ライフサイエンスコーパス: TGF-beta

1 TGF-beta enhanced the expression of ARHGEF1, while a sma

2 TGF-beta has been implicated as a major pathogenic facto

3 TGF-beta inhibition rescued abnormalities in fibrillin-1

4 TGF-beta is a multifunctional cytokine affecting many ce

5 TGF-beta is an anti-inflammatory cytokine whose signalin

6 TGF-beta is pro-metastatic for malignant cancer cells.

7 TGF-beta is pro-metastatic for the late-stage breast can

8 TGF-beta is regulated at the level of activation, but ho

9 TGF-beta is synthesized as a precursor molecule and prot

10 TGF-beta is synthesized as a proprotein that dimerizes i

11 TGF-beta pre-treatment amplified the effects of BK on Rh

12 TGF-beta signaling components were expressed in most HCC

13 TGF-beta signaling has been associated with the tumorige

14 TGF-beta signaling maintains CD103 expression, promotes

15 TGF-beta signaling mediated by pSMAD2, bone morphogeneti

16 TGF-beta was identified as the factor mediating suppress

17 TGF-beta-induced beta-catenin also regulates NR4A1 expre

18 TGF-beta/Fc and nonlytic IL-2/Fc exert a synergistic eff

19 h (SM16, a selective inhibitor of the type 1 TGF-beta receptor activin receptor-like kinase 5, orally

20 (RTA-408) results in the induction of HO-1, TGF-beta, and IL-10, as well as the repression of NF-kap

21 yet tolerogenic phenotype, expressing IL-10, TGF-beta, IL-27, and aldehyde dehydrogenase 1A2 but not

22 okines in the serum (TNF-alpha, IL-6, IL-12, TGF-beta, and VEGF) were down regulated by DMDD.

23 ts independently of the GLP-1/Notch or DAF-7/TGF-beta pathways but together with the DAF-2/insulin IG

24 A TGF-beta-responsive promoter driving luciferase was used

25 Here we report that Activin-beta, a TGF-beta family ligand, is expressed by sensory neurons

26 xtracellular matrix protein and delivering a TGF-beta mAb resulted in a relatively focal uptake in th

27 BRD7 forms a TGF-beta inducible complex with Smad3/4 through its N-te

28 that a pharmacological compound that abates TGF-beta signalling and enhances ERK5 signalling may be

29 Accordingly, TGF-beta signaling inhibition in crude preparations of m

30 , podocyte injury, fibronectin accumulation, TGF-beta expression, and, most notably, age-related impa

31 pulation by secreting products that activate TGF-beta signalling, but the identity of the active mole

32 n cancers and that oncogenic K-RAS activates TGF-beta signaling to promote tumor invasion and metasta

33 cell types, suggesting a possible activation TGF-beta receptor signaling in tumor cells in response t

34 Production of active TGF-beta is regulated at a posttranslational level and i

35 Vector carrying shRNA against TGF-beta, though did not inhibit HBV replication alone,

36 f growth factors, such as IGF-1, VEGF-alpha, TGF-beta, and Wnt proteins that regulate epithelial and

37 ion and neuronal differentiation by altering TGF-beta signaling.

38 y this enigmatic family of membrane-anchored TGF-beta family signaling regulators and link membrane a

39 genase 1A2 but not IL-12 or IL-35; IL-10 and TGF-beta together drove their suppression of TH2 cell pr

40 c levels of type 2 and regulatory (IL-10 and TGF-beta) cytokines.

41 actions and required production of IL-10 and TGF-beta.

42 cortical expression of IL-18, IL-1beta, and TGF-beta, despite a gradual decline in TNF-alpha express

43 In conclusion, activin and TGF-beta are strongly connected signaling pathways that

44 ent TGF-beta superfamily members activin and TGF-beta in advanced colorectal cancer.

45 y that combined serum and tissue activin and TGF-beta ligand levels predicts outcome in CRC patients

46 , IL-4 upward arrow, IL-10 upward arrow, and TGF-beta upward arrow) and enhanced regeneration of dama

47 o fine-tune Smad3 activity in both basal and TGF-beta-stimulated states.

48 rfering RNA suppressed the effects of BK and TGF-beta on RhoA-GTP content, RhoA translocation and MYP

49 multiple inhibitors of Wnt/beta-catenin and TGF-beta pathways, leading to their overactivation.

50 n is essential for vascular development, and TGF-beta signaling plays a critical role in this process

51 cular impacts of altered KLF4 expression and TGF-beta signaling were determined using immunofluoresce

52 The combination of nonlytic IL-2/Fc and TGF-beta/Fc had a synergistic effect to promote engraftm

53 onizes pro-inflammatory actions of FGF23 and TGF-beta.

54 ation of bone marrow-derived fibroblasts and TGF-beta expression.

55 ion of CTLA4 (3 fold), Foxp3 (1.4 folds) and TGF-beta (1.62) in aorta.

56 tion-induced reduction of bone formation and TGF-beta gene expression, we measured mRNA levels of TGF

57 eactions culminate in antibody formation and TGF-beta secretion, respectively, leading to fibrosis.

58 ction, and increased expression of Foxp3 and TGF-beta.

59 at the combination of shRNAs against HBV and TGF-beta could be developed into a viable treatment for

60 The expression of KLF4 and TGF-beta signaling components in primary HCC and their c

61 down-regulating Wnt (beta-catenin, LEF1) and TGF-beta (Smad2/3, collagen type I, alpha-SMA) signaling

62 knockdown inhibited EMT, cell migration, and TGF-beta signaling.

63 reg in the pathogenic development of MMD and TGF-beta in Treg induced VEGF.

64 identified an interaction between moesin and TGF-beta receptor II (TbetaRII) that allows moesin to co

65 d mediates the regulation of PHF8 by MYC and TGF-beta signaling.

66 f oncogenic mutations in Wnt, EGFR, P53, and TGF-beta signaling pathways facilitates efficient tumor

67 f transcriptional regulation during Ras- and TGF-beta-induced EMT that involves alterations of access

68 Blockade of JAK2/STAT3 and TGF-beta signaling by specific inhibitors significantly

69 dings demonstrate that the absence of apical TGF-beta signaling in normal epithelia is primarily a re

70 and induced by COPD-related stimuli, such as TGF-beta, cigarette smoke (CS), and cellular senescence.

71 es given that blockade of exosome-associated TGF-beta or inhibition of exosome release abrogated Tfr

72 antly reduced Col-1 secretion and attenuated TGF-beta induced increment in Col-1 localization at cell

73 In vitro, treatment with NE attenuated TGF-beta-induced accumulation of fibrotic markers.

74 instability or KRAS mutations; (ii) CRIS-B: TGF-beta pathway activity, epithelial-mesenchymal transi

75 that blocks transforming growth factor beta (TGF beta) superfamily inhibitors of erythropoiesis, givi

76 increase in transforming growth factor beta (TGF-beta) and concomitantly an increase in T regulatory

77 Transforming growth factor beta (TGF-beta) is an established regulator of ECM remodeling

78 Transforming growth factor beta (TGF-beta) isoforms are a key group of growth factors tha

79 pe I and II transforming growth factor beta (TGF-beta) receptors (TbetaRI and TbetaRII, respectively)

80 wth factor, transforming growth factor beta (TGF-beta), is thought to play a pivotal role.

81 mediated by transforming growth factor beta (TGF-beta)-containing exosomes released from HCV-infected

82 Transforming growth factor beta (TGF-beta)-induced migration of triple-negative breast ca

83 The transforming growth factor-beta (TGF-beta) network of ligands and intracellular signaling

84 Transforming growth factor-beta (TGF-beta) plays an important role in the development and

85 e canonical transforming growth factor-beta (TGF-beta) signaling pathway in mammalian cells.

86 tivation of transforming growth factor-beta (TGF-beta) signaling pathway is a common feature of hepat

87 al role for transforming growth factor-beta (TGF-beta) signals in safe-guarding specific Treg cell fu

88 mber of the transforming growth factor-beta (TGF-beta) superfamily and has been implicated in various

89 ABSTRACT: Transforming growth factor-beta (TGF-beta), RhoA/Rho-kinase and Src-family kinases (SrcFK

90 Transforming growth factor-beta (TGF-beta), serine proteinases such as trypsin, and prote

91 induced by transforming growth factor-beta (TGF-beta), we identified the TF musculin (MSC) as being

92 regulatory (transforming growth factor beta [TGF-beta]) cytokines.

93 ear export of the receptor and thereby block TGF-beta-induced migration and EMT.

94 Enforced KLF4 expression blocked TGF-beta signal transduction and inhibited cell migratio

95 erall, Shenks inhibited fibrosis by blocking TGF-beta pathway and modulating the oxidant/antioxidant

96 lternative therapeutic modality for blocking TGF-beta signaling in humans.

97 the inactive state through regulation of BMP/TGF-beta signaling.

98 a superfamily pathways that can inhibit both TGF-beta and activin signals while enhancing bone morpho

99 gands mimics the hypertrophy seen with broad TGF-beta blockers, while avoiding the adverse effects du

100 Smad transcription factors activated by TGF-beta or by BMP receptors form trimeric complexes wit

101 erin abundance and stress fiber formation by TGF-beta, gene ontology analysis showed that genes encod

102 e spectrum of biological signals mediated by TGF-beta superfamily members.

103 MFs were stimulated by TGF-beta, cancer cell-CM or cancer cells, with or withou

104 Canonical TGF-beta signaling mobilizes Smad2 and Smad3 transcripti

105 known regulator that restricts non-canonical TGF-beta signaling in NK cells.

106 y mediator of inflammation and non-canonical TGF-beta signalling.

107 a molecular switch that controls the cardiac TGF-beta axis and its early transcriptional effects that

108 molecules to modulate the Wnt/beta-catenin, TGF-beta, and BMP pathways.

109 ted by these mRNAs include Wnt/beta-catenin, TGF-beta, and stem cell signaling.

110 In normal thyroid cells, TGF-beta/SMAD repressed the p27/CDKN1B gene, activating

111 we report a novel finding that, in TM cells, TGF-beta-induced increase in collagen expression is asso

112 ls on the other hand, exhibited constitutive TGF-beta signaling and were less tumorigenic.

113 The switch converting TGF-beta from a tumor-suppressor to tumor-promoter has n

114 Levels of anti-inflammatory cytokine TGF-beta remained practically unaffected in ImI treated

115 The master cytokine TGF-beta mediates tissue fibrosis associated with inflam

116 a group, while dexamethasone (DEX) decreased TGF-beta group mRNA levels in normal mice.

117 on was found to be a novel pathway of direct TGF-beta-dependent Treg-cell suppression of mast cell ac

118 rectal tumors contain mutations that disrupt TGF-beta family member signaling.

119 nesins, KIF5A was notably upregulated during TGF-beta induced mesothelial-mesenchymal transition (Mes

120 neurogenesis and the TGF-beta pathway (i.e. TGF-beta; SMAD-2, -3, and -7; and SMURF-2) in the rat hi

121 fine the relative contribution of endogenous TGF-beta proteins to the negative regulation of muscle m

122 Herein, we describe an engineered TGF-beta monomer, lacking the heel helix, a structural m

123 naling is a prerequisite for PAR2 to enhance TGF-beta signaling, we investigated the effects of PAR2-

124 ivity as wild-type (WT) Arkadia in enhancing TGF-beta signaling responses, while W972R does not.

125 en transferred into mice bearing established TGF-beta-OVA-expressing thymomas, produce high amounts o

126 3 ligase complex, thereby limiting excessive TGF-beta response.

127 ) T cells, independent of Foxp3 or exogenous TGF-beta.

128 eposition, collagen 1 and 3 mRNA expression, TGF-beta production, and activation of alternatively act

129 bined blocking M2 macrophage-derived factors TGF-beta, VEGF and SDF-1 abolished VEGFR1(+) myeloid cel

130 latory cytokine fusion proteins of IL-10/Fc, TGF-beta/Fc, or IL-2/Fc would enhance allogeneic bone ma

131 Thus, we reveal an unrecognized function for TGF-beta signaling as an upstream factor controlling Tre

132 diomyocyte-specific regulatory mechanism for TGF-beta production by PAI-1, which explains the paradox

133 for binding the other receptor required for TGF-beta signaling, the TGF-beta type II receptor (Tbeta

134 Neutralization of HLA-G, TGF-beta, and IL-10 partially restored T cell alloprolif

135 involvement of tolerogenic molecules (HLA-G, TGF-beta, and IL-10) were tested on a mixed lymphocyte r

136 d human airway smooth muscle cells (hASMCs), TGF-beta pre-treatment enhanced the protein expression o

137 In CF-HBEC, TGF-beta increased KL secretion and upregulated FGF rece

138 y supporting a self-sustaining loop for high TGF-beta activity in GIC.

139 egulated at the level of activation, but how TGF-beta is activated in this disease is unknown.

140 We review how TGF-beta family member signaling is altered during devel

141 However, TGF-beta induced apoptosis in normal and benign but not

142 8 modeled molecular mediators, we identified TGF-beta and the matrix metalloproteinases as therapeuti

143 their cognate ligands to type I and type II TGF-beta receptors, indicating that Cripto-1 and Cryptic

144 3 phosphorylation levels and SBE activity in TGF-beta-induced fibroblasts were dramatically decreased

145 se changes could be attributed to changes in TGF-beta and matrix metalloproteinase-9, the downstream

146 h prevented Smad3 from binding to SBE DNA in TGF-beta-responsive SMC gene promoters, resulting in sup

147 sels become dependent on a small increase in TGF-beta signaling via activin receptor-like kinase 5 to

148 trate altered activity of RhoA and increased TGF-beta signaling and ENaC activity.

149 advanced stages of these cancers, increased TGF-beta expression is linked to high metastasis and poo

150 This resulted in increased TGF-beta levels/activity and increased collagen producti

151 These findings link increased TGF-beta pathway activation in ERBB2IP(mut) and STAT3(mu

152 The increased TGF-beta signaling may protect against rapid retinopathy

153 To investigate whether increased TGF-beta signaling could be a therapeutic target for pre

154 We found that carbofuran increases TGF-beta signaling (i.e. increased phosphorylated SMAD-2

155 a rationale to pursue a means of increasing TGF-beta signaling as a potential therapy for Parkinson'

156 t contained rSBEs also effectively inhibited TGF-beta/Smad3 signaling, suggesting that lncRNA-rSBE ma

157 ring progressive kidney injury by inhibiting TGF-beta type 1 receptor.

158 suppresses macrophage activity by inhibiting TGF-beta-activated kinase (TAK1) signaling to NF-kappaB,

159 F-beta signaling, specifically by inhibiting TGF-beta-activated kinase1 (TAK1) phosphorylation.

160 Conversely, depletion of BRD7 inhibits TGF-beta responses.

161 Despite increases in KL, TGF-beta also increased IL-8 secretion via activation of

162 Expression of PD-1, PD-L1, PD-L2, TGF-beta, IL-5, and IL-10 mRNA was measured by real-time

163 ure cytokine dimer from the inactive, latent TGF-beta precursor.

164 provide a new avenue to probe and manipulate TGF-beta signaling and may inform similar modifications

165 rotein levels of fibrosis signaling mediator TGF-beta remained the same and the second messenger, Sma

166 ed that both KL and FGF23 signaling modulate TGF beta-induced IL-8 secretion in CF bronchial epitheli

167 red an lncRNA-based mechanism that modulates TGF-beta/Smad3 signaling during SMC differentiation.

168 etained the same overall structure of native TGF-beta monomers and bound TbetaRII in an identical man

169 nal transcription factor that mediates Nodal/TGF-beta signaling, with cis-regulatory modules (CRMs) d

170 wound healing though increased expression of TGF beta leading to enhanced formation of granulation ti

171 mune diabetes, here we show that ablation of TGF-beta receptor II (TbetaRII) in T cells, but not Foxp

172 t and indirect fibroproliferative actions of TGF-beta.

173 Activation of TGF-beta receptors and p38 MAPK increased glycogen synth

174 pressed in most HCC cells, and activation of TGF-beta signaling promoted cell migration and invasion.

175 Addition of TGF-beta to GF(-) increased RASF attachment (12.7-fold)

176 The addition of TGF-beta/Fc (5- or 10-day treatment) or nonlytic IL-2/Fc

177 Co-administration of TGF-beta shRNA and HBV dual-shRNA decreased HBV DNA, HBV

178 r (BMPR) axis: the anti-proliferative arm of TGF-beta super family of receptors.

179 growth factor (TGF)-beta because blockade of TGF-beta significantly reversed NK anti-fibrotic functio

180 eous stroke because of myeloid deficiency of TGF-beta (transforming growth factor-beta) signaling.

181 models with induced conditional deletion of TGF-beta signaling in the entire eye, the retinal pigmen

182 Although the specific deletion of TGF-beta signaling in the RPE caused no obvious changes,

183 In turn, cell-intrinsic deregulation of TGF-beta signaling is associated with increased function

184 malformations are related to deregulation of TGF-beta/BMP signaling.

185 phorylated SMAD2/3, a downstream effector of TGF-beta Furthermore, in the PD parietal arterioles, C1q

186 rlying cell- and process-specific effects of TGF-beta are poorly understood.

187 ion, but minimally influenced the effects of TGF-beta on cofilin expression and phosphorylation.

188 n this study, we investigated the effects of TGF-beta on IL-33-mediated mast cell activation.

189 a RhoGEF inhibitor prevented the effects of TGF-beta on RhoA and Rho-kinase activity and contraction

190 nuclear export results in nuclear export of TGF-beta-induced beta-catenin, which then undergoes prot

191 al inflammation, including the expression of TGF-beta, NFkappaB, MCP-1, IL-1, IL-6, ICAM-1, VCAM-1 an

192 esin plays any role during the generation of TGF-beta-induced Tregs (iTregs) is unknown.

193 ppo pathway target genes and marker genes of TGF-beta signaling, including biomarkers of renal diseas

194 However, the importance of TGF-beta-Smad2/3 signaling in fibroblast-mediated cardia

195 bone formation is a result of inhibition of TGF-beta gene expression.

196 cription and, consequently, in inhibition of TGF-beta/Smad3-mediated SMC differentiation.

197 ced inflammation, lower expression levels of TGF-beta and proteases associated with tissue remodeling

198 nervation-induced decrease in mRNA levels of TGF-beta group, while dexamethasone (DEX) decreased TGF-

199 gene expression, we measured mRNA levels of TGF-beta in denervation mouse bone and found decreased m

200 , while cancer cells produced high levels of TGF-beta.

201 a SMAD-independent manner within minutes of TGF-beta stimulation.

202 el predicted that simultaneous modulation of TGF-beta and matrix metalloproteinases would be more eff

203 emical events that lead to overproduction of TGF-beta, oxidative stress, and limited bioavailable nit

204 le of Th1 differentiation in the presence of TGF-beta, suggesting a novel approach to adoptive cell t

205 Despite recent progress, the regulation of TGF-beta type II receptor remains uncertain.

206 ally relevant for force-dependent release of TGF-beta from latency.

207 ARalpha up-regulation leads to repression of TGF-beta signaling, specifically by inhibiting TGF-beta-

208 To investigate the role of TGF-beta and IL-6 in myofibroblasts (MFs) - lung cancer

209 nd SMAD pathways is critical to the roles of TGF-beta in liver fibrosis.

210 essential for the expression of a subset of TGF-beta target genes in hepatic stellate cells, and the

211 l cycle regulator and a downstream target of TGF-beta that mediates its profibrotic activity.

212 n PTC samples from patients, upregulation of TGF-beta, p27, p65 and cyclin D1 mRNA were significantly

213 inhibition of CD8(+) T cells is dependent on TGF-beta and PD-L1.

214 inhibition of CD4(+) T cells is dependent on TGF-beta, whereas inhibition of CD8(+) T cells is depend

215 er effect on IL-8 secretion and no effect on TGF-beta.

216 CC may contribute to activation of oncogenic TGF-beta signaling and subsequent tumor progression.

217 data indicate that KLF4 suppresses oncogenic TGF-beta signaling by activation of Smad7 transcription,

218 e was a positive correlation between Treg or TGF-beta and MMD Suzuki's stage.

219 Other TGF-beta-related signals, such as Vg1/Dvr1/Gdf3, have al

220 nd may inform similar modifications of other TGF-beta family members.

221 lysis (Molecular Mechanisms of Cancer, p53-, TGF-beta-, MAPK- and Wnt-signaling).

222 ermore, while the TAT-SNX9 peptide prevented TGF-beta's profibrotic activity in vitro as well as in 2

223 inhibition or knockout bone marrow prevents TGF-beta activation and protects against PH development.

224 d by reactive oxygen species (ROS), prevents TGF-beta activation of Smad2, therefore limiting Th17 ce

225 interface stabilize a specific integrin/pro-TGF-beta orientation that defines the pathway through th

226 owth factor (GF) domain in each monomer, pro-TGF-beta is secreted and stored in latent complexes.

227 alphaVbeta8 binding to and activation of pro-TGF-beta.

228 g the TAT-SNX9 peptide inhibited profibrotic TGF-beta activity in murine cells and human lung fibrobl

229 of HIV-Tat and cocaine on the proliferative TGF-beta signaling cascade.

230 combined functions of the two most prominent TGF-beta superfamily members activin and TGF-beta in adv

231 iation in human and mouse cells by promoting TGF-beta activation, which in turn was mediated by upreg

232 riguing link between ILEI, the PS1-protease, TGF-beta, and the TGF-beta receptor 1.

233 Cripto-1 and Cryptic recognize and regulate TGF-beta family ligands, are less clear.

234 udy, we show that STAT3 negatively regulates TGF-beta signaling via ERBB2-interacting protein (ERBIN)

235 t mice exhibited changes in genes regulating TGF-beta/BMP/FGF signaling, as well as in genes controll

236 However, to produce cell-specific responses, TGF-beta pathways are heavily regulated by secondary fac

237 Tumor-secreted TGF-beta and granulocyte-macrophage CSF (GM-CSF) enhance

238 Here we show TGF-beta activation by thrombospondin-1 (TSP-1) is both

239 Following the activation of SMADs, TGF-beta also induces a second phase of STAT phosphoryla

240 exosomal miR-19a in activation of the STAT3-TGF-beta pathway in HSC.

241 ion of SMAD3 or CCT6A efficiently suppresses TGF-beta-mediated metastasis.

242 A growth arrest-specific 5 (GAS5) suppresses TGF-beta/Smad3 signaling in smooth muscle cell different

243 driver of thoracic aortic disease, and that TGF-beta overactivity in diseased aortas is a secondary,

244 We find that TGF-beta signaling is operative in mouse primary keratin

245 We found that TGF-beta pre-treatment enhanced acute contractile respon

246 Our data indicate that TGF-beta enhances BK-induced contraction, RhoA transloca

247 eta in murine bronchiolitis obliterans; that TGF-beta and the C' cascade present signaling interactio

248 We further show that TGF-beta and ALK1 are required in IL-37 induced pro-angi

249 In this study, we show that TGF-beta induces p38alpha (mitogen-activated protein kin

250 Beta-catenin/Tcf and the TGF-beta bone morphogenetic protein (BMP) provide critic

251 of proteins involved in neurogenesis and the TGF-beta pathway (i.e. TGF-beta; SMAD-2, -3, and -7; and

252 in, the neuropeptide receptor NPR-1, and the TGF-beta peptide DAF-7 each have stage-specific effects

253 en ILEI, the PS1-protease, TGF-beta, and the TGF-beta receptor 1.

254 via targeting Frizzled receptor 4/6 and the TGF-beta-induced activation of lung fibroblasts by inhib

255 eration, migration, tubule formation and the TGF-beta-induced AKT, SMAD- and ERK-dependent phosphoryl

256 a structural motif essential for binding the TGF-beta type I receptor (TbetaRI) but dispensable for b

257 eals that OTUD1 directly deubiquitinates the TGF-beta pathway inhibitor SMAD7 and prevents its degrad

258 In mice, the TGF-beta superfamily is implicated in the regulation of

259 /CD24- cells, constitutive activation of the TGF-beta axis was both necessary and sufficient to reduc

260 iation factor-15 (GDF-15) is a member of the TGF-beta cytokine superfamily that is widely expressed a

261 dicative of 'imprinting' by cytokines of the TGF-beta family.

262 However, dysregulation of the TGF-beta pathway is responsible for promoting the progre

263 Endoglin is part of the TGF-beta receptor complex and has a crucial role in fibr

264 onses and attenuated the upregulation of the TGF-beta signaling pathway and alpha1-antitrypsin protei

265 so explored the potential implication of the TGF-beta signalling pathway in the pathogenesis of suici

266 ive of receptors for a distinct class of the TGF-beta superfamily ligands.

267 protein (KCP) is a secreted regulator of the TGF-beta superfamily pathways that can inhibit both TGF-

268 n and contribute to the understanding of the TGF-beta-mediated fibrogenic response.

269 related to loss-of-function mutation of the TGF-beta/BMP receptor complex and the second to increase

270 ministration of the bispecific DVD-Ig or the TGF-beta mAb (1-10 mg/kg) but not the FnEDA mAb attenuat

271 enhanced phosphatase activity prevented the TGF-beta-induced collagen expression by TM cells.

272 the prodomain, apply force, and release the TGF-beta growth factor.

273 These findings demonstrate that shifting the TGF-beta superfamily signaling with a secreted protein c

274 eceptor required for TGF-beta signaling, the TGF-beta type II receptor (TbetaRII), as an alternative

275 ition of SMAD2/3 signaling via targeting the TGF-beta receptor 1.

276 Our study demontrated that the TGF-beta and IL-6/JAK2/STAT3 signaling pathways form a p

277 molecule that mediates IL-37 binding to the TGF-beta receptor complex.

278 In this study, we assessed whether the TGF-beta signaling pathway-associated genes of SMAD fami

279 and the Wnt pathway acting together with the TGF-beta pathway in mesendodermal differentiation of mou

280 -37 induces pro-angiogenic responses through TGF-beta, which may act as the bridging molecule that me

281 Thus, TGF-beta-induced nuclear export of NR4A1 in TNBC cells p

282 s that CD4(+) T(Pam3) cells are resistant to TGF-beta-mediated gene expression through Akt activation

283 ptor signaling in tumor cells in response to TGF-beta from the TME.

284 We find that, in response to TGF-beta, cell surface-internalized FN is not degraded b

285 to constrain nuclear pSMAD2/3 in response to TGF-beta.

286 second to increased signaling sensitivity to TGF-beta/BMP.

287 m induction relies on the combination of two TGF-beta-related signals: maternal and ubiquitous Vg1, a

288 arly tumor development in many cancer types, TGF-beta acts as a tumor suppressor, whereas in the adva

289 -6 and MF-CM activated STAT3 and upregulated TGF-beta in cancer cells.

290 is that mediate stellate cell activation via TGF-beta.

291 ed that IL-17A induces epithelial injury via TGF-beta in murine bronchiolitis obliterans; that TGF-be

292 However, whether TGF-beta and Treg cells are part of the same regulatory

293 While TGF-beta signaling has been implicated in zebrafish card

294 ogressive kidney disease in association with TGF-beta overexpression, administration of SRT3025 atten

295 sm compared with recipients conditioned with TGF-beta/MR1/Rapa/100 cGy.

296 Allogeneic BMC engraftment is enhanced with TGF-beta/Fc fusion protein treatment.

297 n that was reversed by the pretreatment with TGF-beta neutralizing Ab or re-expression of Fli1.

298 hromatin regions in EpRas cells treated with TGF-beta.

299 ioned medium (MF-CM) or MFs, with or without TGF-beta signaling inhibitor - SB431542 and/or JAK2/STAT

300 scription factor pathways (for example, Wnt, TGF-beta, mir200, ZEB1, OVOL2, p63 and p300) and transla