ライフサイエンスコーパス: TCR-CD3 complex

1 insight into the overall organization of the TCR-CD3 complex.

2 imals could be activated in vivo through the TCR-CD3 complex.

3 e participation of various components of the TCR-CD3 complex.

4 nits are spread apart upon assembly into the TCR-CD3 complex.

5 ed by antibody-mediated cross-linking of the TCR/CD3 complex.

6 locked normal T cell stimulation through the TCR/CD3 complex.

7 amma chain replaced the CD3zeta chain in the TCR/CD3 complex.

8 hesion by stimulation of T cells through the TCR/CD3 complex.

9 l for assembly and surface expression of the TCR/CD3 complex.

10 ases the cytolytic function initiated by the TCR/CD3 complex.

11 n contact with slides coated with Abs to the TCR/CD3 complex.

12 subunit to the CD3 signaling subunits of the TCR/CD3 complex.

13 ing of the structure and organization of the TCR/CD3 complex.

14 receptor (TCR) zeta chain, a subunit of the TCR/CD3 complex.

15 l surface receptors, such as the eight-chain TCR:CD3 complex.

16 ransport, and cell surface expression of the TCR:CD3 complex.

17 the ligation-induced down-modulation of the TCR:CD3 complex.

18 T cells through the T cell antigen receptor (TCR)-CD3 complex.

19 ssembly and function of the T cell receptor (TCR)-CD3 complex.

20 t remarkably similar to the T cell receptor (TCR)-CD3 complex.

21 mplex and downmodulates the T-cell receptor (TCR)-CD3 complex.

22 from that delivered by the T cell receptor (TCR)-CD3 complex.

23 tween ZAP70 and the T cell antigen receptor (TCR)/CD3 complex.

24 ered by ligation of Fas and T cell receptor (TCR)/CD3 complex.

25 stinguish between triggered and nontriggered TCR-CD3 complexes.

26 ombinations of wild-type and mutant ITAMs in TCR-CD3 complexes.

27 tide led to the engagement of less than 1000 TCR/CD3 complexes.

28 mal sequestration and degradation of surface TCR:CD3 complexes.

29 l surface expression of the T-cell receptor (TCR)/CD3 complex, a complex essential to T-cell activati

30 ce CD3zeta, which is not associated with the TCR:CD3 complex, after T cell stimulation.

31 systems have indicated that signals from the TCR/CD3 complex alone are sufficient to induce T cell un

32 cyte activation through the T cell receptor (TCR)/CD3 complex alters the avidity of the cell surface

33 th ligands specific for the T-cell receptor (TCR)-CD3 complex and CD28 receptors.

34 The T cell receptor (TCR)-CD3 complex and the costimulatory molecule CD28 are

35 Syk binds to the T cell receptor (TCR)-CD3 complex and transduces the TCR-mediated signal

36 Antibodies to the T cell receptor (TCR)/CD3 complex and the costimulatory CD28 receptor ind

37 may interact directly or indirectly with the TCR-CD3 complex and influence the signal transduction pr

38 Here we simultaneously tracked TCR-CD3 complex and phosphoinositide 3-kinase activity i

39 In addition to the TCR-CD3 complex and the two major coreceptors, CD4 and C

40 f multiple signaling pathways coupled to the TCR-CD3 complex and to the CD28 costimulatory molecule.

41 Combined triggering of TCR-CD3 complexes and NKG2D induced interleukin 2 produc

42 cells following engagement of the alphabeta-TCR/CD3 complex and CD28.

43 Bypass of both the TCR/CD3 complex and IL-1R and direct activation of prote

44 gnal derived from ligand binding to both the TCR/CD3 complex and IL-1R receptor mediates rapid activa

45 To confirm that PKA-I activation via the TCR/CD3 complex and IL-1R requires antecedent protein ty

46 ly capable of efficient interaction with the TCR/CD3 complex and may couple the TCR/CD3 complex to ot

47 signaling modules are directly linked to the TCR/CD3 complex and that they can be dissociated from ea

48 ion usually require stimulation via both the TCR/CD3 complex and the CD28 costimulatory receptor.

49 e a simple system for the stimulation of the TCR/CD3 complex and the CD28 receptor using substrates w

50 n presenting cells with the T-cell receptor (TCR)/CD3 complex, and triggering a cascade of signaling

51 tanding of the molecular organization of the TCR-CD3 complex, and provides a conceptual framework for

52 on of protein tyrosine kinases, a functional TCR/CD3 complex, and leukocyte-specific tyrosine kinase.

53 of the TCR chains and proper assembly of the TCR-CD3 complex are defective.

54 tructures of extracellular components of the TCR-CD3 complex are known, the transmembrane (TM) domain

55 ly than controls to activation through their TCR/CD3 complex, as measured by proliferation and induct

56 results firmly establish that the alphabeta TCR-CD3 complex assembled in the ER is monovalent and co

57 zeta in T cell development in vivo but that TCR/CD3 complexes associated with FcR gamma rather than

58 the JCI, evidence is presented that an anti-TCR/CD3 complex autoantibody present in SLE sera can bin

59 may be a uniquely accessible surface in the TCR/CD3 complex, because there is overlap between the bi

60 extremely proximal events downstream of the TCR/CD3 complex by focusing on the activation of ZAP-70.

61 refore, we conclude that in primary T cells, TCR/CD3 complexes can be found that are physically and f

62 C class II Ags results in formation of a CD4-TCR/CD3 complex capable of maximal signal transduction.

63 Cross-linking of the TCR/CD3 complex caused an immediate increase in [Ca2+]i

64 merization, and prevented aggregation of the TCR/CD3 complex colocalized with lipid rafts.

65 a suggest that T cell activation through the TCR/CD3 complex controls CD2 lateral mobility by a Ca2+/

66 CD5 co-cross-linking with the TCR-CD3 complex down-regulated the TCR-CD3-increased Ca2

67 regulates expression of the T cell receptor (TCR)-CD3 complex during a specific stage of thymocyte de

68 pse and cytoskeletal changes that occur upon TCR/CD3 complex engagement is still poorly understood.

69 that neonatal T cells activated through the TCR/CD3 complex express CD40L and use it to promote CD86

70 l characteristics of the components of these TCR-CD3 complex family members.

71 Clusters of T cell receptor (TCR)/CD3 complex formed in parallel with clusters of ago

72 Ligation of the TCR:CD3 complex gives rise to the generation of two tyro

73 The expression of bivalent TCR/CD3 complexes has implications regarding potential m

74 ied CD3+ IEL T cells were stimulated via the TCR-CD3 complex, high proliferative responses and cytoki

75 olocalizes with the T cell antigen receptor (TCR).CD3 complex in antigen-stimulated T cells and is in

76 that engagement of T cell antigen receptor (TCR)/CD3 complex in either Jurkat cells or peripheral bl

77 the ligation of Fas or the T-cell receptor (TCR)/CD3 complex in Emu-IEX-1 mice that direct the gene

78 We found that only TCR-CD3 complexes in dense clusters were phosphorylated

79 ERK phosphorylation events downstream of the TCR/CD3 complex, in addition to their failure to undergo

80 d differently to different structures of the TCR-CD3 complex induced by bound peptides.

81 s initiated by conformational changes of the TCR/CD3 complex, induced by a pulling force originating

82 Engagement of the T-cell receptor (TCR)-CD3 complex induces a rapid increase in the activit

83 ross-linking of the T cell antigen receptor (TCR)-CD3 complex induces rapid tyrosine phosphorylation

84 Triggering of the T cell antigen receptor (TCR).CD3 complex induces its ubiquitination.

85 Stimulation of the T cell antigen receptor (TCR).CD3 complex induces rapid tyrosine phosphorylation

86 be costimulatory with signaling through the TCR/CD3 complex inducing interleukin 2-dependent thymocy

87 n microscopy to quantify the organization of TCR-CD3 complexes into nanoscale clusters and to disting

88 raction between CD8 and the T cell receptor (TCR)-CD3 complex is constitutive or antigen induced.

89 The T-cell receptor (TCR)-CD3 complex is critical for T-cell development and

90 The eight-subunit T cell receptor (TCR)-CD3 complex is the primary determinant for T cell f

91 The T cell antigen receptor (TCR)-CD3 complex is unique in having ten cytoplasmic imm

92 Expression of the T-cell receptor (TCR):CD3 complex is tightly regulated during T-cell deve

93 We exploited the observation that the TCR-CD3 complex is clustered on T cells that have been a

94 the targeted delivery of Lck to the relevant TCR-CD3 complex is their most important function.

95 ulation and association of FcRgamma with the TCR/CD3 complex is a hallmark of systemic lupus erythema

96 In the presence of U24, the TCR/CD3 complex is endocytosed but is not recycled back

97 A+ T cells, but not CD45RO+ T cells, via the TCR/CD3 complex is sufficient to confer the ability to p

98 osine phosphorylated upon stimulation of the TCR/CD3 complex is the 120-kDa product of the c-cbl prot

99 Here, we show that the TCR:CD3 complex is constitutively ubiquitylated in immat

100 We show that the TCR:CD3 complex is very stable and is rapidly internaliz

101 luster of differentiation 3 (CD3) molecules (TCR-CD3 complex) is a key component in the primary funct

102 M1 associates with and recruits SHP-1 to the TCR/CD3 complex leading to decreased phosphorylation of

103 of T cells and that cross-linking of the new TCR/CD3 complex leads to a dramatic increase of intracyt

104 TCR/CD3 complex-mediated signals play critical roles in

105 , we have examined the in vivo role of a key TCR/CD3 complex molecule zeta-chain in regulating the di

106 ll surface, the T cell receptor for antigen (TCR)-CD3 complex must assemble in the endoplasmic reticu

107 but lack expression of the T-cell receptor (TCR)-CD3 complex on the cell surface.

108 rence in the regulation of expression of the TCR/CD3 complex on CD4+ and CD8+ T cells.

109 of the B cell-specific antigen CD19 and the TCR/CD3 complex on effector T cells.

110 Stimulation of the TCR/CD3 complex on T cells initiates rearrangement of th

111 peripheral T lymphocytes do not express the TCR/CD3 complex on their surface due to retention in the

112 Stimulation of the TCR/CD3 complex on these patients' T cells revealed defe

113 employing monoclonal antibodies against the TCR-CD3 complex or soluble peptide antigens are producin

114 ail inhibited or costimulated, respectively, TCR/CD3 complex plus CD28 mediated activation with the i

115 In response to stimulation through the TCR/CD3 complex, PP MC exhibit vigorous proliferation, m

116 ction between the intracellular regions of a TCR-CD3 complex recognizing its cognate peptide-major hi

117 ellular domains (ECDs) play in the assembled TCR-CD3 complex remain unclear.

118 etion of CEACAM1 in T cells caused increased TCR-CD3 complex signaling.

119 o differentially down modulate expression of TCR/CD3 complex subunits.

120 P MC, but not PLN MC, stimulated through the TCR/CD3 complex suppress proliferation of purified PLN T

121 erve as coreceptors for the T-cell receptor (TCR)/CD3 complex that are engaged coordinately with TCR

122 and expressed the intermediate levels of the TCR-CD3 complex that is characteristic of resting NK1.1+

123 lower threshold of activation through their TCR-CD3 complex that renders them more susceptible to st

124 eads to an increased pool of fully assembled TCR-CD3 complexes that are capable of recycling back to

125 irectly determined using intact radiolabeled TCR-CD3 complexes that were isolated with a sequential,

126 by flow cytometry, we unexpectedly observed TCR/CD3 complexes that contained two TCRs per complex.

127 eraction with MHC class II molecules and the TCR:CD3 complex through p56lck.

128 ecruits the Src kinase p56(Lck) (Lck) to the TCR-CD3 complex to phosphorylate the ITAMs, initiate int

129 mplex while localizing p56(lck) (lck) to the TCR/CD3 complex to facilitate early signaling events.

130 ostimulatory signal that cooperates with the TCR/CD3 complex to induce T cell activation, cytokine pr

131 with the TCR/CD3 complex and may couple the TCR/CD3 complex to other surface components capable of e

132 racellular signaling domains that couple the TCR/CD3 complex to the downstream signaling machinery.

133 The TCR:CD3 complex transduces signals that are critical for

134 Engagement of the TCR/CD3 complex triggers a cascade of events that result

135 urther analyses showed that recycling of the TCR-CD3 complex was impaired, leading to increased lysos

136 Third, the recruitment of ZAP-70 to the TCR/CD3 complex was seen only in animals with an increas

137 e of bivalency among fully assembled, mature TCR/CD3 complexes was sufficient to impact the functiona

138 nd functional cell surface expression of the TCR-CD3 complex were restored.

139 eads coated with antibodies specific for the TCR-CD3 complex were sufficient to induce T cell polariz

140 k-accessible PRS ("open-CD3"), although most TCR-CD3 complexes were inaccessible to Nck ("closed-CD3"

141 In contrast, soluble antibodies to the TCR.CD3 complex were ineffective, indicating that they f

142 urkat cells, which coexpress PECAM-1 and the TCR/CD3 complex, were INDO-1AM-labeled and then incubate

143 y related components of the T cell receptor (TCR)-CD3 complex which is essential for the assembly and

144 ma-chain expression when stimulating via the TCR/CD3 complex with anti-CD3 Ab.

145 bitory for T cell responses initiated by the TCR/CD3 complex with the inhibition dependent upon the I

146 en Th1 cells were activated only through the TCR/CD3 complex, with or without IL-2 costimulation.