ライフサイエンスコーパス: TCRgammadelta

1 all of which were CD4(+)CD8(-)TCRalphabeta(+)TCRgammadelta(-).

2 lta form of the T-cell receptor for antigen (TCRgammadelta).

3 TCRalphabeta(+)CD4(-)CD8(-) cells co-express TCRgammadelta.

4 stics of extrathymic populations, expressing TCRgammadelta(+) (28%), the CD8alphaalpha homodimer (11%

5 ltaneous expression in progenitor cells of a TCRgammadelta and a pre-TCR on alphabeta/gammadelta line

6 t, in theory, could simultaneously express a TCRgammadelta and a pre-TCR.

7 rs analyzed two poorly understood receptors, TCRgammadelta and B-cell receptors (BCR), in allograft r

8 aseline with which to compare the effects of TCRgammadelta and BCR deficiency.

9 esponses mediated by DCs and IL-17-producing TCRgammadelta(+) and CD4(+) Th17 T cells following TLR7

10 8(+) T cells and macrophages, and subsets of TCRgammadelta(+) and NK1.1(+) T cells.

11 alent in WT, T-deficient (TCRalphabeta(-/-), TCRgammadelta(-/-)), and Toll-like receptor 4 (TLR4)-def

12 Graft survival was extended in the TCRgammadelta- and BCR-deficient mice.

13 Anti-TCRgammadelta antibody-induced gammadelta T-cell depleti

14 a specific anatomic site indicates that for TCRgammadelta, as for immunoglobulin, conformation is as

15 in a small fraction of cells in wt mice, the TCRgammadelta can drive the differentiation of alphabeta

16 D3+/CD5+ (approximately 1-5%), and NKR-P1dim/TCRgammadelta+/CD3+/CD5+ (approximately 0.5-2%).

17 her than B lymphocytes, then TCRalphabeta or TCRgammadelta, CD4 or CD8, and Th1 or Th2 lineage.

18 in the intraepithelial lymphocyte CD8alpha(+)TCRgammadelta(+)/CD8alpha(+)TCRalphabeta(+) ratio.

19 We have previously described a murine TCRgammadelta cell clone, TgI4.4, that is reactive to he

20 habeta development is normal, as are NKT and TCRgammadelta cell production.

21 ated that although IL-7 was not required for TCRgammadelta cell proliferation, it was required to pro

22 A subset of TCRgammadelta cells and CD161-expressing thymocytes expr

23 Although TCRgammadelta cells are absent from IL-7(-/-) mice, TCRg

24 Therefore, TCRgammadelta cells are capable of recognizing a variety

25 ures that are capable of being recognized by TCRgammadelta cells are unclear.

26 in addition to TCRVgamma gene rearrangement, TCRgammadelta cells differentiating from late fetal live

27 airway inflammation, clusters of B cells and TCRgammadelta cells in lung tissue, increased serum IgE

28 In contrast, the numbers of TCRgammadelta cells in other tissues of TCRgammadelta-tr

29 had similar numbers of fetal thymus-derived TCRgammadelta cells in their skin.

30 orm of gI suggests that HSV-1 recognition by TCRgammadelta cells in vivo is not limited by cell-speci

31 n addition, the recent descriptions of human TCRgammadelta cells recognizing mycobacterium-derived lo

32 Thus, fetal TCRgammadelta cells required IL-7 for TCR rearrangement,

33 es in developmental requirements for IL-7 by TCRgammadelta cells were noted and were linked to deriva

34 adelta cells are absent from IL-7(-/-) mice, TCRgammadelta cells were restored to the thymus and peri

35 of numerous antigenic ligands recognized by TCRgammadelta cells, detailed information concerning the

36 alpha-/- mice selectively lack CD8alphaalpha TCRgammadelta cells, whereas IL-2Rbeta-/- mice show a si

37 ing some but not all of the TCRalphabeta and TCRgammadelta cells-expressed the CD43 S7(-) reactive de

38 required to prolong the life span of mature TCRgammadelta cells.

39 HIV-1 infection induced depletion of CD4(+) TCRgammadelta cells.

40 on of specific pathogens, as is the case for TCRgammadelta cells.

41 ) cells and the generation of atypical CD8(+)TCRgammadelta(+) cells.

42 Thymic CD27+IFN-gamma+CCR9+alpha4beta7+TCRgammadelta+ cells migrate to the periphery, particula

43 Consistent with this, skin-resident TCRgammadelta+ cells, known as dendritic epidermal T cel

44 al lymphocytes that are commonly enriched in TCRgammadelta+ cells.

45 share an unconventional phenotype with their TCRgammadelta(+) counterparts.

46 red with their TCRalphabeta(+)CD8beta(+) and TCRgammadelta(+) counterparts.

47 ight genes that were at higher levels in the TCRgammadelta-deficient group, suggesting that these rec

48 re expressed at lower levels in the BCR- and TCRgammadelta-deficient groups, respectively.

49 CD8- or TCRgammadelta-deficient mice were not protected from thr

50 vel was high and clonality was detected in a TCRgammadelta expressing tumor.

51 orcine gammadelta T cells have two levels of TCRgammadelta expression.

52 We show here that TCRgammadelta gene rearrangements are suppressed in TCRa

53 r T cells containing productively rearranged TCRgammadelta genes have additional requirements for IL-

54 ere are two CD3gammaepsilon dimers for every TCRgammadelta heterodimer.

55 scent approaches to determine the valency of TCRgammadelta heterodimers and CD3gammaepsilon dimers in

56 w TCRgammadelta(med) cells can be induced to TCRgammadelta(hi) but only under IL-2 influence.

57 ls are mostly CD2(+)CD8(-) and CD2(+)CD8(+), TCRgammadelta(hi) cells are highly enriched for CD2(-)CD

58 Moreover, TCRgammadelta(hi) cells can generate TCRgammadelta(med)

59 ery of both TCRalphabeta(+)CD8alphaalpha and TCRgammadelta(+) IEL is constructed differently than oth

60 le TCRalphabeta(+)CD8alphaalpha IEL resemble TCRgammadelta(+) IEL, they are a unique population of ce

61 We observed that TCRgammadelta IELs exhibit unique microbiota-dependent l

62 we investigated the functional attributes of TCRgammadelta+ IELs isolated from intestinal biopsies of

63 demonstrate that human small intestinal CD8+TCRgammadelta+ IELs may have regulatory potential in cel

64 iduals on GFD have a higher frequency of CD8+TCRgammadelta+ IELs that express the inhibitory NK recep

65 owing infection, represents up to 15% of the TCRgammadelta(+) iIELs, and is dependent on the MHC clas

66 ural killer T cells, CD8+ T lymphocytes, and TCRgammadelta intraepithelial lymphocytes.

67 and/or maintenance of gammadelta T cells and TCRgammadelta(+) intraepithelial lymphocytes.

68 zation of tissue-resident V(gamma)5V(delta)1 TCRgammadelta+ intraepithelial T cells and Langerhans ce

69 Clarity requires a better understanding of TCRgammadelta itself, not only through identification of

70 duce CD4+Foxp3+ regulatory T cells, although TCRgammadelta+LAP+ cells do not themselves express Foxp3

71 TCRgammadelta+LAP+ cells express antigen presentation mo

72 Identification of TCRgammadelta+LAP+ regulatory cells provides an avenue f

73 Here, we propose that thymic TCRgammadelta-ligand engagement versus ligand-independen

74 TCR)-negative and strikingly associated with TCRgammadelta lineage T-ALLs, as defined by expression o

75 innate, T cell receptor (TCR)alphabeta, and TCRgammadelta lineages, expand in early tumors.

76 Whereas TCRgammadelta(med) cells are mostly CD2(+)CD8(-) and CD2

77 reover, TCRgammadelta(hi) cells can generate TCRgammadelta(med) cells but never the opposite.

78 he only exception is the thymus, where a few TCRgammadelta(med) cells can be induced to TCRgammadelta

79 Coculture of sorted TCRgammadelta+NKG2A+ IELs, IL-15-stimulated TCRalphabeta

80 n productive rearrangement and expression of TCRgammadelta or TCRbeta genes, but whether it is an ins

81 a(+) intraepithelial T cells that are either TCRgammadelta(+) or TCRalphabeta(+).

82 ed gammadelta T cells and their fetal thymic TCRgammadelta precursors, and it is the most abundantly

83 genic receptor is expressed relatively late, TCRgammadelta rearrangements occur normally such that TC

84 TCR ligands, but also by correlating thymic TCRgammadelta signalling with commitment to gammadelta e

85 ction from gammadelta T cells in response to TCRgammadelta stimulation.

86 haalpha(+)TCRalphabeta(+)and CD8alphaalpha(+)TCRgammadelta(+) subsets that exist in the absence of IL

87 ligand leads to greater numbers of Th17 and TCRgammadelta T cells and exacerbated development of pso

88 bitors reduced IFN-gamma production by human TCRgammadelta T cells and IL-17 and IFN-gamma production

89 ic effector Th2 cells and was independent of TCRgammadelta T cells and IL-22.

90 n linked with IL-17 production characterizes TCRgammadelta T cells as an efficient first line of defe

91 TCRgammadelta T cells were the major IL-17-producing pop

92 fied in vitro as NK cells, CD8+ T cells, and TCRgammadelta T cells.

93 el, the expansion of a CD8alphabeta(+)CD94(-)TCRgammadelta(+) T cell subset within the iIEL populatio

94 n, promoted the expression of IL-17A in both TCRgammadelta(+) T cells and CD4(+) Th17 cells.

95 Therefore, suppression of intestinal TCRgammadelta(+) T cells by Treg cells maintains enteric

96 later waves in the adult and constitute most TCRgammadelta(+) T cells in secondary lymphoid tissue.

97 xpressed by the earliest waves of developing TCRgammadelta(+) T cells in the fetal thymus, destined f

98 These results suggest that TCRgammadelta(+) T cells may play a role in the liver pa

99 s activation and proliferation of intestinal TCRgammadelta(+) T cells observed in PDK1-deficient mice

100 and/or HBV) or nonviral hepatitis contained TCRgammadelta(+) T cells that could be expanded in vitro

101 This dysregulation of intestinal TCRgammadelta(+) T cells was attributable to a reduction

102 Conversely TCRgammadelta(+) T cells were normal in the VDR KO mice.

103 TCRgammadelta(+) T cells were responsible for the inflam

104 torspira: Leptospira stimulation of purified TCRgammadelta(+) T cells, obtained from 8-day cultures o

105 al controls had no preferential expansion of TCRgammadelta(+) T cells.

106 IFN-gamma and TNF-alpha production by liver TCRgammadelta(+) T cells.

107 fected individuals contained high numbers of TCRgammadelta(+) T cells.

108 ) increase in the number of peripheral blood TCRgammadelta(+) T cells.

109 ion is dependent on both TCRalphabeta(+) and TCRgammadelta(+) T cells.

110 Surprisingly, none of these liver TCRgammadelta(+) T-cell lines could recognize any of the

111 Liver TCRgammadelta(+) T-cell lines from HCV-infected individu

112 IL-17-producing T cell receptor gammadelta (TCRgammadelta) T cells share characteristic features wit

113 Th1 or Tc1 cytokine production and CD8+ and TCRgammadelta+ T cell-mediated GVHD, but abrogates GVL.

114 receptor-alphabeta (TCRalphabeta)+ and CD4-8-TCRgammadelta+ T cells.

115 lineage T-ALLs, as defined by expression of TCRgammadelta, TCRdelta and/or TCRgamma rearrangements b

116 nt clonotypic heterodimers (TCRalphabeta and TCRgammadelta) that define the alphabeta and gammadelta

117 anti-Thy1.2 mAb, indicating that CD4(-)CD8(-)TCRgammadelta(+)Thy1.2(+)NK1.1(-) cells (gammadelta T ce

118 CD31 expression on TCRgammadelta thymocytes is very similar to that of CD4

119 The number of TCRgammadelta thymocytes was 10-fold reduced in TCRgamma

120 TCRgammadelta thymocytes were productively infectable by

121 percentages of both CD4-CD8- thymocytes and TCRgammadelta+ thymocytes suggest that pTalpha plays a c

122 notion that TCRalphabeta can substitute for TCRgammadelta to permit a gammadelta lineage choice and

123 to the thymus and periphery by expression of TCRgammadelta transgenes.

124 re importantly, DN2 and DN3 progenitors from TCRgammadelta transgenic mice have strong biases for opp

125 gammadelta thymocytes was 10-fold reduced in TCRgammadelta-transgenic IL-7(-/-) embryos; however, adu

126 ng in neonatal thymus, thymus cellularity of TCRgammadelta-transgenic IL-7(-/-) mice dropped signific

127 TCRgammadelta-transgenic IL-7(-/-) mice were generated t

128 s of TCRgammadelta cells in other tissues of TCRgammadelta-transgenic IL-7(-/-) mice were not complet

129 transgenic IL-7(-/-) embryos; however, adult TCRgammadelta-transgenic IL-7(-/-) or IL-7(+/-) mice had

130 tial of single thymocytes from wild-type and TCRgammadelta-transgenic mice at two sequential early de

131 ere expressed by IL-7(+/-) but not IL-7(-/-) TCRgammadelta-transgenic mice, providing direct support