ライフサイエンスコーパス: TAP

1 TAP binding protein, related (TAPBPR), a widely expresse

2 TAP is a central component of the peptide-loading comple

3 TAP is a heterodimer formed by the association of two ha

4 TAP of the UL28 protein from vFH476-infected cells, foll

5 TAP of UL28 complexes from cells infected with each doma

6 TAP plays an essential role in the antigen presentation

7 TAP shuttles proteasomal degradation products into the l

8 TAP translocates cellular peptides across the endoplasmi

9 TAP-1 mRNA was expressed in many tissues, and TAP-1 prot

10 TAP-1 plays a significant physiological role in controll

11 TAP/p32, similar to NAP-1, NLP, and Nph, facilitates nuc

12 alian alpha-tocopherol associated protein-1 (TAP-1) as a functional ortholog of cgr-1.

13 elated genes, including Ly6a (encoding Sca-1/TAP), Ly6e (Sca-2/Tsa1), Ly6g (Gr-1), and gpihbp1 (GPI-a

14 the presence of Lambda-[Ru(TAP)2(dppz)](2+) (TAP = 1,4,5,8-tetraazaphenanthrene, dppz = dipyrido[3,2-

15 ited-state quenching of [Ru(TAP)2(HAT)](2+) (TAP = 1,4,5,8-tetraazaphenanthrene, HAT= 1,4,5,8,9,12-he

16 alating photoreagent Ru[(TAP)(2)PHEHAT](2+) (TAP = 1,4,5,8-tetraazaphenanthrene; PHEHAT = 1,10-phenan

17 Ar(4)TAPs bearing various substituents in meso-phenyls and an

18 al tetraaryltetraanthra[2,3]porphyrins (Ar(4)TAPs) was developed.

19 of Tsg101, an ESCRT-1 component, to the P(7)TAP motif in the p6 region of Gag.

20 ccurs through the upregulation of Rab7 and a TAP-independent pathway that prime CTL responses.

21 A quantitative comparison between a TAP LPG and a non-TAP LPG was carried out to highlight t

22 molecule pulldown (SiMPull), we determined a TAP/tapasin ratio of 1:2, consistent with previous studi

23 e, single-blinded study compared 2 groups (a TAP block and PILA) with a standard anesthetic technique

24 AP affinity is imported into phagosomes in a TAP- and ATP-dependent manner, as expected.

25 all three viral ligands were presented in a TAP-dependent manner despite originating from different

26 ion, as evidenced by enhanced rejection of a TAP-deficient tumor in vivo.

27 erventions: Patients randomized to receive a TAP block with local anesthetics and dexamethasone, PILA

28 Herein, using a TAP-independent polyclonal vaccinia virus-polyspecific C

29 metrically assessed using the computer-aided TAP (Test Battery of Attentional Performance).

30 iously characterized histone chaperones, and TAP/p32 has no known function in chromatin metabolism.

31 animals with infundibular scarring (INF and TAP).

32 inhibited the interaction between HDAg-L and TAP and blocked HDV virion assembly and secretion.

33 he persistent deficits in the Type-1 NSC and TAP reservoirs.

34 antioxidant capacity assessed using ORAC and TAP assays correlated with individual metabolites.

35 n the side chains of the antigen peptide and TAP.

36 e improved proportionally most in the PI and TAP groups in relation to the extent of RV dilation.

37 by the HLA-B27 molecules was proteasome and TAP-independent and not restricted to Antigen-Presenting

38 its localization with respect to Aly/REF and TAP/NXF1 in living cells during viral infection.

39 The TAO and TAP TAVR groups were similar in terms of device success

40 molecules on the surface of both TAP(+) and TAP(-) cells.

41 AP-1 mRNA was expressed in many tissues, and TAP-1 protein colocalized with Ras and Raf at the cell m

42 morphic genes encoding classical class I and TAPs allows co-evolution, leading to a single dominantly

43 We find REST regulates both QNPs and TAPs, and importantly, ribosome biogenesis, cell cycle a

44 The NXF1:NXT1 complex (also known as TAP:p15) is a general mRNA nuclear export factor that is

45 are found on the cell surface, with the B15 TAPs restricting the peptides available.

46 f receiving additional peptides from the B21 TAPs.

47 Because TAP function is necessary for proper MHC class I-associa

48 t irreversibly inhibit Ubl proteases) before TAP (tandem affinity purification) that allows for effic

49 that the N-terminal 14 aa residues bestowed TAP-independent upregulation of HLA-E, whereas C region

50 tiation and reveals the interactions between TAP and RNAP holoenzyme responsible for transcription ac

51 The REF/ALY mRNA export adaptor binds TAP/NXF1 via an arginine-rich region, which overlaps wit

52 exes or tumor or infected cells with blocked TAP molecules are able to present HLA class I ligands ge

53 by inhibiting the proteasome or by blocking TAP-mediated peptide transport using viral inhibitors.

54 ntrol T23D3 molecules on the surface of both TAP(+) and TAP(-) cells.

55 the chaperone tapasin organizes by bridging TAP to MHC class I and recruiting accessory molecules su

56 ucted not only by B cells but in addition by TAP-deficient T2-cells.

57 teps of substrate translocation catalyzed by TAP.

58 to present HLA class I ligands generated by TAP-independent processing pathways.

59 and release of HDV particles are mediated by TAP and Aly.

60 into dendritic cell phagosomes, mediated by TAP transporters recruited from the endoplasmic reticulu

61 or efficient displacement of RNA from REF by TAP in vivo.

62 at imposes the block in peptide transport by TAP.

63 nerated by the proteasome and transported by TAP meet MHC-I molecules for loading has been a matter o

64 Protamine chaperone TAP/p32 dissociates DNA-protamine complexes in vitro onl

65 Previous data show that chicken TAP genes have high allelic polymorphism, with peptide t

66 Here, we compared TAP function and interaction with tapasin of a range of

67 study, the host cellular RNA export complex TAP-Aly was found to form a complex with HDAg-L, but not

68 ology with the antigen translocation complex TAP, but is also able to restore antigen processing in h

69 demonstrate that a single heterodimeric core-TAP complex is active in peptide binding, which is tight

70 ancestral nucleobase, is mixed with a crude TAP+ribose reaction mixture, micrometer-length supramole

71 CT TAP restaging altered management in 6.7% of patients, wh

72 ged pre- and post-CRT with MR imaging and CT TAP were included.

73 omography of thorax, abdomen, and pelvis (CT TAP) to identify distant metastases.

74 T cell line, two conserved vaccinia-derived TAP-independent HLA-B*0702 epitopes were identified.

75 ve evolved strategies either to downregulate TAP expression or directly inhibit TAP activity.

76 ), and combined infundibular-PV dysfunction (TAP).

77 lled and randomly assigned to receive either TAP or sham blocks after caesarean section.

78 antigen supply to MHC I molecules in the ER, TAP assembles a macromolecular peptide-loading complex (

79 ed for immunotherapy against immune-escaped, TAP-deficient tumor cells expressing low levels of MHC-I

80 In evolution, TAP appeared together with effector cells of adaptive im

81 This study examines TAP block analgesic efficacy after caesarean section in

82 infrared excitation and emission of this FAP-TAPs provides a new spectral range for photosensitizer p

83 ir pretreatment performance in three of five TAP subtasks (vigilance, P < 0.001; shared attention: op

84 lective of individual peptide affinities for TAP, revealing the underlying mechanism of peptide-stimu

85 asymmetric ABC exporters in general, and for TAP in particular.

86 assays, hyporesponsiveness was observed for TAP-deficient NK cells derived from four patients.

87 endogenous pathway by its independence from TAP and tapasin and its sensitivity to inhibitors of lys

88 Furthermore, TAP-tagged KREPB6, KREPB7, and KREPB8 complexes isolated

89 Here, the heterodimeric TAP complex was purified and reconstituted in nanodiscs

90 We observed that a peptide with high TAP affinity is imported into phagosomes in a TAP- and A

91 able to restore antigen processing in human TAP-deficient cells.

92 study, we determined the structure of human TAP bound to ICP47 by electron cryo-microscopy (cryo-EM)

93 cryo-electron microscopy structure of human TAP in complex with its inhibitor ICP47, a small protein

94 ation of an antigenic peptide bound to human TAP.

95 These studies identify TAP-1 as a critical modulator of Ras-mediated cellular s

96 ophilus RNAP sigma(A) holoenzyme, a class II TAP-dependent promoter, and a ribotetranucleotide primer

97 These include RNA polymerase II, TAP/NXF1, and Hsc70.

98 e in the presence of concomitant INF (54% in TAP versus 14% in PI; p = 0.03).

99 demonstrated that TEIPP-specific T cells in TAP-deficient mice have largely been deleted by central

100 In contrast, a decrease in TAP/NXF1 levels severely impaired export of ICP27 and po

101 Defects in TAP account for immunodeficiency and tumour development.

102 chlamydial challenge, (i) mice deficient in TAP I (and therefore the major histocompatibility comple

103 HLA-E ligand derived from the D8L protein in TAP-deficient vaccinia virus-infected cells.

104 lude that all three tapasin-binding sites in TAP cooperate to achieve high transporter stability and

105 Simvastatin (30 mg/kg) increased TAP activity on day 11 compared with the saline group.

106 nregulate TAP expression or directly inhibit TAP activity.

107 t viruses have evolved strategies to inhibit TAP so that they may go undetected by the immune system.

108 orm of CPXV012 that is capable of inhibiting TAP.

109 st bacterial factor identified that inhibits TAP function and MHC class I antigen presentation.

110 LCMS proteomic analysis of LAP-TAP-purified proteins from HeLa cells containing a tetra

111 the NLS failed to interact with full-length TAP.

112 nd biochemical evidence that the Mex67-Mtr2 (TAP-p15) heterodimer, best characterized for its essenti

113 mutations of CRM1 (Exportin-1), MEX67/MTR2 (TAP/p15), and five nucleoporins cause accumulation of un

114 ative comparison between a TAP LPG and a non-TAP LPG was carried out to highlight the improvement of

115 However, individuals with nonfunctional TAP complexes or tumor or infected cells with blocked TA

116 Notably, TAP works as a molecular diode, translocating peptide su

117 both mRNAs is dependent on the cellular NXF1/TAP pathway, but it is unclear how they are recruited to

118 olvement of the nuclear export receptor NXF1/TAP in the nuclear export of gammaretroviral RNA transcr

119 Absence of TAP activity even increased the MHC-I presentation of th

120 understanding of the mechanism of action of TAP is limited by the absence of experimental structures

121 es ATP binding to TAP and, thus, activity of TAP, thereby preventing the presentation of viral peptid

122 ism of peptide-stimulated ATPase activity of TAP.

123 So far, neither the architecture of TAP nor the mechanism of viral inhibition has been eluci

124 However, the efficacy of TAP blocks in low-resourced settings where patients do n

125 Both the modeling and manufacturing of TAP LPGs were discussed.

126 selection, we combined homology modeling of TAP with experimental measurements to identify several T

127 Here, we present homology models of TAP built on the crystal structures of P-glycoprotein, A

128 h Aly/REF or TAP/NXF1, and overexpression of TAP/NXF1 did not promote the export of ICP27 to the cyto

129 in, which plugs the translocation pathway of TAP from the cytoplasmic side.

130 mall hairpin RNA-mediated down-regulation of TAP or Aly reduced nuclear export of HDAg-L and assembly

131 +ribose reaction is a beta-ribofuranoside of TAP, which we term TARC.

132 The peptide binding site of TAP is located at the hydrophobic boundary of the cytoso

133 delineate different conformational states of TAP in a native subcellular membrane environment.

134 ructurally distinct conformational states of TAP.

135 also establishes the molecular structure of TAP to facilitate mechanistic studies of the antigen pre

136 to directly interact with the N terminus of TAP, whereas an HDAg-L mutant lacking the NLS failed to

137 Our studies highlight the potential of TAPs for single-dose treatment of Pf malaria in combinat

138 n contrast, the translocation specificity of TAPs from the low-expressing B21 haplotype is even more

139 Three tapasin binding sites on TAP have been described, two of which are located in the

140 By transferring an optimized TAP tag combined with state-of-the-art mass spectrometry

141 ICP27 did not colocalize with Aly/REF or TAP/NXF1, and overexpression of TAP/NXF1 did not promote

142 with state-of-the-art mass spectrometry, our TAP protocol enables the discovery of interactors for lo

143 a variant of the Taylor aggression paradigm (TAP) allowing to differentiate between reactive (provoke

144 Models for peptide-TAP complexes were generated, which indicate bent confor

145 ied, revealing a complex scenario of peptide-TAP recognition.

146 no atomic-resolution information on peptide-TAP interactions has been obtained, hampering a mechanis

147 erase (ALT), and total alkaline phosphatase (TAP) were evaluated.

148 This targeted and activated photosensitizer (TAPs) approach enables protein inactivation, targeted ce

149 cacy of using a transversus abdominis plane (TAP) block in a randomized, double-blind, placebo-contro

150 Transversus abdominis plane (TAP) block provides 12-24 h of analgesia to the parietal

151 e efficacy of a transversus abdominis plane (TAP) block with dexamethasone sodium phosphate and prepe

152 er cladding mode near its turn-around point (TAP) was the strategy adopted to achieve good performanc

153 ed by the known contributions of polymorphic TAP variants to peptide selection, we combined homology

154 we propose the Threshold Average Precision (TAP-k), a measure closely related to the well-known aver

155 g SDS-PAGE gels and coprecipitates with Prm1-TAP, indicating that Prm1 is a disulfide-linked homodime

156 the tandem affinity purification procedure (TAP).

157 e transporter associated with Ag processing (TAP) translocates proteasomally derived cytosolic peptid

158 e transporter associated with Ag processing (TAP).

159 nsporter associated with antigen processing (TAP) and class Ia has been documented in endothermic bir

160 nsporter associated with antigen processing (TAP) and MHC I to tapasin, which is responsible for MHC

161 nsporter associated with antigen processing (TAP) and then loaded onto the nascent MHC I molecules, w

162 nsporter associated with antigen processing (TAP) complex, which transfers the peptide products of pr

163 nsporter associated with antigen processing (TAP) constitutes a focal element in the adaptive immune

164 nsporter associated with antigen processing (TAP) enables the flow of viral peptides generated in the

165 nsporter associated with antigen processing (TAP) is a 150 kDa heterodimeric ABC transport complex th

166 nsporter associated with antigen processing (TAP) is a member of the ATP binding cassette (ABC) trans

167 nsporter associated with antigen processing (TAP) is an ATP-binding cassette (ABC) transporter essent

168 nsporter associated with antigen processing (TAP) participates in immune surveillance by moving prote

169 nsporter associated with antigen processing (TAP) plays a critical role in the MHC class I antigen pr

170 nsporter associated with antigen processing (TAP) translocates the viral proteolytic peptides generat

171 nsporter associated with antigen processing (TAP), results in strongly decreased surface display of p

172 nsporter associated with antigen processing (TAP)-mediated transport of antigen peptides.

173 nsporter associated with antigen processing (TAP).

174 nsporter associated with antigen processing (TAP).

175 nsporter associated with antigen processing (TAP).

176 opyrimidine, TAP) and ribose, which produces TAP-ribose conjugates in high yield (60-90%).

177 tiating into transit-amplifying progenitors (TAPs) and newborn neurons.

178 NSCs and transiently amplifying progenitors (TAPs) resulted in generation of fewer YFP+ granule neuro

179 Tapasin is required to promote TAP stability, but through which binding site(s) it is a

180 by the HLA-A2 molecules required proteasome, TAP and professional APC.

181 y the two HLA-B27 molecules was proteasome-, TAP-, and APC-independent whereas the presentation by th

182 this assumption, we found that proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase

183 amin E. alpha-Tocopherol-associated protein (TAP) was found to be one of the major alpha-tocopherol b

184 lasmic reticulum, the transmembrane proteins TAP and tapasin that facilitate peptide binding to MHCI

185 es, our sequencing of affinity-purified Puf3-TAP associated mRNAs (RIP-seq) identified mRNAs encoding

186 d an optimized tandem affinity purification (TAP) approach from Arabidopsis thaliana toward Oryza sat

187 eloped a novel tandem-affinity purification (TAP) approach using hexahistidine and BirA-specific biot

188 ased approach, tandem affinity purification (TAP) followed with mass spectrometry (MS), we identified

189 either a small tandem affinity purification (TAP) tag or the green fluorescent protein (GFP) attached

190 re isolated by tandem-affinity purification (TAP) using recombinant viruses expressing either a full-

191 ss-linking and tandem affinity purification (TAP), we herein identify sorting nexin 6 (SNX6) as a BAC

192 protein A- and tandem affinity purification (TAP)-tagged proteins from eukaryotic cells, but because

193 ected cells by tandem affinity purification (TAP).

194 e based on the tandem affinity purification (TAP).

195 25 nm (for the determination of AMP, PG, PV, TAP and FFC), 240 nm (for OXA, CLO and DICLO) and 278 nm

196 e margin of safety, and a high success rate, TAP blocks remain under used in settings where patients

197 informed written consent, patients received TAP or sham blocks after caesarian section.

198 as significantly lower in patients receiving TAP block with bupivacaine compared with the control (pr

199 ort components, and the mRNA export receptor TAP are required for accumulation of the naturally intro

200 accessing the cellular mRNA export receptor TAP/NXF, which guides mRNA through the nuclear pore comp

201 CP27 interacts with the mRNA export receptor TAP/NXF1 and binds RNA through an RGG box motif.

202 to the cytoplasm through the export receptor TAP/NXF1, and ICP27 must be able to interact with TAP/NX

203 n partners, including the transport receptor TAP of the host cell nuclear transport machinery, severa

204 In this study, we found that reduced TAP expression was significantly correlated with Her2/ne

205 Reducing TAP-1 expression by RNA interference increased Ras/ERK s

206 in controlling cell division, since reducing TAP-1 expression increased the oncogenic capacity of Ras

207 rginine methylation has no effect on the REF:TAP interaction.

208 Therefore, the frequently reported TAP dependence of cross-presentation of phagocytosed OVA

209 s-presentation of OVA-Le(X) neither required TAP-transporters nor Cathepsin-S and was still observed

210 The transapical route (TAP) is the current alternative but is associated with l

211 this work, we purified the complex with Rrp6-TAP, identified the co-purified proteins by mass spectro

212 d(TCGGCGCCGA) in the presence of Lambda-[Ru(TAP)2(dppz)](2+) (TAP = 1,4,5,8-tetraazaphenanthrene, dp

213 lds of guanine photo-oxidation by Lambda-[Ru(TAP)2(dppz)](2+) have been compared in 5'-{CCGGATCCGG}2

214 The excited-state quenching of [Ru(TAP)2(HAT)](2+) (TAP = 1,4,5,8-tetraazaphenanthrene, HAT

215 ctions of the intercalating photoreagent Ru[(TAP)(2)PHEHAT](2+) (TAP = 1,4,5,8-tetraazaphenanthrene;

216 SAHA-TAP demonstrates cytotoxicity activity against various c

217 After incubation of SAHA-TAP with an HDAC, the thiol of a conserved HDAC cysteine

218 to the hydroxamic acid warhead (termed SAHA-TAP).

219 xperimental measurements to identify several TAP residues that interact with peptides.

220 cation of the TAP-tagged UL17 or a similarly TAP-tagged UL25 protein clearly demonstrated that the tw

221 at TAP-1 operates at the level of Raf, since TAP-1 function negatively regulated the amount of Raf-1

222 entation, is ATP-dependent but substantially TAP-independent.

223 I in complex with the peptide editor TAPBPR (TAP-binding protein-related), a tapasin homolog.

224 es reconstituted with purified, N-terminally TAP-tagged Drs2p, both ATPase and flippase activity were

225 Collectively, these results confirm that TAP can import peptides into phagosomes, but they sugges

226 processed cytosolically, we demonstrate that TAP transport and new protein synthesis are required for

227 Biochemical analyses indicated that TAP-1 operates at the level of Raf, since TAP-1 function

228 The structure indicates that TAP stimulates isomerization through simple, adhesive, s

229 We propose that TAP/TPN complex formation is driven by hydrophobic inter

230 Here we show that TAP-independent presentation can be mediated by autophag

231 We show that TAP/p32 is required for the removal of Drosophila protam

232 The TAP block procedure is beneficial in reducing postoperat

233 The TAP translocates peptide Ags into the lumen of the endop

234 The TAP-k web server and downloadable Perl script are freely

235 In contrast, the TAP-k satisfies most of the criteria desired in an ideal

236 ere we further advanced the workflow for the TAP approach and determined the infection-dependent inte

237 QoR-40 scores on postoperative day 1 for the TAP block group (median [interquartile range (IQR)], 178

238 es, and with all degrees of movement for the TAP group (appendix).

239 Results: The mean (SD) ages in the TAP block (n = 19), PILA (n = 24), and control (n = 23)

240 t reduction of opioid use in the PACU in the TAP block group (median [IQR], 0 [0-1.3]) when compared

241 studies elucidate structural changes in the TAP NBD in response to nucleotides and substrate, provid

242 The effects of the TAP block and PILA on pain in the postoperative care uni

243 reover, staining following inhibition of the TAP demonstrated that all three viral ligands were prese

244 I expression due to mutations in one of the TAP genes.

245 With time, the pain scores of the TAP group changed a little, whereas a decreasing trend c

246 deterioration was observed in animals of the TAP group.

247 TAP1/TAP2 complexes, but the location of the TAP peptide-binding pocket remains unknown.

248 A major product of the TAP+ribose reaction is a beta-ribofuranoside of TAP, whi

249 Purification of the TAP-tagged UL17 or a similarly TAP-tagged UL25 protein c

250 ing and 3' end formation with loading of the TAP/NXF1 export receptor onto mRNA.

251 g/kg), 35 young healthy adults performed the TAP during functional magnetic resonance imaging (fMRI).

252 ient to form an annular belt surrounding the TAP complex.

253 ber of epitopes can be presented through the TAP-independent pathway, the precise mechanism for which

254 the trial and were randomized to undergo the TAP block procedure with either bupivacaine (n=24) or sa

255 and RPS-BLAST provided examples of using the TAP-k and pooled ROC(n) scores to evaluate sequence retr

256 viously found in editosomes isolated via the TAP-tagged endonucleases KREN1, KREN2, or KREN3.

257 eine residue is covalently appended with the TAP promoiety.

258 y and find that several arginines within the TAP and RNA binding domains are methylated in vivo.

259 In addition, thiamphenicol (TAP) and florfenicol (FF), antibiotics with a structure

260 (CLO), dicloxacillin (DICLO), thiamphenicol (TAP), florfenicol (FFC) and chloramphenicol (CAP) were s

261 o bind HLA-A*0201, 10 were confirmed through TAP-deficient T2 cell HLA stabilization assay.

262 es on HLA class I by generating them through TAP-independent processing pathways.

263 These TIPS-TAPs are either crystalline or amorphous, depending upon

264 ational arrest that precludes ATP binding to TAP and, thus, activity of TAP, thereby preventing the p

265 ptide transport by inhibiting ATP binding to TAP.

266 it triggers transfer of the RNA from REF to TAP.

267 Similar to TAP deficiency in the absence of a regular CD8 T-cell co

268 se as a genetic determinant of resistance to TAPs.

269 somal vacuoles, to which peptide transporter TAP and upregulated MHC class I (MHC I) are recruited.

270 ents like proteasome and peptide transporter TAP.

271 The structure shows that ICP47 traps TAP in an inactive conformation distinct from the normal

272 n scores at each time and type of treatment (TAP vs sham blocks) was assessed using general linear mo

273 midine nucleobase (2,4,6-triaminopyrimidine, TAP) and ribose, which produces TAP-ribose conjugates in

274 malarial compounds, the triaminopyrimidines (TAPs), which emerged from a phenotypic screen against th

275 c cells, and HeLa cells expressing truncated TAP subunits.

276 lus transcription activator protein TTHB099 (TAP) [homolog of Escherichia coli catabolite activator p

277 a from 76 consecutive patients who underwent TAP TAVR at our site.

278 locked, as well as individuals with unusable TAP complexes, are able to present peptides on HLA class

279 Based on similar results obtained using TAP mutants that lack tapasin binding to either N-termin

280 Editosomes isolated via TAP tag fused to KREPB6, KREPB7, or KREPB8 have a common

281 her than SIINFEKL import into phagosomes via TAP.

282 r regression by dipalmitoylated peptides was TAP independent.

283 Apparently, this cross-presentation was TAP-independent, as it was conducted not only by B cells

284 When TAP binds a REF:RNA complex, it triggers transfer of the

285 Cancerous cells and infected cells in which TAP is blocked, as well as individuals with unusable TAP

286 ied the UL15, UL28, and UL33 subunits, while TAP of vFH499-infected cells confirmed previous findings

287 These data may explain why TAP-deficient individuals live normal life spans without

288 e classical MHC class I gene coevolving with TAP transporters, whereas class I genes are poorly expre

289 HDAg-L was found to colocalize with TAP and Aly in the nucleus.

290 The TAO approach, compared with TAP TAVR, was associated with lower combined bleeding an

291 in vivo and invitro, interacts directly with TAP (Tip-associated protein; the major mRNA export recep

292 is highly polymorphic, but co-evolution with TAP and class I genes remains unclear.

293 XF1, and ICP27 must be able to interact with TAP/NXF1 for efficient export of HSV-1 early and late tr

294 interactions, including the interaction with TAP/NXF1.

295 nto the ER membrane, where it interacts with TAP.

296 ICP27 binds viral mRNAs and interacts with TAP/NXF, providing a link to the cellular mRNA export pa

297 binds cellular mRNAs and also interacts with TAP/NXF.

298 ive binding mode via the PHEHAT ligand, with TAP-mediated hydrogen bonding capabilities.

299 fect is more extensive than in patients with TAP deficiency.

300 tered paracetamol-diclofenac with or without TAP blocks.