ライフサイエンスコーパス: TCRdelta

1 alyzed in mice that lack gammadelta T cells (TCRdelta(-/-)).

2 l receptor (TCR) loci: TCRbeta, TCRgamma and TCRdelta.

3 In the subsequent CD44lowCD25+ stage, most TCRdelta alleles are fully recombined, whereas TCRbeta r

4 we show that approximately half of the total TCRdelta alleles initiate rearrangements at the CD44high

5 egments rearranged to other gene segments of TCRdelta and alpha.

6 no gross deficiency in rearrangements of the TCRdelta and certain gamma loci in pre-T cells, and a fu

7 ns of TCRgamma genes occur concurrently with TCRdelta and D-Jbeta rearrangements, but before Vbeta ge

8 velopmental stage-specific activities of the TCRdelta and TCRalpha enhancers (Edelta and Ealpha), res

9 ias toward productive rearrangements of both TCRdelta and TCRgamma genes among CD44highCD25+ thymocyt

10 , as defined by expression of TCRgammadelta, TCRdelta and/or TCRgamma rearrangements but no complete

11 in similar levels of IL-17A in the lungs of TCRdelta(-/-) and wild-type C57BL/6 mice.

12 gammadelta cell-deficient mice (TCRdelta(-/-)) and KGF-deficient mice (KGF(-/-)), but no

13 Functional blocking anti-TCRdelta antibody was administered therapeutically, and

14 d restriction on the variable gene usage for TCRdelta assembly.

15 coded by TRAV and TRAJ segments and those of TCRdelta by TRDV, TRDD, and TRDJ segments.

16 aratope structure; additionally, nurse shark TCRdelta CDR3 are more similar to IgH CDR3 in length and

17 ement in CD4(-)CD8(-) thymocytes to form the TCRdelta chain of the gammadelta TCR and V-Jalpha rearra

18 functions with TCRdelta promoters to mediate TCRdelta-chain gene assembly in DN thymocytes.

19 TCRdelta-chain genes are assembled in CD4(-)CD8(-) (doub

20 mmadelta T-cell receptor (TCR) incorporating TCRdelta-chain variable-region-2 [Vdelta2((+))], which a

21 oration of D segments into IgH, TCRbeta, and TCRdelta chains also contributes to junctional diversifi

22 nctionally rearranged TCRbeta, TCRgamma, and TCRdelta chains by means of transgenes.

23 ose of mice transgenic for both TCRgamma and TCRdelta chains, and numbers of alphabeta thymocytes sim

24 lates strongly with a somatically recombined TCRdelta complementarity-determining region 3 (CDR3) mot

25 )/(-) females was actually higher than in B6.TCRdelta(-)/(-) controls.

26 romosomal translocations between TCRbeta and TCRdelta D gene segments are also increased in the core

27 The mouse TCRalpha/TCRdelta/Dad1 gene locus bears a locus control region (L

28 T-cell receptor delta (TCRdelta)-deficient mice showed a decrease in IL-17 prod

29 Strikingly, the lack of gammadelta TILs in TCRdelta-deficient but also in CCR2-deficient mice enhan

30 Analysis of TCRdelta-deficient mice indicated that gammadelta T cell

31 rmal hyperplasia in Il23r(-/-)Rag1(-/-)- and Tcrdelta-deficient mice, which can be prevented by neutr

32 F-mediated chromatin loop directly regulated TCRdelta diversity and indirectly regulated TCRalpha div

33 in chicken and turkey is reminiscent of the TCRdelta duplication that is present in nonplacental mam

34 Here we report that deletion of the TCRdelta enhancer (Edelta), which initiates TCRdelta rea

35 s contribute to spontaneous keratitis in B10.TCRdelta(-)/(-) female mice, nor does it appear to depen

36 ice have dry eyes compared with resistant B6.TCRdelta(-)/(-) females and also rederived the B10.TCRde

37 Tear production in B10.TCRdelta(-)/(-) females was actually higher than in B6.T

38 om wild-type donors reduced keratitis in B10.TCRdelta(-)/(-) females.

39 did not significantly reduce disease in B10.TCRdelta(-)/(-) females.

40 s, only a few are predominantly used for the TCRdelta gene assembly, while most are for TCRalpha.

41 The status of TCRdelta gene rearrangements in the remaining alphabeta-

42 several in-frame VDJdelta rearrangements in TCRdelta gene-deficient mice are strikingly underreprese

43 This variation is prominent in TCRdelta gene-deficient mice but is also detectable in w

44 n contrast, the T-cell receptor delta chain (TCRdelta) gene is silent in human prostate.

45 Assembly of TCRalpha and TCRdelta genes from the TCRalpha/delta locus is tightly

46 n the rearrangement of endogenous Vdelta7(+) TCRdelta genes, which paired with the Vgamma2(+) TCRgamm

47 Nurse shark TCRdelta have long CDR3 loops compared with the other th

48 The configuration of the second TCRdelta in chicken and turkey is reminiscent of the TCR

49 rganization suggests an origin of the second TCRdelta in the former lineage involving gene duplicatio

50 The second TCRdelta is not found in another avian lineage, the pass

51 The repertoire of TCRdelta is polyclonal in all subsets, indicating that t

52 s features analogous to a recently described TCRdelta isoform in sharks.

53 D genes in the TCRbeta and TCRdelta loci are flanked by a 12RS and 23RS, and their

54 nformation is available for the TCRgamma and TCRdelta loci.

55 y associated with V(D)J recombination at the TCRdelta locus as the molecular origin of both lymphocyt

56 e results indicate that rearrangement at the TCRdelta locus can precede that of TCRbeta locus recombi

57 nged with a random productivity profile; the TCRdelta locus contained primarily nonproductive rearran

58 open Jdelta1 and Ddelta2 coding ends at the TCRdelta locus in SCID thymocytes.

59 an genomes revealed the presence of a second TCRdelta locus in the Galliformes.

60 The TCRdelta locus is contained within the TCRalpha locus; T

61 This second TCRdelta locus is nonsyntenic to the conventional TCRalp

62 In this article, we report that in the TCRdelta locus, the Rag proteins are not the major deter

63 The study tested whether susceptible B10.TCRdelta(-)/(-) mice have dry eyes compared with resista

64 in the absence of Vgamma1(+) T cells in B10.TCRdelta(-)/(-) mice may be insufficiently checked to pr

65 Rederived B10.TCRdelta(-)/(-) mice still developed keratitis.

66 d perivascular adipose tissue was blunted in Tcrdelta(-/-) mice (P<0.01).

67 d-type mice, both of which were abrogated in Tcrdelta(-/-) mice (P<0.01).

68 TCRdelta(-/-) mice also exhibited >60% reduction in plat

69 The cytokine response in the brain of TCRdelta(-/-) mice appears to be a mixed type1/type 2 re

70 swelling is reduced by approximately 50% in TCRdelta(-/-) mice compared with wild-type mice.

71 Immunopathological studies indicated that TCRdelta(-/-) mice develop little inflammatory response

72 TCRdelta(-/-) mice exhibited reduced inflammation and de

73 to be devoid of any DETC, we discovered that TCRdelta(-/-) mice have alphabeta TCR-expressing DETC wi

74 TCRdelta(-/-) mice have elevated viral loads and greater

75 l proliferation in wild-type mice but not in TCRdelta(-/-) mice or KGF(-/-) mice.

76 BL/6 (B6) wild-type, B6 TCRbeta(-/-), and B6 TCRdelta(-/-) mice received anti-CD4 and anti-CD8 mAbs,

77 TCRdelta(-/-) mice receiving a single irr-spz immunizati

78 r dermal gammadeltaT cell reconstitution and TCRdelta(-/-) mice reconstituted with Vgamma6 develop ps

79 Adoptive transfer of gammadelta T cells to TCRdelta(-/-) mice reduced the susceptibility of these m

80 Sporozoite-challenged TCRdelta(-/-) mice showed a significant (P < 0.01) incre

81 Approximately 15% of TCRdelta(-/-) mice survived primary infection with WN vi

82 A greater percentage of TCRdelta(-/-) mice than of immunocompetent mice progress

83 In contrast, transfer of CD8(+) T cells from TCRdelta(-/-) mice that survived primary challenge with

84 stored neutrophil and platelet influx in the TCRdelta(-/-) mice to wild-type levels and increased CXC

85 merism was enhanced in both TCRbeta(-/-) and TCRdelta(-/-) mice treated with anti-CD4, anti-CD8, and

86 Increased rat chimerism was observed in TCRdelta(-/-) mice treated with anti-CD4, anti-CD8, and

87 In support of this result, TCRdelta(-/-) mice were also found to be more susceptibl

88 Treatment of TCRdelta(-/-) mice with rIL-22 significantly promoted wo

89 ossed with gammadelta T cell-deficient mice (TCRdelta(-/-) mice) yielding TRAMP x TCRdelta(-/-) mice,

90 t mice (TCRdelta(-/-) mice) yielding TRAMP x TCRdelta(-/-) mice, a proportion of which developed more

91 In TCRdelta(-/-) mice, Mesocestoides corti metacestodes pre

92 Male C57BL/6 wild-type and Tcrdelta(-/-) mice, which are devoid of gammadelta T cel

93 ely transferred into intracranially infected TCRdelta(-/-) mice.

94 hanced by anti-Thy1.2 and anti-NK1.1 mAbs in TCRdelta(-/-) mice.

95 gammadelta T-cell-deficient (TCRdelta(-/-)) mice have significantly reduced inflammat

96 gammadelta T-cell-deficient (TCRdelta(-/-)) mice on a C57BL/6 background were challen

97 stinal lamina propria and Peyer's patches of TCRdelta-/- mice compared with the orally immunized cont

98 In contrast, double-positive thymocytes from TCRdelta-/- mice display random proportions of TCRgamma

99 The TCRdelta-/- mice produced much lower levels of IgA antib

100 reconstitute the barrier function defect in TCRdelta-/- mice, while Vgamma5-/- mice also show enviro

101 , and fecal samples were markedly reduced in TCRdelta-/- mice.

102 es in gamma/delta T cell receptor-deficient (TCRdelta-/-) mice versus control mice of the same geneti

103 activation in vivo, we analyzed DETC in the TCRdelta(-/-) mouse.

104 Mice deficient in gammadelta T cells (TCRdelta(-/-)) or wild-type mice treated systemically wi

105 Edelta functions with TCRdelta promoters to mediate TCRdelta-chain gene assemb

106 The defective TCRdelta rearrangement of the 129-"Vdelta7" gene was ass

107 TCRdelta enhancer (Edelta), which initiates TCRdelta rearrangement, significantly improves alphabeta

108 d in conjunction with TCRgamma, TCRbeta, and TCRdelta rearrangements.

109 Those that dominate the adult TCRdelta repertoire are hyperacetylated in DN thymocytes

110 followed as a consequence of the restricted TCRdelta repertoire.

111 e to D and J segments and dominate the adult TCRdelta repertoire.

112 ments contributes substantially to the adult TCRdelta repertoire.

113 uble-positive thymocytes to generate diverse TCRdelta repertoires and TCRalpha repertoires, respectiv

114 Unlike previous reports in which the TCRdelta(-/-) skin was found to be devoid of any DETC, w

115 ta(-)/(-) females and also rederived the B10.TCRdelta(-)/(-) strain to test for the role of an infect

116 portant gene loci, including one between the TCRdelta/TCRalpha gene segments and the ubiquitously exp

117 chain, and its size was severely reduced in TCRdelta(-/-) Tg-gammadelta mice.

118 devoid of T cells (B6.129P2-Tcrbeta(tm1Mom) Tcrdelta(tm1Mom)/J) show protection against pathogenic c

119 Expression of these atypical TCRdelta transcripts with a VH domain paired with Cdelta

120 the activation status in blood, the type of TCRdelta variant used in blood, and small but significan