ライフサイエンスコーパス: T-cell differentiation

1 and a transcription program associated with T cell differentiation.

2 ption factors NFAT and AP-1 promote effector T cell differentiation.

3 mulation in a subset of proteins critical to T cell differentiation.

4 nd two key transcription factors involved in T cell differentiation.

5 ivation for survival and to prevent terminal T cell differentiation.

6 labor among DC subsets in regulating CD8(+) T cell differentiation.

7 ibit Ag-specific T cell priming and regulate T cell differentiation.

8 in 1 (BLIMP1) is a master regulator of B and T cell differentiation.

9 suggesting that it is associated with early T cell differentiation.

10 eleven translocation (TET)2 regulates CD8(+) T cell differentiation.

11 unx3, a nuclear factor crucial for cytotoxic T cell differentiation.

12 ortant role in T cell development and mature T cell differentiation.

13 egulatory network that shapes the balance of T cell differentiation.

14 T cell expansion and favored central memory T cell differentiation.

15 nd silencing of Cd4 and Cd8 during alphabeta T cell differentiation.

16 s to resist M. tuberculosis infection-driven T cell differentiation.

17 the adaptive immunity through regulation of T cell differentiation.

18 relaxing the repression of genes that direct T cell differentiation.

19 e is known regarding their role in human CD8 T cell differentiation.

20 ling promoted IL-7Ralpha expression and CD8+ T cell differentiation.

21 ific expression patterns for lincRNAs during T cell differentiation.

22 ith previously unappreciated roles in CD8(+) T cell differentiation.

23 amily in influencing effector and memory CD8 T cell differentiation.

24 expression also changes dramatically during T cell differentiation.

25 e receptors control both effector and memory T cell differentiation.

26 on factors essential for effector and memory T cell differentiation.

27 sharing and acted as regulatory stimuli for T cell differentiation.

28 that CARMA1 also plays an essential role in T cell differentiation.

29 t, and all 5 subsets were capable of ex vivo T cell differentiation.

30 flammatory cytokines and supports regulatory T cell differentiation.

31 attern recognition was required for effector T cell differentiation.

32 subsets and the continuous nature of CD8(+) T cell differentiation.

33 change dynamically as cells progress through T cell differentiation.

34 ynamic transcriptome necessary for efficient T cell differentiation.

35 ession, and a subsequent role in guiding CD8 T cell differentiation.

36 nt mice, was not sufficient to normalize CD8 T cell differentiation.

37 positive histone modifications during memory T cell differentiation.

38 a progressive and selective model of CD4(+) T cell differentiation.

39 n produce significantly different results in T cell differentiation.

40 re SCC and correlated with increasing CD8(+) T cell differentiation.

41 DC) and the consequence of that in DC-driven T cell differentiation.

42 CMV) infection, paralleling antigen-specific T cell differentiation.

43 itatively, to promote robust effector CD8(+) T cell differentiation.

44 RNA processing and splicing factors to drive T cell differentiation.

45 tch signaling pathway during effector CD8(+) T cell differentiation.

46 tabolic reprogramming that supports effector T cell differentiation.

47 endogenous PU.1 allows precocious access to T-cell differentiation.

48 been implicated in the regulation of CD4(+) T-cell differentiation.

49 assembly of complexes that broadly influence T-cell differentiation.

50 sion patterns conducive to IFN signaling and T-cell differentiation.

51 tigen (Ag)-presenting pDCs directly regulate T-cell differentiation.

52 nd other genes that are essential for normal T-cell differentiation.

53 n factor whose ectopic expression can arrest T-cell differentiation.

54 immunology based on its ability to influence T-cell differentiation.

55 delta2 T cells and inversely correlated with T-cell differentiation.

56 re all factors that influence peripheral CD8 T-cell differentiation.

57 STAT5, but not ERK, and does not support CD8 T-cell differentiation.

58 ght participate in the control of gammadelta T-cell differentiation.

59 ghput analyses of positive selection and CD8 T-cell differentiation.

60 ealed several phosphatases that regulate CD4 T-cell differentiation.

61 o natural killer T cell (NKT) and gammadelta T-cell differentiation.

62 ed CD25 in controlling IL-2 availability and T-cell differentiation.

63 while retaining the ability to enhance naive T-cell differentiation.

64 e induction of tolerogenic regulatory CD4(+) T-cell differentiation.

65 shown to restrict T-cell function and impact T-cell differentiation.

66 BAC in coordinating the signals required for T-cell differentiation.

67 usly uncharacterized gene, fam49ab, inhibits T-cell differentiation, a phenotype that can be rescued

68 The thymus is required for T cell differentiation; a process that depends on which

69 , induce the expression of genes involved in T-cell differentiation, activation, and proliferation.

70 terestingly, the rate of naive-to-memory CD8 T cell differentiation after a peptide-coated dendritic

71 repress PD-1 during the early stages of CD8 T cell differentiation after acute infection with lympho

72 hat PPARgamma in addition to regulating CD4+ T cell differentiation also plays a major role controlli

73 itis virus (LCMV) strains, we uncovered that T cell differentiation and acquisition of a chronic or e

74 mechanism that is required for effector CD8 T cell differentiation and adaptive immune responses.

75 opment were repressed, and those involved in T cell differentiation and apoptosis were elevated.

76 , whereas enforced EBF1 expression inhibited T cell differentiation and caused rapid loss of Gata3 mR

77 g phagocyte microbicidal capacity to driving T cell differentiation and cytotoxic activity.

78 logy, as well as how metabolic changes drive T cell differentiation and fate.

79 tocompatibility complex, thereby influencing T cell differentiation and fate.

80 TOs provide a robust tool for studying human T cell differentiation and for the future development of

81 molecules like ICOS are crucial in mediating T cell differentiation and function after allergen conta

82 posure to an AhR ligand directly alters CD4+ T cell differentiation and function later in life.

83 MHC class II (MHCII)-influenced CD4(+) T cell differentiation and function play critical roles

84 lar immunotherapies in cancer, and to direct T cell differentiation and function towards non-pathogen

85 we tested the role of STAT5 in CD8(+) memory T cell differentiation and function using a model system

86 n important role for these structures in the T cell differentiation and function.

87 vealed critical roles for mTOR in regulating T cell differentiation and function.

88 p'n'collar homology (Bach)2 in orchestrating T cell differentiation and function.

89 tigen presentation, cytokine modulation, and T cell differentiation and has emerged as a promising th

90 of how environmental-driven cues can impact T cell differentiation and have implications for autoimm

91 n family cytokines involved in regulation of T cell differentiation and homeostasis.

92 glucosamine may be an important modulator of T cell differentiation and immune homeostasis.

93 Thus, induction of Fas signaling enhanced T cell differentiation and impaired antitumor immunity,

94 Notch is a critical regulator of T cell differentiation and is activated through proteoly

95 Mechanisms for human memory T cell differentiation and maintenance have largely been

96 nges, including histone methylation, control T cell differentiation and memory formation, though the

97 mechanisms that contribute to helper CD4(+) T cell differentiation and plasticity.

98 thymic environment is essential to maintain T cell differentiation and prevent the emergence of cent

99 cts lupus development by regulating effector T cell differentiation and promoting TFHs at the expense

100 mediate human TCR-alphabeta and -gammadelta T cell differentiation and provide a mechanistic insight

101 ors, revealing early compartmentalization of T cell differentiation and regulation.

102 which otherwise acts to promote conventional T cell differentiation and restrict Treg function.

103 used on the faithful in vitro restoration of T cell differentiation and selection.

104 y which aerobic glycolysis promotes effector T cell differentiation and suggest that LDHA may be targ

105 s strongly induced CD4(+)Foxp3(+) regulatory T cell differentiation and suppressed Th1 and Th17 diffe

106 mmune responses occur, are known to regulate T cell differentiation and survival.

107 ole of TSC1, an mTOR signaling regulator, in T cell differentiation and the balance between T cell-me

108 ermine the relevance of these Eph ligands in T cell differentiation and thymus histology.

109 y a key mechanism of DC-mediated coupling of T cell differentiation and trafficking that orchestrates

110 ch have critical functions in central-memory T cell differentiation and trafficking.

111 lasts resulted in impaired follicular helper T cell differentiation and, consequently, in reduced num

112 tor Thpok is required for intrathymic CD4(+) T cell differentiation and, together with its homolog LR

113 alignant state accompanied with an arrest in T-cell differentiation and acquisition of somatic Notch1

114 that Ndfip1 is progressively induced during T-cell differentiation and activation in vivo and that i

115 ng from the T-cell receptor (TCR) conditions T-cell differentiation and activation, requiring exquisi

116 the role of upstream PI3K isoforms in CD8(+) T-cell differentiation and assessed the potential use of

117 s unravel a new pathway orchestrating CD4(+) T-cell differentiation and demonstrate that NAD(+) may s

118 eated exposure to antigen, delaying effector T-cell differentiation and exhaustion.

119 , we assessed the long-term effect of CD8(+) T-cell differentiation and function in 131 patients who

120 (miRNAs) are emerging as key controllers of T-cell differentiation and function.

121 e signals playing a critical role in driving T-cell differentiation and function.

122 ly expressed E3 ubiquitin ligase involved in T-cell differentiation and in a wide range of inflammato

123 sitive regulator that is essential for naive T-cell differentiation and in vivo T-cell responses to a

124 asis, best demonstrated by defects in thymic T-cell differentiation and peripheral lymphoid homeostas

125 mportance of epigenetic regulation of CD8(+) T-cell differentiation and the likely role that transcri

126 emature defects in mTEC-dependent regulatory T-cell differentiation and thymocyte maturation, which p

127 of NFATc1 activity is vital in facilitating T-cell differentiation and to prevent Notch3-induced T-a

128 d B cell proliferation, antibody production, T cell differentiation, and cytokine production, which c

129 dings shed new light on the role of IL-21 in T cell differentiation, and have relevant implications f

130 (SOCS) proteins are key regulators of CD4(+) T cell differentiation, and in particular, we have recen

131 TOR pathway is a key driver of murine CD4(+) T cell differentiation, and induction of regulatory T (T

132 ults in the dysregulation of splicing during T cell differentiation, and knockdown of hnRNP L or hnRN

133 la carte cytokine secretion profiles, biased T cell differentiation, and local delivery of non-native

134 tory T cell generation, restraining effector T cell differentiation, and potentiating memory T cell d

135 ession, abrogated EBF1-driven suppression of T cell differentiation, and prevented B cell differentia

136 to nucleosomal regulation of transcription, T cell differentiation, and the inflammatory response an

137 cluding the regulation of T cell activation, T cell differentiation, and the regulation of lymphocyte

138 has been shown to have profound influence on T cell differentiation, and use of distinct AhR ligands

139 s of transcription activation and inhibiting T-cell differentiation, and have clinical potential as a

140 olved in the regulation of immune responses, T-cell differentiation, and immunity.

141 ated protein kinase important for apoptosis, T-cell differentiation, and inflammatory responses.

142 However, current models for memory CD8(+) T cell differentiation are derived from pathogen-free la

143 contribute to effector versus memory CD8(+) T cell differentiation are poorly understood.

144 umours characterized by very early arrest in T-cell differentiation, are most related to haematopoiet

145 y 5-8 cell divisions, unusually rapid memory T cell differentiation as measured by phenotype and mito

146 ction and that this led to biased helper CD4 T cell differentiation as well as impaired antibody resp

147 replication drove increased effector CD8(+) T cell differentiation, as expected.

148 rize this phenotype, we used in vitro CD4(+) T cell-differentiation assays and show that NLRX1-defici

149 T cell maturation confirmed early arrest of T cell differentiation at the T cell progenitor stage in

150 Wnt signaling is important for T-cell differentiation at the early CD4(-)CD8(-) stage a

151 h as regulation of Th1, Th17, and regulatory T cell differentiation, B cell proliferation, and Ig cla

152 -) mice have normal Th1, Th2, and regulatory T cell differentiation but show defective Th17 different

153 have examined pathways controlling effector T cell differentiation, but less is known about the fate

154 en implicated in the very earliest stages of T cell differentiation, but members of a family of Ras a

155 te that Ikaros plays a critical role in CD4+ T cell differentiation by integrating specific cytokine

156 CD4(+) T-cell differentiation by primary human B cells was inve

157 unctions of BET-family proteins during early T-cell differentiation causes long-lasting suppression o

158 Using in vitro T cell differentiation cultures we were able to validate

159 ursors and gradually decreases during normal T-cell differentiation, differences in ABT-199 sensitivi

160 During effector CD8 T cell differentiation, DNA methylation was remodeled su

161 mouse norovirus (MNV) to investigate CD8(+) T cell differentiation during chronic infection.

162 hes to examine the requirements of genes for T cell differentiation during infection are time consumi

163 ed a unique role for A2aRs in regulating CD4 T cell differentiation during vaccination.

164 ns in T cells to examine genes that regulate T cell differentiation during viral infection, and that

165 e a new mechanism that controls intrahepatic T-cell differentiation during atherosclerosis developmen

166 nct contributions of these parameters to CD4 T-cell differentiation during infection.

167 IL-6 plays an important role in controlling T-cell differentiation, especially the development of Th

168 Thus, ADAP regulates CD8 T cell differentiation events following acute pathogen c

169 Now, multiple additional T cell differentiation fates are recognized with distinc

170 ave the capacity to regulate effector CD8(+) T cell differentiation-for example, inflammatory cytokin

171 nocarcinoma cell lines stimulated regulatory T cell differentiation from naive CD4(+) T cells.

172 efects, which were manifest at all stages of T-cell differentiation from early thymic pre-T cells to

173 regulator of mTOR signaling, which regulates T cell differentiation, function, and trafficking.

174 Understanding intrathymic T cell differentiation has been greatly aided by the dev

175 L-23 has been well studied in the context of T cell differentiation; however, its role in the differe

176 to understand the mechanisms underlying Th17 T cell differentiation in both mouse and human.

177 these findings suggest a novel model for CD8 T cell differentiation in humans that is based on the lo

178 ntifies miR-210 as an important regulator of T cell differentiation in hypoxia, which can limit immun

179 pathogens in the periphery elicits effector T cell differentiation in local lymph nodes followed by

180 Thus, the cytokine acts to control cytotoxic T cell differentiation in lymphoid and peripheral organs

181 , TLR ligands, on effector and memory CD8(+) T cell differentiation in mice.

182 s animal development; for example, mammalian T cell differentiation in the thymus and neuroblast spec

183 ITK-Syk oncogene expression induces terminal T cell differentiation in the thymus by activating Blimp

184 e transcription factor ThPOK promotes CD4(+) T cell differentiation in the thymus.

185 fore, examined cytokine signaling and CD4(+) T cell differentiation in these cohorts to characterize

186 educes Th17 skewing and increases regulatory T cell differentiation in vitro when cultured in RPMI 16

187 -3 protein acutely at specific points during T cell differentiation in vitro.

188 f the immune response, but their role in CD8 T cell differentiation in vivo is not known.

189 o inhibit telomerase activity and accelerate T cell differentiation in vivo.

190 complications and a skewed follicular helper T-cell differentiation in defined monogenic immunodefici

191 remodeling of the IL2 and IL17A gene during T-cell differentiation in favor of effector memory T cel

192 ered resistance to infection, and influenced T-cell differentiation in response to a de novo viral in

193 demonstrate alterations in markers of CD8(+) T-cell differentiation in response to this metabolite.

194 ing RNA-mediated, reduction of Gata3 rescued T-cell differentiation in the absence of E2A and restric

195 ages of T-cell development in the thymus and T-cell differentiation in the periphery.

196 pective roles of these genes in human CD8(+) T-cell differentiation in vivo and in vitro.

197 al species have been identified that promote T-cell differentiation, in particular T-helper 17 and T-

198 otch receptor-ligand interactions throughout T cell differentiation, including the final step of CD8

199 Naive CD4(+) T cell differentiation into distinct subsets of T helper

200 Infections induce pathogen-specific T cell differentiation into diverse effectors (Teff) tha

201 ts a role for these receptors in skewing CD8 T cell differentiation into effector and memory cells an

202 mat, GATA3 and others is essential for naive T cell differentiation into effector T cells.

203 ispecific fusion protein also directed early T cell differentiation into Foxp3-positive regulatory T

204 ain receptors was essential for naive CD4(+) T cell differentiation into HA1-specific Th17.

205 Bcl6 is required for CD4 T cell differentiation into T follicular helper cells (T

206 response to antigen, promoting naive CD4(+) T cell differentiation into T helper 1 (Th1) and T helpe

207 produce cytokines that promote naive CD4(+) T cell differentiation into T helper 1 (Th1), Th17, and

208 ajor intracellular pathways involved in CD4+ T cell differentiation into T helper 1 (Th1), Th2, Th17

209 drug treatment caused a striking bias of CD4 T cell differentiation into Th1 cells and substantially

210 Our study indicates that ABCG1 regulates T cell differentiation into Tregs, highlighting a pathwa

211 Activation, ex vivo expansion of T cells, differentiation into a regulatory subset, and i

212 cept of strict fate commitment during CD4(+) T-cell differentiation into distinct subsets.

213 Dendritic cells (DCs) direct CD4(+) T-cell differentiation into diverse helper (Th) subsets

214 the small intestine and colon, and inhibits T-cell differentiation into Th1 cells under different cy

215 e report that Jmjd3 ablation promotes CD4(+) T-cell differentiation into Th2 and Th17 cells in the sm

216 ttle information about the role of RA in CD8 T cell differentiation is available, and even less on ce

217 Because T cell differentiation is finely tuned by multiple posit

218 Thus, anamnestic memory T cell differentiation is flexible, and abundant quantit

219 eutic option, but the role of IL-21 in human T cell differentiation is incompletely understood.

220 CD4(+) T cell differentiation is regulated by specialized antig

221 At issue is whether the state of T cell differentiation is specified by initial condition

222 The skewing of T-cell differentiation is concomitant with changes in th

223 xia on gene regulation, we hypothesized that T-cell differentiation is controlled by hypoxia.

224 hough our understanding of miRNA function in T-cell differentiation is still rudimentary, the availab

225 anscription factor also important for NK and T cell differentiation, is expressed by multiple innate

226 n-1 (Blimp-1), a critical regulator of B and T cell differentiation, is highly expressed in memory CD

227 arget of rapamycin pathway influences CD4(+) T cell differentiation; low levels favor regulatory T ce

228 od; however, one key regulator of memory CD8 T cell differentiation, mammalian target of rapamycin ki

229 We examined the requirement of the T cell differentiation marker killer cell lectin-like re

230 The expression of T cell differentiation markers is known to increase duri

231 a key regulatory role of Id2 during effector T cell differentiation necessary to limit IL-10 producti

232 for traditional biological concepts, such as T cell differentiation or cell cycle regulation, in exis

233 nses both in vitro and in vivo by regulatory T-cell differentiation or directly inhibiting T-cell-med

234 T cell differentiation originally was considered a dicho

235 em and suggests that leptin signaling during T cell differentiation plays a crucial role in T cell pe

236 the active form of vitamin D3, during CD8(+) T-cell differentiation prevents IL-4-induced conversion

237 However, the role of the Th1 CD4(+) T cell differentiation program on the ability to control

238 killer cell cytolytic activity and modulates T cell differentiation programs in response to antigen,

239 activation imprints unique and long lasting T-cell differentiation programs.

240 f rapamycin (mTOR) are central regulators of T cell differentiation, proliferation, metabolism, and s

241 ogical inhibition of regulators that mediate T cell differentiation promotes the differentiation of a

242 n methods ultimately inform models of memory T cell differentiation, protection, and vaccine translat

243 We developed a stage-specific T cell differentiation protocol to validate genetic corr

244 cell receptor signaling (PTPRN2, RLTPR), and T-cell differentiation (RARA).

245 both constitutively expressed during CD8(+) T cell differentiation, regulated the formation of termi

246 s; however, the regulation of mTOR-dependent T cell differentiation remains elusive.

247 tudied, but how they influence memory CD8(+) T cell differentiation remains poorly defined.

248 How MyD88 regulates helper T-cell differentiation remains largely unknown, however.

249 gical processes, but its in vivo function in T-cell differentiation remains unknown.

250 he effect of hypercholesterolemia on hepatic T-cell differentiation remains unknown.

251 T cell differentiation requires appropriate regulation o

252 -cell differentiation, with a leaky block in T-cell differentiation resulting in an oligoclonal T-cel

253 stases, but the proportions of CD8(+) cells, T cell differentiation stage, and expression of costimul

254 .0001), with the latter independently of the T cell differentiation state.

255 This indicates that CD4 T cell differentiation status differentially affects LRA

256 rs is modulated by conditions such as CD4(+) T cell differentiation, stimulation, tissue location, or

257 critically important molecules required for T cell differentiation, such as JAK2 and IL12RB2, are re

258 on of its decisive role in peripheral CD8(+) T-cell differentiation, suggests a common regulatory fun

259 and relapsing" form of FHL related to B- and T-cell differentiation/survival, T-cell activation, and

260 in EAE, with effects on cytokine production, T-cell differentiation, T-cell-endothelial cell interact

261 identify BACH2 as a key regulator of CD4(+) T-cell differentiation that prevents inflammatory diseas

262 As IRF4 governs B-cell and CD4(+) T-cell differentiation, the identification of its decisi

263 TECs are essential for T-cell differentiation; they originate from a bipotent p

264 Anti-TIM-3 drives CD8 T cell differentiation through activation of the mTORC1

265 nt during Ag stimulation directly influences T cell differentiation through mTORC1.

266 gs reveal that the Id2/E2A axis orchestrates T cell differentiation through the induction or repressi

267 Herein, we provide an updated perspective on T cell differentiation through the lens of recent advanc

268 cate KLF2 is pivotal for coordinating CD4(+) T cell differentiation through two distinct and compleme

269 We show that NAD(+) regulates CD4(+) T-cell differentiation through tryptophan hydroxylase-1

270 ifferent sources converges to match effector T cell differentiation to the demands of an infection.

271 e loss of aPKC unexpectedly increased CD8(+) T cell differentiation toward a short-lived, terminal ef

272 Skewing T cell differentiation toward a Th2-dominated phenotype

273 Skewing of CD4(+) T cell differentiation toward Ag-specific regulatory T c

274 ZIKV infection was characterized by a CD4 T cell differentiation toward effector cells and by a lo

275 beta signaling axis that ultimately enhances T cell differentiation toward Th1.

276 immune dysregulation had a skewed memory CD4 T-cell differentiation toward a CXCR3(+)CCR6(-) TH1 phen

277 es of MS, although the factors that regulate T-cell differentiation toward pathogenic T helper-1/T he

278 of this receptor with certain ligands favors T-cell differentiation toward regulatory T cells, and pa

279 s of ACC1 did not compromise effector CD8(+) T cell differentiation upon listeria infection but did r

280 Analysis of T cell differentiation using Bcl6-deficient mice has bee

281 of the method by mapping nucleosomes during T cell differentiation using nuclei from effector T-cell

282 roviding clear evidence that B7-H1 modulates T cell differentiation via a novel receptor.

283 ts identify Jmjd3 as an epigenetic factor in T-cell differentiation via changes in histone methylatio

284 Overall, T cell differentiation was enhanced in sites of viral pe

285 The regulation of CD4+ T cell differentiation was mediated at least in part thr

286 T-cell differentiation was assessed by using intracellul

287 ney transplantation, circulating CD4 and CD8 T-cell differentiation was established by determining th

288 T-cell differentiation was investigated in the mesenteri

289 ng the cytokine that is important for B- and T-cell differentiation was knocked into its respective m

290 menn syndrome (OS) patient, similar impaired T-cell differentiation was observed, due to increased si

291 TH1, TH17, and CD8(+) memory T-cell differentiation was significantly reduced, and T

292 ding a transcription repressor essential for T cell differentiation, was deleted in over one-half of

293 m, whereby the androgen milieu modulates CD4 T-cell differentiation, was ascertained as we found that

294 To study the spectrum of T cell differentiation, we have analyzed an infection wi

295 in TCR signal strength could regulate CD8(+) T cell differentiation, we investigated the transcriptio

296 describing the data in normal physiology and T-cell differentiation, we will present examples of the

297 S1PR1 was progressively downregulated during T cell differentiation whereas S1PR2 expression remained

298 the bioenergetic and biosynthetic demands of T-cell differentiation, whether metabolism might control

299 bit an imbalance in effector and memory CD8+ T cell differentiation, which impairs the formation of m

300 ly found that EGR2 promotes peripheral naive T-cell differentiation, with delayed T-cell receptor-ind