ライフサイエンスコーパス: T-type calcium channel

1 that this channel is a low-voltage-activated T-type calcium channel.

2 lcium transients due to strong expression of T-type calcium channels.

3 differentially inhibit Cav3 isoforms of the T-type calcium channels.

4 neurons are almost exclusively dependent on T-type calcium channels.

5 sufficiently hyperpolarized to de-inactivate T-type calcium channels.

6 logically distinct from L-, N-, P/Q-, R- and T-type calcium channels.

7 none or graded manner, due to recruitment of T-type calcium channels.

8 a low-threshold calcium current mediated by T-type calcium channels.

9 selective blocker of low-voltage-activated, T-type calcium channels.

10 perpolarization "primes" (deinactivates) the T-type calcium channel, a depolarizing input will "trigg

11 aracterization of the subunit composition of T-type calcium channels and help determine their involve

12 This toxin distinguishes between alpha 1G T-type calcium channels and other types of voltage-gated

13 were consistent with the known properties of T-type calcium channels, and the voltage dependence was

14 pretreatment with the novel mixed N-type and T-type calcium channel antagonist 1-(6,6-bis(4-fluorophe

15 Using a selective T-type calcium channel antagonist, we describe a T-type

16 ry of a novel series of potent and selective T-type calcium channel antagonists is reported.

17 dependence was blocked by application of the T-type calcium channel antagonists Ni2+ and mibefradil.

18 sed by AMPA-R and NMDA-R antagonists but not T-type calcium channel antagonists.

19 Our results indicate that T-type calcium channels are critical regulators of a C.

20 quency band (0.75-1.5 Hz) only when thalamic T-type calcium channels are functionally active.

21 T-type calcium channels are important modulators of both

22 Low-threshold activated T-type calcium channels are present at the synapse, alth

23 s suggest that both alpha1A P/Q- and alpha1G T-type calcium channels are required for the dynamic con

24 T-type calcium channels are responsible for generating l

25 Low-voltage-activated (T-type) calcium channels are responsible for burst firin

26 We define T-type calcium channels as a target of Abeta-NgR signali

27 ene encoding Ca(v)3.2 low-voltage-activated, T-type calcium channels associated with bursting behavio

28 The effect of T-type calcium channel block was more pronounced after B

29 (100 nM), and by 26+/-3% (n=90 cells) by the T-type calcium channel blocker flunarizine (1 microM).

30 Ethosuximide, a T-type calcium channel blocker, eliminated busting in le

31 ility and burst firing, and selective triple T-type calcium channel blockers could offer a new way to

32 ives as potent, selective, brain-penetrating T-type calcium channel blockers.

33 ines as brain penetrant and selective triple T-type calcium channel blockers.

34 as potent, selective, and brain-penetrating T-type calcium channel blockers.

35 was unaltered in the presence of L-, R- and T-type calcium channel blockers.

36 The T-type calcium-channel blockers, nickel (3 micromol/l) a

37 In burst mode, dendritic T-type calcium channels boosted small synaptic inputs an

38 anic blocker to selectively block the native T-type calcium channel, but the potency and mechanism of

39 e found that pulvinar neurons expressed more T-type calcium channels (Ca(v) 3.2) and more small condu

40 block of this drug on the three recombinant T-type calcium channels (Ca(V)3.1, Ca(V)3.2, and Ca(V)3.

41 etinoic acid receptor beta 2 (RAR beta), and T-type calcium channel (CACNA1G) genes, and methylated i

42 1), retinoic acid receptor beta 2 (RARbeta), T-type calcium channel (CACNA1G), and multiple endocrine

43 d this area, we identified a gene encoding a T-type calcium channel, CACNA1G, as a target for hyperme

44 approved drug mibefradil, which inhibits the T-type calcium channel Cav3.2.

45 sion of L-type calcium channel (Cav1.2), not T-type calcium channel (Cav3.2), was up-regulated.

46 Pharmacological block of T-type calcium channels (Cav3), although not noticeably

47 at remains poorly understood with respect to T-type calcium channels (Cav3).

48 The corresponding mutations affect the T-type calcium channel CCA-1 and symmetrically re-tune i

49 The robust E2 regulation of T-type calcium channels could be an important mechanism

50 zation-activated cation channel currents and T-type calcium channel currents may account for some of

51 cal blockers we showed that L-, P/Q-, R- and T-type calcium channels do not contribute to the spontan

52 CaV3.2 T-type calcium channels, encoded by CACNA1H, are express

53 tch between firing modes depends on Ca(v)3.1 T-type calcium channels enriched in thalamic relay neuro

54 Although 17beta-estradiol (E2) modulates T-type calcium channel expression and function, little i

55 ripts (alpha1G, alpha1H, and alpha1I) of the T-type calcium channel family (CaVT).

56 Other members of the T-type calcium channel family were also regulated by syn

57 External pH (pH(o)) modifies T-type calcium channel gating and permeation properties.

58 lectively identify Cacna1g, one of the three T-type calcium channel genes, as a key component of a ge

59 cular cloning of low-voltage activated (LVA) T-type calcium channels has enabled the study of their r

60 w calcium antagonist that selectively blocks T-type calcium channels, has been shown to be an effecti

61 Low-voltage-activated (LVA) T-type calcium channels have a wide tissue distribution

62 ously, it was shown that mice lacking CaV3.1 T-type calcium channels have altered sleep/wake activity

63 The aim was to investigate the role of the T-type calcium channel in HMSM by characterizing mRNA ex

64 befradil completely and reversibly inhibited T-type calcium channels in freshly isolated rat cerebell

65 based on our biophysical characterization of T-type calcium channels in Purkinje cells suggests that

66 have identified a potential central role for T-type calcium channels in regulating body weight mainte

67 acologic inhibition or knockdown of Ca(v)3.1 T-type calcium channels in the auditory thalamus substan

68 believe to be a previously unknown role for T-type calcium channels in the regulation of sleep and w

69 The role of P/Q- and T-type calcium channels in the rhythmic oscillatory beha

70 inhibition of CaV3.2 low-voltage-activated (T-type) calcium channels in pain pathways.

71 is a useful tool for probing the effects of T-type calcium channel inhibition.

72 more, we find that coexpression of TRPC5 and T-type calcium channels is sufficient to reconstitute a

73 Previous data have indicated that T-type calcium channels (low-voltage activated T-channel

74 The T-type calcium channel may play a role in this process.

75 Low voltage-activated (LVA), T-type, calcium channels mediate diverse biological func

76 sociated with calpain-1 activation following T-type calcium channel opening, and resulted in the trun

77 ting sodium channel inactivation, inhibiting T-type calcium channels, or enhancing gamma-aminobutyric

78 T-type calcium channels play a key role in neuronal exci

79 T-type calcium channels play essential roles in regulati

80 membrane potential allows activation of the T-type calcium channels, promoting rhythmic high-frequen

81 T-type calcium channels represent a key pathway for Ca(2

82 H channels determined impact of 1 variant on T-type calcium channel responsiveness to ethosuximide.

83 Our analysis with R- and T-type calcium channels revealed that differences in the

84 port the existence of a syntaxin-1A/Ca(v)3.2 T-type calcium channel signaling complex that relies on

85 +), using whole-cell recordings from alpha1G T-type calcium channels stably expressed in HEK 293 cell

86 t studies have highlighted the importance of T-type calcium channels (T-channels) in peripheral nocic

87 te a prominent role of low-voltage-activated T-type calcium channels (T-channels) in the firing activ

88 Recent studies indicate that T-type calcium channels (T-channels) in the thalamus are

89 T-type calcium channels (T/Ca(v)3-channels) are implicat

90 ons in a hyperpolarized state for recruiting T-type calcium channels that are important for burst fir

91 We examined a homology model of the T-type calcium channel to look for possible routes of dr

92 tion of a potent and selective antagonist of T-type calcium channels, TTA-A2, to normal-weight animal

93 INTERPRETATION: Four T-type calcium channel variants and 1 ABCB1 transporter

94 In T-type calcium channels, verapamil blocks with micromola

95 gene of the pore-forming alpha1G subunit for T-type calcium channel were used.

96 Although T-type calcium channels were first described in sensory

97 overexpressing the Cacna1g gene for alpha1G T-type calcium channels were generated with low and high

98 at estrogen regulates the mRNA expression of T-type calcium channels, which leads to increased functi

99 toxin (kurtoxin) that binds to the alpha 1G T-type calcium channel with high affinity and inhibits t