ライフサイエンスコーパス: TAO

1 TAO and similar SHAM-sensitive alternative oxidases (AOX

2 TAO is a diiron protein that transfers electrons from ub

3 TAO is present at a reduced level in the procyclic form

4 TAO kinases are activated acutely by ionizing radiation,

5 To learn more about TAO/KIN-18 function, we studied how expression of consti

6 Thousand and one amino acid (TAO) kinases are Ste20p-related MAP kinase kinase kinase

7 tion by the ATM protein kinase in cells; and TAO and p38 activation is compromised in cells from a pa

8 nase mutants, we found that MEKs 3 and 6 and TAOs were required for p38 activation by carbachol or th

9 the inclusion criteria, 740 (8.8%) developed TAO (mean follow-up, 374 days since initial GD diagnosis

10 ors that may increase the risk of developing TAO among patients with GD.

11 s used to determine the hazard of developing TAO among persons with newly diagnosed GD, with adjustme

12 s associated with a 74% decreased hazard for TAO (adjusted HR, 0.26 [95% CI, 0.12-0.51]) compared wit

13 iated with substantially reduced hazards for TAO among patients with GD, preventive measures for this

14 The new susceptibility region for TAO at 16q12 harbors variants that correlate with the ex

15 tor might represent a therapeutic target for TAO.

16 the growth medium produces a non-functional TAO.

17 d the expression of IL-6, IL-8, and MCP-1 in TAO fibroblasts but failed to do so in control cultures.

18 blasts diffusely in the body is causative in TAO and pretibial myxedema with even increased urinary s

19 ise a large subset of orbital fibroblasts in TAO.

20 could be further upregulated by IFN-gamma in TAO and control fibroblasts.

21 hyaluronan accumulation and inflammation in TAO derive from enhanced biosynthetic activities of orbi

22 r the natural course of tissue remodeling in TAO.

23 hid fecundity was decreased significantly in TAO plants compared with other lines.

24 Early reports suggested that in TAO, both Tg and TSHR become overexpressed in orbital ti

25 tinct loci explained 6.0% of the variance in TAO.

26 ced MCP-1, IL-6, and IL-8 more vigorously in TAO-derived fibroblasts.

27 ) plants that have either high (PAO) or low (TAO) ascorbate oxidase (AO) activities relative to the w

28 and truncated fragments of dominant negative TAOs inhibit the activation of p38 by DNA damage.

29 onserved EXXH motif abolished the ability of TAO to complement the heme-deficient Escherichia coli st

30 t of ortho-phenanthroline on the activity of TAO was completely alleviated by the addition of iron in

31 ce of iron are essential for the activity of TAO.

32 ests that iron is needed for the activity of TAO.

33 xygenase 2 inhibitors and the development of TAO.

34 Eyes of TAO patients with DON showed delayed P100 latencies, dec

35 The inhibition of TAO by salicylhydroxamic acid (SHAM) or ascofuranone is

36 Inhibition of TAO expression by siRNA also decreases p38 activation by

37 Manifestations of TAO measured by hazard ratios (HRs) with 95% CIs.

38 entify those who developed manifestations of TAO.

39 n-binding residues within the EXXH motifs of TAO abolished the ability to confer SHAM-sensitive respi

40 in understanding the site-specific nature of TAO and the development of specific therapies.

41 The restrictive ophthalmopathy of TAO may be associated with more sustained ocular hyperte

42 dings may be relevant to the pathogenesis of TAO and provide insights into previously unrecognized, p

43 vitro; radiation induces phosphorylation of TAO on a consensus site for phosphorylation by the ATM p

44 ysis of 9 genome-wide association studies of TAO (total of 5462 asthmatic patients with a broad range

45 levels of IGF-1R and TSHR on the surfaces of TAO and control orbital fibroblasts and thyrocytes and e

46 Several new studies address the therapy of TAO, ranging from retrobulbar to oral to intravenous glu

47 To explore events downstream of TAOs, the effects of TAO2 on ternary complex factors (TC

48 contrast, IGF-1R levels are 3-fold higher on TAO vs control fibroblasts.

49 forms of Trypanosoma brucei depend solely on TAO for respiration.

50 els are 11-fold higher on thyrocytes than on TAO or control fibroblasts.

51 riants associated with time to asthma onset (TAO).

52 Thyroid-associated ophthalmopathy (TAO) is a common and debilitating manifestation of Grave

53 Thyroid-associated ophthalmopathy (TAO), an autoimmune component of Graves' disease, is ass

54 enesis of thyroid-associated ophthalmopathy (TAO), the orbital manifestation of GD, remains uncertain

55 nked with thyroid-associated ophthalmopathy (TAO).

56 known as thyroid-associated ophthalmopathy (TAO).

57 orbit to thyroid-associated ophthalmopathy (TAO).

58 re severe thyroid-associated ophthalmopathy (TAO).

59 enesis of thyroid-associated ophthalmopathy (TAO).

60 blindness in thyroid associated orbitopathy (TAO).

61 Trypanosome alternative oxidase (TAO) is the cytochrome-independent terminal oxidase of t

62 se known as trypanosome alternative oxidase (TAO).

63 telangiectasia mutated (ATM) phosphorylates TAOs in vitro; radiation induces phosphorylation of TAO

64 organisms but not in mammals, thus rendering TAO an important chemotherapeutic target for African try

65 Among the identified MST3 substrates, TAO kinases regulate dendritic filopodia and spine devel

66 These findings indicate that TAO kinases are regulators of p38-mediated responses to

67 Taken together, these studies suggest that TAO protein kinases relay signals from carbachol through

68 These results suggest that TAO proteins lie in stress-sensitive kinase cascades and

69 The TAO (for thousand-and-one amino acids) protein kinases a

70 The TAO and TAP TAVR groups were similar in terms of device

71 The TAO approach, compared with TAP TAVR, was associated wit

72 The TAO trial (Treatment of Acute Coronary Syndrome With Ota

73 abolism, were increased significantly in the TAO plants in response to aphid perception relative to o

74 the lines, the effect being the least in the TAO plants.

75 Here we show that the TAO kinases mediate the activation of p38 in response to

76 TAVR via the TAO approach is technically feasible, seems to be associ

77 Alternative oxidases similar to TAO have been found in a wide variety of organisms but n

78 l feasibility and safety of the transaortic (TAO) transcatheter aortic valve replacement (TAVR) appro

79 he expression level of mutated and wild type TAO (35 kDa) remained unaltered.

80 5% of the control cells containing wild type TAO.

81 inoperable, severe aortic stenosis underwent TAO TAVR in our institution.

82 Cells in which TAO kinases have been knocked down are less capable of e

83 We detected 5 regions associated with TAO at the genome-wide significant level (P < 5 x 10(-8)

84 are far more frequent in vivo in donors with TAO compared with healthy subjects.

85 ned with informed consent from patients with TAO and from patients undergoing surgery for other nonin

86 that orbital fibroblasts from patients with TAO expressed elevated levels of CD40.

87 ination of orbital tissue from patients with TAO reveals similar colocalization to cell membranes.

88 cytes is markedly increased in patients with TAO, suggesting that this receptor might represent a the

89 expression in fibroblasts from patients with TAO.