ライフサイエンスコーパス: T-cell receptor

1 he surface of Tregs stimulated through their T cell receptor.

2 ngths between a self-peptide and the various T cell receptors.

3 bles the binding of human CD1c self-reactive T-cell receptors.

4 a lentiviral vector expressing HCV-specific T-cell receptors.

5 inding of the Fc region of these proteins to T cells receptors.

6 T cell receptors activated the T cell proteome and phosp

7 We demonstrate that TDBs trigger T cell receptor activation by inducing target clustering

8 be Ca(2+) signals reported by Salsa6f during T cell receptor activation in naive T cells, helper Th17

9 ormation, cell protrusion and migration, and T cell receptor activation.

10 DCAF1 is upregulated on T-cell receptor activation and critical for activation-i

11 inated phosphatase activities at the site of T-cell receptor activation, which is important for limit

12 ansgenically expressing the diabetogenic AI4 T-cell receptor adoptively transferred disease to otherw

13 arcinoma and express a limited repertoire of T-cell receptors against tumour-associated antigens.

14 intained CD62L expression when activated via T cell receptor alone or in combination with costimulato

15 both by the germline encoded elements of the T cell receptor alpha and beta chain and, surprisingly,

16 on germ line encoded portions of CDR3 of the T cell receptor alpha chain.

17 ow that directing a CD19-specific CAR to the T-cell receptor alpha constant (TRAC) locus not only res

18 s a tool to classify and number antibody and T-cell receptor amino-acid variable domain sequences.

19 persistence and antitumor effects in murine T cell receptor and chimeric antigen receptor gene thera

20 the immunological synapse together with the T cell receptor and enhances the T cell receptor-induced

21 at the T cell:APC interface thereby linking T cell receptor and Notch signaling pathways.

22 1/Ndfip2 regulate the cross talk between the T-cell receptor and cytokine signalling pathways to limi

23 MDSCs use NO to nitrate both the T-cell receptor and STAT1, thus inhibiting T-cell activa

24 y recognize peptide/MHC complexes with their T-cell receptors and initiate adaptive immune responses.

25 nding to CD3, the signaling component of the T-cell receptor, and a tumor target have shown clinical

26 ytotoxic T-lymphocyte-associated protein 4), T-cell receptor, and Csnk2b-related pathways in regulati

27 Platelet glycoprotein Ib, T-cell receptor, and integrins are used as examples to i

28 were reconstituted with HIV Env gp120, anti-T cell receptor (anti-TCR) monoclonal antibody, and ICAM

29 ined potent inhibitory activity that reduced T-cell receptor, B-cell receptor, and interferon signali

30 In these individuals, T cell receptor beta (TCRbeta) analysis revealed that cl

31 60% of cells have recombined the DNA of one T cell receptor beta (TCRbeta) V-to-DJ-joined allele in

32 sequencing to compare the global changes in T cell receptor beta chain complementarity determining r

33 , using mice expressing one of two different T cell receptor beta chains and various MHC alleles, we

34 T cell receptor beta RNA was measured as a control to as

35 ased on the mutually exclusive expression of T cell receptor beta-chain constant domains 1 and 2 (TRB

36 tarity-determining-region 3 (CDR3) of mature T-cell receptor beta (TCRB) can be used as an immune DNA

37 ytokines when stimulated with FVIII2194-2213 T-cell receptor beta (TCRB) gene sequencing of 15 T-cell

38 r CD8+ T-cells subsets were reconstituted in T-cell receptor beta knockout mice by adoptive transfer,

39 T-cell subsets in T-cell receptor beta knockout mice were reconstituted by

40 ed by vector integration site sequencing and T-cell receptor beta-chain rearrangement sequencing, cor

41 Using T-cell receptor-beta sequencing and tumour reactivity as

42 ing recent force-dependent lifetime data for T cell receptors bound to various ligands.

43 the interaction between MHC-II molecule and T-cell receptor but also, critically, by promoting B7-2/

44 disruption of Lck kinase, PLC-gamma1 or the T cell receptor complex inhibits light-evoked Ca(2+) tra

45 are on components of the same multimolecular T-cell receptor complex.

46 proximal signaling events downstream of the T-cell receptor complex.

47 ic monoclonal antibodies (mAb) targeting the T-cell receptor coregulatory molecule GITR exert potent

48 cent variant and provide a means for probing T-cell receptor cross-reactivity.

49 cing of immunoglobulin heavy chain (IGH) and T-cell receptor delta (TRD) loci.

50 n activated T cells, and ultimately augments T-cell-receptor-dependent production of interleukin 2 by

51 Gabapentin impairs the T-cell receptor-driven calcium response and cytokine pro

52 Cavbeta antisense reduces T-cell receptor-driven calcium responses and cytokine pr

53 reminiscent of mechanical regulation of the T-cell receptor, E-cadherin, and Notch pathways, suggest

54 wn that Foxo3 expression was increased after T cell receptor engagement and played a specific role in

55 ocompatibility complex and cognate alphabeta T cell receptor engagement.

56 Using this mouse model, we show that T-cell receptor engagement is critical for malignant tra

57 Although T-cell receptor engagement was sufficient to induce CD39

58 shorter telomeres but increased single-joint T-cell receptor excision circle content and CD31(+) naiv

59 Analysis of 20 patient samples with low T-cell receptor excision circle numbers on newborn scree

60 g the degree of self-reactivity displayed by T-cell receptors expressed by Treg cells.

61 finities of PD-1 are as high as those of the T cell receptor for agonist pMHC and of LFA-1 (lymphocyt

62 ells in the lamina propria and activation of T cell receptor gammadelta-expressing intraepithelial ly

63 associated with CMV and EBV infections, and T-cell receptor gammadelta(+) T cells were predominantly

64 cell subsets (CD4, CD8, WC-1, and gammadelta T cell receptor [gammadelta-TCR]) and cytokines examined

65 cytometry, examination of blood smears, and T cell receptor gene rearrangements), and performed musc

66 ral virologic control by sequencing viruses, T cell receptor genes, HIV integration sites, and cellul

67 Quantitative next generation sequencing of T-cell receptor genes revealed distinct oligoclonal CD4(

68 tigen receptors of jawed vertebrates (B- and T-cell receptors), heterodimers formed by pairs of Ig do

69 ndard MRD monitoring based on immunoglobulin/T-cell receptor (Ig/TCR) gene rearrangements and with qu

70 er with the T cell receptor and enhances the T cell receptor-induced activation of CD4 T cells.

71 ient NOD mice showed significantly decreased T-cell receptor-induced IL-2, IFN-gamma, and GM-CSF expr

72 that positive selection-induced MHC bias of T cell receptors is affected both by the germline encode

73 Diversity of antibodies and T cell receptors is generated by gene rearrangement depe

74 ntigen, the non germline encoded elements of T cell receptors may help the proteins cope with the ext

75 tion of cytotoxic T lymphocytes depends upon T cell receptor-mediated let-7 downregulation.

76 n patients with HCV infection in response to T-cell receptor-mediated but not cytokine-mediated stimu

77 Indeed, thrombin directly enhanced T-cell receptor-mediated interferon gamma production by

78 The MAIT cell response to T-cell receptor-mediated stimulation did not change duri

79 ors highlighting selection for activation of T-cell receptor/NF-kappaB signaling.

80 pment were associated with the expression of T cell receptor of higher functional avidity for self-an

81 Sequence analysis of T-cell receptors of CD8(+) T cells revealed the presence

82 thetic chimeric antigen receptors or natural T-cell receptors of diverse specificities provides engin

83 , but self-antigens presented by CD1c to the T-cell receptors of these cells are poorly understood.

84 T cells as an important subset of alphabeta T cell receptor-positive cells residing in mouse kidney.

85 The pre-T cell receptor (pre-TCR) guides early thymocytes throug

86 Here, surface-expression of a pre-T cell receptor (pre-TCR) induces thymocyte metabolic ac

87 The pre-T cell receptor (pre-TCR) is a pTalpha-beta heterodimer

88 e used to study host gene expression, B-cell/T-cell receptor profiles (BCR/TCR), and potential viral

89 racterized by expression of a semi-invariant T-cell receptor, rapidly produce copious amounts of dive

90 Mature T cells bearing alphabeta T cell receptors react with foreign antigens bound to al

91 sed, and 1-DER T cells carrying a transgenic T-cell receptor reactive to Der p 1 allergen were used a

92 T-cell receptor rearrangements were functionally require

93 A NO donor inhibited OT II T cell receptor recognition of OT II specific tetramers,

94 Based on T cell receptor repertoire analysis, we found that PD-1-

95 lls/muL, CD45RA < 10%, or a restricted Vbeta T-cell receptor repertoire (<13 of 24 families) were ass

96 differentiation resulting in an oligoclonal T-cell receptor repertoire and enhanced cytokine secreti

97 While AD harbors a highly polyclonal T-cell receptor repertoire, and despite the lack of info

98 . reuteri did not shape the DP-IEL-TCR (TCR, T cell receptor) repertoire but generated indole derivat

99 munological functions, including antigen and T cell receptor repertoires, mechanisms of nonpeptidic a

100 son with WT mice, AQP4(-/-) mice used unique T-cell receptor repertoires for recognition of these two

101 uencing (WES), RNA sequencing (RNA-seq), and T cell receptor sequencing (TCR-seq) of pretreatment tum

102 High-throughput T cell receptor sequencing approaches have opened up new

103 the major histocompatibility complex and the T cell receptor (Signal 1) and between CD80 or CD86 and

104 In the face of persistent antigen, chronic T cell receptor signaling drives T lymphocytes to a func

105 We conclude T cell receptor signaling via Itk controls the developme

106 remodeling (ARHGEF3), RNA splicing (U2AF1), T-cell receptor signaling (PTPRN2, RLTPR), and T-cell di

107 cts in immune cells including suppression of T-cell receptor signaling and promoting efficient produc

108 ecently described scaffolding protein in the T-cell receptor signaling pathway.

109 f Sevenless (SOS) networks, derived from the T-cell receptor signaling system, on supported membranes

110 ly critical in Treg, acting there to control T-cell receptor signaling, cell proliferation, and survi

111 SFK SH2 domains in kinase autoinhibition and T-cell receptor signaling, monobodies binding the Src an

112 Here we show that Itk, a mediator of T cell receptor signalling required for Th2 immune respo

113 rail is an E3 ubiquitin ligase that inhibits T-cell receptor signalling in CD4(+) T cells.

114 thymocyte survival such as RORgammat and for T-cell receptor signalling including Zap70 and CD8, thro

115 Protein kinase-A activation downstream of T-cell receptor signalling inhibits macroautophagy upon

116 PD-1 signalling', 'allograft rejection' and 'T-cell receptor signalling', among others.

117 microscopy and T cells transfected with the T-cell receptor specific for the birch pollen allergen B

118 ion using flow cytometry, immunoglobulin and T-cell receptor spectratyping, and deep sequencing of im

119 croRNA content in EVs released upon in vitro T cell receptor stimulation of Th1, Th17, and T regulato

120 Upon T cell receptor stimulation, CD4(+) T helper (Th) lympho

121 Upon T cell receptor stimulation, these T cells also produced

122 We revealed that altering T-cell receptor stimulation influenced recruitment of mR

123 g enough to discriminate pMHC half-lives and T cell receptor (TCR) accumulation selectively stabilize

124 g pathway on model membranes, beginning with T cell receptor (TCR) activation and ending with actin a

125 old CD8+ T cells expressing clonal anti-H2K T cell receptor (TCR) alloreactive for MHC I, graft surv

126 the H3.3K27M mutation, complementary DNA for T cell receptor (TCR) alpha- and beta-chains were cloned

127 ccordance with the requirement that both the T cell receptor (TCR) and CAR be engaged to accelerate T

128 izing high-throughput screening (HTS) of the T cell receptor (TCR) and immunostaining, we found that

129 gation on exhausted CD8(+) T cells inhibited T cell receptor (TCR) and interleukin-2 (IL-2) signaling

130 They can cross-link the T cell receptor (TCR) and major histocompatibility compl

131 ry of this cell-cell interface, within which T cell receptor (TCR) and peptide major histocompatibili

132 on of genes associated with Notch receptors, T cell receptor (TCR) assembly, and TCR-mediated signali

133 olecule), and physically associates with the T cell receptor (TCR) at the center of the immunological

134 ne whether intratumoral and peripheral blood T cell receptor (TCR) clonality inform clinical outcomes

135 cells are activated through ligation of the T cell receptor (TCR) complex, leading to the induction

136 lly promoting allorecognition either through T cell receptor (TCR) crossreactivity or independently f

137 r TH cells, exhibit delayed receptor-induced T cell receptor (TCR) downmodulation, enhanced TCR signa

138 The activation of NF-kappaB downstream of T cell receptor (TCR) engagement is a key signaling step

139 nse by measuring the binding strength of its T cell receptor (TCR) for peptide-loaded MHCs (pMHC) on

140 Although antigen recognition mediated by the T cell receptor (TCR) influences many facets of Foxp3(+)

141 Triggering of the T cell receptor (TCR) integrates both binding kinetics a

142 Affinity and dose of T cell receptor (TCR) interaction with antigens govern t

143 develop from DP cells after partial-agonist T cell receptor (TCR) interactions with self-peptide/MHC

144 activation following antigen binding to the T cell receptor (TCR) involves the mobilization of intra

145 provides a critical second signal alongside T cell receptor (TCR) ligation for naive T cell activati

146 We discovered a non-MHC-linked Ir gene in a T cell receptor (TCR) locus that was required for CD8(+)

147 a hepatitis B virus-specific (HBV-specific) T cell receptor (TCR) may supplement HBV-specific immune

148 HLA-A*02:01 molecules for recognition by the T cell receptor (TCR) of cytotoxic T cells.

149 (pMHC) on an antigen-presenting cell to the T cell receptor (TCR) on a T cell.

150 rom high affinity agonist recognition by the T cell receptor (TCR) or from a death receptor, such as

151 nnate-like T cells expressing the gammadelta T cell receptor (TCR) rather than the alphabeta TCR coul

152 governing mycolate antigenicity for the GEM T cell receptor (TCR) remain poorly understood.

153 l compartment must contain diversity in both T cell receptor (TCR) repertoire and cell state to provi

154 exhibited mature naive phenotypes, a diverse T cell receptor (TCR) repertoire and TCR-dependent funct

155 Defects in T cell receptor (TCR) repertoire are proposed to predisp

156 In each individual, a highly diverse T cell receptor (TCR) repertoire interacts with peptides

157 The regulatory T cell (T reg cell) T cell receptor (TCR) repertoire is highly diverse and s

158 The prevalent Vdelta1 T cell receptor (TCR) repertoire is private and initiall

159 MHC specificity of the T cell receptor (TCR) repertoire is shaped during thymic

160 chnology, but these animals contain a biased T cell receptor (TCR) repertoire that might affect immun

161 W131A mutant mice with wild-type T cell receptor (TCR) repertoires exhibited relatively n

162 Diversity of T cell receptor (TCR) repertoires, generated by somatic

163 T cell receptor (TCR) sequences are very diverse, with m

164 ese individual cells, coupled with assembled T cell receptor (TCR) sequences, enable us to identify 1

165 alyzed by whole-exome, transcriptome, and/or T cell receptor (TCR) sequencing.

166 forces play increasingly recognized roles in T cell receptor (TCR) signal transduction.

167 In Th2 cells, T cell receptor (TCR) signaling activates the transcript

168 previously demonstrated that Tpl2 regulates T cell receptor (TCR) signaling and modulates T helper c

169 e underscore temporal integration of digital T cell receptor (TCR) signaling as the basis for achievi

170 Strong T cell receptor (TCR) signaling largely induces cell dea

171 Mechanistically, T cell receptor (TCR) signaling molecule protein kinase

172 This is potentially attributed to decreased T cell receptor (TCR) signaling strength due to ineffici

173 species (ROS) are needed to achieve optimal T cell receptor (TCR) signaling.

174 Here we examined how T cell receptor (TCR) signals establish and arbitrate Bc

175 by a fate-determination process mediated via T cell receptor (TCR) signals for differentiation into d

176 atibility complex (MHC)-restricted alphabeta T cell receptor (TCR) T cells and non-MHC-restricted gam

177 This family includes T cell receptor (TCR) that is critically involved in imm

178 Malaria antigen-specific B5 T cell receptor (TCR) transgenic (Tg) T cells from chron

179 or of TEIPP-specific T cells, using a unique T cell receptor (TCR) transgenic mouse model.

180 ed a broad repertoire of target antigens and T cell receptor (TCR) usage, with initial evidence of pu

181 v) MAIT cell responses to SEB can occur in a T cell receptor (TCR) Vbeta-specific manner but are larg

182 n-specific recognition by T cells is via the T cell receptor (TCR) which is unique for each T cell.

183 ns, T cells interact through their alphabeta T cell receptor (TCR) with peptide-major histocompatibil

184 OT-II mice expressing a transgenic T cell receptor (TCR) with specificity for ovalbumin (OV

185 rentiate in response to signals engaging the T cell receptor (TCR), express high levels of the immuno

186 ned by a heterodimeric surface receptor, the T cell receptor (TCR), that mediates recognition of path

187 differentiation, namely on the role of both T cell receptor (TCR)-dependent and TCR-independent fact

188 e (IP3) production, leading to a decrease in T cell receptor (TCR)-dependent intracellular Ca(2+) res

189 Vgamma9Vdelta2 cells underwent rapid T cell receptor (TCR)-dependent proliferation and functi

190 ar potassium concentration ([K(+)]e) impairs T cell receptor (TCR)-driven Akt-mTOR phosphorylation an

191 ipheral tissues, SFB selectively expand dual T cell receptor (TCR)-expressing Th17 cells recognizing

192 producing the cytokine when stimulated in a T cell receptor (TCR)-independent manner but failed to d

193 thereby contributing to host resistance in a T cell receptor (TCR)-independent manner.

194 t studies have identified several subsets of T cell receptor (TCR)-negative IELs with intriguing prop

195 Using T cell receptor (TCR)-transgenic CD8 T cells and immuniz

196 is thought to suppress signaling through the T cell receptor (TCR).

197 cytotoxic lymphocytes, derived from innate, T cell receptor (TCR)alphabeta, and TCRgammadelta lineag

198 mmunology as T cells activated through their T cell receptors (TCR) by protein antigens orchestrate i

199 Characterisation of the T cell receptors (TCR) involved in immune responses is i

200 limit T-cell efficacy, including suboptimal T-cell receptor (TCR) activation and an immunosuppressiv

201 During early T-cell receptor (TCR) activation, phosphorylation of lin

202 T-cell receptor (TCR) allorecognition is often presumed

203 m human IgA CH3, IgD CH3, IgG1 CH3, IgM CH4, T-cell receptor (TCR) alpha/beta, and TCR gamma/delta co

204 al or mMUD HSCT after depleting GvHD-causing T-cell receptor (TCR) alphabeta CD3(+) cells from the gr

205 uction of IgE synthesis is transferable with T-cell receptor (TCR) alphabeta(+)CD4(+)CD25(-) cells, w

206 ll function is the interaction between their T-cell receptor (TCR) and CD1d-antigen complex.

207 Although the T-cell receptor (TCR) and LFA-1 can generate intracellul

208 In addition, we showed that the T-cell receptor (TCR) beta-chain of our nTreg model was

209 or histocompatibility class II molecules and T-cell receptor (TCR) beta-chain variable domains (Vbeta

210 ncy is initiated in early thymocytes, before T-cell receptor (TCR) beta-rearrangement, which is bypas

211 To define the role of individual T-cell receptor (TCR) clonotypes in differential antivir

212 Next-generation sequencing of the T-cell receptor (TCR) genes from blood or prostate tissu

213 ed MHC class II (MHC-II) gene, HLA-DR2a, and T-cell receptor (TCR) genes specific for MBP87-99/DR2a t

214 ically modified to express a cancer-specific T-cell receptor (TCR) has shown significant therapeutic

215 h recognizes insulin B15-23 via an alphabeta T-cell receptor (TCR) incorporating TRAV8-1/TRAJ9 and TR

216 revealed that repetitive stimulation of the T-cell receptor (TCR) induced AICD, as a result of activ

217 Signaling through the T-cell receptor (TCR) is critical for T-cell development

218 The T-cell receptor (TCR) is required for maturation and fun

219 s), created by transduction of a recombinant T-cell receptor (TCR) isolated from a hemophilia A subje

220 lls comprise a first line of defense through T-cell receptor (TCR) recognition of stressed cells.

221 d: the Chimeric Antigen Receptors (CARs) and T-cell Receptor (TCR) redirection.

222 nflicting literature on the diversity of the T-cell receptor (TCR) repertoire in lesional AD, and its

223 T-cell receptor (TCR) repertoires directed to some immun

224 ted antigens is predicted to be reflected in T-cell receptor (TCR) repertoires.

225 mponents of T-cell tolerance, which includes T-cell receptor (TCR) self-reactivity, costimulation, cy

226 at T cell subsets may vary in their relative T-cell receptor (TCR) sensitivity.

227 By analyzing T-cell receptor (TCR) sequence repertoires taken from th

228 tion with high-risk HLA genes using a direct T-cell receptor (TCR) sequencing approach without long-t

229 Furthermore, T-cell receptor (TCR) sequencing identified many expande

230 ivirus (formerly named GBV-C) interfere with T-cell receptor (TCR) signaling by novel RNA and protein

231 deep sequencing of a gene panel enriched in T-cell receptor (TCR) signaling elements.

232 ffinity T cells missed by tetramers, using a T-cell receptor (TCR) signalling reporter and micropipet

233 itive (DP) thymocytes respond to intrathymic T-cell receptor (TCR) signals by undergoing positive sel

234 uates the NF-kappaB signal transduction upon T-cell receptor (TCR) stimulation by specifically suppre

235 Even though T-cell receptor (TCR) stimulation together with co-stimu

236 -specific CD8 T cells in vitro with a second T-cell receptor (TCR) that recognizes a bacterial antige

237 T-cell receptor (TCR) triggering and subsequent T-cell a

238 ) mutations to assess T-cell development and T-cell receptor (TCR) V(D)J recombination.

239 ch the interaction of a clonotypic alphabeta T-cell receptor (TCR) with a peptide-loaded major histoc

240 Repetitive stimulation of T-cell receptor (TCR) with cognate antigen results in ro

241 unotherapy, we isolated an HLA-A2-restricted T-cell receptor (TCR) with high avidity for human TERT f

242 Adoptively transferred T-cell receptor (TCR)-engineered T cells depend on host-

243 arization of the centrosome were unaffected, T-cell receptor (TCR)-mediated signaling and recruitment

244 owever, common Treg expansion approaches use T-Cell Receptor (TCR)-mediated stimulation which also ca

245 ESK1 is a human, T-cell receptor (TCR)-mimic antibody that binds with sub

246 on CD8 for ligand-induced activation via the T-cell receptor (TCR).

247 Strikingly, we found that antigen receptor [T-cell receptor (TCR)] signaling regulates this process

248 Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit high affinity to self-pep

249 Inherent intermediate- to low-affinity T-cell receptors (TCR) that develop during the natural c

250 in the context of MHC I and can be bound by T-cell receptors (TCR).

251 cell activation by linking antigen receptor (T cell receptor, TCR) signals to downstream pathways.

252 The extent to which T cell receptors (TCRs) are biased towards MHC proteins

253 T cell receptors (TCRs) are protein complexes formed by

254 en (pHLA) to screen for antigens of "orphan" T cell receptors (TCRs) expressed on TILs from human col

255 of T cells is mediated by the engagement of T cell receptors (TCRs) followed by calcium entry via st

256 ow co-crystal structures of MR1 complexed to T cell receptors (TCRs) from two classes of MAIT-type ce

257 alphabeta T cell receptors (TCRs) interact with peptides bound to

258 d lymphocytes expressing neoantigen-specific T cell receptors (TCRs) isolated from peripheral blood r

259 we investigated the clonal diversity of the T cell receptors (TCRs) of infiltrating IFN-gamma and IL

260 Here, anti-HCV T cell receptors (TCRs) recognizing the HCV nonstructura

261 (MAIT) cells is the expression of TRAV1-2(+) T cell receptors (TCRs) that are activated by riboflavin

262 During thymic selection, T cells bearing T cell receptors (TCRs) with high affinity for self-anti

263 domains of immune receptors (antibodies and T cell receptors (TCRs)) is of key importance in the und

264 ures can be identified by documenting public T cell receptors (TCRs), we profiled the T cell repertoi

265 is targeted by multiple clones with distinct T cell receptors (TCRs).

266 s using chimeric antigen receptors (CARs) or T cell receptors (TCRs).

267 How T-cell receptors (TCRs) can be intrinsically biased towa

268 Glycolipid antigens recognized by alphabeta T-cell receptors (TCRs) drive the activation of invarian

269 ls receiving T cells expressing SIV-specific T-cell receptors (TCRs) had significantly fewer viral ge

270 red to express chimeric antigen receptors or T-cell receptors (TCRs) has demonstrated clinical effica

271 Thus, T-cell receptors (TCRs) isolated from minor H antigen-sp

272 we sought to identify the alpha-beta paired T-cell receptors (TCRs) of tumor-infiltrating lymphocyte

273 nity-maturation campaigns for antibodies and T-cell receptors (TCRs) operate on the residues at the b

274 mpatibility complex (MHC) class I-restricted T-cell receptors (TCRs) or chimeric antigen receptors to

275 Enhanced affinity T-cell receptors (TCRs) provide an ideal approach to tar

276 T cells become activated when T-cell receptors (TCRs) recognize agonist peptides bound

277 Transfer of T-cell receptors (TCRs) specific for tumor-associated an

278 Previous studies have demonstrated that T-cell receptors (TCRs) that focus on a minimal motif wi

279 A-A2 produce cytotoxic T lymphocytes bearing T-cell receptors (TCRs) that recognize the immunodominan

280 lymphocytes use surface [Formula: see text] T-cell receptors (TCRs) to recognize peptides bound to M

281 relatively weak affinity of most anti-cancer T-cell receptors (TCRs), there is growing emphasis on im

282 We bred miR-146a-deficient mice with 2D2 T cell receptor-Tg mice to generate 2D2 CD4 T cells that

283 , such as chimeric antigen and high-affinity T-cell receptors to deepen the adaptive immune response;

284 patic cytokines, and (via the semi-invariant T-cell receptor) to bacteria translocated from the gut.

285 esent peptides to T cells displaying a large T-cell receptor (TR) repertoire, MH1Like proteins, such

286 gen presentation from DCs to CD4(+) T cells (T cell receptor transgenic OT-II) was measured via a [(3

287 acities of B cells were studied by using new T-cell receptor transgenic 1-DER mice specific for the D

288 Similar effects were not produced with T-cell receptor transgenic CD8(+) T cells, implicating t

289 insulin B-chain-specific CTL from different T-cell receptor transgenic mice (G9Calpha(-/-)) expressi

290 Here, we used an autoimmune-prone T-cell receptor transgenic mouse (2D2) and a mouse-adapt

291 Using T-cell receptor transgenic reporter mice, we demonstrate

292 T-cell receptor variable beta-chain analysis was perform

293 nant T cells expressing an SEA-nonresponsive T-cell receptor variable region beta chain are nonrespon

294 roduced high levels of IL-10 and had diverse T cell receptor Vbeta repertoires with an oligoclonal ex

295 We sequenced T-cell receptor Vbeta genes in expanded microbe-reactive

296 lls and intestinal tissue, and had a diverse T-cell receptor Vbeta repertoire.

297 res with an oligoclonal expansion in CDR3 of T cell receptor Vbeta14.

298 Moreover, specific T cell receptor-Vbeta5.(1/2) and TCR-Vbeta11 clonal dele

299 ses in this pathway, Lck and ZAP-70, for the T cell receptor zeta chain and the scaffold proteins LAT

300 Donor and recipient rs2056626 (CD247: T-cell receptor zeta subunit) GG or GT genotypes were as