ライフサイエンスコーパス: T-cell-specific

1 we found that the increase in Treg cells in T cell-specific A20-deficient mice was already observed

2 Furthermore, T cell-specific ABCG1 deficiency led to a 30% increase i

3 -deficient mice fed a high-cholesterol diet, T cell-specific ABCG1 deficiency protected against ather

4 Notably, T cell-specific ablation of IL-10 produced pathologies t

5 Here, we have shown that the T cell-specific ablation of MyD88 in mice impairs not on

6 We demonstrate for the first time that T cell-specific ablation of Nrp-1 expression results in

7 Here we showed that T cell-specific ablation of the common interleukin-6 (IL

8 T cell-specific ablation of the gene that encodes LKB1 r

9 In the thymus, T cell-specific ablation of the Roquin paralogs leads to

10 In peripheral organs, T cell-specific ablation of Vps34 had a profound impact

11 IL-7Ralpha transgenesis or T-cell-specific ablation of Gfi-1 restored IL-7Ralpha ex

12 In vivo, T-cell-specific ablation of murine Gclc prevented autoim

13 Using mice with T-cell-specific ablation of Raptor/mTORC1 or Rictor/mTOR

14 Here we show that T-cell-specific ablation of the kinase TBK1 promotes T-c

15 T cell-specific abrogation of type I IFN signaling showe

16 Therefore, T cell specific actions of IL-10 can support autoimmune

17 These data demonstrate that T cell-specific activation of Nrf2 protects from IR-indu

18 the Rous sarcoma (Src) homology 2-domain of T cell-specific adaptor (TSAd), which in turn regulates

19 Thus, T cell-specific alternative activation of p38 is an impo

20 Here we show that T cell-specific and activation-dependent alternative spl

21 /kg body weight), alone or combined with the T-cell-specific antibody anti-T-cell receptor (TCR) (0.5

22 T cell-specific augmentation of Nrf2 significantly incre

23 knowledge, a quantitative framework bridging T cell-specific biology with concepts developed for inte

24 oreover, soluble LAG-3 can serve as an early T-cell-specific biomarker for type 1 diabetes onset and

25 of the T-cell receptor pathway and reside at T-cell-specific boundaries of repressive and active chro

26 cell reprogramming by introducing individual TS cell-specific 'CAG' factors (Cdx2, Arid3a and Gata3),

27 Additionally, complementation of a T cell-specific caspase 8 deficiency with a loss of Ripk

28 Cardiac function significantly declined in T-cell-specific CD4-Cre(+/)(-)CD73(flox/flox) mice ident

29 e aortic constriction (TAC) using global and T-cell-specific CD73(-)(/-) mice.

30 egulatory cytokines, and this is restored by T-cell-specific CEACAM1 expression.

31 R insulators predicted here show evidence of T-cell-specific chromatin barrier and gene regulatory ac

32 Using a T cell-specific conditional Id2 knockout mouse model, we

33 Here we report that mice with a T-cell-specific conditional knockout of HGK (T-HGK cKO)

34 Regulation of the gene encoding the T cell-specific coreceptor CD4 in helper and cytotoxic T

35 Thus, the phenotype of T cell-specific Coronin 1a deletion resembles the phenot

36 d by the deletion of Coronin 1a Furthermore, T cell-specific Coronin 1a knock-out mice were largely r

37 this research question, we have generated a T cell-specific Coronin 1a knock-out mouse (Coro1a(fl/fl

38 During the early phase of ALI (day 1), T cell-specific CREMalpha overexpression enhances the nu

39 gE concentrations in the blood of sensitized T cell-specific Cyp27b1-KO mice support a lymphocyte-dri

40 T cell-specific deficiency in TRAF3 resulted in a two- t

41 T cell-specific deficiency of the genome organizer Satb1

42 We further show that T-cell-specific deficiency of Fabp4 and Fabp5 (Fabp4/Fab

43 We show that T cell-specific deletion and early pharmaceutical inhibi

44 T cell-specific deletion of acetyl coenzyme A carboxylas

45 anticancer functions in vivo, and mice with T cell-specific deletion of Atg5 have reduced tumour out

46 fferentiation of plasma cells, and mice with T cell-specific deletion of Blimp-1 (Blimp-1CKO mice) de

47 ) and regulatory (Treg) cells, and mice with T cell-specific deletion of Blimp1 (Blimp1CKO mice) spon

48 T cell-specific deletion of Gfi1 results in aberrant exp

49 T cell-specific deletion of Lis1 resulted in depletion o

50 Mice harboring a T cell-specific deletion of Pdpn developed exacerbated E

51 In addition, we studied AAI in mice with a T cell-specific deletion of recombination signal-binding

52 T cell-specific deletion of talin in Tln1(fl/fl)Cd4(Cre)

53 Evaluation of mice with a T cell-specific deletion of the gene encoding the negati

54 Here, we used inducible and CD4 T cell-specific deletion of the gene encoding the TGF-be

55 We found that T cell-specific deletion of the gene encoding tuberous s

56 In this study, we demonstrate that T cell-specific deletion of the IL-6 receptor alpha chai

57 helper lineage plasticity, we used mice with T cell-specific deletion of the methyltransferase DNMT3a

58 Here we report that mice with T cell-specific deletion of the miR-17 approximately 92

59 T cell-specific deletion of the receptor for transformin

60 ion mediated by its RING domain: mice with a T cell-specific deletion of the ROQUIN RING domain have

61 Here, we generate mice with a T cell-specific deletion of the scaffold protein A kinas

62 T cell-specific deletion of the tumor suppressor PTEN in

63 In this study, we report that T cell-specific deletion of Tsc1, a negative regulator o

64 Mice with a T cell-specific deletion of Twist1 demonstrate increased

65 In this study, we show that T-cell specific deletion of Pak2 gene in mice resulted i

66 drug targets, we have generated mice with a T-cell specific deletion.

67 ns in T cells, we generated mice harboring a T-cell-specific deletion of A(2A)R.

68 T-cell-specific deletion of dynamin 2, an essential comp

69 Mice with T-cell-specific deletion of GATA3 did not develop coliti

70 zenesulfonic acid to control mice, mice with T-cell-specific deletion of GATA3, and mice with deletio

71 We report here that T-cell-specific deletion of mTOR results in dramatically

72 T-cell-specific deletion of the gene encoding Vps34 resu

73 T cell-specific DeltaE2Smurf2 degrades wild-type Smurf2

74 Assessment of regulatory T cell-specific demethylated region methylation status i

75 Regulatory T cell-specific demethylation region (TSDR) demethylatio

76 However, mice expressing a T cell-specific dominant-negative TGF-beta receptor II (

77 Mice with T cell-specific dynamin 2 deficiency had profound lympho

78 epitopes of walnut have been studied, CD4(+) T cell-specific epitopes for walnut remain uncharacteriz

79 We note an over-representation of T cell-specific eQTLs among susceptibility alleles for a

80 T cell-specific Etv5-deficient and littermate control mi

81 Here, we report that T cell-specific expression of a Bcl2 BH3 mutant transgen

82 Conversely, mice with T cell-specific expression of a transgene encoding miR-1

83 We found that T cell-specific expression of Bim during early/cortical,

84 In this study, we show that T cell-specific expression of the ITK-Syk oncogene in mi

85 Major Peak are required to recapitulate the T-cell specific expression of Bcl11b in stable reporter

86 ed the addition of the Major Peak to exhibit T-cell specific expression.

87 st generated Kras(G12D) transgenic mice with T-cell-specific expression of the pan-Notch inhibitor, d

88 e protein increased Wnt-induced beta-catenin/T cell-specific factor-mediated transcriptional activity

89 e transcriptional start sites of B-cell- and T-cell-specific factors.

90 ats can be readily optimized to redirect CAR-T cells (specific for the corresponding FITC or PNE) to

91 T cells specific for 36 WT-1 peptides were evaluable for

92 fer model using paired donor B cells and CD4 T cells specific for a BCR-derived peptide.

93 howed that induction of airway memory CD4(+) T cells specific for a conserved epitope shared by SARS-

94 In adoptive transfer experiments, maternal T cells specific for a fetal alloantigen proliferate aft

95 is was evaluated in two models, one in which T cells specific for a hen-egg white lysozyme (HEL) pept

96 reagents to understand how endogenous CD4(+) T cells specific for a house dust mite (HDM) allergen fo

97 to CD44-high memory phenotype cells, whereas T cells specific for a non-self-viral antigen retained a

98 ient with metastatic cholangiocarcinoma, CD4 T cells specific for a peptide from a mutated region of

99 ytoplasmic tail had the same number of naive T cells specific for a peptide:MHCII ligand as wild-type

100 hed alloantibody may also be provided by CD4 T cells specific for a second "helper" alloantigen.

101 g TRAPeS with transcriptome analysis of CD8+ T cells specific for a single epitope from Yellow Fever

102 We demonstrate that memory CD8 T cells specific for a single immunodominant epitope (S4

103 this study indicate that a high frequency of T cells specific for a single myelin Ag, rather than inc

104 Here we present a strategy to render T cells specific for a tumor in the absence of a truly t

105 These studies demonstrate that naive CD4 T cells specific for a viral glycoprotein can be stimula

106 also gives critical insight into how CD4(+) T cells specific for Ag expressed in the liver are recru

107 In support of this hypothesis, we detected T cells specific for all 20 amino acid variants at the p

108 nterferon-gamma (IFN-gamma)-producing CD8(+) T cells specific for all four TAA in the periphery as we

109 mic preference by tracking polyclonal CD4(+) T cells specific for an MHC class II-bound peptide from

110 ients of OT-I T cell receptor transgenic CD8 T cells specific for an ovalbumin (OVA) peptide, IL-1 re

111 mmune system, but the low frequency of naive T cells specific for any one pathogen means dependence o

112 orce a state of self-tolerance in developing T cells specific for BCR V region sequences, thus ensuri

113 As CD8(+) T cells specific for beta cell Ags are also present in p

114 Only T cells specific for beta-cell antigens localized in isl

115 ertoire showed a high frequency of activated T cells specific for both IRBP tetramers in Aire(-/-) mi

116 and lacking SIINFEKL enabled coinflation of T cells specific for both SIINFEKL and nonrecombinant Ag

117 In vivo killing assays revealed that CD8(+) T cells specific for both viruses were equally cytolytic

118 In mice, CD4+ T cells specific for cardiac alpha myosin heavy chain (a

119 This work demonstrates that CD4 T cells specific for CF can amplify disease severity aft

120 rgence of ACPAs in the absence of detectable T cells specific for citrullinated antigens: ACPAs could

121 ART on restoring pre-existing memory CD4(+) T cells specific for common copathogens is still unclear

122 Inducing memory CD8(+) T cells specific for conserved antigens from influenza A

123 accination induced readily detectable CD4(+) T cells specific for conserved portions of hemagglutinin

124 by HSV-specific CD8 T cells compared to CD8 T cells specific for control viruses, Epstein-Barr virus

125 lthy donors' monocytes and in vivo activated T cells specific for CpPLD that infiltrate atherosclerot

126 ell or hardly cross-presented, mainly CD8(+) T cells specific for cross-presented epitopes were gener

127 ted that the administration of donor-derived T cells specific for cytomegalovirus or Epstein-Barr vir

128 from the blood is significantly enriched for T cells specific for cytomegalovirus-pp65 (immunodominan

129 Surprisingly, we found that CD4 T cells specific for different epitopes exhibited distin

130 he realization that the populations of naive T cells specific for different foreign peptide:MHC (p:MH

131 t & Microbe, Moguche et al. (2017) show that T cells specific for different immunodominant vaccine an

132 unexpected complexity in the response of CD8 T cells specific for different viral epitopes that were

133 The phenotype and function of CD8(+) T cells specific for each epitope were compared in HLA-A

134 ed target cells so poorly relative to CD8(+) T cells specific for early lytic cycle antigens.

135 T cells specific for EBV antigens have also produced com

136 Donor T cells specific for either determinant from AQP4(-/-),

137 Casp11(-/-) T cells specific for endogenous Ags were more readily de

138 ins unclear whether it can effectively prime T cells specific for endogenous antigens expressed by po

139 ll expansions in magnitude, activated CD4(+) T cells specific for epitopes in the latent antigen EBNA

140 Moreover, donor naive T cells specific for exogenous and self/tumor antigens p

141 In blood samples from controls, CD4(+) T cells specific for FlaX, A4-fla2, or YidX had a T-help

142 this molecular strategy to render cytotoxic T cells specific for fungi.

143 Here we studied polyclonal CD4(+) T cells specific for green fluorescent protein expressed

144 ), CD8(+), and gammadelta T cells, including T cells specific for highly conserved influenza peptides

145 irculating CD4(+)CD8(+) double-positive (DP) T cells specific for HIV Ags.

146 CD4(+) T cells specific for human CMV (HCMV) are elevated in HI

147 ulate the expansion and activation of CD8(+) T cells specific for idealized or established melanoma a

148 We isolated circulating CD4(+) T cells specific for immunoglobulin-derived neoantigens

149 hallenge of KSHV-infected B cells with CD4(+)T cells specific for LANA, a protein expressed in all KS

150 of naive CD8(+) T cells into primary CD8(+) T cells specific for LCMV GP(33-41) was relatively norma

151 correlated with the frequency of circulating T cells specific for leukemia-associated antigens, indic

152 laque psoriasis harbour CD4(+) and/or CD8(+) T cells specific for LL37, an antimicrobial peptide (AMP

153 T cells specific for LMP as well as nonviral tumor-assoc

154 CD4(+) memory T cells specific for measles are maintained nearly exclu

155 We found that A(2A)R-proficient CD8(+) T cells specific for melanoma cells displayed a relative

156 Using TCR-redirected CD8+ T cells specific for MHC-I-restricted HBV epitopes, we s

157 Importantly, CD4(+) T cells specific for mycobacterial ribosomes accumulate

158 ional capacity, and memory profile of CD4(+) T cells specific for Mycobacterium tuberculosis and CMV

159 The adoptive transfer of T cells specific for native tumor antigens (TAs) is an i

160 KL epitope inflated and profoundly dominated T cells specific for nonrecombinant (i.e., MCMV-derived)

161 Moreover, when the virus encoded SIINFEKL, T cells specific for nonrecombinant Ags displayed a phen

162 transgenic mice had fewer peripheral CD8(+) T cells specific for NRP-V7 than control mice.

163 It is also unclear whether CD4+ T cells specific for one epitope are more protective tha

164 fic for one epitope are more protective than T cells specific for other epitopes.

165 ransfer into coinfected mice, transgenic CD8 T cells specific for OVA(257-264) failed to proliferate

166 entral memory, and/or effector memory CD4(+) T cells specific for overlapping peptides spanning the e

167 tileukemic effects can be delivered by donor T cells specific for particular minor histocompatibility

168 Molecular mimicry occurs when T cells specific for peptide epitopes derived from patho

169 CD8(+) T cells specific for pp65, IE1, and IE2 are present at h

170 We found that CD4(+) T cells specific for Salmonella peptide:MHC class II (MH

171 ed the number and function of endogenous CD4 T cells specific for segmented filamentous bacterium (SF

172 ntigens are generally weak, and high avidity T cells specific for self-antigens are deleted in the th

173 However, the CD8 T cells specific for self-TAs had a lower functional avi

174 nstrated that the clonal abundance of CD4(+) T cells specific for self-tumor antigen positively corre

175 It remained unknown, however, whether CD8(+) T cells specific for single ID or SD peptides could be p

176 However, CD8(+) T cells specific for subdominant epitopes lose functiona

177 In ISAT, activated CD4+ T cells specific for T4p2553 are detected before the dis

178 Transduced ANS8 CAR T cells specific for the A2 domain proliferated in respo

179 sed tetramer reagents to detect autoreactive T cells specific for the Aire-dependent tissue-specific

180 In this study, we identified CD4+ T cells specific for the Aspergillus proteins Crf1 and c

181 igens, and we described Th as well as CD8(+) T cells specific for the autoallergen Hom s 2, the alpha

182 induces high levels of antibodies and CD4(+) T cells specific for the circumsporozoite protein (CSP).

183 T cells and the functional pattern of CD8(+) T cells specific for the entire hepatitis B virus proteo

184 ether with engineered RMS-directed cytotoxic T cells specific for the fetal acetylcholine receptor.

185 T cells in a study subject harboring CD8(+) T cells specific for the given epitope) was lower in MS

186 +) T cells while sparing more differentiated T cells specific for the human herpesviruses cytomegalov

187 Using retrogenic CD8(+) T cells specific for the M. tuberculosis Ag TB10.4 (EsxH

188 Antibodies and T cells specific for the major birch pollen allergen Bet

189 study, we use a transgenic mouse model with T cells specific for the merozoite surface protein (MSP)

190 ity of these mice to expand epitope-specific T cells specific for the model antigen ovalbumin express

191 o enhance immunogenicity and accumulation of T cells specific for the native determinant.

192 Antigen-experienced T cells specific for the Qa-1(b)-FL9 complex were freque

193 When mice were infected with these viruses, T cells specific for the SIINFEKL epitope inflated and p

194 ccumulation and systemic expansion of CD8(+) T cells specific for the TRAMP C2-specific antigen SPAS-

195 cytotoxic effect on tumor cells, whereas CAR-T cells specific for the tumor antigen GD2 (GD2.CAR-T ce

196 long-term persistence of alloreactive memory T cells specific for the tumor, often these T cells fail

197 Surprisingly, no T cells specific for the viral epitope were stimulated i

198 In the periphery, T cells specific for the WT1 antigen differentiated into

199 Because T cells specific for these antigens are present with low

200 T cells specific for these antigens expanded in patients

201 Unfortunately, the avidity of T cells specific for these antigens is limited by centra

202 Average naive precursor frequencies of T cells specific for these different epitopes in the hum

203 We then determined that chronic CD8 T cells specific for these epitopes were more likely pre

204 proteins and reduce the impact of the CD8(+) T cells specific for these epitopes.

205 CD4 T cells specific for these HLA class II molecules recogn

206 etramers detected high frequencies of CD4(+) T cells specific for these ligands in all HLADP2+ CBD pa

207 class II tetramers, we verified that memory T cells specific for these modified epitopes were detect

208 T cells specific for these modified self-antigens then p

209 h)1 phenotype; a larger proportion of CD4(+) T cells specific for these proteins in patients with CD

210 ong lipid Ags tested, and polyfunctional CD4 T cells specific for this lipid simultaneously expressed

211 flected by the presence of infiltrating CD8+ T cells specific for tumor antigens within the tumor mic

212 tetramer reagents were designed to identify T cells specific for two different peptide epitopes of I

213 The frequency of CD4(+) T cells specific for U1-70(131-150):I-E(k) (without phos

214 The number of T cells specific for various antigens can vary dramatica

215 single sample, and detect low-frequency CD8 T cells specific for virus- or cancer-restricted antigen

216 driven cancers is to elicit cytotoxic CD8(+) T cells specific for virus-derived peptides.

217 In immunized mice, CD4 T cells specific for vWFA2 were detected, and their indu

218 To test this hypothesis, IFN-gamma-producing T cells specific for ZnT8 in the peripheral blood of 35

219 The number (fold difference from PRE) of T-cells specific for CMV pp65 (2.6), EBV LMP2A (2.5), an

220 at is overexpressed on tumor vasculature and T-cells specific for the tumor antigens gp100 (PMEL), TR

221 We previously identified a T cell-specific Gata3 enhancer (Tce1) lying 280 kb downs

222 T cell-specific gene ablation of Notch1 and Notch2 impai

223 Bcl11b is a T-cell specific gene in hematopoiesis that begins expres

224 ression program is followed by activation of TS cell-specific genes by CAG factors.

225 udies leveraging pharmacologic inhibition or T cell specific genetic deletion of signaling components

226 T domains, was originally characterized as a T cell-specific genome organizer whose aberrant overexpr

227 for physiological T cell responses by using T cell-specific Gpx4-deficient mice.

228 In vivo, T-cell-specific GR deletion in pregnant animals undergoi

229 T cell-specific Grb2(fl/fl) Lckcre(tg) Grb2-deficient mi

230 colitis model, we demonstrate a key role for T cell-specific IL-1 receptor (IL-1R) signals in the acc

231 Using T cell-specific IL-4/IL-13-deficient mice and basophil-d

232 llergic asthma was assessed weekly in CD4(+) T cell-specific IL-4Ralpha-deficient BALB/c mice (Lck(cr

233 f CD4(+) T cells and B cells, but not CD8(+) T cells; specific increases in the total numbers of Th1

234 e followed the fates of CCR2(-/-) T cells in T cell-specific inflammatory models.

235 ression of its targets, we characterized its TS cell-specific interactome using mass spectrometry.

236 However, recent studies in mice with T cell-specific Irf8 disruption under direction of the L

237 ell development and differentiation by using T-cell-specific Klf4-knockout (KO) mice.

238 Using mice with either T cell-specific loss or constitutive activation of TGF-b

239 Mice with T-cell-specific loss of the tumor suppressor gene PTEN e

240 or of NF-kappaB kinase beta (caIKKbeta) in a T cell-specific manner, we demonstrate that chronic inhi

241 A-binding protein T-cell factor 1 (Tcf-1), a T-cell-specific mediator of Wnt signaling.

242 l role of miR-17-92 in TH17 differentiation: T cell-specific miR-17-92 deficiency reduced TH17 differ

243 n was protective against mortality in a CD8+ T cell-specific model of pneumonitis.

244 he inducible costimulator (ICOS) molecule, a T-cell-specific molecule that belongs to the CD28/CTLA-4

245 Using T cell-specific murine lines genetically altered in expr

246 T cell-specific NIK ablation reduced the frequency of ef

247 genes appeared to normalize rapidly, whereas T cell-specific normalization occurred over six weeks.

248 ctivation of CD8(+) T cells within tumors of T cell-specific Nrp-1-deficient mice.

249 Mice with T cell-specific over-expression of Bcl-2, that blocks mu

250 T cell-specific overexpression of DeltaE2Smurf2 increase

251 e have demonstrated that, although mice with T cell-specific overexpression of miR-27 harbor dysregul

252 In contrast, T cell-specific overexpression of PDPN resulted in profo

253 T cell-specific pan-Notch blockade prolonged heart allog

254 l of C. difficile infection in wild-type and T cell-specific PPARgamma null mice.

255 gulated and IL-10 downregulated in colons of T cell-specific PPARgamma null mice.

256 THEMIS, a T cell-specific protein with high expression in CD4(+)CD

257 e selection is enabled by the ability of the T-cell-specific protein Themis to specifically attenuate

258 T-cell-specific PRR-knockout mice had a significant decr

259 This explains the T-cell-specific Rac1-targeting therapeutic action of 6-T

260 cells through the generation and analysis of T cell-specific RASA1 and NF1 double-deficient mice.

261 We used a T cell-specific RASA1-deficient mouse model to investiga

262 To dissect the T cell-specific response to IL-10 during organ-specific

263 c role of Shp1, we characterized mice with a T cell-specific Shp1 deletion (Shp1fl/fl CD4-cre).

264 e mechanism of action of SLP-2, we generated T cell-specific SLP-2-deficient mice.

265 Gag p24 and Nef CD8+ T cell-specific soluble virus inhibition was common amon

266 Compared with WT animals, mice with T cell-specific Stim1 deletion died prematurely during t

267 cid-related orphan receptor Cv2 (RORCv2) and T-cell-specific T-box transcription factor (Tbet).

268 TCF-1; also known as transcription factor 7, T-cell specific, TCF7), is a critical regulator in T-cel

269 we show that mice expressing a constitutive T-cell-specific ThPOK transgene (ThPOK(const) mice) deve

270 , and exhaustion status of TG-resident CD8(+)T cells specific to 40 epitopes derived from HSV-1 gB, g

271 Using human CD8(+) T cells specific to a lung tumor-associated Ag, we show

272 V susceptibility and phenotypes of human CD4 T cells specific to Ad5 and CMV, two viruses that have b

273 CD8(+) T cells specific to caspase-cleaved antigens derived fro

274 with expansion of IFN-gamma-producing CD4(+) T cells specific to ColV and KAT, but not ColII.

275 rossreactive neutralizing antibodies, CD8(+) T cells specific to conserved viral epitopes correlated

276 surrounding normal breast tissue to identify T cells specific to each, as well as their abundance in

277 transendothelial migration of CD8+ effector T cells specific to graft antigens and that both steps o

278 CMV persistence did not further erode memory T cells specific to LCMV.

279 hibited reduced frequency and numbers of CD8 T cells specific to Mycobacterium bovis bacille Calmette

280 Further, CD8(+) T cells specific to sporozoite surface-expressed CSP and

281 CD4(+) T cells specific to the HCMV proteins studied were predo

282 MHC in the presence of naive TCR transgenic T cells specific to the MHC class II-peptide combination

283 n of lymphocytes and proliferation of CD8(+) T cells specific to tumor-associated antigens, resulting

284 ells (20%-90%, averaging over 50%) of CD4(+) T cells specific to viral antigens in adults who had nev

285 However, the possible role of CD8(+) T cells, specific to HLA-restricted gB epitopes, in prot

286 dence from C57BL/6 mice suggests that CD8(+) T cells, specific to the immunodominant HSV-1 glycoprote

287 Thus, TCF1, a constitutively expressed T cell-specific transcription factor, is a critical nega

288 tosis and markedly lower islet expression of T cell-specific transcription factor-1 (TCF1, encoded by

289 yeloid and dendritic cell potential is lost, T-cell specific transcription factors subsequently induc

290 es illuminate the roles of three of the most T-cell specific transcription factors.

291 activates transcription in partnership with T-cell-specific transcription factor 1 (Tcf-1).

292 report that Bcl11b, previously considered a T-cell-specific transcription factor, acted directly ups

293 ASPP 049 rapidly activated T-cell-specific transcription factor/lymphoid enhancer b

294 xpression of many T-lineage genes, including T-cell-specific transcription factors Gata3 and Bcl11b,

295 TS cells by direct binding and regulation of TS cell-specific transcription factors including Elf5 an

296 and sufficient for critical aspects of Gata3 T cell-specific transcriptional activity.

297 CD4-driven T cell-specific transgenic overexpression of mir-146a an

298 cells were hypoproliferative, yet mice with T cell-specific Usp9x deletion had elevated numbers of a

299 Mice with a T cell-specific UTX deletion had fewer Tfh cells, reduce

300 Whole-body VDR KO, T cell-specific VDR (T-VDR) KO, B cell-specific VDR (B-V