ライフサイエンスコーパス: TCR gene

1 ha chain locus, which deletes the introduced TCR gene.

2 al vectors using the well-characterized OT-1 TCR genes.

3 lineage commitment and allelic exclusion of TCR genes.

4 romoting elements are a conserved feature of TCR genes.

5 teins encoded by non-productively rearranged TCR genes.

6 e present paper, we discuss rearrangement of TCR genes.

7 ced by transfection and amplification of the TCR genes.

8 l-specific transcriptional regulation of the TCR genes.

9 ments during the recombinatorial assembly of TCR genes.

10 e "conventional" translocon organization for TCR genes.

11 habeta, that have endogenously prerearranged TCR genes.

12 a, gamma, and delta T cell antigen receptor (TCR) genes.

13 xpressed a variety of Vbeta T-cell receptor (TCR) genes.

14 led immunoglobulin (Ig) and T cell receptor (TCR) genes.

15 epair (NER) or transcription coupled repair (TCR) genes.

16 genomic scale structural detail of marsupial TCR genes, a lineage of mammals used as models of early

17 The action of TdT on mouse TCR genes accounts for approximately 90% of T cell reper

18 Thus, genomic polymorphism of TCR genes (along with the correct HLA alleles) determine

19 hich may explain the increased expression of TCR gene and accelerated transition of CD25(+)CD44(-) (D

20 le to initiate V(D)J recombination in Ig and TCR genes and lack functional T and B lymphocytes.

21 Site-specific mutagenesis of cloned TCR genes and transfection into Jurkat cells were used t

22 ress tumor antigen-specific T-cell receptor (TCR) genes and generated T lymphocytes by coculture with

23 double-negative (DN) thymocytes to assemble Tcrd genes and in CD4(+)CD8(+) double-positive thymocyte

24 llowed by the introduction of tumor-specific TCR genes, and that proved safer and more effective than

25 umor cells were CD3(-)/CD56(+); had germline TCR genes; and strongly expressed CD30, epithelial membr

26 echanisms ensuring the ordered expression of TCR genes are critical for proper T cell development.

27 Like Ig genes, TCR genes are formed by somatic rearrangements of noncon

28 uences from different species indicated that TCR genes are highly stable across primates.

29 e show in this work that Vgamma4 and Vgamma6 TCR genes are rearranged, and sterile Vgamma4 and Vgamma

30 Immunoglobulin (Ig) and T cell receptor (TCR) genes are assembled during lymphocyte maturation th

31 locations in T cells, involving a break in a TCR gene, are characteristically associated with either

32 T cell-specific genes, such as TCR genes, are regulated by a T cell enhanceosome consis

33 ed based on TREC levels and T-cell receptor (TCR) genes, as well as analysis of several sequential hu

34 xpression of both alpha/beta and gamma/delta TCR genes at an early level of vertebrate phylogeny and

35 f functional, in-frame rearrangements of the TCR genes, but the mechanism that controls the lineage c

36 The ordered assembly of immunoglobulin and TCR genes by V(D)J recombination depends on the regulate

37 xtensively using a combination of individual TCR gene cloning, followed by sequence analysis.

38 A chimeric TCR gene, comprising an anti-hapten single-chain Ab vari

39 es, dTregs were retrovirally transduced with TCR genes conferring specificity for H-2K(d) presented b

40 pic analyses of the reconstituted TRBV4-1(+) TCR genes confirmed CD1c-restricted autoreactivity of th

41 Ig and T cell receptor (TCR) genes consist of separate genomic elements, which m

42 approximately 50% of mice with prerearranged TCR genes develop spontaneous T cell lymphomas, which or

43 hermore, the undersized N regions in revised TCR genes distinguish these sequences from those generat

44 Overall, single TCR gene editing represents a clinically feasible approa

45 We developed the TCR gene editing technology that is based on the knockou

46 ould be reproduced in autologous settings by TCR gene-engineered lymphocytes.

47 iNKT cells in mice through T-cell receptor (TCR) gene engineering of hematopoietic stem cells (HSCs)

48 RTEs contained higher levels of signal joint TCR gene excision circles and were more responsive to in

49 TCR genes exhibit greater sequence diversity in individu

50 TCR gene expression was augmented, whereas NK receptor,

51 conserved with respect to V beta and V alpha TCR gene expression.

52 of GATA-3 and limiting GATA-3 regulation of TCR gene expression.

53 te development, the T-cell antigen receptor (TCR) gene expression is controlled by its promoter and e

54 IBM there is a restricted expression of the TCR gene families among the autoinvasive T lymphocytes w

55 D1d, use a restricted albeit distinct set of TCR gene families, and contribute to the early burst of

56 ns for generating potent Ag complex-specific TCR genes for use in the study of T cell interactions an

57 Transgenic NOD mice carrying alphabeta TCR genes from a class I MHC (Kd)-restricted, pancreatic

58 The TCR genes from an autoreactive K14-A(beta)b CD4 hybridom

59 ed transgenic mice expressing the rearranged TCR genes from an encephalitogenic or a nonencephalitoge

60 unction of T-CD4 T cells in-depth, we cloned TCR genes from T-CD4 T cells and generated transgenic mi

61 eneration sequencing of the T-cell receptor (TCR) genes from blood or prostate tissue was used to qua

62 this obstacle is to mutate T-cell receptor (TCR) genes from naturally occurring T cells to enhance t

63 Both Ig and TCR genes have been defined in most of the major lineage

64 etically primitive vertebrate class in which TCR genes have been identified, is addressed.

65 Thus, while it has been suggested that the TCR genes have been selected by evolution for MHC bindin

66 re have demonstrated skewed distributions of TCR genes in HIV-infected subjects but cannot directly m

67 aled a public clonotype using TRAV17/TRBV7-3 TCR genes in six out of seven HLA-B*51:01(+) patients.

68 Sequence analysis of TCR genes in Stat5b-CA Treg cells indicated that ectopic

69 elected for TRAV8/TRAJ52 (CATDLNTGANTGKLTFG) TCR genes in Th1 cells and TRBV16/(TRBD1/2)TRBJ1-7 (CGGK

70 ese mice have prerearranged T-cell receptor (TCR) genes in all cells.

71 of immunoglobulin (Ig) and T cell receptor (TCR) genes in B and T cell precursors.

72 of immunoglobulin (Ig) and T-cell receptor (TCR) genes in lymphocytes by V(D)J recombinase is essent

73 of immunoglobulin (Ig) and T cell receptor (TCR) genes in many species that are not commonly studied

74 d1 has a broader expression pattern than the TCR genes, in terms of both tissue and temporal specific

75 After transfer of the P14 TCR genes into HSCs and subsequent reconstitution of irr

76 Redirecting Ag specificity by transfer of TCR genes into PBLs is an attractive method to generate

77 We show that co-transfer of CD3 and TCR genes into primary murine T cells enhanced TCR expre

78 Transducing high-affinity TCR genes into T lymphocytes is an emerging method to im

79 n of tumor antigen-specific T-cell receptor (TCR) genes into lymphocytes redirects T cells to lyse tu

80 Transfer of tumor-specific T-cell receptor (TCR) genes into patient T cells is a promising strategy

81 Successful assembly of TCR genes is followed by surface TCR expression and test

82 issue- and stage-specific assembly of Ig and TCR genes is mediated by a common V(D)J recombinase comp

83 embly of immunoglobulin and T cell receptor (TCR) genes is blocked by defective V(D)J recombination s

84 he transfer of high-avidity T cell receptor (TCR) genes isolated from rare tumor-specific lymphocytes

85 rogenitors in the marrow have rearranged the TCR gene loci, express Valpha and Vbeta genes as well as

86 ass II (MHC II) in mice containing the human TCR gene loci.

87 the immunoglobulin (Ig) and T cell receptor (TCR) gene loci allows for the generation of B and T lymp

88 activity and functional memory formation of TCR gene modified T cells in vivo.

89 The function of T-cell receptor (TCR) gene modified T cells is dependent on efficient sur

90 NY-ESO-1(+)/HLA-A*02(+) tumor cell lines by TCR gene-modified CD4(+) T cells.

91 ith a loss of target cell specificity of the TCR gene-modified cells.

92 Substitutions that enhance the reactivity of TCR gene-modified T cells to the cognate Ag complex were

93 Extensive homology to human TCR genes, natural chimerism, and susceptibility to infl

94 enic mice have been made from the rearranged TCR genes of several of these, of which that specific fo

95 two monkeys early after infection expressed TCR genes of the V beta 13 family; 70% of these V beta 1

96 reflect intrinsic limitations of the pool of TCR genes or lipid Ags.

97 that have not successfully rearranged their TCR genes or that express a receptor with subthreshold a

98 rangements, did not sufficiently account for TCR gene organization, which limits secondary rearrangem

99 Rearrangements, expression and signaling of TCR genes play an indispensable role in this development

100 complex (MHC) class II and T-cell receptor (TCR) gene polymorphisms play important roles in rodent s

101 -joining proteins to form a functional Ig or TCR gene product, while the signal ends form a signal jo

102 positive and negative regulatory elements in TCR gene promoters, the promoter activities from 13 huma

103 Cloned cdr2-specific TCR genes provide a clinically relevant means for immuno

104 TCR gene rearrangement and expression are central to the

105 erogeneous in developmental potential before TCR gene rearrangement and suggest that in some precurso

106 Quantitative RT-PCR assessment of different TCR gene rearrangement events revealed lower levels in M

107 itored indirectly by measuring the levels of TCR gene rearrangement excision circles in peripheral T

108 cular, we now have a better understanding of TCR gene rearrangement in endomysial T cells, regulation

109 , these findings demonstrate that productive TCR gene rearrangement is associated with events that ca

110 No TCR gene rearrangement is observed in G/M cells from non

111 own-regulation of the protein RAG2, on which TCR gene rearrangement obligatorily depends.

112 tromal signals that induce functions such as TCR gene rearrangement reside mainly in the outer half o

113 in all cases and an identical clonal IgH or TCR gene rearrangement was found on PCR analysis of DNA

114 The latter involves RAG re-expression, TCR gene rearrangement, and expression of a novel TCR.

115 tailed, comprehensive computer simulation of TCR gene rearrangement, incorporating the interaction of

116 pment of T cell precursors in the absence of TCR gene rearrangement, recombinase-activating gene-defi

117 tment is determined before or independent of TCR gene rearrangement.

118 YDbSmcy share an invariant Vbeta8.2-Jbeta2.3 TCR gene rearrangement.

119 se mice are determined by factors other than TCR gene rearrangement.

120 e negative, DN) thymocytes is independent of TCR gene rearrangement; however, induction of CD5 surfac

121 ised DNA products of baboon T-cell receptor (TCR) gene rearrangement (signal-joining TCR excision cir

122 previously shown to impair T cell receptor (TCR) gene rearrangement and to cause a partial block in

123 of immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangement are reflected in the accessibili

124 cal Ig heavy chain (IgH) or T-cell receptor (TCR) gene rearrangement at initial diagnosis and subsequ

125 excisional DNA products of T-cell-receptor (TCR) gene rearrangement to measure thymic output directl

126 by measuring the excisional DNA products of TCR-gene rearrangement.

127 Further, because TCR gene rearrangements are generally limited to T linea

128 that differ from the mouse are the status of TCR gene rearrangements at the nonexpressed loci, the ti

129 p study of the junctional diversity of these TCR gene rearrangements focuses on characterization of t

130 flow cytometry and by the presence of clonal TCR gene rearrangements in four patients' posttreatment

131 Analysis and interpretation of Ig and TCR gene rearrangements in the conventional, low-through

132 el of lineage commitment in which sequential TCR gene rearrangements may influence alphabeta/gammadel

133 We analyzed the sequences of Ig and TCR gene rearrangements obtained at presentation and rel

134 by polymerase chain reaction analysis of Ig/TCR gene rearrangements, and patients were assigned to a

135 ment expressing a repertoire biased to early TCR gene rearrangements, we developed a mouse model in w

136 circles created by alphabeta and gammadelta TCR gene rearrangements.

137 vival of TN cells and its role in regulating TCR gene rearrangements.

138 well as analysis of several sequential human TCR gene rearrangements.

139 studies that have assessed T-cell receptor (TCR) gene rearrangements (GRs) present at different anat

140 based on immunoglobulin/T-cell receptor (Ig/TCR) gene rearrangements and with quantification of IKZF

141 Progenitor cells undergo T cell receptor (TCR) gene rearrangements during their intrathymic differ

142 flow cytometry, and clonal T-cell receptor (TCR) gene rearrangements in two of two pretreatment bloo

143 Immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements provide clonal markers useful f

144 sity, as detected by Ig and T-cell receptor (TCR) gene rearrangements, may represent a very useful pr

145 urface antigens, and clonal T-cell receptor (TCR) gene rearrangements.

146 81/CD42, and all had clonal T-cell receptor (TCR) gene rearrangements.

147 d that T cells expressing introduced CD3 and TCR genes recognized lower concentration of antigen than

148 transition, a survival program is initiated, TCR gene recombination ceases, cells migrate into a new

149 These data indicate a direct role for ATM in TCR gene recombination in vivo that is critical for surf

150 o the definitive process of T cell receptor (TCR) gene recombination, are presently emerging.

151 h Edelta and that might function to regulate Tcrd gene recombination events.

152 versity (D), and joining (J) segments of the TCR genes result in deletion of the intervening chromoso

153 re unable to properly rearrange their Ig and TCR genes, resulting in a severe combined immunodeficien

154 Our data suggest that a TCR gene segment in or linked to this 47-kb region may b

155 recombinase cleavage of RSSs flanking Ig and TCR gene segments in nuclei.

156 The full complement of TCR gene segments is finally known and should prove a va

157 n leading to the inactivation or deletion of TCR gene segments is unknown.

158 ch control chromatin accessibility at Ig and TCR gene segments to the RAG-1/RAG-2 recombinase complex

159 nes was examined to determine whether common TCR gene segments were used preferentially.

160 genes, the random, inexact recombination of TCR gene segments, and the vast array of possible self a

161 The rearrangement of particular Ig and TCR gene segments, however, is tightly regulated with re

162 nded DNA breaks (DSB) adjacent to the Ig and TCR gene segments.

163 les immunoglobulin (Ig) and T cell receptor (TCR) gene segments during lymphocyte development.

164 Restricted use of T cell receptor (TCR) gene segments is characteristic of several induced

165 Murine Tcra and Tcrd gene segments are organized into a single genetic l

166 The Tcra/Tcrd locus recombines Tcrd gene segments in CD4(-)CD8(-) double-negative thymo

167 Recombination of murine Tcrd gene segments is known to be regulated, at least in

168 MHC-II) gene, HLA-DR2a, and T-cell receptor (TCR) genes specific for MBP87-99/DR2a that were derived

169 T cell rearrangement of the T cell receptor (TCR) genes TCRalpha and delta is specifically regulated

170 dity, and the clones utilize a biased set of TcR genes that favor two combinations, Valpha12-beta5.1

171 gions of immunoglobulin and T-cell receptor (TCR) genes, the V(D)J recombination reaction can in prin

172 This work enables the design of safer TCR gene therapies for cancer immunotherapy.

173 ng of TGF-beta signaling blockade to enhance TCR gene therapy against advanced cancers.

174 D8-LV represents a powerful novel vector for TCR gene therapy and other applications in immunotherapy

175 a signaling in TCR-modified T cells enhances TCR gene therapy efficacy in an autochthonous mouse tumo

176 This clinical trial extends the reach of TCR gene therapy for patients with metastatic cancer.

177 TCR gene therapy is a promising approach for the treatme

178 However, TCR gene therapy is hindered by the transient presence a

179 To define a safe clinical setting for HMMR-TCR gene therapy, we analyzed transgenic T-cell recognit

180 and were analyzed as therapeutic targets for TCR gene therapy.

181 finity TCRs can then be developed for use in TCR gene therapy.

182 nificant implications for the improvement of TCR gene therapy.

183 T cell receptor (TCR) gene therapy can reconstitute CD8 T cell immunity i

184 dition to being CD3(-)/CD56(+) with germline TCR genes, these cells were CD25(+)/CD122(+)/granzyme B(

185 The ability of this anti-gp100 TCR gene to transfer high avidity Ag recognition to engi

186 The transfer of TCR genes to mature T cells to generate tumor-reactive T

187 l promoter are important for enhancer driven TCRD gene transcription.

188 Similarly to unedited T cells redirected by TCR gene transfer (TCR transferred [TR]), SE T cells eff

189 We here show that it is possible to improve TCR gene transfer by adding a single cysteine on each re

190 redirection of normal T cell specificity by TCR gene transfer can have potential applications in tum

191 an HSCs established durable, high-efficiency TCR gene transfer following long-term transplantation in

192 ificant implications for the optimization of TCR gene transfer immunotherapies widely applicable to c

193 TCR gene transfer installed BOB1 specificity and reactiv

194 TCR gene transfer into a TCR-deficient alpha beta T cell

195 TCR gene transfer into hematopoietic stem cells (HSCs) i

196 modeling of modified TCR through retroviral TCR gene transfer into Rag(-/-) mice confirmed the biolo

197 Additionally, TCR gene transfer offers unique opportunities to study t

198 However, TCR gene transfer results in competition for surface exp

199 TCR gene transfer to patient PBL can produce CTL with an

200 in cell-based assays and in a mouse model of TCR gene transfer-induced graft-versus-host disease.

201 n of autologous melanoma Ags following gp100 TCR gene transfer.

202 d antimelanoma activity following anti-gp100 TCR gene transfer.

203 d safer and more effective than conventional TCR gene transfer.

204 TCR-gene transfer represents an effective way to redirec

205 n that can be applied for the improvement of TCR-gene transfer-based treatments.

206 ome painting analyses showed no evidence for TCR gene translocations in p53-deficient thymomas, altho

207 Clonotypic T cell receptor (TCR) genes undergo ordered rearrangement and expression

208 gender-specific developmental differences in TCR gene usage and coding joint processing that could di

209 Presence of dominant clonotypes with limited TCR gene usage for both TCR alpha- and beta-chains in ty

210 TCR gene usage in the response to HA/HLA-DR appears to c

211 Da-reactive T cell Ag fine specificities and TCR gene usage in this model.

212 Analysis of TCR gene usage showed that the predominant V(alpha) segm

213 However, our knowledge of TCR gene usage within the primary intestinal tissue of H

214 ction and analyzed the cellular composition, TCR gene usage, and cytokine production of granuloma-inf

215 Despite this convergent TCR gene usage, structural and functional assays demonst

216 ed from the same subject, but show different TCR gene usage.

217 autoimmune diseases characterized by common TCR gene usage.

218 this study, we analysed the T-cell receptor (TCR) gene usage by endomysial T lymphocytes in three seq

219 Restricted T cell receptor (TCR) gene usage has been demonstrated in animal models o

220 of the differences in their T cell receptor (TCR) gene usage, all these Th1 clones required W144 as t

221 x class II restriction, and T cell receptor (TCR) gene usage.

222 ect to expression of cell surface molecules, TCR gene utilization, binding of tetrameric KdHA complex

223 to determine detailed T cell epitope(s) and TCR genes utilized by Dsg3-specific T cells.

224 and CD103 and display selective usage of the TCR gene Vbeta9.

225 Expression of this TCR gene was confirmed by Western blot analysis, immunoc

226 asic protein (MBP)-specific T cell receptor (TCR) genes, we have previously shown that mice bearing e

227 4(+) T cells engineered with this anti-gp100 TCR gene were Ag reactive, suggesting CD8-independent ac

228 The prerearranged TCR genes were expressed abnormally early in hemopoietic

229 The TCR genes were expressed in CD4+CD8- and CD4-CD8+ (singl

230 TCR genes were isolated from C6VL, a T cell tumor of C57

231 alpha and beta TCR genes were isolated from these clones, and TCR RNA w

232 The transmembrane encoding domains of the TCR genes were replaced by sequences encoding for phosph

233 een years have passed since T-cell receptor (TCR) genes were identified (reviewed in [1]).

234 om Ag-recognition elements such as alphabeta-TCR genes with the desired specificity, or Ab variable d