ライフサイエンスコーパス: T-cell precursor

1 potent thymocyte matures into the definitive T cell precursor.

2 t of Tregs on high-avidity NY-ESO-1-specific T cell precursors.

3 PU.1 enhancer in B cells but a repressor in T cell precursors.

4 romote the generation of thymus-repopulating T cell precursors.

5 suggesting that it may act only on immature T cell precursors.

6 he naive T cell pool contained self-reactive T cell precursors.

7 e observed from both naive and memory CD8(+) T cell precursors.

8 stulate that irradiation affects intrathymic T cell precursors.

9 s fails to induce negative selection of CD4+ T cell precursors.

10 een, during the generation of virus-specific T cell precursors.

11 ary immune response or as a cache for excess T cell precursors.

12 Ig) and T cell receptor (TCR) genes in B and T cell precursors.

13 dent effect on antigen-specific naive CD4(+) T cell precursors.

14 P), common lymphoid progenitors (CLP), and B/T cell precursors.

15 seeding the thymus from bone marrow-derived T cell precursors.

16 the generation of CD8(+) effector and memory T cell precursors.

17 nsion and survival characteristics of CD8(+) T cell precursors.

18 lenced through different mechanisms in early T cell precursors.

19 ints that control the intrathymic journey of T cell precursors.

20 aturation in lal(-/-) mice due to defects in T cell precursors.

21 major determinant in the survival of memory T cell precursors.

22 eterodimers play a role in transformation of T-cell precursors.

23 eight times with continued increases in CEA T-cell precursors.

24 rease in the level of EBV-specific cytotoxic T-cell precursors.

25 and Utx, in non-dividing intrathymic CD4(+) T-cell precursors.

26 -cell receptor (TCR), from an array of naive T-cell precursors.

27 precursors as compared with the conventional T cell precursors, 2) the CD28 receptor density on cell

28 ection was associated with reduced naive CD8 T cell precursors above the loss attributable to aging.

29 thymi, with reductions in double-negative 4 T cell precursors, accompanied by reduced numbers of bot

30 Early T cell precursor acute lymphoblastic leukemia (ETP-ALL)

31 Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL)

32 Mutations in DNM2 are common in early T-cell precursor acute lymphoblastic leukemia.

33 cell clones were derived from a common naive T cell precursor after skin immunization, generating ove

34 body titers and a high frequency of specific T-cell precursors after a single inoculation in BALB/c m

35 phoblastic leukemia (T-ALL), including early T-cell precursor ALL (ETP-ALL) cases with poor prognosis

36 ne expression pattern similar to human early T-cell precursor ALL, and were resistant to the potent a

37 tial for the generation of B cell but not of T cell precursors, although the differentiation of the l

38 ed a dramatic increase in E7-specific CD8(+) T cell precursors and an impressive antitumor effect aga

39 in transgenic mice, retrovirally transduced T cell precursors and cell lines showed that the pTalpha

40 Decreased intrathymic T cell precursors and decreased generation of mature T c

41 ted defects--drastic reduction in true naive T cell precursors and impaired proliferative capacity of

42 ral lymphopenia caused by reduced numbers of T cell precursors and mature lymphocytes.

43 and senescence pathways, starts in immature T cell precursors and surprisingly not in mature T cells

44 zed old mice lose >/= 70% of Ag-specific CD8 T cell precursors and that many of the remaining precurs

45 regulatory network for the specification of T cell precursors and the choice of T as opposed to myel

46 sting a defect during thymic colonization by T cell precursors and/or during the differentiation of t

47 r T cells generated from naive or memory CD4 T-cell precursors and distinguished effector from memory

48 Because BCL-2 shows high expression in early T-cell precursors and gradually decreases during normal

49 of Sca-1(+)c-kit+ cells, Thy1(+)CD25+ early T cell precursors, and B220(+)CD43(-/lo) cells that, whe

50 lved in generating IL-7Ralphahigh memory CD8 T cell precursors, and consequently, protective memory C

51 increase in the number of E7-specific CD8(+) T cell precursors ( approximately 30-fold compared with

52 Additionally, a much higher frequency of T cell precursors are found among SCID-repopulating cell

53 ding CD8 T cells, indicating that CD8 memory T cell precursors are not selected by IL-7/IL-7Ralpha in

54 IL-17-producing effector T-cells from naive T-cell precursors are being rapidly discovered and are p

55 are specifically up-regulated in intrathymic T cell precursors as compared with myeloid progenitors.

56 increase in the number of E7-specific CD8(+) T-cell precursors as well as a potent CD4-independent an

57 mma-interferon-secreting, E7-specific CD8(+)-T-cell precursors as well as stronger tumor prevention a

58 eatly suppressed the generation of cytotoxic T-cell precursors, as assessed by secondary stimulation

59 leads to enhanced immigration of bone marrow T-cell precursors, as manifested by both an early increa

60 CD47(high) status marked central memory CD4 T cell precursors at an early time point of the IR.

61 stimulate differentiation and maturation of T-cell precursors, avian thymic hormone (ATH) is nonethe

62 ived factor (SDF)-1 is a chemoattractant for T cells, precursor B cells, monocytes, and neutrophils.

63 Development of immature T cell precursors beyond the beta-selection checkpoint i

64 -ATc1 act together to promote development of T cell precursors beyond the beta-selection checkpoint t

65 nitors and CD4(+)CD8(+) double-positive (DP) T cell precursors, but increased frequencies of CD4(+) a

66 Multiple subsets of the bone marrow contain T cell precursors, but it remains unclear which is most

67 istocompatibility complex class I binding to T-cell precursors called thymocytes.

68 Extrathymic T cell precursors can be detected in many tissues and re

69 Although self-reactive T-cell precursors can be eliminated upon recognition of

70 We found that allogeneic T-cell precursors can be transferred to irradiated indiv

71 conditioning is required for engraftment of T-cell precursors capable of supporting robust T-cell re

72 vival and proliferation of hematopoietic and T cell precursor cells in vitro.

73 ted hematopoietic chimeras in which very few T cell precursors could develop.

74 imiting-dilution analysis (LDA) of cytotoxic T-cell precursors (CTLp) at sequential time points durin

75 The relative number of intrathymic NK T cell precursors decline in a linear manner with gestat

76 epitope was due to a limited number of CD8+ T cell precursors directed to JHA 210-219.

77 trinsic developmental defects in intrathymic T cell precursors do not contribute to age-related decli

78 ation, thus affecting the survival of a B or T cell precursor during receptor gene rearrangements.

79 all cases, we find that high-avidity CD8(+) T cell precursors, either naive or memory, massively exp

80 Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL

81 Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL

82 Early T-cell precursor (ETP) acute lymphoblastic leukemia/lymp

83 or T-cell lineages with the high-risk early T-cell precursor (ETP) and Ph-like ALL clustering as a d

84 Early T-cell precursor (ETP) leukaemias have been recently rec

85 postulated that T-ALL originating from early T-cell precursors (ETPs), a recently defined subset of t

86 y reported that NY-ESO-1-specific naive CD4+ T cell precursors exist in most individuals but are supp

87 After our observation that intrathymic T cell precursors expressing a human CD25 reporter under

88 response, we show generation of CD8+ memory T cell precursors expressing lymphoid homing molecules (

89 an additionally generate mature NK cells and T cell precursors expressing the correctly spliced IL-2R

90 that frequencies of naive and memory CD8(+) T cell precursors for whole viruses can be remarkably hi

91 To generate large numbers of T-cell precursors for adoptive therapy, we cultured mous

92 between the affinity of the TCR expressed by T-cell precursors for self-antigens and the proper devel

93 in the attraction and lineage commitment of T cell precursors, Foxn1 regulates the expression of gen

94 tetrameric complexes (tHLA) vaccine-elicited T cell precursor frequencies (Tc-pf) in melanoma patient

95 Although distinct inflammatory milieu and T cell precursor frequencies influenced the differentiat

96 hese "hidden" epitopes may be very low naive T cell precursor frequencies.

97 To examine CD8(+) T-cell precursor frequencies for whole viruses, we devel

98 e tetramer (tHLA), we enumerated MA-specific T cell precursor frequency (TCPF) directly in PBMC from

99 ide tetramers (tHLA) vaccine-elicited CD8(+) T cell precursor frequency among PBMC in 13 patients wit

100 imiting dilution analysis indicated that the T cell precursor frequency among the healthy human adult

101 We investigated the role of antigen-specific T cell precursor frequency as a possible cell-extrinsic

102 Vaccine-induced enhancement of T cell precursor frequency could be detected with tHLA i

103 Naive T cell precursor frequency determines the magnitude of i

104 01/peptide tetramers (tHLA) vaccine-elicited T cell precursor frequency directly in PBMC of patients

105 ed the possibility that variations in CD4(+) T cell precursor frequency following transplantation mig

106 Third, the autoreactive T cell precursor frequency for both CD4 and CD8 cells is

107 T cell precursor frequency increased from undetectable t

108 Our data suggest that Ag-specific naive T cell precursor frequency may be predetermined and that

109 We show here that naive T cell precursor frequency profoundly influenced the pat

110 positively selecting ligand influences naive T cell precursor frequency remains undefined.

111 onstrates the functional relevance of CD8(+) T cell precursor frequency to tumor immunity and autoimm

112 However, the xenogeneic T cell precursor frequency was found to be markedly high

113 Alloreactive T cell precursor frequency was measured in vivo using fl

114 CD8 T cell number (i.e., primary memory CD8 T cell precursor frequency) present during secondary inf

115 ependent of early instructional programming, T cell precursor frequency, and Ag availability.

116 In these instances the naive CD8(+) T cell precursor frequency, directly measured by tetrame

117 strains is independent of the H-2 locus and T cell precursor frequency.

118 After vaccination, the mean peptide-specific T-cell precursor frequency to the HLA-A2 peptides increa

119 e presence of homeostatic expansion and high T-cell precursor frequency, both obstacles to tolerance

120 pal pathway of alpha/beta T cell maturation, T cell precursors from the bone marrow migrate to the th

121 tion of primary virus-specific CD4+ and CD8+ T cell precursors from the mediastinal lymph nodes to th

122 onclude that ex vivo generated MHC-disparate T-cell precursors from any donor can be used universally

123 PU.1 also diverts normal T-cell precursors from wild type or Bcl2-transgenic mice

124 OP9-DL1-derived T-cell precursors gave rise to host-tolerant CD4+ and CD

125 nitors (ETPs), the most immature intrathymic T-cell precursors, harvested from the involuted thymus e

126 ing T cells, but its function in intrathymic T-cell precursors has been poorly defined.

127 resent distinct lineages or whether the same T-cell precursors have the capacity to be selected on ei

128 molecular subtypes of T-ALL, including early T-cell precursor, HOXA-positive, LEF1-inactivated, and T

129 erate the Vgamma2/Vdelta7(+) skin gammadelta T cell precursors in fetal thymi of the B6 background mi

130 xtrapolation, and few direct observations of T cell precursors in NZB mice have been performed.

131 To analyze the early development of T cell precursors in the absence of TCR gene rearrangeme

132 We now show that gamma delta T cell precursors in the lung epithelium of both euthymi

133 lopment of cryptopatches (CP), aggregates of T cell precursors in the mouse small intestine.

134 T cells can differentiate from CCR6(+) naive T cell precursors in the presence of IL-2, IL-1beta, TGF

135 increase in the number of E7-specific CD8(+) T cell precursors in vaccinated mice (around 50-fold) an

136 equired to generate mTregs from naive CD4(+) T cell precursors in vivo.

137 g regulatory T cells (TR1) from conventional T-cell precursors in both murine and human systems.

138 ion of induced Tregs (iTregs) from naive CD4 T-cell precursors in the periphery.

139 Similarly, more differentiated NZB T cell precursors included in the intrathymic pool of CD

140 Administration of OP9-DL1-derived T-cell precursors increased resistance to infection with

141 T cell receptor (TCR) signaling in committed T cell precursors inhibit E47 DNA-binding activity and i

142 ronment also supports the differentiation of T cell precursors into CD4+ and CD8+ T cells.

143 otent as they inhibit the differentiation of T cell precursors into mature cytotoxic T lymphocytes (C

144 lper type 2 (TH2) cells from uncommitted CD4 T cell precursors is activation of the STAT6 transcripti

145 nitial number of naive virus-specific CD4(+) T cell precursors is low (< or =10(4) per spleen) do the

146 he differentiation of these cells from naive T cell precursors is, however, unclear.

147 o inhibit Th2 cell generation from naive CD4 T cell precursors, it has been inferred that TLR4 signal

148 s suggest that CLPs may not be physiological T cell precursors, it is generally accepted that CLPs ar

149 The reversion likely occurred in a prethymic T-cell precursor, leading to a chimeric T-cell repertoir

150 Early T-cell precursor leukaemia (ETP-ALL) is a high-risk subt

151 ns' respective abilities to generate splenic T cell precursors (Lin(-)Thy1.2(+)CD25(+)IL7Ralpha(+)) a

152 Thus, CTP represent T lineage-committed T cell precursors linking extrathymic with intrathymic l

153 hat the adoptive transfer of OP9-DL1-derived T-cell precursors markedly enhances T-cell reconstitutio

154 Thus, memory CD8(+) T cell precursor maturation is an active process depende

155 transition from the first to second wave of T cell precursors maturing in neonatal thymus, thymus ce

156 f adoptively transferred bone marrow-derived T cell precursors maturing in the presence of the establ

157 The results imply that in T cell precursors, Notch/Delta signaling normally acts t

158 cell receptor (TCR) gamma rearrangements in T cell precursors of the mouse adult thymus.

159 vo LDA and found frequencies of naive CD8(+) T-cell precursors of 1 in 1,444 for vaccinia virus (VV)

160 -ESO-1-specific pre-existing naive CD4+CD25- T cell precursors or spontaneously induced CD4+ T cell e

161 helper cell precursors (pTH), and cytotoxic T cell precursors (pCTL) by limiting dilution analysis.

162 alterations in the composition of naive CD4 T cell precursor pools, with sustained quantitative redu

163 with progressively smaller and lower avidity T cell precursor pools.

164 cted central nervous system as well as naive T cell precursor pools.

165 While early thymic T cell precursor populations and their maturational sequ

166 iding less than 1,200 EBV-specific cytotoxic T-cell precursors, populations of EBV-specific CTL in th

167 The absence of T cell precursor potential, both in vivo and in vitro, i

168 omponents of regulatory change through which T cell precursors progress from primitive multipotency t

169 Thus, the frequency of neonatal T cell precursors rather than repertoire diversity exert

170 Thus, NOD T cell precursors reveal divergent, lineage-specific dif

171 that this tissue must be seeded with memory T cell precursors shortly after activation.

172 data suggest that age-associated changes in T cell precursors should be considered when attempts to

173 CD4+ Valpha24 NK T cell precursors show features of mature NK T cells, su

174 Recipients of OP9-DL1-derived T-cell precursors showed increased thymic cellularity an

175 zed patients the expansion of cytolytic CD8+ T cell precursors specific for melanoma differentiation

176 eral blood measurable frequency of cytotoxic T-cell precursors specific for underglycosylated mucin.

177 frequency in the naive cell pool of specific T cell precursors, such an analysis has been obscured by

178 ced effector functions; and (iii) generating T-cell precursors that complete development after adopti

179 By tracing the fate of single T cell precursors, this study shows that there is no com

180 miting dilution assays, we examined the CD4+ T cell precursor (Thp) frequency in C57BL/6 mice infecte

181 Development of immature T-cell precursors (thymocytes) to either the CD4 helper

182 ulation by IGF-1, we examined its effects on T-cell precursors, thymocytes, and thymic epithelial cel

183 cells die, and only a small number of memory T cell precursors (TMPs) survive to form a pool of long-

184 Moreover, the capacity of NZB bone marrow T cell precursors to colonize the thymus and the ability

185 not sufficient to divert class I-restricted T cell precursors to the CD4 lineage.

186 chemokine receptor involved in migration of T cell precursors to the thymus.

187 ibited high frequencies of CD4(+) and CD8(+) T-cell precursors to both B5 (19.8 and 20%, respectively

188 T-cell precursors transduced to express a chimeric recep

189 expression of >100 regulatory genes in early T-cell precursors using realtime RT-PCR.

190 Incomplete recovery of naive CD8(+) T cell precursors was observed in septic mice, suggestin

191 The frequency of early T-cell precursors was increased in Tgfb2+/- mice, sugges

192 sor cells, as well as a decrease in CD4-CD8- T cell precursors, was also observed in a murine C57BL/6

193 receptor alpha (Ptcra) regulatory elements, T cell precursors were identified in peripheral blood.

194 More surprisingly, virus-specific T cell precursors were now detected from days 5 to 6 aft

195 Peptide-specific T-cell precursors were not centrally deleted in MUC1-Tg

196 Further increases in CEA-specific T-cell precursors were seen when local granulocyte-macro

197 ession of alphabetaTCR on immature CD4- CD8- T cell precursors, which play a crucial role in promotin

198 o lymphoid-primed multipotent progenitors to T-cell precursors, which are stages of differentiation d

199 once thought to depend on the interaction of T cell precursors with thymic epithelial cells.

200 ous immunity to NY-ESO-1 had specific CD4(+) T-cell precursors with high avidity to NY-ESO-1 under ti