ライフサイエンスコーパス: TCR alpha-beta

1 TCR alpha beta transgenic (Tg) mice have no such delay,

2 TCR alpha beta+ intestinal intraepithelial lymphocytes (

3 The Y-Ae mAb and the 1H3.1 TCR-alpha beta (V alpha 1/V beta 6) are two immune recep

4 The human T cells are all TCR alpha beta(+) and display a restricted TCRV beta rep

5 L-7(-/-)) mice have reduced numbers of B and TCR alpha beta cells, but lack mature TCR gamma delta ce

6 ma delta IELs and on subsets of NK cells and TCR alpha beta IELs.

7 nalysis of the thymocytes derived from Atm-/-TCR alpha beta+ and control mice suggested that Atm is i

8 of the T-dependent immune responses in Atm-/-TCR alpha beta+ mice indicated that Atm is dispensable f

9 Analysis of the Atm-/-TCR alpha beta+ mice indicated that the transgenic TCR a

10 relB mutant mice, positive selection of both TCR alpha beta and delta gamma T cells appeared to proce

11 All were CD3+, TCR-alpha beta+.

12 It is shown here that a CD4+CD8+ TCR alpha beta+ cell line with a TCR of known Ag and cla

13 CD4, CD8, T-cell receptor alpha/beta chain (TCR alpha beta), and TCR gamma delta.

14 ed antibodies in the absence of conventional TCR alpha beta+ T cell help.

15 Unlike conventional T cells, DNtg TCR alpha beta+NK1.1+ cells from anti-HY/Rag-2(-/-) H-2b

16 Fewer DNtg TCR alpha beta+NK1.1+ cells were found in H-2b females (

17 ve selecting background), and almost no DNtg TCR alpha beta+NK1.1+ cells were detected in H-2d animal

18 The number of DNtg TCR alpha beta+NK1.1+ cells was m prominent in male H-2b

19 Our results indicate that DNtg TCR alpha beta+NK1.1+ cells are positively selected by s

20 an increase of IL-4 secretion by CD4(+)DX5(+)TCR alpha beta(+)CD62L(low) T cells but not to increased

21 expressing thymocytes, some of which express TCR-alpha beta, suggests that the system will be valuabl

22 alpha+ IEL, although they are deficient for TCR alpha beta+ CD8 alpha beta+ cells.

23 nto the role of class I molecules in forming TCR alpha beta+ CD8+ IEL populations, we have analyzed t

24 TCR and to shield CD8(-)4(-) thymocytes from TCR alpha beta signals that impair thymocyte proliferati

25 pmental defects in Atm-/- mice, a functional TCR alpha beta transgene was introduced into these mutan

26 We find that K-/-D-/- mice have TCR alpha beta+ CD8 alpha alpha+ IEL, although they are

27 We identified TCR alpha beta pairs in the absence of accessory molecul

28 bset of the GFP-expressing cells, whereas in TCR alpha beta cells, endogenous IL-2 is more likely to

29 d immunoglobulin fractions from PyV-infected TCR alpha beta knockout mice protected SCID mice from th

30 contrast, the functional differentiation of TCR alpha beta cells and the development of TCR gamma de

31 Here, we show that premature expression of TCR alpha beta on early thymocytes curtails thymocyte ex

32 First, the early formation of TCR alpha beta appears to impair the formation and funct

33 T cells that express intermediate levels of TCR alpha beta molecules (TCRint) and the DX5 Ag (believ

34 is involved in the expansion/recruitment of TCR alpha beta+ CD8+ IEL following microbial colonizatio

35 l line, 175.2, resulted in the expression of TCR-alpha beta, and the transfectant contained a 35-kDa

36 T cell receptor (TCR) alpha beta knockout or TCR alpha beta gamma delta knockout mice contained IgG2a

37 Second, the premature TCR alpha beta contact with intrathymic MHC molecules fu

38 ch delay, consequently expressing rearranged TCR alpha beta proteins early in the ontogeny.

39 bly, among 55 T cell clones sharing the same TCR alpha beta rearrangement 18 different KIR phenotypes

40 This indicates that at least some TCR alpha beta+ CD8 alpha alpha+ IEL require only noncla

41 ls in Ii zero mice exhibit decreased surface TCR-alpha beta levels and express markers of T cell acti

42 cytes, believed to be caused by premature Tg TCR alpha beta expression via unknown mechanism(s).

43 her in vivo transgene expression levels than TCR alpha beta cells.

44 The TCR alpha beta or -gamma delta chains bind the peptide l

45 fe than in younger animals, and affected the TCR alpha beta+ CD8+ T cells more than the gamma delta T

46 tinal IELs, but only on those expressing the TCR alpha beta receptor and not the TCR gamma delta cell

47 Of the TCR alpha beta+ cells, the transgene was expressed in bo

48 lls more than the gamma delta T cells or the TCR alpha beta+ CD4+CD8- population.

49 Surprisingly, the TCR alpha beta+ CD8 alpha alpha+ IEL are significantly i

50 (LPLs), both of which preferentially use the TCR-alpha beta.

51 increased numbers of circulating and tissue TCR-alpha beta, CD4- CD8- T cells.

52 T cell maturation was strictly restricted to TCR-alpha beta T cells as the absolute number of thymic

53 pha beta+ mice indicated that the transgenic TCR alpha beta can rescue the defective T cell different

54 Unlike TCR-alpha beta cells, TCR-gamma delta cells express a di

55 for all the subjects 98% of the T cells were TCR-alpha beta-positive.

56 ndogenous IL-2 RNA upon stimulation, whereas TCR alpha beta cells express more IL-2 than GFP RNA.

57 Positive selection of T cells begins with TCR alpha beta lo thymic progenitors.