ライフサイエンスコーパス: TGase 1

1 n B sequences were used for cross-linking by TGase 1.

2 The TGase 1, 2, and 3 enzymes expressed in epithelia use the

3 The present studies demonstrate that loss of TGase 1 activity is not restricted to mutations that dir

4 The loss of transglutaminase 1 enzyme (TGase 1) activity causes lamellar ichthyosis.

5 the levels of expression and activity of the TGase 1 and 2 enzymes were both increased in the cortex

6 ween SPRs and loricrin, this means that both TGase 1 and 3 are required for cross-linking SPR1 protei

7 Interestingly, the TGase 1 and 3 enzymes and their proteolytically processe

8 atinocyte membranes distort the structure of TGase 1 and facilitate the access of water into its acti

9 When recombinant human TGase 1 and involucrin were reacted on the surface of sy

10 se observations, we found that inhibition of TGase-1 and the JAK2-Stat-3 signaling pathway decreased

11 ily by the TGase 3 enzyme, a minor extent by TGase 1, and probably not by TGase 2.

12 ow here that the equilibrium partitioning of TGase 1 between the cytosol and membranes is controlled

13 We propose a model in which involucrin and TGase 1 bind to membranes shortly after expression in di

14 TGase-1, but not TGase-2, -5, and -7, was expressed in R

15 nto large polymers can occur only by further TGase 1 cross-linking of an initial TGase 3 reaction.

16 However, inhibition of TGase-1 decreased phosphorylation of Stat-3 but not JAK2

17 nsequences of diminished barrier function in TGase 1 deficiency models.

18 de evidence that XI is also a consequence of TGase 1 dysfunction.

19 Conversely, overexpresssion of TGase-1 enhanced the JAK2-dependent transcriptional acti

20 we show that the membrane-bound form of the TGase 1 enzyme can also form ester bonds between specifi

21 further evidence for the pivotal role of the TGase 1 enzyme in CE formation.

22 In reactions of involucrin with TGase 1 enzyme in solution, 80 of its 150 glutamines ser

23 eveloping CE by further cross-linking by the TGase 1 enzyme.

24 f other substrates used by free or SLV-bound TGase 1 enzyme.

25 amellar ichthyosis resulting from defects of TGase 1 enzyme.

26 The transglutaminase 1 (TGase 1) enzyme is essential for the assembly of the cel

27 The transglutaminase 1 (TGase 1) enzyme is involved in the formation of a cornif

28 M1 gene that encodes the transglutaminase 1 (TGase 1) enzyme, which is critical for the assembly of t

29 ation increases the repertoire of functional TGase 1 forms, depending on the differentiation state of

30 Da anchorage fragment facilitates binding of TGase 1 forms, supporting a mechanism of cycling back on

31 homology-derived three-dimensional model of TGase 1 generated from the known x-ray structure of the

32 Our data reveal a dual role for TGase 1 in epidermal barrier formation and provide insig

33 In this study, we examined the role of TGase-1 in proliferation of renal proximal tubular cells

34 Overexpression of Stat-3, JAK2, and/or TGase-1 in RPTC revealed that JAK2 is indispensable for

35 TGase 1 is a complex enzyme existing as both cytosolic a

36 TGase 1 is a key component of barrier formation in kerat

37 Moreover, TGase 1 is proteolytically processed, and the major func

38 Transglutaminase-1 (TGase-1) is a Ca(2+)-dependent enzyme capable of cross-l

39 virus and keratinocytes a number of reported TGase 1 mutants.

40 el system for characterizing the function of TGase 1 on the surface of synthetic lipid vesicles (SLV)

41 However, on SLV carrying both involucrin and TGase 1, only five glutamines serve as donors, of which

42 With TGase 1, only one glutamine on the head domain and one l

43 These results demonstrate that TGase-1 plays an important role in regulation of renal e

44 TGase-1 to induce Stat-3 phosphorylation and TGase-1 potentiates JAK2-induced Stat-3 phosphorylation.

45 -palmitoyl adducts are less than that of the TGase 1 protein, suggesting a mechanism for cycling off

46 Sequencing of tryptic peptides from TGase 1-reacted involucrin showed a large increase in de

47 Recombinant baculovirus-expressed human TGase 1 readily binds to SLV and becomes active in cross

48 Treatment with MDC or TGase-1 siRNA decreased Stat-3 but not Akt phosphorylati

49 nt tissues, at least three of which, namely, TGase 1, TGase 2 (tissue transglutaminase), and TGase 3,

50 c antibodies that in fact three members, the TGase 1, TGase 2, and TGase 3 enzymes, and are different

51 RPTC revealed that JAK2 is indispensable for TGase-1 to induce Stat-3 phosphorylation and TGase-1 pot

52 Finally, TGase-1 was found to interact with JAK2, and this intera

53 disease affect the structure and function of TGase 1, we have expressed in baculovirus and keratinocy

54 surface regulates the steric interaction of TGase 1 with substrates such as involucrin to permit spe

55 ective TGase inhibitor or down-regulation of TGase-1 with small interfering RNA (siRNA) decreased RPT