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1 ment of CAV but inhibited the effect of CD25 T cell depletion.
2 sma cells/plasmablasts was reduced following T cell depletion.
3 mice suppressed HIV replication and reversed T cell depletion.
4 ivation of the inflammasome resulting in CD4 T cell depletion.
5 ration that follows antibody-mediated CD4(+) T cell depletion.
6 s a major site of HIV replication and CD4(+) T cell depletion.
7 llmark of HIV-1 and SIV infections is CD4(+) T cell depletion.
8 site of viral replication and severe CD4(+) T cell depletion.
9 of SIV infection despite the mucosal CD4(+) T cell depletion.
10 increased HIV infection, virus release, and T cell depletion.
11 e of calcineurin inhibitors, steroids or pan-T cell depletion.
12 zed immune activation and progressive CD4(+) T cell depletion.
13 th increasing serum and tissue levels during T cell depletion.
14 importance of abortive infection in driving T cell depletion.
15 nfection and the homeostatic response to CD4 T cell depletion.
16 oss of antibody production depends on CD4(+) T cell depletion.
17 o explain the mechanism of HIV-1 Env-induced T cell depletion.
18 even in the context of a significant CD4(+) T cell depletion.
19 s without requirement for in vitro CD4+CD25+ T cell depletion.
20 necropsy, and no virus emerged after CD8(+) T cell depletion.
21 d ongoing EAE, which was abrogated by CD8(+) T cell depletion.
22 14, and 28 d postinfection even after CD4(+) T cell depletion.
23 ation, chronic immune activation, and CD4(+) T cell depletion.
24 and a failure of disease to recur after CD3 T cell depletion.
25 to AA rupture, which was attenuated by CD8+ T cell depletion.
26 ion largely manifests itself in vivo as CD4+ T cell depletion.
27 ed with chronic immune activation and CD4(+) T cell depletion.
28 ng of the early steps of HIV-1 infection and T cell depletion.
29 eir concerted effect in inducing resting CD4 T cell depletion.
30 site of ongoing viral replication and CD4(+) T cell depletion.
31 o and can induce peripheral and systemic CD4 T cell depletion.
32 hisms (SNPs) in the ZNRD1 region with CD4(+) T-cell depletion.
33 antibody responses in the setting of CD4(+) T-cell depletion.
34 ll transplantation that incorporates in vivo T-cell depletion.
35 , where HIV-1 infection causes severe CD4(+) T-cell depletion.
36 n that contribute to enhanced fusion and CD4 T-cell depletion.
37 noma even in the context of CD25+ regulatory T-cell depletion.
38 hase inhibitor (aminoguanidine) or by CD4(+) T-cell depletion.
39 r human immunodeficiency virus entry and CD4 T-cell depletion.
40 iency virus (SIV) and a site for severe CD4+ T-cell depletion.
41 1) infection and is a site for severe CD4(+) T-cell depletion.
42 , three of which developed peripheral CD4(+) T-cell depletion.
43 and an increased use of peripheral blood and T-cell depletion.
44 ), of these, 129 (64.5%) received an in vivo T-cell depletion.
45 nged with HBV after antibody-mediated CD4(+) T-cell depletion.
46 id tissue (LT) fibrosis, which causes CD4(+) T-cell depletion.
47 donor (D-) transplants and is exacerbated by T-cell depletion.
48 umbers of effector T cells in the tumor, and T cell depletion abolished the reduced tumor growth obse
50 ombination with CD40-CD154 blockade and CD8+ T-cell depletion abrogated transplant arteriosclerosis (
51 P < .001) but not by donor type or by use of T-cell depletion, adoptive immunotherapy, or rituximab.
55 t viral replication in the context of CD4(+) T cell depletion and elevated immune activation associat
57 c therapies may offer approaches to moderate T cell depletion and improve immune reconstitution durin
60 ocyte antigen antibodies and the kinetics of T cell depletion and recovery among pediatric renal tran
62 sIL-15 complexes in response to Ab-mediated T cell depletion and TBI, suggesting products of cell de
64 sidered today as the driving force of CD4(+) T-cell depletion and acquired immunodeficiency syndrome
66 ction is characterized by progressive CD4(+) T-cell depletion and CD8(+) T-cell expansion, and CD4(+)
68 he two signature events in HIV infection-CD4 T-cell depletion and chronic inflammation-and creates a
74 hese data suggest mechanisms for mucosal CD4 T-cell depletion and interventions that might aid in the
75 FIV-C36 causes fulminant disease with CD4(+) T-cell depletion and neutropenia but no significant path
76 isition and averting systemic infection, CD4 T-cell depletion and pathologies that otherwise rapidly
78 ected blood to a naive animal induced memory T-cell depletion and thrombocytopenia within 3 months in
79 ng (RIC), nonmyeloablative (NMA) transplant, T-cell depletion and variations in graft vs. host diseas
80 s not always associated with severity of CD4 T cell depletion, and different opportunistic pathogens
81 ave evidence of ongoing inflammation, CD4(+) T cell depletion, and perhaps even inflammation-associat
82 and compared their replication efficiencies, T cell depletion, and the activation status of infected
83 of homeostatic proliferation and regulatory T cell depletion, and which promote tumor rejection via
85 total body irradiation, immunotoxin mediated T-cell depletion, and a short course of cyclosporine.
86 graft after adoptive transfer, without prior T-cell depletion, and whether the large amounts of circu
87 diation exposure, light skin color, sex, and T-cell depletion are risk factors for cutaneous malignan
88 , we sought to determine the level of CD4(+) T cell depletion as well as the degree and extent of HIV
89 ression was not associated with rapid CD4(+) T cell depletion, as CD4(+) T cell decline resembled oth
90 (TBI), cyclophosphamide, or Thy1 Ab-mediated T cell depletion, as well as in RAG(-/-) mice; interesti
91 on induced by memory helper T cells, and CD8 T cell depletion at the time of transplantation or deple
92 ts employing costimulation blockade-based or T-cell depletion-based conditioning with 1 or 3 Gy total
94 rotein-specific Ab responses, and gammadelta T cell depletion before infectious challenge did not abl
96 ti-TCRgammadelta antibody-induced gammadelta T-cell depletion blunted Ang II-induced SBP rise and end
97 Anti-CD3 administration induces transient T cell depletion both in preclinical and in clinical stu
99 ce to tolerance induction seen with subtotal T cell depletion can be overcome in two different ways:
102 ti-IL-7 receptor blocking antibody following T cell depletion, combined with the mammalian target of
103 ade 3-4 adverse events, many associated with T-cell depletion, compared with 13 in the placebo group,
105 ceptor alpha (IL-7Ralpha) alone or following T cell depletion confers an advantage for allograft surv
108 t reduced infectious ZIKV levels, and CD8(+) T cell depletions confirmed that CD8(+) T cells mediated
109 viral replication in GALT and marked CD4(+) T-cell depletion correlated with decreased expression le
114 and usually does not induce significant CD4+ T cell depletion despite high levels of virus replicatio
116 Consistent with this observation, CD4(+) T cell depletion did not affect the DENV-specific IgG or
118 erleukin-10 (IL-10), although in vivo CD8(+) T cell depletion did not significantly alter Mtb burden.
119 kine (CXC-motif) ligand 1 expression, CD8(+) T-cell depletion did not directly affect monocyte recrui
120 e control, because 2B4 blockade after CD8(+) T-cell depletion did not further aggravate symptoms of E
121 volved in this NK maturation arrest, because T-cell depletion did not restore NK-cell development.
122 treatment with cyclophosphamide or specific T cell depletion does not impact the course of disease o
124 were evaluated, including pharmacokinetics, T-cell depletion, dose response and kinetics, depletion/
125 a revised paradigm wherein severe GALT CD4+ T cell depletion during acute pathogenic HIV and SIV inf
127 ost pathway that plays a central role in CD4 T cell depletion during disease progression to AIDS.
128 tive understanding of the mechanisms driving T cell depletion during HIV infection.IMPORTANCE In HIV-
129 despite similar viral replication and CD4(+) T cell depletion during primary SIV infection, CD4(+) T
130 ested as one of the major mechanisms of CD4+ T cell depletion during the course of HIV type 1 (HIV-1)
131 ery are similar to those that blunted CD4(+) T cell depletion during the time before HAART became ava
134 e show that PD-L1 blockade together with CD4 T cell depletion effectively rescued deeply exhausted CD
136 ditioning (RIC), neither ex vivo nor in vivo T-cell depletion (eg, antithymocyte globulin) convincing
137 ation diminished skeletal metastasis whereas T-cell depletion enhanced it, even in the presence of zo
138 u, chronic inflammation and Ag exposure, CD4 T-cell depletion, etc., alone does not cause poly- and a
140 calreticulin, prophylactic immunization and T-cell depletion experiments showed that melphalan admin
145 his study demonstrates that generalized CD4+ T cell depletion from the blood and mucosal tissues is n
147 ant immunologic parameters that include CD4+ T cell depletion, generalized immune activation, and dep
151 protocols use unmanipulated (without ex vivo T-cell depletion) haploidentical grafts combined with en
153 r data suggest that IL-7R blockade following T cell depletion has potential as a robust, immunosuppre
156 m and redox state are associated with CD4(+) T cell depletion, immune activation, and inflammation.
157 arks of human HIV infection including CD4(+) T-cell depletion, immune activation, and development of
158 nization are associated with generalized CD4 T-cell depletion, impaired antigen-specific proliferatio
161 e gut-associated lymphoid tissue (GALT) CD4+ T cell depletion in lentiviral infections was assessed b
163 demonstrated that acute, SIV-induced CD4(+) T cell depletion in sooty mangabeys does not result in i
167 nfected humans, our data suggest that CD4(+) T cell depletion in the setting of HIV disease may refle
168 isms have been invoked to account for CD4(+) T cell depletion in this setting, but the quantitative c
174 cted chimpanzees revealed significant CD4(+) T-cell depletion in all infected individuals, with evide
175 +CD25- effector T cells after thymectomy and T-cell depletion in CBA mice that received CBK (H2k+Kb)
180 (+) T cells in PLCgamma2(-/-) mice or CD8(+) T-cell depletion in Lyn(-/-) mice normalized tumor growt
181 Viremia remained undetectable after CD8(+) T-cell depletion in seven vaccinated animals that had su
184 ficient mice but was abrogated completely by T-cell depletion in vivo, suggesting T-cell dependence.
187 protection was significantly reduced by CD8 T cell depletion, indicating a critical role for CD8 T c
189 Orai1(-/-) mice showed strong resistance to T cell depletion induced by injection of anti-CD3 Ab.
190 Blockade of CD154 alone or combined with T cell depletion inhibits generation of the humoral immu
191 otential new therapeutics, centered on naive T-cell depletion, interleukin-17/21 inhibition, kinase i
196 blood transplantation (CBT) without in vivo T-cell depletion is increasingly used to treat high-risk
197 tion and CD8(+) T-cell expansion, and CD4(+) T-cell depletion is linked directly to the risk for oppo
200 suggests that the subtype 5-associated CD4+ T-cell depletion is unlikely to simply reflect higher le
201 transmission and replication as well as CD4+ T-cell depletion, it is important to understand the natu
202 are usually nonselective and cause wholesale T cell depletion leaving the individual in a severely im
203 ven by IL-7 as a homeostatic response to CD4 T cell depletion, levels of phosphorylated STAT-5 were f
204 itioning regimen consisting of pretransplant T cell depletion, low-dose total body irradiation and po
207 de following anti-CD4- and anti-CD8-mediated T cell depletion markedly prolonged skin allograft survi
214 Using Cox regression, outcomes after in vivo T-cell depletion (n = 584 antithymocyte globulin [ATG];
217 by lymphocyte IFN-gamma secretion), and CD8+ T cell depletion of mice prior to injection of MB49 cell
218 utilizing B-cell-deficient mice or targeted T cell depletions of wild-type mice demonstrated that B
219 nd effector/memory conversion of Ag-specific T cells, depletion of peripheral CD4(+) T cells in hemat
220 sks were strongly associated (P < .001) with T-cell depletion of the donor marrow, antithymocyte glob
222 odels of GVHD to evaluate the effect of CD4+ T cell depletion on GVL versus GVHD and revealed that de
224 In this study, we establish that either CD8+ T cell depletion or exposure to restraint stress permit
227 Ab treatment in vivo, CXCR3 blockade, CD8(+) T cell depletion, or IFN-gamma neutralization each inhib
228 dynamics of acute viral replication, CD4(+) T cell depletion, or preinfection levels of microbial tr
230 ency virus (HIV) replication and severe CD4+ T-cell depletion, our understanding is limited about the
231 A generally accepted concept is that graft T cell depletion performed to avoid GVHD yields poorer i
233 tion, although short-term (3-d) local CD4(+) T cell depletion postinfection did not influence chemoki
234 ak viral replication and the nadir of CD4(+) T cell depletion predominantly in lamina propria leukocy
235 Qualitatively different mechanisms of CD4+ T-cell depletion prevail during the acute, chronic and a
238 ears old, without high-risk primary disease, T-cell depletion, previous vaccination for cytomegalovir
239 HIV disease characterized by increasing CD4+ T-cell depletion, profound lymphoid depletion or destruc
241 ral integration has a central role in CD4(+) T-cell depletion, raising the possibility that integrase
243 Antifungal treatment or autoreactive CD4 T cell depletion rescues, whereas oral fungal administra
246 neither spontaneous nor experimental CD4(+) T cell depletion results in substantial levels of in viv
248 llers had significant LT fibrosis and CD4(+) T-cell depletion, similar to noncontrollers, but the so-
249 was significantly reduced by systemic CD4(+) T cell depletion starting before infection, although sho
253 these studies will facilitate development of T-cell depletion strategies to augment the feasibility o
254 recently described hamster model, along with T-cell depletion strategies, we show that CD4(+) T cells
259 vivo cannot account for the extent of CD4(+) T cell depletion, suggesting indirect or bystander mecha
260 show that MRV infects the thymus and causes T-cell depletion, suggesting that other roseoloviruses m
261 hermore, IL-7 inhibition in combination with T cell depletion synergized with either CTLA-4Ig adminis
262 -induced protection of mice was evaluated by T-cell depletion; T lymphocytes were not essential for t
265 tiviral pathways perturbed by in vivo CD8(+) T cell depletion that may contribute to noncytolytic con
266 aracterized by the rapid onset of intestinal T-cell depletion that initiates the progression to AIDS.
267 sepsis characterized by hypercytokinemia and T-cell depletion, the vaccinated mice displayed moderate
269 s antibody-mediated in vivo CD4(+) or CD8(+) T-cell depletion, thus indicating a role for the BM in m
270 in combination with B7-H1 blockade and CD4+ T cell depletion (triple therapy treatment) and monitore
272 de evidence for profound lung mucosal CD4(+) T-cell depletion via a Fas-dependent activation-induced
273 t of tolerance induction by CD3 mAb-mediated T-cell depletion, warranting caution in their use for th
275 : in SIVsmm-infected Rh, the acute GALT CD4+ T cell depletion was persistent and continued with disea
278 V/SIV replication, dissemination, and CD4(+) T cell depletion, we profiled miRNA expression in colon
280 ell responses on the magnitude of the CD4(+) T-cell depletion, we investigated the effect of CD8(+) l
281 ients who received an allogenic HSCT without T-cell depletion were more likely to die (adjusted odds
283 is donor type (mother) and GVHD prophylaxis (T-cell depletion) were also significant predictors of aG
284 to the proliferating pool in response to CD4 T cell depletion, whereas naive CD8 T cell proliferation
285 d by anti-IL-2-neutralizing Ab and by CD4(+) T cell depletion, which abrogated the Gag-specific respo
287 /FasL pathway does play a role in regulatory T-cell depletion, which is likely a result of increased
292 ndomized studies have suggested that in vivo T-cell depletion with anti-T-lymphocyte globulin (ATLG;
293 rates were significantly lower after in vivo T-cell depletion with ATG (relative risk [RR] = 0.66; P
297 eased SIV reservoir size and accelerated CD4 T-cell depletion with progression to AIDS despite decrea
298 (+) individuals demonstrated profound CD4(+) T-cell depletion with reduced CD4/CD8 T-cell ratios in b
300 macaques showed distinct patterns of CD4(+) T-cell depletion, with a selective loss of memory cells
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