ライフサイエンスコーパス: TARC

1 TARC, MDC, and SDF-1 increased intracellular calcium con

2 TARC, which also induced calcium mobilization in CCR4 tr

3 inducible expression of CC (I-309, Exodus-1, TARC, RANTES, MCP-1, MDC, and MIP-1 alpha and -1 beta),

4 accharide (LPS)-induced production of MCP-1, TARC, and MDC by DCs was clearly enhanced.

5 iated cytokines and chemokines (IL-5, IL-13, TARC/CCL17), but not IFN-gamma levels, significantly cor

6 -regulated chemokine/CC chemokine ligand 17 (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22)

7 ulinemia and elevated levels of serum IL-18, TARC and fecal EDN.

8 IL-17A and TARC/CCL17 were significantly augmented in patients that

9 MDC (macrophage-derived chemokine/CCL22) and TARC (thymus and activation-regulated chemokine/CCL17),

10 dko mice involving eotaxin, MARC (CCL7), and TARC (CCL17).

11 Our results suggest that CCR4 and TARC are important in the recognition of skin vasculatur

12 s to generate chemokines such as eotaxin and TARC.

13 Since MDC and TARC are both expressed in the thymus, one role for thes

14 In addition, the genes for MDC and TARC are encoded by human chromosome 16.

15 MDC and TARC competed for binding to CCR4, while no binding comp

16 Both MDC and TARC functioned as chemoattractants for CCR4 transfectan

17 dy that CCR4 is a major receptor for MDC and TARC on T lymphocytes, as anti-CCR4 mAbs significantly i

18 The MDC and TARC receptor CCR4 was expressed on platelets, and an an

19 s the secretion of the CC-chemokines MDC and TARC.

20 R4, the common specific receptor for MDC and TARC.

21 ibit the migration of these cells to MDC and TARC.

22 TSLP and TARC/CCL17 expression correlated with airway obstruction

23 Immunohistochemistry reveals anti-TARC reactivity of venules and infiltration of many CCR4

24 cellular provenance of TSLP, Th2-attracting (TARC/CCL17, MDC/CCL22, I-309/CCL1), and Th1-attracting (

25 CCR4 antibody blocked aggregation induced by TARC or MDC.

26 emokine production of CCL22 (MDC) and CCL17 (TARC), two chemokines previously shown to be important i

27 ation of CXCL10 (IP-10), CCL22 (MDC), CCL17 (TARC), CCL-2 (MCP-1) and CCL-13 (MCP-4) in both asthma g

28 We furthermore show that the chemokine CCL17/TARC, but not CCL27/CTACK, was sufficient to induce the

29 relation exists among CCR4, its ligand CCL17/TARC, and the cutaneous lymphocyte-homing process.

30 ngs demonstrate that RSV induces a chemokine TARC that has the potential to recruit Th2 cells to the

31 he thymus and activation-regulated chemokine TARC, were unchanged.

32 e cytokine responses, and altered chemokine (TARC and CCL17) responses.

33 thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC)), CD (10 pr

34 s thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC).

35 Thymus- and activation-regulated chemokine (TARC) recruits Th2 cells to sites of inflammation.

36 , thymus and activation-regulated chemokine (TARC), and I-309] and two RNases (angiogenin and RNase 4

37 MDC), thymus activation-regulated chemokine (TARC), and stromal cell-derived factor one (SDF-1) are h

38 , thymus and activation regulated chemokine (TARC), eotaxin, and eotaxin-2 acted specifically on in v

39 d thymus and activation-regulated chemokine (TARC), has been implicated as a preferential marker for

40 , thymus and activation-regulated chemokine (TARC), IL-8, monocyte chemoattractant protein-1 (MCP-1),

41 , thymus and activation-regulated chemokine (TARC), soluble interleukin 6 receptor (sIL-6R), and solu

42 thymus- and activation-regulated chemokine (TARC), which contains 37% identical amino acids.

43 (thymus and activation-regulated chemokine (TARC)/CCL17, macrophage-derived chemokine (MDC)/CCL22, I

44 f Thymus and Activation-Regulated Chemokine (TARC/CCL17) and interleukin (IL)-5 and an increase in IP

45 e thymus and activation-regulated chemokine (TARC; CCL17) is displayed by cutaneous (but not intestin

46 L12), thymus activation regulated chemokine (TARC; or CCL17), and macrophage-derived chemokine (MDC;

47 nd thymus- and activation-related chemokine (TARC) by DCs.

48 C), thymus and activation-related chemokine (TARC), C10), and d) constitutive (lungkine, secondary ly

49 r thymus and activation regulated chemokine; TARC) and CCL22 (or macrophage-derived chemokine; MDC),

50 roduction of the T(H)2-attracting chemokines TARC (thymus and activation-regulated chemokine; also kn

51 efore respond to its ligands, the chemokines TARC and MDC.

52 ptosis and cell migration toward chemokines (TARC/CCL17, IP-10).

53 In contrast, TARC, MCP-1, and MDC were not induced, suggesting the ex

54 ted with GITR: Fc FP confirmed corresponding TARC and MCP-1 protein production by keratinocytes.

55 The corresponding receptors for eotaxin, TARC, and IP-10 are also differentially expressed on Th1

56 In desensitization Ca flux experiments, TARC and STCP-1 bound to a common receptor and therefore

57 se data suggest a positive feedback loop for TARC production between RSV infection and Th2 cytokines.

58 (CCR4), recently shown to be a receptor for TARC.

59 Staining for TARC was present on lacrimal gland ductular cells but no

60 acute RSV infection of BALB/c mice increased TARC production in the lung.

61 After RSV infection, TARC production significantly increased in the vaccinia

62 Moreover, vorino-stat inhibited TARC secretion by dendritic cells that were activated by

63 metalloproteinases 2 and 9, chemokines (KC, TARC), and cytokines (IFN-gamma) seen in bronchoalveolar

64 Cells expressing the CCR4 ligand TARC (thymus- and activation-regulated chemokine) were d

65 The chemokines Mig (CXCR3 ligand), TARC (CCR4 ligand), and MCP-2 (CCR5 ligand) were detecte

66 abundant expression of the two CCR4 ligands TARC/CCL17 and MDC/CCL22.

67 ytes express CCR4 and respond to its ligands TARC and MDC, whereas Th1 lymphocytes express CXC chemok

68 e expression pattern of CCR4 and its ligands TARC/CCL17 and MDC/CCL22 in the peripheral blood and ski

69 se findings suggest that the chemokines MDC, TARC, and SDF-1, which may be produced during inflammato

70 Moreover, TARC induces integrin-dependent adhesion of skin (but no

71 by killing CCR4(+) cells through delivery of TARC-fused toxins or depleting Tregs and preventing lung

72 ry pads activates remotely the expression of TARC/CCL17 and MDC/CCL22 in the lungs.

73 rated a marked increase in the production of TARC.

74 synergistic effect of RSV and IL-4/IL-13 on TARC production reflected differential induction of NF k

75 Serum TARC may be related to the part of gastrointestinal food

76 -tested negative milk-specific IgE and serum TARC levels (2210 pg/mL).

77 gative milk-specific IgE and very high serum TARC levels (25200 pg/mL) at the time of onset.

78 ipheral eosinophilia (5820 /muL), high serum TARC levels (4730 pg/mL) and positive milk-specific IgE

79 al eosinophilia (2923 /muL), very high serum TARC levels (49100 pg/mL) and positive milk-specific IgE

80 We measured serum TARC (Thymus and activation-regulated chemokine, CCL-17)

81 k-specific IgE (0.42 UA/mL) and normal serum TARC levels (1250 pg/mL).

82 negative milk-specific IgE and normal serum TARC levels (198 pg/mL).

83 a beta-ribofuranoside of TAP, which we term TARC.

84 memory T cells, which uniformly express the TARC receptor CC chemokine receptor (CCR)4.

85 regulatory T cells (Tregs) that express the TARC/MDC-specific chemokine receptor CCR4, thus generati

86 me 16q13, the same position reported for the TARC gene.

87 nd STAT6 by the two stimuli (both are in the TARC promoter).

88 In line with this, TARC/CCL17 (a CCR4 ligand) induces preferential chemotax

89 ectin ligand+ T cells migrate efficiently to TARC and to CTACK.

90 fully desensitized a subsequent response to TARC.

91 robust chemotactic and adhesive responses to TARC, consistent with a selective role for CCR4 in skin

92 Cells expressing mRNA encoding TSLP, TARC/CCL17, MDC/CCL22, and IP-10/CXCL10, but not I-TAC/C

93 lium and submucosa expressing mRNA for TSLP, TARC/CCL17, MDC/CCL22, and IP-10/CXCL10, but not I-TAC/C

94 Our data implicate TSLP, TARC/CCL17, MDC/CCL22, and IP-10/CXCL10 in asthma pathog

95 the asthmatic biopsies which correlated with TARC and MDC expression and airway obstruction.