ライフサイエンスコーパス: TATA box

1 n start sites and a proximal Sp1 site but no TATA box.

2 core motifs located downstream from the p21 TATA box.

3 ng sites (TFBSs) and their distance from the TATA box.

4 ergo nucleosome remodeling tend to contain a TATA box.

5 ity to stabilize the binding of TFIID to the TATA box.

6 ) core promoter motif is associated with the TATA box.

7 y as the start was moved downstream from the TATA box.

8 tinct preference for the DPE relative to the TATA box.

9 s are not the only selective pressure on the TATA box.

10 dependent on other bases within a particular TATA box.

11 making them similar to those on a consensus TATA box.

12 residues directly upstream of the SV40 early TATA box.

13 ding protein (TBP/Spt15) associated with the TATA box.

14 rated promoter-like activity and possessed a TATA box.

15 d by its separation distance relative to the TATA box.

16 mutational target size and the presence of a TATA box.

17 t multiple sites 40-120 bp downstream of the TATA box.

18 ctivator-recruited SAGA transfers TBP to the TATA box.

19 tiator sequence downstream of a nonconsensus TATA box.

20 upstream and within the major groove of the TATA Box.

21 ce preference for the downstream half of the TATA box.

22 f CRELD2, this region is GC-rich and lacks a TATA box.

23 e general transcription factors requires the TATA box.

24 T, Est-1, Oct-1, CNBP, and NFkB, but lacks a TATA box.

25 endent on sequences upstream of the archaeal TATA box.

26 transcriptional initiation sites and lacks a TATA box.

27 sive contacts upstream and downstream of the TATA box.

28 identified core promoter elements, such as a TATA box.

29 RNA polymerase II complex at the downstream TATA box.

30 0 (ORF50)/Rta responsive element (RRE) and a TATA box.

31 to a 22-bp sequence that does not resemble a TATA box.

32 ich our data suggest is positioned by a weak TATA box.

33 open chromatin configuration at the fbp1(+) TATA box.

34 for an extended distance of 1.2 kb from the TATA box.

35 etween positions -70 and -9, centered on the TATA box.

36 iched in other well-known motifs such as the TATA box.

37 strongly at the tandem CCAAT motifs near the TATA box.

38 mine (poly-T), as well as to the traditional TATA box.

39 TATA box to the same extent as the consensus TATA box.

40 res to the amplification associated with the TATA box.

41 binds to core promoter DNA, recognizing the TATA-box.

42 m, may help initiate transcription from weak TATA boxes.

43 for the low transcription levels of the weak TATA boxes.

44 ption factor binding sites and high affinity TATA boxes.

45 cleosome is positioned over its three-phased TATA boxes.

46 ate with either transcription start sites or TATA boxes.

47 s and are embedded with precisely positioned TATA boxes.

48 nlike TBP, TRF2 fails to bind DNA containing TATA-boxes.

49 n from nucleotides -372 to +814, a canonical TATA box (-38/-32), and putative transcription factor bi

50 ecruit the TATA-binding protein (TBP) to the TATA box, a critical step in eukaryotic gene regulation.

51 D-dominated genes, RNR3 contains a consensus TATA-box, a feature of SAGA-regulated core promoters.

52 instead of binding together with TBP at the TATA box, activator-recruited SAGA transfers TBP to the

53 ion motifs enriched in the bimodal gene set (TATA boxes, alternative promoters, methlyation) have kno

54 by eukaryotic RNA polymerases to bind to the TATA box, an eight-basepair DNA promoter element, to ini

55 Archaeal promoters consist of a TATA box and a purine-rich adjacent upstream sequence (t

56 iption from core promoters containing both a TATA box and an Initiator (INR) element but not from "TA

57 oter region of the AKR1C1 gene consists of a TATA box and an inverted CCAAT binding site.

58 omoter sequence (1389 bp) showed a consensus TATA box and cis-acting binding sites for several potent

59 NA Pol II and phospho-Ser2 CTD Pol II on the TATA box and coding regions.

60 Unlike TBP, TRF2 does not bind to the TATA box and could thus function as a new system factor

61 olled by many different elements such as the TATA box and downstream core promoter element (DPE).

62 ce or absence of sequence motifs such as the TATA box and DPE.

63 KLF5's promoter lacks a TATA box and has a GC-rich region.

64 ID shown to bind specific DNA sequences (the TATA box and initiator, respectively), raising the quest

65 lements identified, the sequence of a native TATA box and its significance remain elusive.

66 ase II promoters with varying spacing of the TATA box and start site.

67 scription from two core promoter motifs, the TATA box and the downstream core promoter element (DPE).

68 specific core promoter elements such as the TATA box and the initiator (INR) remains unclear and cor

69 es between the HCMV immediate-early (IE) US3 TATA box and the upstream NF-kappaB-responsive enhancer

70 P II forms an open promoter complex near the TATA box and then scans the template DNA strand for star

71 y to expectation, a nucleosome occluding the TATA box and transcription start sites did not impede tr

72 Its promoter is devoid of a TATA box and transcription starts at multiple sites.

73 ences are flexible with the exception of the TATA box and TSS, which are rigid regions irrespective o

74 TATA boxes and C/EBP-binding motifs are also present in

75 The 5' flanking regions contain putative TATA boxes and cAMP-response elements (CREs), but the TA

76 s and cAMP-response elements (CREs), but the TATA boxes and CREs exhibit gene-specific sequences, and

77 opy genes, duplicate genes tended to contain TATA boxes and less DNA methylation in the promoter regi

78 This is the first study to reveal that TATA boxes and poly (A) tails are direct targets for BBR

79 The present study demonstrates that TATA boxes and poly (A) tails are the first and second p

80 transcriptional start site elements such as TATA boxes and Sp1 sites.

81 The most conserved promoter (P3) contains a TATA-box and displays in vivo enhancer activity in a pat

82 the Inr, but functions independently of the TATA-box and DPE.

83 s lacking conventional core elements such as TATA-box and Initiator.

84 cur in all promoter sets except those with a TATA-box and without a CpG island in human.

85 es around - 34 to - 23 (expected position of TATA box) and the TSS were informative in discriminating

86 Only 29 TSS were associated with a canonical TATA box, and 14 initiated within or near the previously

87 egion, a third has a 17-bp deletion near the TATA box, and a fourth contains a Ds insertion in exon1.

88 We found that a downstream promoter element, TATA box, and GC box/Sp1 site at -29 are all individuall

89 of core promoter motifs, e.g. the initiator, TATA box, and the downstream core promoter element (DPE)

90 core promoter sequence elements such as the TATA box appear to be much less frequent than thought.

91 Characteristic "CAAT" and "TATA" boxes are absent within 1.5 kb of the transcriptio

92 example, recent studies have pointed to the TATA box as a sequence feature that can influence expres

93 In addition to a TATA box at -30 relative to the LT(i) mRNA start sites,

94 TBPc associates more rapidly than TBP to TATA box bearing DNA and dissociates more slowly.

95 th the N-terminal domain actively modulating TATA box binding by TBP and nonionic detergent modulatin

96 Direct, quantitative comparison of TATA box binding by TBP and TBPc reveals greater affinit

97 n of histone H3 at Lys-4, and recruitment of TATA box binding protein (TBP) and RNA polymerase II, bu

98 ce that inducibly express one copy of mutant TATA box binding protein (TBP) at different ages by tamo

99 esses trpEGCFBAD transcription by preventing TATA box binding protein (TBP) binding to the TATA box s

100 activating protein complex (SNAP(c)) and the TATA box binding protein (TBP) for basal transcription,

101 The TATA box binding protein (TBP) is a central component of

102 The TATA box binding protein (TBP) is the platform for assem

103 Rb binds and represses Brf-1 and TATA box binding protein (TBP), subunits of RNA pol III-

104 etail the interactions of initiation factors TATA box binding protein (TBP), transcription factor IIB

105 RT), and binding domains for USF, TFIIB, and TATA box binding protein (TBP).

106 eneral transcription machinery proteins, the TATA box binding protein (TBP).

107 Serial first [TATA box binding protein-associated factor (TBP)] and th

108 ractors identified the PHD finger of TAF3, a TATA box binding protein-associated factor with importan

109 HD finger (BRPF) family member BRPF2 and the TATA box binding protein-associated factors TAF1 and TAF

110 ly of a preinitiation complex containing the TATA- box binding protein (TBP), transcription factor B

111 hdiesterase, and TAF12, an RNA polymerase II TATA-box binding factor, cause CIN when overexpressed in

112 der these experimental conditions identified TATA-Box Binding Protein (TBP) and Importin 8 (IPO8) to

113 of the polyglutamine (polyQ) tract in human TATA-box binding protein (TBP) causes the neurodegenerat

114 TATA-box binding protein (TBP) is an essential factor th

115 The TATA-box binding protein (TBP) is required by eukaryotic

116 pression of the general transcription factor TATA-box binding protein (TBP) leads to increased RNA sy

117 archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of

118 TBP (TATA-box binding protein) is a central transcription fac

119 t of proteins (e.g alpha-synuclein, insulin, TATA-box binding protein, Sup35, p53), independent of th

120 are either independent or dependent on TAFs (TATA-box Binding Protein-Associated Factors).

121 genes are the most prominent targets of the TATA-box binding protein.

122 tion factor D (TFIID) complex is composed of TATA box-binding protein (TBP) and 13 TBP-associated fac

123 se I, and chemical cross-linking assays with TATA box-binding protein (TBP) and Rep68 indicate that b

124 which are bound by the transcription factors TATA box-binding protein (TBP) and TFB.

125 How TATA box-binding protein (TBP) and the TBP-associated fa

126 pha DNA-binding domain binds directly to the TATA box-binding protein (TBP) and, through this interac

127 In addition, c-Rel and TATA box-binding protein (TBP) appeared to occupy the pr

128 found to be dependent not upon the canonical TATA box-binding protein (TBP) but instead upon the TBP-

129 Here, we show that the TATA box-binding protein (TBP) interacts with the Cnd2 k

130 ssays that binding interactions of the human TATA box-binding protein (TBP) were disrupted on 2-chlor

131 s of the RNA polymerase (I, II, or III), the TATA box-binding protein (TBP), and transcription factor

132 en shown previously that ICP4 interacts with TATA box-binding protein (TBP), TFIIB, and the TBP-assoc

133 n complex (OC) composed of the promoter DNA, TATA box-binding protein (TBP), transcription factor B (

134 TATA box-binding protein (TBP)-associated factors (TAFs)

135 assays revealed that the IR2P interacts with TATA box-binding protein (TBP).

136 rotein and mRNA of TFIIIB subunits, Brf1 and TATA box-binding protein (TBP).

137 nits contribute to overall functions of this TATA box-binding protein (TBP)/TBP-associated factor (TA

138 t1 (modifier of transcription 1) dissociates TATA box-binding protein (TBP):DNA complexes, offering a

139 DNA through interactions with promoter-bound TATA box-binding protein and transcription factor IIB.

140 These findings demonstrate how mutant TATA box-binding protein at the endogenous level affects

141 Mutant TATA box-binding protein binds more tightly to the trans

142 Neuronal expression of mutant TATA box-binding protein causes age-dependent neurologic

143 However, UBF recruits the pol I-specific, TATA box-binding protein containing complex SL1 and pol

144 model that expresses one copy of the mutant TATA box-binding protein gene, which encodes a 105-gluta

145 polymerase II (RNAPII), enhanced binding of TATA box-binding protein to RNAPII and selectively promo

146 Here we show that TBP (TATA box-binding protein)-related factor TRF2, but not T

147 ion of TFIID in a simple system, we depleted TATA box-binding protein-associated factor (TAF)1 from D

148 ed by a polyglutamine tract expansion in the TATA box-binding protein.

149 ral transcription factor TFIID comprises the TATA-box-binding protein (TBP) and approximately 14 TBP-

150 0 (Rplp0), non-POU domain containing (Nono), TATA-box-binding protein (Tbp) and eukaryotic translatio

151 or 1, a multisubunit complex composed of the TATA-box-binding protein (TBP) and three TBP-associated

152 Here we consider the concept of TATA-box-binding protein (TBP) family proteins as "syste

153 TATA-box-binding protein (TBP)-related factor 3, TRF3 (a

154 romoters by mimicking and replacing cellular TATA-box-binding protein (TBP).

155 expanded polyglutamine (polyQ) repeat in the TATA-box-binding protein (TBP).

156 be overcome by cooperative interactions with TATA-box-binding protein at a U6 promoter but not at a U

157 nalysis of the heat-shock gene hsp82 and the TATA-box-binding protein gene tbp in multiple bdelloid s

158 approach and identified the Drosophila TBP (TATA-box-binding protein)-related factor 2 (TRF2) as an

159 biochemistry, and genetics to show that TBP (TATA-box-binding protein)-related factor 2 (TRF2) select

160 -initiation complex by M. thermautotrophicus TATA-box-binding protein, transcription factor B, and RN

161 into the co-evolution hypothesis of MBF1 and TATA-box-binding proteins.

162 ted promoters revealed previously identified TATA box, BRE, and the putative initiator element.

163 ment over the promoter region tend to have a TATA box buried in an NPS and tend to be highly regulate

164 eam regions of the genes lack a conventional TATA box but contain CpG islands, cCpG-I and cCpG-II for

165 core promoter of porcine TGFBR1 gene lacks a TATA box but contains GC boxes and CAAT boxes.

166 and transcription factor IIB and requires a TATA box but not a transcription factor IIB recognition

167 n of the BHLF1 transcript or deletion of the TATA box, but not the putative ATG initiation codon, red

168 es not require either the forward or reverse TATA boxes, but is instead dependent on residues in the

169 Carcinogen adducts that bind to the TATA box can hamper this important process.

170 expression, affected by the sequence of the TATA box, can be beneficial after an acute change in env

171 al gamma-gene promoter, i.e. CACCC, CCAAT or TATA box, can be disrupted without affecting the activat

172 C-terminal extension interacts with the TBP/TATA box complex and contributes to the recruitment of B

173 The TATA box consensus sequence is a good predictor of promo

174 adenosine monophosphate (CldAMP)-substituted TATA box consensus sequences.

175 in the yeast genome are heavily biased to be TATA box containing genes and not to be DPN genes.

176 erspecies genetic rewiring due to unbalanced TATA box-containing genes among the yeasts.

177 Strikingly, TATA box-containing genes are associated with responses

178 Initiation of human Pol III from TATA box-containing Pol II promoters under conditions wi

179 -RACE experiments that established a second, TATA box-containing promoter (P2) upstream of the third

180 In TATA-box-containing promoters, nucleosome architecture i

181 At TATA-box-containing promoters, which are depleted of TFI

182 act, CldAMP substitution for dAMP within the TATA box decreased in vitro pol II transcription by appr

183 nd that the p21 core promoter directs rapid, TATA box-dependent assembly of RNAP II preinitiation com

184 For instance, TBP activates TATA-box-dependent core promoters, whereas TBP-related f

185 usion protein is able to recruit pol III for TATA box-directed transcription of linear and supercoile

186 (containing the TA-rich region, GCC-box, and TATA-box) displayed a 30-fold induction by MeJA treatmen

187 at TAF11/TAF13 competes for TBP binding with TATA-box DNA, and also with the N-terminal domain of TAF

188 Interestingly, the TATA box does not play a role in Crz transcription in mo

189 T-rich promoter category the position of the TATA-box does not correlate with the transcription start

190 promoter both upstream and downstream of the TATA box during closed complex formation.

191 ) in intron 3 of this gene, which contains a TATA-box element and p53-DNA-binding sequences.

192 la homeotic (Hox) gene promoters, which lack TATA-box elements, contain functionally important DPE mo

193 sequence located proximally upstream of the TATA box enhances transcription from a minimal CYC1 prom

194 nd specific promoter architectural features (TATA box enrichment, CpG island depletion).

195 the early promoter, with one adjacent to the TATA box (ERR1) and one approximately 600 bp upstream fr

196 d one approximately 600 bp upstream from the TATA box (ERR2).

197 trasting developmental stage preferences and TATA box frequencies.

198 tein (TBP) affinity alone does not determine TATA box function.

199 moter P2, located upstream of P1, contains a TATA box, GC boxes, a CCAAT box and GATA and ets consens

200 M1BP and GAF genes, a significant portion of TATA box genes appear to be controlled at preinitiation

201 xpression in a predictable fashion, stronger TATA boxes have very little effect on noise in our synth

202 CT complex (yFACT) promotes TBP binding to a TATA box in chromatin both in vivo and in vitro.

203 TSSs) occur about 30-35 bp downstream of the TATA box in metazoans, TSSs are located 40-120 bp downst

204 The TATA binding protein (TBP) binds to TATA boxes in core promoters and bends the TATA DNA.

205 bending by human TBP on consensus and mutant TATA boxes in the absence and presence of TFIIA.

206 R inhibits gene transcription by binding the TATA boxes in the transcriptional regulatory region, but

207 ectly regulates gene expression by targeting TATA boxes in transcriptional regulatory regions as well

208 Finally, we show that although stronger TATA boxes increase expression in a predictable fashion,

209 Eliminating the distal LANApi TATA box increased maximal output and lowered the induct

210 ed by mutations in TBP or by deletion of the TATA box, indicating that TBP binding is a prerequisite

211 SCP1 contains four core promoter motifs-the TATA box, initiator (Inr), motif ten element (MTE) and d

212 d consist of functional elements such as the TATA box, initiator, and downstream core promoter elemen

213 functional core promoter motifs (such as the TATA-box, initiator [Inr], and downstream core promoter

214 in which canonical sequence features such as TATA-box, Initiator, and GC content do play a significan

215 several criteria including identification of TATA boxes, INRs, and DPEs plus support from proteomic a

216 U6 genes utilize a PSEA but have a TATA box instead of the PSEB.

217 ic protein-DNA recognition events, the PwTBP-TATA box interaction is accompanied by a large negative

218 other functional class, conservation of the TATA box is highly predictive of iHMR maintenance, refle

219 RNA Pol II recruitment to the target gene TATA box is not required for the intergenic transcriptio

220 ase II transcription machinery that binds to TATA boxes located in the core promoter regions of many

221 ic stability of complexes on a non-consensus TATA box, making them similar to those on a consensus TA

222 tein interactions, such as those involved in TATA-box-mediated transcription initiation and the utili

223 inal domain of TAF1 previously implicated in TATA-box mimicry.

224 A canonical TATA box motif was identified upstream of the major star

225 While the presence of a TATA-box motif in the promoter has been strongly linked

226 5'-flanking region showed that the classical TATA-box motif near transcription initiation sites was a

227 contains a high GC content, a non-canonical TATA box, multiple stimulating protein 1 (SP1)/GC elemen

228 in whole-cell extracts or in vivo with these TATA box mutants indicated that factors, other than thos

229 g highly purified proteins and CYC1 promoter TATA box mutants.

230 tems, utilizing reduction of noise levels by TATA box mutations and noise propagation in transcriptio

231 Specifically, we introduce TATA box mutations into promoters driving TetR expressio

232 plain the experimentally observed effects of TATA box mutations.

233 ranscriptionally favorable locations for the TATA box near the nucleosomal DNA-entry site and at dyad

234 was mapped at -27 from the ATG has neither a TATA box nor a CCAAT box.

235 TATA binding protein (TBP) and TFIID to the TATA box of core promoters and ICP4 has been shown to in

236 ze the binding of either TBP or TFIID to the TATA box of representative early, late, and INR-mutated

237 The dodecamer contains the TATA box of the adenovirus major late promoter.

238 itate TFIIA stabilized binding of TBP to the TATA box of the early tk promoter.

239 ene: these changes require initiation at the TATA box of the gene.

240 t effectively stabilize TFIID binding to the TATA box of the INR-mutated late promoter.

241 can no longer stabilize TFIID binding to the TATA box of the late promoter and requires the additiona

242 ATP-dependent chromatin remodeling near the TATA box of the RANTES promoter.

243 equence (TGTAAATA) is a perfect match to the TATA box of the RNA polymerase III-transcribed U6 small

244 When the TATA box of the tk promoter or the initiator element (IN

245 could stabilize the binding of TFIID to the TATA box of the wild-type gC promoter.

246 demonstrate that the effect of changing the TATA box on gene expression is the same for all syntheti

247 we analyze the effects of different strength TATA boxes on various aspects of combinatorial cis-regul

248 me transcription start site, and depend on a TATA box or AT-rich region but not the downstream promot

249 the presence of consensus motifs such as the TATA box or initiator elements, which attract and direct

250 The expression of genes that contain TATA box or occupied proximal nucleosome (OPN) tends to

251 On the other hand, genes without TATA box or with depleted proximal nucleosome (DPN) are

252 activation, whereas disrupting the predicted TATA boxes or Oct-1 binding elements had no effect.

253 transcriptional activity upon mutation of a TATA-box or DPE can be compensated by the addition of an

254 The mutable genes were enriched for TATA boxes possibly because they are larger mutational t

255 depletion irrespective of the presence of a TATA-box, possibly reflecting a weaker contribution to T

256 e 2.5-kb mpz mRNA is expressed from a single TATA box promoter.

257 es transcription of the IMPDH gene (IMD2) at TATA box-proximal "G" sites, producing attenuated transc

258 a transcription factor binding site and the TATA box region in an inducible yeast promoter and measu

259 The Mig1 repressor binding and putative TATA box regions were unchanged among four mutant promot

260 ported that the region upstream of the UL127 TATA box repressed expression from the UL127 promoter.

261 escribed repressor element that overlaps the TATA box restored promoter activity in TBP-het cells, su

262 eliminate the RNA Pol II PIC by deleting the TATA-box resulted in loss of transcription, but enhancer

263 omoter CpG methylation nearby site-alpha and TATA box, reversible after DNA methyltransferase 1 deple

264 TA function and structure depend both on the TATA box sequence and on the TBP species.

265 the TATA binding protein to bind a distinct TATA box sequence and promote antimicrobial peptide expr

266 udy the recognition of a PT-ACRAMTU-modified TATA box sequence by TATA-binding protein (TBP).

267 tiple approaches have arrived at a consensus TATA box sequence of TATA(T/A)A(A/T)(A/G).

268 ATA box binding protein (TBP) binding to the TATA box sequence.

269 Comparison of the 5'-UTR and TATA box sequences of CYP85A1 and CYP85A2 revealed high

270 mal kinetics even in the absence of the PHO5 TATA box, showing that transcription of the gene itself

271 Putative CAAT-like box, but not TATA-box sites were identified.

272 ately upstream and downstream of the BRE and TATA box suggest that the composition and structure of a

273 resence of a functional RRE and a downstream TATA box suggested that this region serves as an ORF50/R

274 ith codon usage is comparable to that of the TATA box, suggesting that the effect of translation on n

275 affected by helical phasing relative to the TATA box, suggesting that Z-DNA effects transcription wi

276 ss evident at promoters containing canonical TATA boxes, suggesting a model where transcription initi

277 c promoter libraries with different strength TATA boxes, suggesting that many of the salient aspects

278 However, a "strong" TATA box ("TATAAA") eliminates the need for the PU.1 bin

279 TATA-containing promoters have the canonical TATA box (TATAWAWR).

280 omain-wide remodeling, while deletion of the TATA box that nearly abolishes transcription is permissi

281 One critical element of promoters is the TATA box, the docking site for the RNA polymerase holoen

282 les carrying a single mutation in either the TATA-box, the TATA-element or the proximal CBE had undet

283 As GABP is widely expressed, a strong TATA box thus alleviates promyelocytic cell specificity

284 ther independently or cooperatively with the TATA box to direct PIC formation and transcription; and

285 mble studies, TBP was found to bend a mutant TATA box to the same extent as the consensus TATA box.

286 says and maps to a region extending from the TATA box to the transcription initiation site.

287 A" element (-32/-27), a "weak" but essential TATA box, to bring TBP/TFIID to the transcription start

288 We found that Dfa(A) acts as a repressor of TATA-box transcriptional promoters.

289 and unbending revealed that on the consensus TATA box two kinetically distinct populations of TBP-DNA

290 T-ACRAMTU adducts in the minor groove of the TATA box was varied by selective elimination of potentia

291 Applying criteria associated with TATA boxes we queried several Saccharomyces genomes and

292 o the sequence requirements for a functional TATA box, we performed transcription reactions using hig

293 nd complexes between TBP and a non-consensus TATA box were kinetically unstable even at 50 mM KCl.

294 single operator site was moved closer to the TATA box, whereas for multiple operator-containing promo

295 transcriptional mechanism from the canonical TATA box, which does not correlate with paused Pol II on

296 n to have an essential element suggestive of TATA boxes, which are potential targets for the TATA-bin

297 alysis of merA mRNA predicted a noncanonical TATA box with nonstandard transcription start site spaci

298 ited sharp bends at points downstream of the TATA box, with an important consequence: The DNA at the

299 lexes to closely opposed forward and reverse TATA boxes, with forward transcription being transiently

300 This process depends on a TATA box within the PRY3 ORF.