ライフサイエンスコーパス: T-cell factor

1 and Mad, and as a cosuppressor of Drosophila T cell factor.

2 hancing the interaction of beta-catenin with T-cell factor.

3 and upregulated lymphoid-enhancing factor 1/T cell factor 1 (LEF1/TCF1), the ultimate executor of th

4 ed for T(H)2 differentiation, was induced by T cell factor 1 (TCF-1) and its cofactor beta-catenin, m

5 T cell factor 1 (TCF-1) is a transcription factor known

6 ere we report that ILC2 development required T cell factor 1 (TCF-1, the product of the Tcf7 gene), a

7 In this study, we demonstrate that T cell factor 1 (TCF-1; encoded by Tcf7), a transcriptio

8 T cell factor 1 (Tcf1) is essential for several of these

9 T cell factor 1 (Tcf1) is essential for T cell developme

10 The Wnt-responsive transcription factor T cell factor 1 (Tcf1) is well known for its role in thy

11 ression of key transcription factors such as T cell factor 1 and Eomesodermin are highly sensitive to

12 hou et al. demonstrate an important role for T cell factor 1 in regulating CD8(+) T cell memory via c

13 egion indicates that IFN-gamma, NF-IL-6, and T cell factor 1/lymphoid enhancer-binding factor 1 are m

14 ansducers of Wnt signaling in the intestine, T-cell factor 1 (TCF-1) and TCF-4, have opposing functio

15 these precursors is the DNA-binding protein T-cell factor 1 (Tcf-1), a T-cell-specific mediator of W

16 Here we show that a transcription factor, T-cell factor 1 (TCF-1; also known as transcription fact

17 rogram have been identified, e.g., GATA3 and T cell factor-1 (TCF-1) (gene name Tcf7).

18 T cell factor-1 (TCF-1) and lymphoid enhancer factor-1 (

19 T cell factor-1 (TCF-1) and lymphoid enhancer-binding fa

20 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the

21 nd had higher expression of CD27, CXCR3, and T cell factor-1 (TCF-1), each a marker that is individua

22 In this article, we demonstrate that T cell factor-1 (TCF1) negatively regulates the expressi

23 slocation of beta-catenin, the expression of T-cell factor-1 (TCF1) and subsequent activation of the

24 kb region of the CTLA-4 promoter requires a T-cell factor-1/lymphoid enhancing factor-1 consensus si

25 athway in ES cells, the transcription factor T-cell factor-3 (Tcf3), co-occupies promoters throughout

26 -negative lymphoid enhancer factor 1 (LEF-1)/T cell factor 4 (TCF-4) and secreted Frizzled receptor p

27 as an enhancer of MYC expression by binding T cell factor 4 (TCF4) and influencing Wnt signaling.

28 catenin and can suppress its coactivation of T cell factor 4 (Tcf4) in prostate cancer (PCa) cells.

29 signaling via AKT activates the beta-catenin/T cell factor 4 pathway in DCs and programs them to driv

30 Activation of beta-catenin/T cell factor 4 was critical to induce regulatory molecu

31 The effects of K-ras(Val12) on VEGF and T-cell factor 4 (TCF-4) promoter activity, nuclear level

32 ICAT, an inhibitor of T-cell factor 4 (TCF-4), and E-cadherin binding to beta-

33 at the downstream effector of Wnt signaling, T-cell factor 4 (TCF-4), is part of a transcriptional co

34 We have identified two T-cell factor 4 (Tcf-4)-binding elements (TBE1 and TBE2)

35 The active beta-catenin binds with T-cell factor 4 (Tcf4) and activates beta-catenin/Tcf-de

36 t fashion with the Wnt/beta-catenin mediator T-cell factor 4 (TCF4) at CTTTG motifs as well as at AP-

37 pression of genes controlled by beta-catenin/T-cell factor 4 (TCF4) complexes.

38 signals as shown by reduced activity of the T-cell factor 4 (TCF4) transcription factor.

39 ssion of cyclin A2, cyclin B1, survivin, and T-cell factor 4 genes.

40 racted with the Wnt pathway nuclear effector T-cell factor 4 in 4 different human colorectal cancer-d

41 expression of inhibitor of beta-catenin and T-cell factor 4 in LMSP cells, but not in mature leiomyo

42 This coincided with increased beta-catenin-T-cell factor 4 interaction and cyclin-D1 expression.

43 OX-2) protein and activates the beta-catenin/T-cell factor 4 signaling pathway that mediates the onco

44 attenuated by axin or dominant-negative (dn) T-cell factor 4(TCF4), suggesting crosstalk of G-17 with

45 ominant-negative mutant constructs to either T-cell factor 4, the downstream effector of Wnt signalin

46 1-beta-catenin complex, which interacts with T-cell factor 4/lymphoid enhancer factor 1 transcription

47 Promoter analysis suggested that the T cell factor-4 (TCF-4E) transcription factor is respons

48 In addition, PGE2 induced the expression of T cell factor-4 transcription factor, which formed trans

49 ction with a dominant-negative construct for T cell factor-4, a downstream effector of beta-catenin s

50 binant adenovirus encoding dominant-negative T-cell factor-4 (RAd/dnTCF), which blocks Wnt/beta-caten

51 ulation of beta-catenin, which then binds to T-cell factor-4 (Tcf-4), causing increased transcription

52 otein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter.

53 segments of beta-catenin partners, including T-cell factor-4.

54 We have cloned T-cell factor 4N (TCF-4N), an alternative isoform of TCF

55 Single nucleotide polymorphisms in the T-cell factor 7-like 2 (TCF7L2) gene, associated with T2

56 n expression and suppression of beta-catenin/T cell factor activation.

57 ulated the JNK pathway, but not beta-catenin/T cell factor activity.

58 t13 nuclear forms increased the beta-catenin/T-cell factor activity in HEK293 cells and increased apo

59 5a led to a notable decrease in beta-catenin-T-cell factor activity, cyclin-D1 expression, and cell p

60 ating EMT by modulating nuclear beta-catenin/T-cell factor activity.

61 by Wnt target gene activation and endogenous T-cell factor activity.

62 nin is the major transcriptional cofactor of T cell factor and plays a role in thymocyte development.

63 rotein interaction, reflecting the fact that T-cell factor and AR have overlapping binding sites on b

64 ll growth by disruption of both beta-catenin/T-cell factor and beta-catenin/AR protein interaction, r

65 tional activity of its heterodimeric partner T-cell factor and their target gene AXIN2, leading to th

66 expression of exogenous ZMIZ2 augments TCF (T cell factor) and beta-catenin-mediated transcription.

67 The association of beta-catenin, T-cell factor, and lymphoid enhancer transcription facto

68 a-catenin activated a reporter responsive to T-cell factor, and this activation was augmented by LMP2

69 t3a, as revealed by lymphoid enhancer factor/T-cell factor/beta-catenin reporter activity and beta-ca

70 a small molecule that specifically inhibits T-cell factor/beta-catenin transcription in a cyclic AMP

71 h factor receptor promoter analysis showed a T-cell factor-binding site, and subsequent reporter assa

72 pathway, Dickkopf-1 and a dominant-negative T cell factor construct, did not reduce motility.

73 n expression and activates beta-catenin/Tcf (T-cell factor)-dependent transcription in colon tumor ce

74 els and had the ability to potently activate T cell factor-dependent transcription and promote neopla

75 we show that PGE2 activated the beta-catenin/T cell factor-dependent transcription in colon cancer ce

76 al stabilization of beta-cat is required for T cell factor-dependent transcription of numerous downst

77 DMSO provoked T cell factor-dependent transcriptional activity; thus,

78 A beta-catenin/T cell factor-dependent transcriptional program is criti

79 e first bacterial toxin reported to activate T-cell factor-dependent beta-catenin nuclear signaling i

80 beta-Catenin/T-cell factor-dependent promoter activity was markedly a

81 ells inhibits colony growth and beta-catenin/T-cell factor-dependent transcription.

82 ion ensues, mediated in part by beta-catenin/T-cell factor-dependent transcriptional activation.

83 al Wnt signaling inhibitor dominant-negative T cell factor does not alter ERK nuclear translocation o

84 A detail study showed that both PITX2 and T-cell factor elements and the interaction with their bi

85 promoter region has revealed the presence of T cell factor-, Ets-, and AP-1-binding motifs.

86 eptor (AR), and the Lymphoid Enhancer Factor/T Cell Factor family member, Lef1.

87 ed binding site for lymphoid enhancer factor/T-cell factor family proteins, which mediate the transcr

88 nd sequestering beta-catenin (beta-cat) from T-cell factor family transcription factors.

89 interacts with transcription factors such as T-cell factor, forkhead box protein O, and hypoxia induc

90 ater PU.1 activities are antagonistic to pro-T cell factors, however, including E proteins, Myb, Gfi-

91 sal lesion; and (c) the putative role of non-T-cell factors in driving mucosal response to gliadin.

92 ls that miR-125a suppresses several effector T-cell factors including Stat3, Ifng and Il13.

93 s by inducing Wnt/beta-catenin signaling and T-cell factor-induced gene transcription.

94 f beta-catenin and its subsequent binding to T-cell factors induces differentiation.

95 Both microbial products and T cell factors influence dendritic cell (DC) maturation.

96 eta-catenin, thereby preventing beta-catenin/T-cell factor interaction and alteration of growth-contr

97 t away from its transcription factor partner T-cell factor, it is not known if this is the mechanism

98 d Wnt/beta-catenin-mediated transcription in T-cell factor-lacZ transgenic mice.

99 The lymphoid enhancer factor 1/T cell factor (LEF/TCF) family of transcription factors

100 Lymphoid enhancer factor/T-cell factor (LEF/TCF) are transcription factors that m

101 are members of the lymphoid enhancer factor/T-cell factor (LEF/TCF) family.

102 n of gene expression requires binding of LEF/T-cell factor (LEF/TCF) transcription factors to Wnt res

103 effect is mediated, at least in part, by two T-cell factor/LEF-binding sites within the proximal prom

104 tion by lymphocyte enhancer binding factor 1/T cell factor (LEF1/TCF) proteins with the assistance of

105 Lymphoid-enhancing factor/T-cell factors (LEF1/TCF) are a high-mobility group of t

106 cells the Gq pathway suppresses beta-catenin-T cell factor/lymphocyte enhancer factor-1 transcription

107 r, it induces beta-catenin up-regulation and T-cell factor/lymphocyte enhancement factor-dependent tr

108 -1 (Lef-1Delta20), one of the members of the T-cell factor/lymphocyte enhancer factor (Tcf/Lef) famil

109 tional repression by modulating beta-catenin/T-cell factor/lymphocyte enhancer factor activity.

110 and NFkappaB-p65, inhibition of beta-catenin-T-cell factor/lymphocyte enhancer factor and NFkappaB-sp

111 ing to activation of beta-catenin-associated T-cell factor/lymphocyte enhancer factor transcriptional

112 Although NO also activated the beta-catenin.T-cell factor/lymphocyte enhancing factor transcriptiona

113 ent also decreased the beta-catenin-mediated T cell factor/lymphoid enhancer factor (TCF/LEF) reporte

114 T cell factor/lymphoid enhancer factor (TCF/LEF) transcr

115 beta-catenin during liver regeneration using T cell factor/lymphoid enhancer factor (TCF/LEF)-reporte

116 nally regulated, as it induced CD4 mRNA, and T cell factor/lymphoid enhancer factor sites were identi

117 ranslocation into the nucleus, and activated T cell factor/lymphoid enhancer factor transcription fac

118 protein expression and beta-catenin-mediated T cell factor/lymphoid enhancer reporter (TOPflash) acti

119 rget genes primarily by associating with the T cell factor/lymphoid enhancer-binding factor (TCF/Lef)

120 in the promoter of BACE1 containing putative T-cell factor/lymphoid enhancer binding factor-1 (TCF/LE

121 ves as a transcriptional coactivator for the T-cell factor/lymphoid enhancer factor (TCF/LEF) family

122 complexes with sequence-specific DNA-binding T-cell factor/lymphoid enhancer factor (TCF/LEF) family

123 x2/HDAC1 repressor complex to a Wnt-mediated T-cell factor/lymphoid enhancer factor (TCF/LEF) transcr

124 Moreover, Wnt3a-induced beta-catenin/T-cell factor/lymphoid enhancer factor (TCF/LEF) transcr

125 , nuclear translocation and interaction with T-cell factor/lymphoid enhancer factor (TCF/LEF) transcr

126 hat epidermal growth factor (EGF) stimulates T-cell factor/lymphoid enhancer factor (Tcf/Lef) transcr

127 enhancers contain a single, highly conserved T-cell factor/lymphoid enhancer factor binding site that

128 d enhancer transcription factors of multiple T-cell factor/lymphoid enhancer factor regulatory elemen

129 d GSK-3beta phosphorylation and beta-catenin/T-cell factor/lymphoid enhancer factor signaling leading

130 A shear stress-induced increase in T-cell factor/lymphoid enhancer factor transcriptional a

131 ced the ability of Dvl3 to activate TCF/LEF (T-cell factor/lymphoid enhancer factor)-driven transcrip

132 n transcriptional activity by competing with T-cell factor/lymphoid enhancer factor.

133 pidermoid carcinoma (A253) cells contain the T-cell factor/lymphoid enhancer-binding factor (TCF/LEF)

134 rget genes through its interactions with the T-cell factor/lymphoid enhancer-binding factor (TCF/Lef)

135 evelopment by regulating gene expression via T-cell factor/Lymphoid enhancer-binding factor (Tcf/Lef)

136 the downstream targets Tau, beta-catenin and T-cell factor/lymphoid enhancing factor (TCF/LEF).

137 the adenomatous polyposis coli-beta-catenin-T-cell factor/lymphoid enhancing factor pathway, induces

138 esses beta-catenin-mediated transcription on T-cell factor/lymphoid enhancing factor.

139 iCl treatment drives beta-catenin to bind to T-cell factor/lymphoid-enhancer factor response elements

140 fically inhibits Wnt signaling, beta-catenin/T-cell factor/lymphoid-enhancer factor-dependent transcr

141 f E-cadherin and suppression of beta-catenin/T cell factor may be an important mechanism underlying t

142 egulates beta-catenin, inhibits beta-catenin/T cell factor-mediated transactivation, and induces cell

143 machinery in osteocytes, albeit beta-catenin/T cell factor-mediated transcription is not required.

144 actions through stimulating the beta-catenin/T cell factor-mediated transcription, which plays critic

145 in, and associated lymphoid-enhancing factor/T cell factor-mediated transcription.

146 ediated transcription at the expense of Wnt-/T-cell factor-mediated transcription and osteoblast diff

147 nd SB216763 increased beta-catenin-dependent T-cell factor-mediated transcription.

148 cdc80 is required for the full inhibition of T-cell factor-mediated transcriptional activity, down-re

149 t within an individual, the impacts of other T cell factors on HIV-1 escape should be considered in t

150 in that I-mfa affects both Axin function and T-cell factor- or LEF-regulated transcription in the Wnt

151 Activation of the beta-catenin/T cell factor pathway by EBV may contribute to the lymph

152 y is markedly stimulated by the beta-catenin/T-cell factor pathway.

153 ons, we concomitantly evaluated the Wnt-TCF (T-cell factor) pathway.

154 ctors produced by activated CD4 autoreactive T cells, factors produced by nonlymphoid cells, such as

155 Lymphoid enhancer factor/T-cell factor promoter activity was upregulated by KM-GS

156 eased activity of a lymphoid enhancer factor/T-cell factor promoter reporter, and enhanced accumulati

157 tion, activation of lymphoid enhancer factor/T-cell factor protein-sensitive transcription, and promo

158 Wnt3a stimulates lymphoid enhancer factor/T-cell factor protein-sensitive transcription, i.e. the

159 Lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) mediate Wnt signals in

160 constitutive activation of beta-catenin/TCF (T cell factor)-regulated gene expression occur in many c

161 g to the ability of beta-catenin to activate T cell factor-regulated genes.

162 xpression of the PKCbetaII- and beta-catenin/T-cell factor-regulated genes PKCbetaII, cyclooxygenase

163 nd lymphoid enhancer-binding factor 1 (LEF1)/T cell factor regulates proliferation in stem cells and

164 Using T cell factor reporter assays, we found that membrane-as

165 nal activity was assessed with the TOPFLASH (T cell factor reporter plasmid) luciferase assay.

166 tivates a lymphocyte enhancer-binding factor-T cell factor reporter.

167 ce microscopy and a lymphoid enhancer factor/T-cell factor reporter assay were used to detect nuclear

168 Using a T-cell factor reporter zebrafish we confirm that DOCK4 i

169 Conversely, co-expression of beta-catenin/T cell factor repressed AR stimulation of AR-responsive

170 ated that liganded AR repressed beta-catenin/T cell factor-responsive reporter gene activity.

171 tenin, the major transcriptional cofactor of T cell factor, results in increase in both CD4SP and CD8

172 ll molecule that down-regulates beta-catenin/T cell factor signaling by specifically binding to cycli

173 enin, a central mediator of Wnt-beta-catenin-T cell factor signaling pathway, impairs traversal throu

174 OPN is a target gene for beta-catenin-T cell factor signaling, which is commonly disturbed dur

175 AGbetaC/PLIN2 associations and beta-catenin T-cell factor signaling (beta-CTS).

176 Forced inhibition of beta-catenin/T-cell factor signaling in AT2 cultures leads to increas

177 Wnt-beta-catenin-T-cell factor signaling is causally linked to c-myc-depe

178 ll growth, NO-ASA inhibited the beta-catenin/T-cell factor signaling pathway (IC(50), 1.1 microM), nu

179 lls the effect of NO-ASA on the beta-catenin/T-cell factor signaling pathway, nuclear factor-kappaB,

180 that EP(2) and EP(4) receptors can activate T-cell factor signaling; however, EP(2) receptors did th

181 lls up-regulates the endogenous beta-catenin/T cell factor-signaling activity.

182 aling protects against the downregulation of T-cell factors so that a T-cell transcriptional network

183 any other retinoid compound, on beta-catenin/T-cell factor-stimulated cyclin D1 promoter activity in

184 lted in increased levels of the beta-catenin/T-cell factor target genes c-myc and cyclin D1.

185 Beta-catenin and T cell factor (Tcf) are distal components of the highly

186 to the nucleus, where it interacts with the T cell factor (TCF) family of DNA binding proteins to re

187 by the Wnt pathway transcriptional effector T cell factor (TCF) in an estrogen receptor (ER) depende

188 h induced by Wnt-3a and in the activation of T cell factor (TCF) induced by Wnt-1.

189 gnaling by the developmentally important Wnt/T cell factor (TCF) pathway.

190 T cell factor (Tcf) proteins bind beta-catenin and are d

191 TM40D-MB cells also have a higher T cell factor (TCF) reporter activity than TM40D cells.

192 s containing leukocyte enhancer factor (LEF)/T cell factor (TCF) response elements.

193 o was associated with decreased beta-catenin-T cell factor (TCF) signaling, loss of plasma membrane-a

194 a-catenin and thus antagonizing beta-catenin/T cell factor (TCF) signaling, or by other signaling pat

195 o implicated in CaP progression via beta-cat/T cell factor (Tcf) signaling.

196 Although beta-catenin is known to upregulate T cell factor (TCF) target gene expression in CaP cells,

197 t can interact with the transcription factor T cell factor (TCF) to transactivate gene expression.

198 anBP3 export factor antagonizes beta-catenin/T cell factor (TCF) transcription by targeting the signa

199 e increased Numb mRNA and protein levels and T cell factor (Tcf) transcriptional activity via inhibit

200 of beta-catenin, a critical coactivator for T cell factor (TCF), enhances DP thymocyte survival via

201 ila, target gene regulation is controlled by T cell factor (TCF), which binds to specific DNA sequenc

202 upstream of the transcriptional activity of T cell factor (TCF), which is required for EMT to procee

203 t enhanced function of transcription factors T cell factor (TCF)-1 and beta-catenin regulate the freq

204 T cell factor (TCF)-1 and lymphoid enhancer-binding fact

205 In this work, we demonstrate that T cell factor (TCF)-1 regulates DP thymocyte survival by

206 or PU.1, growth factor independence (Gfi)-1, T cell factor (TCF)-1, and Runx factors and their intera

207 T cell factor (TCF)-1/beta-catenin pathway has previousl

208 or expression of a dominant negative form of T cell factor (TCF)-4.

209 promoter 1 of the LEF1 gene is activated by T cell factor (TCF)-beta-catenin complexes in transient

210 mbers show that only Wnt-2 activates Rfz9 in T cell factor (TCF)-dependent transcription.

211 uce lymphocyte enhancer-binding factor (LEF)/T cell factor (TCF)-dependent transcriptional activities

212 -catenin nuclear translocation and activates T cell factor (TCF)-luciferase reporter activity.

213 nin and, thus, beta-catenin participation in T cell factor (TCF)-mediated transcription.

214 , PS-1(L286V), causes a dramatic increase in T cell factor (TCF)/beta-catenin transcription in PC-12

215 beta-Catenin partners with members of the T cell factor (TCF)/LEF transcription factors to regulat

216 ift assays, and transient transfections with T cell factor (TCF)/lymphoid enhancer factor (LEF) optim

217 es nuclear translocation of beta-catenin and T cell factor (TCF)/lymphoid enhancer factor-1 (LEF-1),

218 beta-catenin, transcriptional activation of T cell factor (Tcf)/lymphoid-enhancer factor (Lef), and

219 ciated with Wnt-responsive enhancers through T cell factors (TCF) and kept silent by Groucho/TLE co-r

220 ent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1/lymphoid enhancer factor (Lef) 1 t

221 antagonize while others enhance beta-catenin/T-cell factor (TCF) activity.

222 an interact with beta-catenin (beta-cat) and T-cell factor (TCF) and that the nuclear accumulation of

223 rous transactivating factors, including four T-cell factor (TCF) binding elements (TBEs).

224 The aberrant formation of the beta-catenin/T-cell factor (Tcf) complex leads to many cancers and or

225 Activation of the beta-catenin/T-cell factor (TCF) complex occurs in most colon tumors,

226 tivation by a complex of beta-catenin with a T-cell factor (TCF) family member.

227 n in the cytoplasm favors its binding to the T-cell factor (TCF) family of DNA-binding proteins, and

228 ulates the transcriptional properties of the T-cell factor (TCF) family of DNA-binding proteins.

229 e nucleus and associates with members of the T-cell factor (TCF) family of transcription factors.

230 mbers of the lymphoid-enhancing factor (LEF)/T-cell factor (TCF) family, only TCF4 showed more effect

231 rs of the lymphoid enhancer factor 1 (LEF-1)/T-cell factor (TCF) family.

232 -Catenin/Armadillo: the outcome is to oppose T-cell factor (TCF) function and Wg/Wnt pathway signalin

233 A-metabolizing enzymes via the beta-catenin/T-cell factor (TCF) pathway in DCs.

234 The Wnt/beta-catenin/T-cell factor (Tcf) pathway is aberrantly up-regulated i

235 o serve as a transcriptional coactivator for T-cell factor (TCF) proteins, the downstream transcripti

236 ivation and decreases Notch and beta-catenin/T-cell factor (TCF) reporter activity resulting from Msi

237 Wnt proteins can be assessed using different T-cell factor (TCF) reporter assays as a readout for Wnt

238 y that growth factors stimulate beta-catenin/T-cell factor (TCF) signaling in primary VSMCs.

239 Inhibition of Wnt/beta-catenin/T-cell factor (TCF) signaling induces proliferation of m

240 Beta-catenin/T-cell factor (Tcf) signaling is constitutively active i

241 o-oncogene, c-myc, by elevating beta-catenin/T-cell factor (TCF) signaling.

242 stabilization and activation of beta-catenin/T-cell factor (TCF) signaling.

243 tion assays showed that the putative SBE and T-cell factor (TCF) sites were able to bind a complex co

244 ivation of lymphoid enhancer factor 1 (LEF1)/T-cell factor (TCF) target genes underlie the oncogenic

245 in neoplastic transformation is dependent on T-cell factor (TCF) transcription factors, but specific

246 ability of beta-catenin to bind and activate T-cell factor (TCF) transcription factors.

247 of Wnt-responsive genes in conjunction with T-cell factor (TCF) transcription factors.

248 Aberrant T-cell factor (TCF) transcription is implicated in the m

249 ignaling to suppress beta-catenin levels and T-cell factor (TCF) transcriptional activity in colon tu

250 Foxm1 decreased T-cell factor (TCF) transcriptional activity induced by

251 ell proliferation by inhibiting beta-catenin/T-cell factor (TCF) transcriptional activity.

252 dherens junction in cell adhesion and as the T-cell factor (TCF) transcriptional coactivator in canon

253 Sox9 and T-cell factor (TCF) x lymphoid enhancer factor (LEF) fac

254 yclin D1 is mainly regulated by beta-catenin/T-cell factor (TCF), TCF-4 response element was used in

255 e is a significant increase in expression of T-cell factor (TCF)-1, Runx2, and the RUNX2 target gene

256 ctional cooperation between beta-catenin and T-cell factor (TCF)-2 resulted in the downregulation of

257 erizing in vivo their chromatin occupancy by T-cell factor (Tcf)-4 and beta-catenin, transcriptome, a

258 l and Slug promote formation of beta-catenin-T-cell factor (TCF)-4 transcription complexes that bind

259 ession of the KCNQ1 promoter by beta-catenin:T-cell factor (TCF)-4.

260 T-cell factor (TCF)-beta-catenin complexes bind to Wnt r

261 promoter analyses revealed three functional T-cell factor (TCF)-binding sites in the promoter of HEF

262 GSK3beta, stabilized beta-catenin, enhanced T-cell factor (TCF)-dependent gene activation and induce

263 oth beta-catenin and Wnt ligands to activate T-cell factor (TCF)-dependent gene transcription, a majo

264 eta-catenin with concomitant upregulation of T-cell factor (TCF)-dependent transcription in both zebr

265 otent and specific inhibitor of beta-catenin/T-cell factor (TCF)-dependent transcription, and that th

266 To evaluate T-cell factor (Tcf)-dependent transcriptional activity o

267 g to gene activation by beta-catenin and the T-cell factor (TCF)-lymphoid enhancer factor (LEF) famil

268 g to the ability of beta-catenin to activate T-cell factor (TCF)-mediated transcription.

269 s a key role in Wnt signaling via effects on T-cell factor (TCF)-mediated transcription.

270 tenin levels, resulting in marked effects on T-cell factor (TCF)-regulated transcription.

271 vation of downstream genes with beta-catenin/T-cell factor (Tcf)-responsive promoters.

272 targeting to cadherin adhesive complexes, or T-cell factor (TCF)-transcriptional complexes is less we

273 istically by TGF-beta/Smads and beta-catenin/T-cell factor (TCF).

274 nal co-activators beta-catenin/Armadillo and T-cell factor (TCF).

275 ssion caused by transcription factors of the T-cell factor (TCF)/beta-catenin family.

276 was also found that PGF2alpha-could activate T-cell factor (Tcf)/beta-catenin signaling in cells expr

277 Antagonism of T-cell factor (Tcf)/beta-catenin signaling with dominant

278 (NF-1) recognition element near a consensus T-cell factor (TCF)/LEF binding site.

279 tenin signaling is primarily mediated by the T-cell factor (TCF)/Lef-1 family of transcription factor

280 -catenin, when complexed with members of the T-cell factor (TCF)/leukocyte enhancer factor family of

281 NB1 constitutively activate the beta-catenin/T-cell factor (TCF)/lymphoid enhancer factor (LEF) signa

282 gene transcription through the activation of T-cell factor (TCF)/lymphoid enhancer factor (LEF) trans

283 omponent of the Wnt pathway, which activates T-cell factor (TCF)/lymphoid enhancer factor (LEF) trans

284 dent by the presence of conserved functional T-cell factor (TCF)/lymphoid enhancer-binding factor (LE

285 pathway promotes pluripotency by alleviating T cell factor TCF3-mediated repression of the PTN.

286 Transfecting cells with a dominant-negative T-cell factor (TCF4), the specific inhibitor of the beta

287 on did not appear to require the function of T-cell factors (TCFs), suggesting a mechanism independen

288 Here we describe the discovery of a T cell factor, TIP (T cell immunomodulatory protein), wh

289 cretion of MMP-7 and promoted the binding of T cell factor to the MMP-7 promoter in kidney epithelial

290 e cell line expressing human CD40L, and with T cell factors to stimulate the in vitro production of A

291 ion of the limited pool of beta-catenin from T-cell factor- to FoxO-mediated transcription in osteobl

292 sion, stabilized beta-catenin, and activated T cell factor transcription factor activity and expressi

293 atenin and altered lymphoid-enhancing factor/T cell factor transcription.

294 T activation, cytosolic beta-catenin levels, T-cell factor transcription activity, and expression of

295 ting of five consensus binding sites for the T-cell factor transcription factor.

296 ient to prevent FoxO-mediated suppression of T-cell factor transcription.

297 type III B cell lines, and that beta-catenin/T cell factor transcriptional activity is significantly

298 for cell growth inhibition, but beta-catenin/T-cell factor transcriptional activity is not involved i

299 at overexpress effectors of the beta-catenin/T cell factor Wnt pathway, the amplification of progenit

300 ses the binding elements of PITX2 as well as T-cell factor (Wnt-responsive), in close proximity, wher