ライフサイエンスコーパス: TDM

1 TDM measurements were determined by commercial ELISA (LI

2 TDM-IPIV promotes a hypercoagulopathy state, independent

3 Analysis of 14 TDMs by methylation-specific PCR and by bisulfite genomi

4 onjunction with virtual RLGS to identify 150 TDMs.

5 One hundred twelve IBD patients (with 214 TDM measurements, CD/UC 84/28, male/female 50/62, mean a

6 . tuberculosis, suggesting the presence of a TDM-specific esterase in this pathogen.

7 ich an immobile hydrophobic layer supports a TDM-rich, two-dimensionally fluid leaflet.

8 In addition, TDM modification by the cyclopropane synthase pcaA was b

9 s that the mechanisms responsible for DM and TDM formation might be closely related.

10 Mice that received TDM-IV and TDM-IPIV had inflammatory pathologic findings with incre

11 crophages were equally responsive to TDB and TDM.

12 erformed TDM on HBase by up to 351 times and TDM on MySQL Cluster by up to 9 times.

13 nform clinical decision making when applying TDM in a reactive setting.

14 icate that 5% or more of the CpG islands are TDMs, disputing the general notion that all CpG islands

15 ic DNA-containing Double Minute chromosomes (TDMs).

16 Anti-trehalose 6,6'-dimycolate (TDM) IgG responses were the strongest predictor for diff

17 Trehalose 6,6'-dimycolate (TDM) is a cell wall glycolipid and an important virulenc

18 Trehalose 6,6'-dimycolate (TDM) is the most abundant, most granulomagenic, and most

19 ia recognition of trehalose-6,6'-dimycolate (TDM), has opened avenues for the rational design of such

20 ll wall component trehalose 6,6'-dimycolate (TDM).

21 ycolipids such as trehalose 6,6'-dimycolate (TDM; cord factor).

22 Trehalose 6'6-dimycolate (TDM) activates innate inflammation and likely also stimu

23 terial cord factor trehalose-6,6-dimycolate (TDM), is a potent adjuvant inducing strong Th1 and Th17

24 Trehalose-6,6-dimycolate (TDM), the mycobacterial cord factor, and its synthetic a

25 Trehalose-6,6-dimycolate (TDM), the mycobacterial cord factor, is an abundant cell

26 ll envelope glycolipid trehalose dimycolate (TDM) is critical for Mtb growth during the first week of

27 f the mycolic acids on trehalose dimycolate (TDM) mediated by proximal cyclopropane synthase of alpha

28 olic acids attached to trehalose dimycolate (TDM) on the murine immune response to infection (see the

29 onomycolate (TMM), and trehalose dimycolate (TDM), important constituents of the outermost layer of t

30 M is newly synthesized trehalose dimycolate (TDM), which is cleaved by a novel TDM-specific serine es

31 n evaluating the implications of the drought TDM.

32 ame, tandem duplication of exons 2 - 7 (EGFR.TDM/2 - 7).

33 High-affinity binding is reduced in EGFR.TDM/18-26, although the t1/2 of receptor internalization

34 however, phosphorylation of the 180-kDa EGFR.TDM/2 - 7 was strongly induced by ligand.

35 demonstrate how this modification can enable TDM applications by quantitatively and dynamically measu

36 use developed software package developed for TDM of mAbs.

37 n 85A more efficiently mycolates TMM to form TDM, whereas C (and to a lesser extent B) has a higher r

38 of i.v. TDM in oil/water emulsion was given (TDM-IV).

39 The responses to TDM-IP, TDM-IV, or TDM-IPIV were consistent between mouse strain

40 current evidence is insufficient to mandate TDM in routine practice, a concerted investigation shoul

41 c polymorphisms (transcript derived markers, TDMs) from an experiment involving two commercial variet

42 on HBase to the traditional SQL data model (TDM) implemented on both HBase and MySQL Cluster, using

43 velopment of a tolerance distribution model (TDM), a novel quantitative tool to assess landscape leve

44 pholipid mixtures with as little as 25 mol % TDM.

45 Therapeutic drug monitoring (TDM) aid therapeutic decision making in patients with in

46 DBS method for therapeutic drug monitoring (TDM) for improving the efficacy and safety of drug thera

47 e importance of therapeutic drug monitoring (TDM) in this population is also explored in this review.

48 range to which therapeutic drug monitoring (TDM) is applied.

49 e reported that therapeutic drug monitoring (TDM) of asparaginase (ASP) activity levels in plasma may

50 Therapeutic drug monitoring (TDM) provides valuable guidance for dose adjustment of a

51 ms that perform therapeutic drug monitoring (TDM) without relying on mAb specific reagents will be ne

52 Therapeutic drug monitoring (TDM), which involves measurement of drug or active metab

53 l candidate for therapeutic drug monitoring (TDM).

54 care method for therapeutic drug monitoring (TDM).

55 aboratories for therapeutic drug monitoring (TDM).

56 The 180-kDa, tandem duplication mutant (TDM) exhibited enhanced basal phosphorylation and impair

57 escribe a 185-kDa tandem duplication mutant (TDM) that is expressed in KE and A-1235 glioma cells, al

58 We introduce a new TDM model that promotes inflammatory lung pathologic fin

59 imycolate (TDM), which is cleaved by a novel TDM-specific serine esterase, Msmeg_1529.

60 c studies, and focused on the application of TDM for biologic therapy, specifically anti-tumor necros

61 rcolation, implying that the connectivity of TDM plays a crucial role in membrane preservation.

62 sh cmaA2-dependent trans-cyclopropanation of TDM as a suppressor of M. tuberculosis-induced inflammat

63 Furthermore, enzymatic hydrolysis of TDM remains conserved in M. tuberculosis, suggesting the

64 ivation through cyclopropane modification of TDM as a critical pathogenic strategy of Mtb.

65 ta, this review does not address the role of TDM for more recently approved biologic agents, such as

66 In order to study the role of TDM in the innate immune response to Mycobacterium tuber

67 ioritized clinical guidelines on the role of TDM in the management of inflammatory bowel disease.

68 d showed agonist activity similar to that of TDM, despite their much simpler structure.

69 inical activity were recorded at the time of TDM.

70 until it is able to activate the toxicity of TDM and initiate necrosis that results in caseating gran

71 was caused by activation of the toxicity of TDM toxicity.

72 mab therapy and support the selective use of TDM in IBD patients treated with adalimumab.

73 estimates about the number and direction of TDMs in FlH(-), as well the electronic structure changes

74 With this set of TDMs, we constructed a genetic map and used it for the g

75 ith 10 mug of i.p. TDM in light mineral oil (TDM-IP).

76 ery of membrane mobility upon rehydration on TDM fraction shows a functional form indicative of spati

77 In defined medium, both oncogenic TDM are constitutively autophosphorylated and inefficien

78 Injections of MTB and/or TDM into sensitized mice induced caseating granulomas th

79 The responses to TDM-IP, TDM-IV, or TDM-IPIV were consistent between mouse strains.

80 e and cytokine release in response to TDB or TDM.

81 knockdown caused on average reduced TDB- or TDM-induced IL-8 production.

82 d reduced phagocytosis of M. tuberculosis or TDM-coated latex beads.

83 olymorphism case, CGDM on HBase outperformed TDM on HBase by up to 351 times and TDM on MySQL Cluster

84 ALB/c mice were injected with 10 mug of i.p. TDM in light mineral oil (TDM-IP).

85 ed with mice injected once with i.v. or i.p. TDM.

86 spectrometry (LC-MS) can be used to perform TDM of mAbs in the same manner as smaller nonbiologic dr

87 and risks of a strategy of routine proactive TDM (during routine clinical care in patients with quies

88 Purified TDM isolated from a cyclopropane-deficient pcaA mutant w

89 Finally, purified TDM lacking trans-cyclopropane rings was 5-fold more pot

90 Noninfectious models using purified TDM oil/water emulsions elicit pathologic findings obser

91 benefits and risks of a strategy of reactive TDM (in patients with active inflammatory bowel disease)

92 Mice that received TDM-IV and TDM-IPIV had inflammatory pathologic findings

93 -specific differentially methylated regions (TDMs) were first identified, and then expression of gene

94 quiescent disease) compared with no routine TDM.

95 the absorption transition dipole moment(s) (TDMs) in the molecular frame of reference.

96 ng an anticancer drug (doxorubicin), several TDM-requiring antidepressant and anti-seizure drugs, fru

97 oped in adipose tissue, but MTB with surface TDM removed induced only acute inflammation that did not

98 ype lectin receptors Mincle and Mcl bind TDB/TDM and activate macrophages and dendritic cells (DC) th

99 ulation of Mincle, resulting in enhanced TDB/TDM-induced kinase activation and more rapid inflammator

100 However, TDB/TDM-triggered kinase activation has not been studied wel

101 SYK-CARD9 signaling plays a key role in TDB/TDM-induced activation of innate immune cells in man as

102 eta showed nearly complete abrogation of TDB/TDM responsiveness, but also failed to upregulate Mincle

103 We performed in vitro analysis of TDB/TDM-stimulated primary human monocytes, macrophages, and

104 In this article, we report that TDB/TDM caused only weak Syk-phosphorylation in resting macr

105 tically, the transcriptional response to TDB/TDM has been defined to require FcRgamma-Syk-Card9 signa

106 To dissect transcriptional responses to TDB/TDM, we mined microarray data and identified early growt

107 s sufficient to confer responsiveness to TDB/TDM.

108 e requirement for Mcl in the response to TDB/TDM.

109 The i.p./i.v. TDM (TDM-IVIP) group was compared with mice injected once wit

110 HBase performed up to 246 times faster than TDM on HBase and 7 times faster than TDM on MySQL Cluste

111 er than TDM on HBase and 7 times faster than TDM on MySQL Cluster.

112 This new model argues that TDM is sufficient to generate the hypercoagulopathy obse

113 We have found that TDM monolayers, in stark contrast to phospholipid membra

114 We found that TDM-coated beads induced MMP-9 expression and activity i

115 ng, and other stresses, we hypothesized that TDM alone may suffice to confer dehydration resistance t

116 rculous granulomas, our results suggest that TDM may drive MMP expression during TB pathogenesis.

117 We speculate that TDMs are formed through the recombination of telomeres w

118 The TDM-based MTBE demonstrated superior sensitivity compare

119 The TDM-IPIV group had increased CD4(+) T cells in lung tiss

120 n inflammatory and T-cell cytokines, and the TDM-IPIV group had further enhancement of IL-10 and gran

121 Raman activities of many analytes hinder the TDM application of SERS.

122 Some of the TDMs are within 5' promoter CpG islands of genes, which

123 The directions of the TDMs in oxidized and semiquinone flavins were characteri

124 re up- or downregulated in response to these TDM-coated beads compared to control beads.

125 le of 17 climate change models to drive this TDM, we estimate that 18% of US ecosystems are vulnerabl

126 Thus, TDM-based MTBE can be potentially used as a screening de

127 this protection from dehydration extends to TDM-phospholipid mixtures with as little as 25 mol % TDM

128 The responses to TDM-IP, TDM-IV, or TDM-IPIV were consistent between mous

129 f loss of response (LOR) to adalimumab using TDM in IBD patients.

130 The i.p./i.v. TDM (TDM-IVIP) group was compared with mice injected onc

131 t day 7, another injection of 10 mug of i.v. TDM in oil/water emulsion was given (TDM-IV).

132 iameter polystyrene microspheres coated with TDM.

133 CCL3, CCL4, and CCL2 after stimulation with TDM, whereas DC responded more strongly to TDB and GM-CS