T-cell clones both GATA3 and RAR-related orphan receptor

77 an CD1a mediates foreign Ag recognition by a T cell clone, but the nature of possible TCR interaction

78 The extent of fluctuation of dominant CD8(+) T-cell clones, but not of CD4(+) counterparts, correlate

79 of immunodominant Treg as well as pathogenic T cell clones can be targeted for potential intervention

80 previously shown that Chlamydia-specific CD4 T cell clones can recognize and be activated by infected

81 e hypothesized that distinct GVHD-associated T-cell clones can be identified during the disease progr

82 une system is its ability to generate B- and T-cell clones capable of recognizing and neutralizing sp

83 For 3 distinct T-cell clones, CD79b specificity was confirmed through C

84 to cause diabetes; and 3) individual CD8(+) T-cell clones chose their cytotoxic weaponry by a yet un

85 ethod, no reactivity was observed by the CD8 T-cell clone, confirming no semidirect alloreactivity.

86 We report that a highly expanded CD4(+) T-cell clone contains an intact provirus.

87 onal tissues, and absolute numbers of unique T-cell clones correlated with respective T-cell counts.

88 ers, an unlabeled influenza peptide reactive T cell clone could be detected at a frequency of 0.1% in

89 owed that a subset of Chlamydia-specific CD4 T cell clones could terminate replication in epithelial

90 annexin A2-specific Vdelta2(neg) gammadelta T-cell clones could be derived from peripheral blood mon

91 ntial TH1 cytokine secretion patterns from a T cell clone cultured under TH1 or TH2 inducing conditio

92 the topography of the expanding CMV-specific T-cell clones, deep sequencing allowed us, for the first

93 measurements of three of these self-reactive T cell clones demonstrated a normal off-rate but a slow

94 alysis of a set of 10 HLA-A*02:01-restricted T cell clones demonstrated that staining with pMHC multi

95 f 14 brain-infiltrating, JCV-specific CD4(+) T cell clones demonstrated that these cells use an unexp

96 Furthermore, promiscuous T-cell clones demonstrated increased functional avidity

97 CD4(+) T cell clones derived from a leprosy lesion and patient

98 ow that in macaques, antigen-specific CD8(+) T cell clones derived from central memory T cells, but n

99 05 HLA-A*0201/NY-ESO-1(157-165)-specific CD8 T cell clones derived from five melanoma patients.

100 d on TCR/CD8:pMHC avidity, as tumor-reactive T cell clones derived from patients vaccinated with the

101 Using a panel of diabetogenic CD4 T cell clones derived from the NOD mouse, we recently id

102 We analyzed individual allospecific T-cell clones derived from a Wiskott-Aldrich syndrome (W

103 Here, we show that, although CD4(+) T-cell clones derived from such cultures recognize HLA c

104 a PmpG(303-311)-specific multifunctional Th1 T cell clone, designated PmpG1.1, from an immune C57BL/6

105 or ablates antigenicity with a wide range of T cell clones despite significantly improving peptide bi

106 cell markers (Foxp3(+) CD25(+)) and cultured T cell clones did not express a cytokine profile that in

107 Individual CD4 T-cell clones differed in their degrees of dependence on

108 sured by allospecific CD4 (indirect) and CD8 T-cell clones (direct) when cells were used.

109 T cell clones directed against the HLA-A*0201-binding WT

110 KK10-stimulated "effective" CD8(+) T-cell clones displayed significantly more rapid TCR sig

111 Finally, IL-10-producing drug-specific T cell clones downregulated the response of autologous e

112 -term fitness advantage to a small number of T-cell clones (e.g., by an increased division rate or de

113 select a comprehensive population of Jurkat T-cell clones, each expressing a single discrete shRNA.

114 The WE14 responses of three NOD-derived CD4 T-cell clones, each with different T-cell receptors (TCR

115 From a CD8(+) T cell clone established by stimulation of HLA-A2(+) CD8

116 genicity of a panel of GAD65-specific CD4(+) T-cell clones established from unimmunized 4- and 14-wee

117 hat cotransfer of MPO431-439-specific CD8(+) T cell clones exacerbated disease mediated by MPO-specif

118 ode of action, a HERV-K(HML-2)-specific CD8+ T cell clone exhibited comprehensive elimination of cell

119 CD4(+)CD25(high)-derived T-cell clones express FOXP3, RORgammat, and IL-17 and ma

120 T-cell clones expressing CCR4 and CCR9 migrated toward C

121 nable monitoring of pathogenic or protective T cell clones following HSCT and cellular therapies.

122 e immune response selectively expands B- and T-cell clones following antigen recognition by B- and T-

123 parameter to rapidly demark cytotoxic CD8(+) T cell clones for further TCR evaluation.

124 escribe how to isolate carbohydrate-specific T cell clones (for which we propose the designation 'Tca

125 T cell receptor (TCR) derived from a CD8(+) T cell clone from an individual with multiple sclerosis

126 immunological synapses (IS) in self-reactive T cell clones from patients with multiple sclerosis and

127 thermore, we demonstrated that MiHA-specific T cell clones from patients with selective GVL reactivit

128 T cell clones from single cell cloning of DRB1*0401/MOG(

129 o characterize in detail JCV-specific CD4(+) T cell clones from the infected tissue during acute vira

130 ta repertoires, 30-33% of IFN-gamma(+)CD4(+) T cell clones from three M. tuberculosis-infected macaqu

131 We have isolated six CD4(+) T cell clones from three such mothers, which all respond

132 its primary CD8(+) T cell responses that, by T cell cloning from infectious mononucleosis (IM) patien

133 tivity to wheat, rye, and barley peptides as T-cell clones from adults with celiac disease.

134 Jug r 2-specific T-cell clones from allergic subjects mainly expressed GA

135 rom one effective and two ineffective CD8(+) T-cell clones from an elite controller into TCR-expressi

136 About half of the generated T-cell clones from children and adults reacted to unknow

137 uten peptide recognition was similar between T-cell clones from children and adults.

138 either HLA-A2 or HLA-B7 were used to isolate T-cell clones from HLA-A*0201 and B*0702-negative indivi

139 gainst gluten by generating T-cell lines and T-cell clones from intestinal biopsies of adults and chi

140 activity was observed for individual CD8(+) T-cell clones from mice bearing BPTF-silenced tumors.

141 cell clone BDC 2.5 as well as the CD8(+) AI4 T-cell clones from T-cell receptor transgenic animals.

142 l receptor beta (TCRB) gene sequencing of 15 T-cell clones from the severe HA subject revealed that a

143 lls, we isolated and characterized 53 CD4(+) T-cell clones from within the residual pancreatic islets

144 reviously reported a highly diabetogenic CD8 T-cell clone, G9C8, in the nonobese diabetic (NOD) mouse

145 ed two functions of cognate antigen-specific T cell clones: gamma interferon (IFN-gamma) production a

146 CD4(+) T cell clones, generated from HLA-DRB1*15:01 transgenic

147 A CD4(+) T cell clone (HC/2G-1) was established by stimulating pe

148 T cell clones identified by their clonotypic sequence as

149 tained at high levels on SIV-specific CD8(+) T cell clones in chronic infection.

150 s, consistent with dysregulated outgrowth of T cell clones in response to persistent antigenic stimul

151 tumoral TCR repertoire revealed expansion of T cell clones in the setting of neoantigen loss.

152 e recognition by an HLA-DR-restricted CD4(+) T-cell clone in response to cognate antigen presented by

153 peptides that strongly stimulated a specific T-cell clone in vitro, but elicited fewer tumor-specific

154 de 2-3 irAEs also had expansion of >/=55 CD8 T-cell clones in blood samples collected before the onse

155 We identified T-cell clones in GI biopsies in a heterogeneous group of

156 to the development of GAD65-specific CD4(+) T-cell clones in NOD mice.

157 ed by marked proliferation of a few dominant T-cell clones in the tumor.

158 1) to EBNA1- and LMP1-specific CD4+ and CD8+ T-cell clones in vitro.

159 However, the other half of T cell clones, including HD4-1C2, cannot proliferate in

160 of human MBP(111-129) (MBP122:Arg)-specific T cell clones, including MS2-3C8 can proliferate in resp

161 rget for three NOD-derived, diabetogenic CD4 T-cell clones, including the well-known BDC-2.5.

162 RIM5alpha transduction of virus-specific CD4 T-cell clones increased and prolonged their ability to s

163 For one, CD4 T cell clone-induced epithelial NO production was critic

164 eptor obtained from a hemophilia A subject's T-cell clone, into expanded human FoxP3(+) Tregs.

165 The BDC2.5 T cell clone is highly diabetogenic, but the transgenic

166 The repertoire of alloreactive T cell clones is distinct for every donor-recipient pair

167 ving a large number of sufficiently abundant T cell clones is important for adequate protection again

168 y de novo priming of newly pathogenic CD8(+) T-cell clones is an alternate mechanism responsible for

169 The pool of naive T-cell clones is diverse and contains cells bearing T-ce

170 gen recognized by an HLA-E-restricted CD8(+) T cell clone isolated from an Mtb latently infected indi

171 confirmed that 17% (range, 13%-33%) of CD8+ T cell clones isolated from 4 vaccinated patients by lim

172 We found that diabetes-inducing CD4 T cell clones isolated from nonobese diabetic mice recog

173 Anti-insulin B:9-23 T cell clones isolated from prediabetic NOD islets have

174 Moreover, CD4(+) cytotoxic T-cell clones isolated from different individuals exhibi

175 ell-characterized dengue virus-specific CD8+ T-cell clones isolated from Pacific Islanders previously

176 Tetramer-positive T-cell clones isolated from T1D subjects that responded

177 Forty-two of 104 tetramer(pos) T-cell clones, isolated from 16 of 17 UCB samples, showe

178 c protein-specific Tim-3(+) encephalitogenic T-cell clone (LCN-8), we found that conditioned medium f

179 hed recognition by the H-2D(b)/Trh4-specific T cell clone LnB5.

180 Aspergillus-specific T-cell clones mainly exhibited a T-helper cell 1 phenoty

181 geneic in vitro expanded SIV-specific CD8(+) T cell clones matched for the relevant restricting MHC-I

182 s that targeting of specific epitopes and/or T-cell clones may be a promising approach to achieve tol

183 ercome this limitation, we isolated a CD8(+) T-cell clone (MEL5) with an enhanced ability to recogniz

184 (koff) of tumor-specific vaccine-induced CD8 T cell clones (n = 139) derived from seven melanoma pati

185 on of CD4(+)CD28(-) cell functionality using T cell clones (n = 536) established from patients with c

186 PBMC and T-cell clones (n = 570, 84% CD4(+)) from blood of pipera

187 e had reconstituted from an epidermal CD8(+) T cell clone of an HLA-C*06:02-positive psoriasis patien

188 t a single patient-derived autoimmune CD8(+) T cell clone of pathogenic relevance in human type I dia

189 hly polymorphic Tp2(49-59) epitope by CD8(+) T cell clones of defined TRB genotype.

190 Further, T cell clones of tetramer-sorted memory cells of healthy

191 ized in the context of the DQ2.3 molecule by T-cell clones of a DQ8/DQ2.5 heterozygous celiac disease

192 sing a 5T murine myeloma model, we generated T-cell clones of different subsets and examined their fu

193 The self-HLA-restricted WT1-specific T cell clones only recognized the WT1 peptide.

194 h all blood and marrow populations have high T cell cloning potential, no T/non-B cells are apparent.

195 esults suggested that expansion of >/=55 CD8 T-cell clones preceded the development of severe irAEs.

196 Surprisingly, 31% of the T-cell clones prepared from 14-week-old but not younger

197 Diabetogenic CD4 T cell clones produce several inflammatory chemokines in

198 However, different T cell clones proliferate at different rates, and some T

199 requirement for expansion of many individual T cell clones, rather than merely expansion of the entir

200 PPD-specific T cell clones readily trafficked to the airway or lung a

201 hat MHC-II-restricted Chlamydia-specific CD4 T-cell clones recognize infected upper reproductive trac

202 were further characterized, and specific CD8 T-cell clones recognized both peptide-pulsed target cell

203 These promiscuous T-cell clones recognized the two epitopes when naturally

204 ncoding TCR alpha and beta polypeptides from T cell clones recognizing virion protein 22 aa 49-57, an

205 s patient-derived preproinsulin-specific CD8 T-cell clones recognizing either an HLA-A2 (A*0201) or H

206 tometric cluster analysis of multiple CD8(+) T-cell clones recognizing the identical HLA-B*2705-restr

207 siveness of effective and ineffective CD8(+) T-cell clones recognizing the identical HLA-B*2705-restr

208 The 20.1 mAb stimulated Vgamma2Vdelta2 T cell clones regardless of their functional phenotype o

209 Recognition by the CD8(+) T cell clone required N-terminal O-linked mannosylation

210 These T-cell clones respond weakly to the peptide WE14, a natu

211 that recognized the cross-reactive epitope, T cell clones responded robustly to cashew, hazelnut and

212 rt controlled the differentiation of the CD8 T cell clones responsive to these epitopes during persis

213 Experiments with T-cell clones revealed that AgmTRIM5alpha could reproduc

214 Effective and ineffective CD8(+) T-cell clones segregated based on responses to HIV-1-inf

215 Emerging T-cell clones should be monitored in patients with AIE w

216 er, a patient-derived PPI(3-11)-specific CD8 T-cell clone shows a proinflammatory phenotype and kills

217 kdown of Cbl-b in human CD8(+)CD28- effector T cell clones similarly restored IL-2 production and pro

218 CTL system model based on a CD8(+)/CD103(-) T cell clone specific of a lung tumor-associated Ag, we

219 nals triggered by the stimulation of the 1G4 T cell clone specific to the tumor epitope NY-ESO-1(157-

220 T cell clones specific for these sequences proliferated

221 fluenza virus, are unable to activate CD8(+) T cell clones specific to cell-associated Ags of capture

222 T-cell clones specific for dominant alpha- or omega-glia

223 CD4(+) T-cell clones specific to LANA, a protein expressed in a

224 We identified and enumerated unique CD8(+) T cell clones specifically induced by this vaccine throu

225 Two VZV-specific CD4 T cell clones (TCC), recovered from the eye of a VZV uve

226 co-culture experiments with Bet v 1-specific T-cell clones (TCCs).

227 Using T cell cloning techniques, a modest increase in the freq

228 tetramers that bind to most insulin-specific T-cell clones tested.

229 We isolated a new KS20-reactive Th1 CD4 T cell clone that rapidly transfers diabetes.

230 The responses of T cell clones that are specific for a major disease-asso

231 Using CD4(+) T cell clones that constitutively express class II MHC,

232 le biopsies demonstrated a limited number of T cell clones that emerged at 3 months after vector admi

233 Self-reactive T cell clones that escape negative selection are either

234 reporting the identity of activated effector T cell clones that expand in response to the YFV 2 weeks

235 tible individuals can trigger viral specific T cell clones that persist within the muscle and lead to

236 pid in vivo expansion of neoantigen-specific T cell clones that were reactive to mutant neopeptides f

237 Furthermore, EATL arose from a single T-cell clone that had been present for several years in

238 mplexes (pMHCs), we examined the ILA1 CD8(+) T-cell clone that responds to a peptide sequence derived

239 FOXP3, allowing the comparison of autologous T-cell clones that do or do not express FOXP3.

240 Identification of specific antigens and T-cell clones that drive the disease will be the first s

241 h this route, we discovered that preinfusion T-cell clones that expressed the IL7 receptor (IL7R) and

242 We isolated T-cell clones that recognized dominant peptides and asse

243 tion of the MEL5 clone, but not other CD8(+) T-cell clones that recognized HLA A*0201-AAGIGILTV poorl

244 body secretion, HLA-DRA-DRB1*0101-restricted T-cell clones that respond to a specific epitope in FVII

245 In particular, large naive T-cell clones that were distinct from memory clones were

246 We identified three sets of T-cell clones that were either frequently involved in GV

247 e of this study was to characterize distinct T-cell clones that were frequently and exclusively invol

248 inherent uncertainty in the number of B- and T-cell clones that will be missing from a blood or tissu

249 s recognized by other Chlamydia-specific CD4 T cell clones, the PmpG(303-311) epitope persisted on sp

250 nts for both the number and the abundance of T cell clones.) The causes of this observation are incom

251 likely that the passage of these autoimmune T cell clones through the disrupted blood-brain barrier

252 CM9-, Nef YY9-, and Vif WY8-specific CD8(+) T cell clones to acutely infected rhesus macaques.

253 igating the mechanism used by a panel of CD4 T cell clones to control Chlamydia replication in epithe

254 and stimulates carbohydrate-specific CD4(+) T cell clones to produce interleukins 2 and 4-cytokines

255 entropy underpinned the ability of the HA1.7 T-cell clone to cross-react with HA(306-318) presented b

256 Transfer of an MPO(409-428)-specific CD4(+) T-cell clone to Rag1(-/-) mice induced focal necrotizing

257 The diabetogenic CD4(+)BDC2.5 (BDC) T cell clone upon transfer into NOD.scid mice induced de

258 Finally, these HPA-1a-specific T cell clones use a variety of T cell receptors, but all

259 ll line showed that a Chlamydia-specific CD4 T cell clone was able to inhibit C. muridarum replicatio

260 The TCR from this high affinity T cell clone was rarely identified in ex vivo evaluation

261 functional avidity and specificity of these T cell clones was analyzed in-depth.

262 The presence of neutrophil autoantibodies or T-cell clone was not associated with any specific clinic

263 ack of focused TCR-peptide binding, the ILA1 T-cell clone was still cross-reactive.

264 tion and the response kinetics of individual T-cell clones was previously unknown.

265 bjects and in 12 of 50 independently derived T cell clones, was TCRBV12-4.

266 Using a high affinity tumor-specific T cell clone, we identified a panel of mimotope vaccines

267 luding 7 L) new epitopes using memory CD8(+) T cell clones, we looked in HLA-matched IM patients and

268 by using well-characterized UCP-specific CD4 T cell clones, we showed that hTERT processing and prese

269 By genomic sequencing of these T-cell clones, we identified a gene encoding a dominant

270 of the 70 most frequent putative pathogenic T cell clones were alphabeta T cells.

271 re in these monkeys indicated that identical T cell clones were capable of recognizing wild-type (WT)

272 We found that Chlamydia-specific CD4 T cell clones were cytolytic, but that cytolysis was not

273 ng replication; however, the most potent CD4 T cell clones were dependent on T cell degranulation for

274 Autoreactive T cell clones were detected in the periphery of Foxn1 co

275 d by IFX-specific T cells, T cell lines, and T cell clones were evaluated at the mRNA and protein lev

276 ELVHFL) or MAGE-A3: 271-279 (FLWGPRALV), and T cell clones were generated.

277 t (i) on average, approximately 2,000 CD8(+) T cell clones were induced by YF-17D, (ii) 5 to 6% of th

278 itro expanded autologous SIV-specific CD8(+) T cell clones were infused 4-9 mo postinfection.

279 E-S)) tetramer(+) cells confirmed that these T cell clones were responsive to both the native and the

280 Vaccine-induced CD8+ and CD4+ T cell clones were shown to recognize NY-ESO-1-expressin

281 Jug r 2-specific T-cell clones were also generated, and mRNA transcriptio

282 blood mononuclear cells and Bet v 1-specific T-cell clones were compared.

283 Several T-cell clones were cross-reactive, especially clones tha

284 amenable to augmentation, HIV-specific CD8+ T-cell clones were derived from HIV-reactive CD28+CD8+ T

285 tide, and only 44% of Art v 125-36 -specific T-cell clones were detected by the tetramer.

286 IL-17(+)FoxP3(+) and IL-17(+) CD4(+) T-cell clones were generated by limiting dilution.

287 T-cell clones were generated from 4 hypersensitive patie

288 ific CD4+, CD8+, and CD4+CD8+, Th2-secreting T-cell clones were generated from three allergic patient

289 ed protein derivative of tuburculin-specific T-cell clones were generated.

290 The CD79b-specific T-cell clones were highly reactive against CD79b-express

291 Small T-cell clones were often observed in T- and NK-cell tumo

292 Most (87%) top expanded lesional T-cell clones were shared with nonlesional tissues, and

293 MART-1(26-35)-specific CD8 T cell clones, which differed in their trogocytosis capa

294 st aggressive of these represented by AI4, a T cell clone with promiscuous Ag-recognition characteris

295 y functional diversity within tumor-specific T cell clones with identical TCR specificity.

296 In summary, IL-17-producing alphabeta T cell clones with psoriasis-specific antigen receptors

297 cuspid CAS valves contains numerous expanded T cell clones with varying degrees of additional polyclo

298 ose that in response to microbial challenge, T-cell clones with a broad range of avidities for foreig

299 for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associat

300 In contrast, permanence of naive T cell clones would be determined by their affinity for