ライフサイエンスコーパス: TCR-delta

1 TCR delta 1 cellular expression was assessed in skin bio

2 TCR delta 1 expression in primary cutaneous lymphomas is

3 TCR delta downregulation in double-positive thymocytes d

4 TCR delta-deficient mice (lacking gammadelta T cells) ex

5 TCR-delta(-/-) mice had decreased clinical manifestation

6 TCR-delta(-/-) mice had decreased eosinophilic infiltrat

7 TCR-delta(-/-) mice produced less Th2-associated cytokin

8 TCR-delta, TAP1, and IL-17RA deficiency specifically aff

9 prognostic value of T-cell receptor-delta 1 (TCR delta 1) expression in primary cutaneous T-cell lymp

10 beta T cells, expressing TCRs comprised of a TCR-delta variable gene (Vdelta1) fused to joining alpha

11 Moreover, the adult TCR-delta repertoire was almost identical at multiple si

12 and BALB/c mice, transient depletion of all TCR-delta(+) cells just before airway challenge resulted

13 s had no effect on AHR, and depletion of all TCR-delta(+) cells was no more effective than depletion

14 To address this issue, we have analyzed TCR delta rearrangements in a panel of mouse splenic gam

15 er (E alpha) in the control of TCR alpha and TCR delta gene rearrangement and expression.

16 the rearrangement of different TCR-beta and TCR-delta genes in thymocytes.

17 s function redundantly, as TCR-beta(-/-) and TCR-delta(-/-) mice were both resistant to OPC.

18 Both TCR-alpha-/beta+ and TCR-delta+ cells were found to be capable of producing I

19 epleted, TCR-delta(-/-) mice was the same as TCR-delta(-/-) mice.

20 showed a marked increase in the number of B, TCR-delta+, and CD4+ TCR-alpha-/beta+ cells, similar to

21 nsferred before challenge into sensitized B6.TCR-delta(-/-) mice.

22 Culture supernatants from both TCR delta -/- and C57BL/6 mice contained interleukin-4,

23 Protection is not affected by TCR-delta, MHCII, TAP1, B cell, IL-17RA, or IL-12p35 def

24 l TCRDV2 transcripts that resemble canonical TCR-delta sequences in mice were present in the intestin

25 the Jdelta3-Cdelta intron, flanking the core TCR delta enhancer (Edelta) both 5' and 3' in a fashion

26 tion, delta chain T-cell receptor-deficient (TCR delta(-/-)) mice exhibited substantially reduced lev

27 WT) C57BL/6 and gammadelta T cell-deficient (TCR-delta(-/-)) mice were immunized intraperitoneally an

28 ssess the role of the T cell receptor delta (TCR delta) enhancer (E delta) in alphabeta and gammadelt

29 junctivitis were lowest in NKT cell-depleted TCR-delta(-/-) mice.

30 llergic conjunctivitis in NKT cell-depleted, TCR-delta(-/-) mice was the same as TCR-delta(-/-) mice.

31 alpha genes, respectively, encoding distinct TCR delta and alpha proteins.

32 tivating VDJ recombination at the endogenous TCR-delta locus.

33 N additions and exonucleolytic digestion for TCR-delta joints.

34 y reduced in cryptopatch cells isolated from TCR delta-deficient mice, indicating that the enrichment

35 more interferon (IFN)-gamma than those from TCR delta -/- mice during early and late phases of infec

36 ll receptor [TCR] alpha -/-) and gammadelta (TCR delta -/-) TCR-deficient C57BL/6 mice and compared w

37 letion of E delta severely impaired germline TCR delta expression in double-negative thymocytes, abse

38 1 or avirulent type II strains of T. gondii, TCR-delta-/- mice rapidly developed severe ileitis.

39 ocalize three MARs associated with the human TCR delta gene.

40 sgenic mice carrying two versions of a human TCR-delta gene minilocus recombination substrate.

41 the use of two Ddelta gene segments in human TCR-delta chains.

42 ed by a B12/23 restriction and ordered human TCR-delta gene assembly requires RUNX1 protein, which bi

43 P(1-20) and alphabeta T cells from immunized TCR-delta(-/-) mice.

44 IRBP-induced T cells from IRBP-immunized TCR-delta(-/-) mice on the C57BL/6 genetic background pr

45 E alpha, implicating additional elements in TCR delta locus accessibility.

46 In TCRbeta(-/-) mice, but not in TCR delta(-/-) mice, donor chimerism was increased by tr

47 nclude that E delta has an important role in TCR delta locus regulation at early, but not late, stage

48 nistration of Ag did not induce tolerance in TCR-delta knockout mice.

49 ontrast, the peritoneal cavities of infected TCR-delta(-/-) mice contained an accumulation of low den

50 s of parasites following L. major infection, TCR delta -/- and C57BL/6 mice effectively controlled th

51 The intestinal TCR-delta repertoire showed increasing restriction with

52 the early period after birth, the intestinal TCR-delta repertoire was polyclonal, and more diverse th

53 n levels of PB cells containing signal joint TCR delta excision circles (TRECs), a molecular marker o

54 Mammalian TCR delta genes are located in the midst of the TCR alph

55 promote TCR alpha rearrangement and maximal TCR delta expression; whereas the TCR delta enhancer (E

56 ctions with additional element(s) to mediate TCR delta rearrangement.

57 c for the V delta 6.3 and V delta 6.4 murine TCR delta chains, we have analyzed the peripheral locali

58 ls from WT or TCR-delta(-/-) mice into naive TCR-delta(-/-) or WT mice.

59 ta 1) was localized to a 2.0-kb region 3' of TCR delta gene segments and 5' of TCR alpha joining gene

60 the developmental stage-specific assembly of TCR delta and alpha variable region genes.

61 and gamma variable region genes, assembly of TCR delta variable region genes exhibits properties of a

62 owever, it was not known whether assembly of TCR delta variable regions genes is regulated in the con

63 rvation that the CDR3 length distribution of TCR delta chains is similar to that of immunoglobulin he

64 velopment and regulation of rearrangement of TCR delta genes.

65 o events, Edelta inactivation and removal of TCR delta from the influence of Ealpha by chromosomal ex

66 ther c-Myb plays a role in the activation of TCR-delta gene rearrangement, we compared VDJ recombinat

67 egment usage and in the junctional region of TCR-delta chains, indicating Vdelta gene-determined reco

68 study, changes in the junctional regions of TCR-delta transcripts in human intestine that occur duri

69 a gene usage in the CNS showed that the only TCR delta V gene families present in the CNS before EAE

70 determinants for CD3, CD4, CD8, TCR-beta, or TCR-delta molecules.

71 ency resolve infection, as do CD8alpha-/- or TCR-delta-/- mice.

72 optive transfer of CD4(+) T cells from WT or TCR-delta(-/-) mice into naive TCR-delta(-/-) or WT mice

73 olecular explanation for the lack of ordered TCR-delta gene assembly in mice and may underlie differe

74 of E alpha with E delta also did not promote TCR delta rearrangement.

75 to additional upstream element(s) to promote TCR delta accessibility.

76 al position relative to 5' sequences rescued TCR delta rearrangement.

77 nhancer (E alpha) demonstrated that residual TCR delta rearrangements were not driven by E alpha, imp

78 ne mRNA levels with thymic signal joint (sj) TCR delta excision circle (TREC) levels, a molecular mar

79 Cox model analysis indicated that TCR delta 1 expression was the factor that was most clos

80 The TCR delta genes were deleted on both alleles in alpha be

81 The TCR delta- and alpha-chain genes lie in a single complex

82 elta enhancer (E delta) is located among the TCR delta segments and functions with additional element

83 three characterized cis-acting elements: the TCR delta enhancer (Edelta), TCR alpha enhancer (Ealpha)

84 cquired J delta 1 usage bias occurred in the TCR delta repertoire.

85 ersely, mice with targeted disruption of the TCR delta chain and expressing no gamma delta TCR(+) cel

86 BEAD-1 blocked the ability of the TCR delta enhancer (Edelta) to activate a promoter when

87 e induces normal V-D-J rearrangements of the TCR delta locus, which like TCR beta, is also actively r

88 nd maximal TCR delta expression; whereas the TCR delta enhancer (E delta) is located among the TCR de

89 Previous data indicated that with the TCR delta enhancer (Edelta) present in the Jdelta3-Cdelt

90 The TCR-delta repertoire in adult human intestine is oligocl

91 ated that a 1.4-kb DNA fragment carrying the TCR-delta enhancer (E(delta)) efficiently activates mini

92 d to characterize fundamental changes in the TCR-delta repertoire in the human intestinal tract durin

93 However, reconstitution of the TCR-delta(-/-) mice before immunization with a small num

94 uring VDJ delta rearrangement contributed to TCR delta repertoire diversification in the first embryo

95 le-deficient mice were generated by treating TCR-delta(-/-) mice with anti-CD1d antibody.

96 cated in a single chromosomal locus in which TCR delta segments are situated between TCR alpha segmen