ライフサイエンスコーパス: TAF

1 TAF accumulated inside genital epithelial cells as TFV-D

2 TAF has the potential advantages that dose adjustment is

3 TAF is formulated to deliver the active metabolite to ta

4 TAF(I)41 immunodepletion from nuclear extracts dramatica

5 TAF(I)41 resides at the rDNA promoter in the nucleolus a

6 TAF(II)105-null B cells can proliferate in response to L

7 TAF(II)250, the largest subunit of the general transcrip

8 TAF-1 is not as universally required as TAF-4, but it is

9 TAF-2, which binds core promoters with TAF-1, appears to

10 TAF-5 (human (h) TAF(II)100) is of particular interest b

11 TAF-dependent (TAF(dep)) promoters require TAFs for tran

12 TAF-I associates with chromatin in vitro and can substit

13 TAFs have also been recently found to enhance antisense

14 binding domain within a Selectivity Factor 1 TAF.

15 P-associated factors (TAFs) called TAF(I)48, TAF(I)63 and TAF(I)110.

16 entially all embryonic transcription, TAF-5, TAF-9, and TAF-10 were dispensable at multiple developme

17 A TAF(ind) UAS fails to recruit TAFs and to direct efficie

18 l cases the transcriptional dependence for a TAF can be explained by a requirement for TBP recruitmen

19 nt transcription when inserted upstream of a TAF(dep) core promoter.

20 can compensate for the absence of TAFs on a TAF(dep) core promoter.

21 eaf1 strain depletes recruitment of TFIID (a TAF-dependent form of TBP) but not the TAF-independent f

22 The TDF analogue tenofovir alafenamide (TAF) has demonstrated equal efficacy but with decreased

23 Tenofovir alafenamide (TAF) is a novel prodrug of tenofovir that efficiently de

24 revention trials, and Tenofovir alafenamide (TAF), an improved prodrug of TFV, interfere with wound h

25 tins on tenofovir (TFV) and TFV-alafenamide (TAF) on HIV infection and intracellular TFV-diphosphate

26 d 11), whereas following differentiation all TAFs are expressed.

27 Since not all TAFs are required in terminally differentiated cells, we

28 s TAF homologs collaborate in an alternative TAF-containing protein complex to regulate a testis-spec

29 one fold TAF(II)s, TAF-9 (hTAF(II)31/32) and TAF-10 (hTAF(II)30), but is distinct from the widespread

30 factors (TAFs) called TAF(I)48, TAF(I)63 and TAF(I)110.

31 M2 with two of these proteins, TAF(II)70 and TAF(II)40, were identified.

32 l embryonic transcription, TAF-5, TAF-9, and TAF-10 were dispensable at multiple developmental and ot

33 ced division of labor between activators and TAF coactivators, thus providing another strategy to acc

34 The domain architecture of CBP and TAF(II)250 families of HATs show significant differences

35 XEZ, HDACm and TAF(II)32 mRNAs are all strongly co-expressed with Xeed

36 lusion that an interaction between hsTBP and TAF(II)s is required for activated transcription in mamm

37 minated genes are largely stress induced and TAF independent, and are downregulated by the coordinate

38 2, suggesting an interaction between SMC and TAF to coordinate their growth.

39 h subunit, and the constellation of TBP- and TAF-associated proteins was directly identified by coupl

40 ate that MPA selectively compromises TFV and TAF protection in blood and genital CD4+ T cells and sug

41 eral transcription factors such as Mot1p and TAFs (TATA-binding protein-associated factors).

42 require TAFs for transcription, and TBP and TAFs are present at comparable levels on these promoters

43 The latter's TATA-binding protein (TBP) and TAFs photocross-link to the promoter from -78 to +10 rel

44 The interaction matrix of Arabidopsis TAFs is largely consistent with the three-lobed topologi

45 one or more TAFs and 16% of yeast genes are TAF independent.

46 lation targets, including SET (also known as TAF-I or PHAPII) and the retinoblastoma protein, RB.

47 TAF-1 is not as universally required as TAF-4, but it is essential for a greater proportion of t

48 required addition of both TBP and associated TAF(II)s, as well as TRAP/Mediator.

49 provides a mechanism that could function at TAF-independent promoters.

50 ted coculture experiments between autologous TAF and TAT.

51 In patients with chronic hepatitis B, TAF appears to be as effective as TDF, with lower bone a

52 The presence of both TAFs 14 and 15 in plants suggests ancient roles for thes

53 the widespread transcription block caused by TAF-4 (hTAF(II)130) depletion.

54 d three TBP-associated factors (TAFs) called TAF(I)48, TAF(I)63 and TAF(I)110.

55 We identified the histone chaperone TAF-I (also known as INHAT [inhibitor of histone acetylt

56 a previously undescribed complex comprising TAFs 2, 6, 7, 11 and TBP.

57 In contrast, TAF had no inhibitory effect on wound closure or tight j

58 In contrast, TAF in MED12-LM proliferated in response to estradiol, w

59 Conversely, TAF-I cannot stimulate transcript elongation when added

60 binding to and sequestering in the cytoplasm TAF-4, a component critical for assembly of TFIID and th

61 o the efficacy of Wnt16 knockdown in damaged TAFs as a promising combinatory strategy to improve effi

62 suggested that while off-targeted NP damaged TAFs and inhibited tumor growth after an initial dose, c

63 d at investigating the effects of NP damaged TAFs on neighboring cells and alteration of stromal stru

64 nal role of TAFs, it is imperative to define TAF-TAF interactions and their topological arrangement w

65 TAF-dependent (TAF(dep)) promoters require TAFs for transcription, and

66 omposition of hESC TAFs, either by depleting TAFs that are present or ectopically expressing TAFs tha

67 displays significant homology to Drosophila TAF(II)110, whereas the other is a predicted zinc bindin

68 lexes, in unicellular genomes, however, each TAF is encoded by a single gene.

69 entage of the yeast genome dependent on each TAF ranges from 3% (TAF2) to 59-61% (TAF9).

70 C. elegans TAF-1 overlaps functionally with the coactivator p300/CB

71 onclude that during C. elegans embryogenesis TAF-1 and TFIID have broad roles in transcription and de

72 e ts13 is mutated in CCG1, the gene encoding TAF(II)250, the largest of the TATA-binding protein-asso

73 c two-hybrid analysis using the 13 essential TAFs of the Saccharomyces cerevisiae TFIID complex and T

74 sitive mutations in each of the 13 essential TAFs.

75 s that are present or ectopically expressing TAFs that are absent, results in misregulated expression

76 on by modulating Mdm-2 binding, facilitating TAF(II)31 recruitment.

77 , the TATA-binding protein-associated factor TAF(II)250 and cyclin D1).

78 The tissue-selective factor TAF(II)105 was originally identified as a component of T

79 ly related to the basal transcription factor TAF(II)250, which is essential for cyclin A transactivat

80 stration of the general transcription factor TAF-4 and is regulated by mechanisms that orchestrate th

81 binding protein (TBP)/TBP-associated factor (TAF) complex.

82 is a TATA-binding protein associated factor (TAF) conserved from yeast to humans and shared by two tr

83 1, a TATA-binding protein Associated Factor (TAF) of the RNA polymerase II transcription initiation f

84 ro transcription, the TBP-associated factor (TAF) subunits recognize downstream promoter elements, ac

85 Of the 14 TBP-associated factor (TAF) subunits that compose TFIID, TAF1 is one of the lar

86 ATA-binding protein (TBP)-associated factor (TAF)-dependent ribosomal protein genes.

87 ATA-binding protein (TBP)-associated factor (TAF).

88 TATA box-binding protein-associated factor (TAF)1 from Drosophila cells and determined the consequen

89 es, TATA-binding protein-associated factors (TAF(II)s) are important for eukaryotic mRNA transcriptio

90 tions with five TATA box-associated factors (TAF(II)s) were mapped, and mutations that disrupt the in

91 of TATA-binding-protein-associated factors (TAF(II)s), and Tra1.

92 TATA-binding protein and associated factors (TAF(II)s), some of which are also present in SPT-ADA-GCN

93 ral TATA binding protein-associated factors (TAFs) and interacts with E proteins (E2A and HEB).

94 ng protein (TBP) and TBP-associated factors (TAFs) and is the only component of the general RNA polym

95 rotein (TBP) and the TBP-associated factors (TAFs) are assembled into a functional TFIID complex with

96 TA-binding protein (TBP)-associated factors (TAFs) as well as the multi-subunit cofactors ARC/CRSP.

97 tein (TBP) and three TBP-associated factors (TAFs) called TAF(I)48, TAF(I)63 and TAF(I)110.

98 the TATA-binding protein-associated factors (TAFs) in TFIID.

99 (TFs) and transcription associated factors (TAFs) representing about 5% of the total annotated seque

100 TA-binding protein (TBP)-associated factors (TAFs) that constitute transcription factor II D (TFIID)

101 TA-binding protein (TBP)-associated factors (TAFs) within the TFIID complex and counteracts negative

102 protein (TBP) and 14 TBP-associated factors (TAFs), can directly recognize core promoter elements and

103 ox-binding protein (TBP)-associated factors (TAFs), evolutionarily conserved from yeast to humans, pl

104 , an assembly of TBP and associated factors (TAFs), is essential for preinitiation complex formation

105 protein (TBP) and 13 TBP-associated factors (TAFs)-assembles into a functional transcription factor i

106 ng protein (TBP) and TBP-associated factors (TAFs)-is a central component of the Pol II promoter reco

107 TBP) and a series of TBP-associated factors (TAFs).

108 tein (TBP) and 12-15 TBP-associated factors (TAFs).

109 protein (TBP) and 14 TBP-associated factors (TAFs).

110 d a set of conserved TBP-associated factors (TAFs).

111 pproximately a dozen TBP-associated factors (TAFs).

112 TBP) and 14 distinct TBP-associated factors (TAFs).

113 TBP) and 14 distinct TBP-associated factors (TAFs).

114 n (TBP) and multiple TBP-associated factors (TAFs).

115 and approximately 14 TBP-associated factors (TAFs).

116 protein (TBP) and 13 TBP-associated factors (TAFs).

117 a complex of TBP and TBP-associated factors [TAFs])-dependent ribosomal protein genes involved in rib

118 laxin increased tumor-associated fibroblast (TAF) interaction with collagen fibers by stimulating bet

119 subset of the tumor-associated fibroblasts (TAF) was found to express B7H1 (PD-L1) and B7DC (PD-L2)

120 ch were mostly tumor-associated fibroblasts (TAF).

121 o, and deplete tumor-associated fibroblasts (TAFs) for improved therapeutic outcomes.

122 (Combo NP) on tumor-associated fibroblasts (TAFs).

123 ilarly depleting two C. elegans histone fold TAF(II)s, TAF-9 (hTAF(II)31/32) and TAF-10 (hTAF(II)30),

124 more society ought to be willing to pay for TAF over TDF, in exchange for its improved toxicity prof

125 ssible, however, the appropriate premium for TAF will likely merit a downward adjustment, using gener

126 oters whose transcriptional requirements for TAFs differ substantially.

127 -specific TAF4b component of TFIID (formerly TAF(II)105) is a transcriptional regulator enriched in t

128 calculated the total attributable fraction (TAF) as a weighted average of these AFs.

129 ts support the clinical investigation of FTC/TAF for PrEP.

130 or up to 19 weeks and received saline or FTC/TAF 24 hours before and 2 hours after each virus inocula

131 Tenofovir alafenamide fumarate (TAF), a new prodrug of tenofovir and a potential success

132 n vivo role of TAF(II)105, we have generated TAF(II)105-null mice by homologous recombination.

133 ranscription of the ribosomal protein genes, TAF-dependent antisense transcription of GAL10 also requ

134 TAF-5 (human (h) TAF(II)100) is of particular interest because it is pred

135 ntified in the carboxyl-terminus of human (h)TAF(I)48.

136 Altering the composition of hESC TAFs, either by depleting TAFs that are present or ectop

137 tive genes are bound by TBP and all six hESC TAFs.

138 Relatively little is known about how TAF(II)s contribute to metazoan transcription in vivo, e

139 However, TAF-5 is apparently not essential for the expression of

140 Human TAF(II)55 (hTAF(II)55), a component of the general trans

141 The interaction between human TBP and human TAF(I)48 was initially examined using the yeast two-hybr

142 py reconstruction of a fully assembled human TAF-less PIC.

143 Here we show that the human TAF(II)43 (TAF8) is an integral component of a functiona

144 units, Set/template-activating factor-Ibeta (TAF-Ibeta) and pp32, specifically bind to unacetylated,

145 ition a nucleosome is a major determinant in TAF(II) dependency of genes in vivo.

146 e lethality of a hamster cell line mutant in TAF(II)250.

147 secretion of Wnt16 in a paracrine manner in TAFs.

148 lyses suggest that, although some individual TAF(II)s are required for transcription of most genes, o

149 firm and extend the proposal that individual TAFs have selective transcriptional roles and distinct f

150 binding protein-associated factor, 250 kDa (TAF(II)250) and the Drosophila developmental protein fem

151 metry confirms the presence of all the known TAFs and TBP, as well as Rsp5, Bul1, Ubp3, Bre5, Cka1, a

152 plex containing TBP:TFIIA:TFIIB, which lacks TAFs, and provides a mechanism that could function at TA

153 Like TAF(II)250, the human TAF1L protein can bind directly to

154 f the Xenopus basal transcription machinery, TAF(II)32.

155 TRAP/Mediator and TFIID (TBP plus the major TAF(II)s) required addition of both TBP and associated T

156 Only TAF(I)96 (the mammalian TAF(I) 68, yeast Rrn7p homolog) overlaps significantly w

157 In this manner, TAFs kinetically repress basal transcription.

158 cubation of p53 mutants with Mdm-2 modulated TAF(II)31 interaction with p53, suggesting Mdm-2 blocks

159 f yeast genes are dependent upon one or more TAFs and 16% of yeast genes are TAF independent.

160 Although higher eukaryotes contain multiple TAF variants that specify tissue- and developmental stag

161 SpRrn7h/murine TAF(I)68, and SpRrn11h/murine TAF(I)48, multiple ones were identified across eukaryote

162 arch for putative homologs of SpRrn7h/murine TAF(I)68, and SpRrn11h/murine TAF(I)48, multiple ones we

163 Furthermore, TFV but not TAF increased elafin and MIP3a secretion following injur

164 dent, and we provide evidence that SAGA, not TAF(II)s within TFIID, are largely responsible for TBP r

165 To evaluate the ability of TAF to modulate tumor-associated T cell (TAT) activation

166 ment is largely unaffected by the absence of TAF(II)105.

167 escribe the first genetics-based analysis of TAF-5 in a metazoan.

168 rodimer interface and extensive cofolding of TAF subunits.

169 We investigated whether the combination of TAF and emtricitabine (FTC) could prevent simian/human i

170 ells, siRNA-mediated decreased expression of TAF(I)41 leads to loss of SL1 from the rDNA promoter in

171 These data suggest that a function of TAF is required for the interaction of TFIID with the cy

172 n together, we conclude that the function of TAF(II)105 in B cells is likely redundant with the funct

173 esults suggest that the specific function of TAF(II)s is to direct the chromatin remodeling step thro

174 Much less is known about the functions of TAF(II)s in metazoans, which have more complex genomes t

175 At elevated levels of TAF treatment to match TFV intracellular TFV-DP concentr

176 ed with TAF-I still requires the presence of TAF-I during the polymerization reaction.

177 To examine the in vivo role of TAF(II)105, we have generated TAF(II)105-null mice by ho

178 also provide evidence for specific roles of TAF HFMs, highlighting the functional significance of HF

179 A subset of TAF proteins is shared in transcription factor II D (TFI

180 n macaques to determine the potential use of TAF for pre-exposure prophylaxis (PrEP) to prevent human

181 ion domain can compensate for the absence of TAFs on a TAF(dep) core promoter.

182 this study, we describe a novel function of TAFs in directing genomic occupancy of a transcriptional

183 into two classes based on the involvement of TAFs.

184 tudies demonstrating the essential nature of TAFs in transcription, very little is known about the su

185 The differential recruitment of TAFs by UASs provides strong evidence for the proposal t

186 (UAS) mediates the selective recruitment of TAFs to TAF(dep) promoters.

187 Emerging consensus regarding the role of TAFs is that TFIID assumes a gene specific activity that

188 To understand fully the functional role of TAFs, it is imperative to define TAF-TAF interactions an

189 TFIID and SAGA share a common set of TAFs, regulate chromatin, and deliver TBP to promoters.

190 Thus, the selective expression and use of TAFs underlies the ability of hESCs to self-renew.DOI:ht

191 g intracellular TFV-DP, but had no effect on TAF inhibition of infection or TFV-DP.

192 that are either independent or dependent on TAFs (TATA-box Binding Protein-Associated Factors).

193 Only TAF(I)96 (the mammalian TAF(I) 68, yeast Rrn7p homolog)

194 pattern: most active genes are bound by only TAFs 3 and 5 along with TBP, whereas the remaining activ

195 n with P300/CBP-associated factor (P/CAF) or TAF(II)250 bromodomains or the P/CAF or GCN5 HAT domains

196 incubation of blood CD4+ T cells with TFV or TAF, Medroxyprogesterone acetate (MPA), but not Levonorg

197 oter recognition factor (Trf2) and an orphan TAF subunit (Taf7l) in mammalian testis-specific gene tr

198 likely redundant with the function of other TAF(II)105-related cellular proteins.

199 pocytes, whereas the expression of all other TAFs tested is slightly reduced.

200 nd c-Jun) and regulatory protein (CBP, p300, TAF(II)250, and polymerase II) binding at both the upstr

201 Paradoxically, TAF carried no mutations in MED12, suggesting an interac

202 ription is initiated with at least partially TAF-free TATA-binding protein.

203 dently arose by retroposition of a processed TAF(II)250 mRNA during primate evolution.

204 the high concentration of collagen-producing TAF.

205 nteraction of M2 with two of these proteins, TAF(II)70 and TAF(II)40, were identified.

206 A TAF(ind) UAS fails to recruit TAFs and to direct efficient transcription when inserted

207 ma was 85% depleted and 87% of the remaining TAFs were TUNEL-positive.

208 ervation that TAF1L can functionally replace TAF(II)250 provides experimental support for the hypothe

209 TAF-dependent (TAF(dep)) promoters require TAFs for transcription, and TBP and TAFs are present at

210 urthermore, the recruitment of Rap1 requires TAF(II)s, suggesting a role for TFIID in stabilizing act

211 he high concentration of estrogen-responsive TAF in MED12-LM explains the inconsistent discoveries be

212 ate increased 1,25-(OH)(2)D(3) responsivity, TAF(II)-17 expression, or nuclear number per osteoclast.

213 leting two C. elegans histone fold TAF(II)s, TAF-9 (hTAF(II)31/32) and TAF-10 (hTAF(II)30), but is di

214 stigated functions of four shared TFIID/SAGA TAF(II)s in Caenorhabditis elegans.

215 l transcription in P0 and P1 by sequestering TAF-4, an essential component of TFIID.

216 Additionally, Set/TAF-Ibeta and pp32 associate with histone deacetylases i

217 of the complex between cytochrome c and SET/TAF-Ibeta.

218 study reveals that the histone chaperone SET/TAF-Ibeta interacts with cytochrome c following DNA dama

219 Finally, Set/TAF-Ibeta and pp32 associate with an endogenous estrogen

220 nucleosome assembly protein 1 and human SET/TAF-1beta/INHAT histone chaperones, Vps75 shows several

221 vivo mechanistic role for the mammalian Set/TAF-Ibeta and pp32 proteins as transducers of chromatin

222 found to competitively hinder binding of SET/TAF-Ibeta to core histones, thereby locking its histone-

223 drugs to silence the oncogenic effect of SET/TAF-Ibeta's histone chaperone activity.

224 sis of cytochrome c-mediated blocking of SET/TAF-Ibeta, which subsequently may facilitate the develop

225 r of acetyltransferases), containing the Set/TAF-Ibeta oncoprotein and pp32 strongly inhibits the HAT

226 try of TFIID subunits indicated that several TAFs are present at more than 1 copy per TFIID complex.

227 mbryonic stem cells (hESCs) contain only six TAFs (TAFs 2, 3, 5, 6, 7 and 11), whereas following diff

228 ovide evidence for a novel component of SL1, TAF(I)41 (MGC5306), which functions in Pol I transcripti

229 Here we show that testis-specific TAF (TBP-associated factor) homologs required for termin

230 ultiple studies indicate that TFIID-specific TAF(II)s are not required for the transcription of most

231 iption of most genes requires TFIID-specific TAF-1.

232 iple TBP-related factors and tissue-specific TAF(II)s suggests the existence of specialized TFIID com

233 also express four additional tissue-specific TAFs: nht (homolog of dTAF4), mia (homolog of dTAF6), sa

234 and the available studies utilizing specific TAFs, we propose a working hypothesis for the arrangemen

235 sformation domain with the human STAGA (SPT3-TAF-GCN5 acetylase) coactivator complex.

236 taxin-7 protein, a member of the STAGA [SPT3-TAF(II)31-GCN5L acetylase] and TFTC (GCN5 and TRRAP) chr

237 clear extracts, transcription induces stable TAF binding to downstream promoter DNA, promoting subseq

238 pe-selective expression of the TFIID subunit TAF(II)105 (renamed TAF4b) in the ovary is essential for

239 t, with genital CD4+ T cells, MPA suppressed TAF inhibition of HIV infection and lowered of TFV-DP co

240 upon the general transcription factor TAF1 (TAF(II)250).

241 ntly from the downstream region and is TAF1 (TAF(II)250) independent.

242 feron mediator CIITA is independent of TAF1 (TAF(II)250) and focuses initiation on the downstream sta

243 stream start sites and is dependent on TAF1 (TAF(II)250), a finding consistent with its role in regul

244 se mutation in the transcription factor TAF1/TAF(II)250 induces the mutant ts13 cells to arrest in la

245 -cross-linking results demonstrate that TAF1/TAF(II)250 interacts with the DCE subelement DNA in a se

246 ic stem cells (hESCs) contain only six TAFs (TAFs 2, 3, 5, 6, 7 and 11), whereas following differenti

247 effect of Combo NP works by first targeting TAFs and is more effective as an anti-tumor therapy than

248 ve histone acetyltransferase domain and TBP, TAF, and promoter binding domains.

249 orts the idea that TBP and, most likely, TBP-TAF complexes, remain promoter- bound for multiple round

250 novel model in which the association of TBP-TAF complexes with chromatin during mitosis marks genes

251 of the five Drosophila genes encoding testis TAF homologs collaborate in an alternative TAF-containin

252 Testis TAFs also promoted relocalization of Polycomb Repression

253 tin immunoprecipitation revealed that testis TAFs bind to target promoters, reduce Polycomb binding,

254 r a greater proportion of transcription than TAF-5, -9, or -10 and is important for transcription of

255 We conclude that TAF in human NSCLC are functionally and phenotypically h

256 es after 48 weeks of therapy have shown that TAF may be a good alternative to TDF for treating chroni

257 These data suggest that TAF(I)41 is integral to transcriptionally active SL1 and

258 We found that TAFs sharply decrease the rate at which Pol II, TFIIB, a

259 The TAF increased stepwise with age.

260 The TAF N-terminal domain (TAND) of TAF1 may play a signific

261 The TAF-targeting capability of Combo NP was evaluated by do

262 or B7DC was able to completely abrogate the TAF-mediated suppression.

263 In contrast, VPN only activates the TAF-independent core promoter and this activity increase

264 prising the TATA-binding protein TBP and the TAF subunits Brf1 and Bdp1.

265 stics provide multiple opportunities for the TAF to influence cellular interactions within the tumor

266 To investigate how the TAF (TATA-binding protein-associated factor) subunits of

267 SL1 and imply a role for SL1, including the TAF(I)41 subunit, in Pol I recruitment and, therefore, p

268 ID (a TAF-dependent form of TBP) but not the TAF-independent form of TBP to the promoters of ribosoma

269 Different members of the TAF family of proteins work in differentiated cells, suc

270 The functions of the TAF subunits of mammalian TFIID in physiological process

271 Overall, the TAF was 0.66 (95% confidence interval [CI]: 0.55-0.78) i

272 tyltransferase) is involved in targeting the TAF-independent form of TBP to the promoters of ribosoma

273 Thus, the TAF represents the overall fraction (where 0.00 = not at

274 ts expression is strictly dependent upon the TAF(II) subunits of TFIID, which are required for the re

275 domain (activation domain 3 [AD3]) with the TAF homology (TAFH) domain of TAF4, (2) is critical for

276 er enhances the interaction of CREB with the TAF(II)130 component of TFIID following its recruitment

277 etry, we define the interactions between the TAFs and uncover a central role for TAF8 in nucleating t

278 The essentiality of the TAFs has made it difficult to ascertain their roles in T

279 AF7), which functions not only as one of the TAFs, but also a coactivator for c-Jun.

280 of DNA and supports basal transcription, the TAFs have essential functions that remain poorly defined

281 es undergo a slow isomerization in which the TAFs reorganize their contacts with the promoter to allo

282 Thus, TAF-I is required to facilitate transcription at a step

283 Thus, TAFs are involved in both establishing an upper limit of

284 OMA-1/2 binding to TAF-4 is developmentally regulated, requiring phosphoryl

285 al human gene, TAF1L, which is homologous to TAF(II)250 and is expressed specifically in the testis,

286 ing Mdm-2 blocks the accessibility of p53 to TAF(II)31.

287 2 facilitates the binding of OMA proteins to TAF-4 and simultaneously inactivates their function in r

288 In vivo, promoter responses to TAF mutations correlate with the level of downstream, ra

289 ediates the selective recruitment of TAFs to TAF(dep) promoters.

290 e that the Mot1p-TBP complex delivers TBP to TAF-independent mRNA encoding genes.

291 for essentially all embryonic transcription, TAF-5, TAF-9, and TAF-10 were dispensable at multiple de

292 In five of eight tumors, TAF elicited a contact-dependent enhancement of TAT acti

293 In the three other tumors, TAF had a net suppressive effect upon TAT activation, an

294 less regulated, but is highly dependent upon TAFs, including those shared between TFIID and SAGA.

295 trong evidence for the proposal that in vivo TAFs are the targets of some, but not all, activators.

296 Whereas TAF-4 was required for essentially all embryonic transcr

297 acetylated lysine 12 on histone H4, whereas TAF(II)250 and PCAF recognized H3 and other acetylated h

298 We propose a new model in which TAFs function as reinitiation factors, accounting for th

299 nt transcription of chromatin assembled with TAF-I still requires the presence of TAF-I during the po

300 TAF-2, which binds core promoters with TAF-1, appears to be required for a similarly substantia