ライフサイエンスコーパス: TLR1

1 TLR1(742A/G(Asn248Ser)) (rs4833095), a coding SNP in LD

2 TLR1, -2, -4, -6, and -13 were significantly upregulated

3 TLR1-7202G (rs5743551) was associated with increased mor

4 TLR1/TLR2 heterodimers recognize triacylated bacterial l

5 We found decreased Toll-like receptor 1 (TLR1) and TLR4 surface expression in HIV-infected U1 mon

6 receptor 2 (IL1R2) and Toll-like receptor 1 (TLR1) SNPs were associated with atopy after correction f

7 ime PCR (qRT-PCR) were Toll-like receptor 1 (TLR1), TLR2, IRAK3, TRAF1, IRG1, PTGS2, MMP9, IFI44, IFI

8 Toll-like receptor 1 (TLR1), TLR2, TLR4, TLR6, nucleotide-binding oligomerizat

9 For example, Toll-like receptor 1 (TLR1)/TLR6/TLR10 gene cluster showed a strong signal of

10 s blunted by a block in Toll-like receptor 1(TLR1) signaling and attenuated in lymphoma patients.

11 poorly to all TLR2/6 (PAM2CSK4, LTA, FSL-1), TLR1/2 (PAM3CSK4), and TLR4 (LPS, MPLA) agonists tested

12 pressant by reducing Toll-like receptor 1/2 (TLR1/2) activation by bacterial lipopeptides.

13 Responses to all Toll-like receptor 1/2 (TLR1/2), TLR2/6, and TLR4 agonists were impaired in the

14 ne system via the Toll-like receptor (TLR) 2/TLR1 complex.

15 Analyses of TLR SNPs revealed that 3 TLR1 SNPs (R80T, S248N, I602S) were significantly associ

16 for immune-related genes (such as OAS1/2/3, TLR1/6/10, and TNFAIP3) and also encompass genes (includ

17 sCD14 significantly enhanced formation of a TLR1.TLR2 lipopeptide ternary complex as measured by siz

18 saccharide (LPS, a TLR4 ligand), Pam3CSK4 (a TLR1/TLR2 ligand), and Fsl-1 (a TLR2/TLR6 ligand) but no

19 Pretreatment of extraintestinal DC with a TLR1/2 agonist was sufficient to induce retinal dehydrog

20 mononuclear cells responded normally to all TLR1/2, TLR2/6, TLR4, TLR7, and TLR8 (R848) agonists tes

21 We analyzed TLR1 genotypes in a pediatric sepsis database and found

22 in cell activation mediated by TLR1 602S and TLR1 602I are observed upon stimulation with soluble myc

23 st, mice receiving TLR2(-/-)OT-1 T cells and TLR1/2 ligand showed minimal therapeutic efficacy.

24 functional studies involving TLR1 G676A and TLR1 G676L resulted in reduced PAM(3)CSK(4) mediated NF-

25 Rs except 10 was detected in primary IEC and TLR1-10 in the cultured cells.

26 ously present, TLR7 and TLR9 infrequent, and TLR1, TLR3, TLR5, TLR6, and TLR8 expressed in selective

27 gs about the association between leprosy and TLR1 variants N248S and I602S have been reported.

28 TLR2 together with TLR1 or TLR6 in mice and TLR1 but not TLR6 in humans.

29 (5- to 10-fold; P < 0.01) by microarray, and TLR1, -2, -4, and -13 were significantly increased (4- t

30 ) induces lipid raft recruitment of TLR2 and TLR1 and their clustering with GD1a, in contrast to the

31 esults in the up-regulation of both TLR2 and TLR1 but the down-regulation of TLR5, the receptor for b

32 gB and gH coimmunoprecipitate with TLR2 and TLR1, indicating that these envelope gp directly interac

33 sitive bacterial infection, through TLR2 and TLR1, may directly promote the elevated trophoblast cell

34 activate inflammatory cells through TLR2 and TLR1.

35 ntibodies to Toll-like receptor 2 (TLR2) and TLR1, indicating that human CD4(+) T cells can use TLR2/

36 ed with BB loop sequences of TLR2, TLR4, and TLR1/6.

37 ails to bind to GD2.F4, a commonly used anti-TLR1 mAb.

38 pulations and a strong trans-eQTL hotspot at TLR1 that decreases expression of pro-inflammatory genes

39 ling may result from alterations in baseline TLR1 surface expression, which was decreased by 36% in o

40 Results indicated an association between TLR1 248S and leprosy in the case-control study (SS geno

41 a-analysis identified an association between TLR1 and H. pylori seroprevalence, a finding that requir

42 We further examined for associations between TLR1 SNPs and mortality in subgroups on the basis of the

43 performed to determine associations between TLR1 SNPs and mortality.

44 e the crystal structure of a complex between TLR1, TLR2, and a lipopeptide ligand.

45 eptors, generated by domain exchange between TLR1 and -6, has revealed that leucine-rich repeats 9-12

46 ted bacterial lipoproteins coordinately bind TLR1 and TLR2, resulting in a stable ternary complex tha

47 uced by PDG was found to be mediated by both TLR1 and TLR2 and that this could be blocked by the pres

48 B by hBD-3 depends on the expression of both TLR1 and TLR2.

49 the sensing of microbial cell components by TLR1 is critical to innate immune defense.

50 ered inflammatory activation was enhanced by TLR1 and suppressed by TLR6.

51 tivation of NF-kappaB, which was enhanced by TLR1 expression and blocked by the Toll/IL-1 receptor/re

52 e differences in cell activation mediated by TLR1 602S and TLR1 602I are observed upon stimulation wi

53 l of murine macrophage responses mediated by TLR1/2 heterodimers through c-Jun N-terminal kinase 1 (J

54 f other microbial-derived agonists shared by TLR1, but not TLR6.

55 drophobic cavity of TLR2 and, in some cases, TLR1, at the vicinity of the dimerization interface; the

56 By coexpressing TLR1 or TLR6 in TLR2-transgenic HEK293 cells or silencin

57 bridized toll-like receptors (TLR) combining TLR1 and TLR2 onto a single sensor surface.

58 ted by immobilizing a mixture of cooperative TLR1 and -2 generate higher responses when exposed to th

59 ignaling, including TLR2 and its coreceptors TLR1 and TLR6, is mediated by a number of specific ligan

60 The MyD88-dependent TLR1, -2, -4, -6, -7, -9, and -11 and IL-18 receptor (IL

61 Diminished TLR1/2 signaling may contribute to the increased infecti

62 ransmembrane domain, is sufficient to direct TLR1 to the cell surface.

63 TLR2, in cooperation with either TLR1 or TLR6, mediates responses to a wide variety of mi

64 TLR2, which forms a heterodimer with either TLR1 or TLR6.

65 ester trophoblast cells are known to express TLR1 and TLR2 and to undergo apoptosis following exposur

66 T cells expressed TLR1, TLR2, TLR4, and TLR9, and the baseline expression

67 LC-like DCs and Mo-DCs expressed TLR1-10 mRNAs at comparable levels.

68 ILC2s expressed TLR1, TLR4, and TLR6, and TLR stimulation induced IL-5 a

69 Lentivirus-expressed TLR1-short hairpin RNA (shRNA) or TLR2-shRNA administrat

70 We found that all three cell types expressed TLR1-6 and TLR9.

71 MSU does not stimulate HEK cells expressing TLR1-11 to activate NF-kappaB.

72 For TLR1, impaired proinflammatory cytokine production due t

73 For TLR1, increased interleukin 10 responses to C. burnetii

74 type for TLR1 rs5743618, the GG genotype for TLR1 rs4833095, the CC genotype for TLR2 rs3804099, the

75 The TT genotype for TLR1 rs5743618, the GG genotype for TLR1 rs4833095, the

76 ness of these LECs to a panel of ligands for TLR1-9 was measured by real-time RT-PCR, ELISA, and flow

77 acid cytoplasmic region that is required for TLR1 surface expression.

78 onding LRR of TLR6 with the LRR derived from TLR1 enables TLR6 to recognize TUL4, FTT1103, and triacy

79 Lungs from TLR1- and TLR6-deficient mice had diminished CXCL1 and C

80 ith mycobacterial agonists, macrophages from TLR1 602S/S individuals resist induction of host arginas

81 Bone marrow-derived macrophages from TLR1- and TLR6-deficient mice produced lower amounts of

82 Furthermore, TLR1 exhibited an Asn248Ser substitution in the extracel

83 ymous SNPs in 11 bovine innate immune genes (TLR1-TLR10, PGLYRP1) for 37 cattle breeds.

84 ymorphisms (tagSNPs) assayed in 4 TLR genes (TLR1, TLR2, TLR4, TLR6) and 2 adaptor molecules (TIRAP,

85 ces in 6 functional variants in 4 TLR genes (TLR1, TLR2, TLR4, TLR6) and the adaptor molecule TIRAP b

86 an monocytes and macrophages from homozygous TLR1 602S individuals are resistant to mycobacterial-ind

87 ivatives indicates that recognition by human TLR1 and -2 does not strictly correlate with the number

88 reported that an I602S polymorphism of human TLR1 is associated with aberrant trafficking of the rece

89 uent single-nucleotide polymorphism of human TLR1 that greatly inhibits cell surface trafficking, con

90 region of the extracellular domain of human TLR1, comprising leucine-rich repeat (LRR) motifs 9-12,

91 biorecognition elements and the hybridized "TLR1 and 2" sensor surface were investigated, understand

92 ual immune functions in the gut and identify TLR1 as a critical innate receptor for protective intest

93 us SNPs in TLR1 are associated with impaired TLR1 function, decreased cytokine responses, and predisp

94 loop of TLR2 and BB loop of TLR1, Gly-676 in TLR1 was rationally mutated to Ala and Leu.

95 containing adaptor protein) is an adaptor in TLR1, TLR2, TLR4, and TLR6 signaling, whereas MyD88 is a

96 This defect in TLR1/2 signaling may result from alterations in baseline

97 a substantial, highly significant defect in TLR1/2-induced TNF-alpha (p = 0.0003) and IL-6 (p < 0.00

98 or TLRs, and we found that mice deficient in TLR1, TLR2, or the TLR adaptor MyD88 generated anti-B. h

99 ve shown previously that genetic defiency in TLR1 promotes acute enteric infection by the proteobacte

100 ace and lipopeptide-binding channel found in TLR1.

101 althy individuals with various haplotypes in TLR1.

102 Polymorphisms in TLR1 (R80T), NOD2 (1007fsX1), and MYD88 (-938C>A) were a

103 Polymorphisms in TLR1 (R80T), NOD2 (L1007fsX1), and MYD88 (-938C>A) are a

104 netic association analysis, polymorphisms in TLR1 (S248N and R80T), TLR2 (P631H), and TLR6 (P249S) we

105 Humans with polymorphisms in TLR1 and NOD2 had reduced cytokine production, compared

106 o determine whether genetic polymorphisms in TLR1 are associated with alterations in Treg suppression

107 how that functional genetic polymorphisms in TLR1 modify surface expression of TLR1 on T lymphocytes

108 Polymorphisms in TLR1, TLR2, and TLR6 are associated with increased susce

109 mmon single-nucleotide polymorphism (SNP) in TLR1 (rs5743618).

110 Nonsynonymous SNPs in TLR1 are associated with impaired TLR1 function, decreas

111 of an effect on immune function are those in TLR1 (1805GG), TLR2 (2258GA), and TLR5 (1174CT).

112 Genetic variation in TLR1 is associated with increased mortality in patients

113 Genetic variation in TLR1 is associated with outcomes in diseases in which re

114 If confirmed, genetic variations in TLR1 may help explain some of the observed variation in

115 The family including TLR1 has more species-specific adaptations than other fa

116 rotein of Mycobacterium tuberculosis induces TLR1/2 heterodimerization to elicit proinflammatory-type

117 Interestingly, TLR1/2 triggering restored BCR functionality, likely bre

118 ected, in vitro functional studies involving TLR1 G676A and TLR1 G676L resulted in reduced PAM(3)CSK(

119 d helix-loop-helix ubiquitous kinase, IRAK1, TLR1, TLR4, TLR6, TLR8, TLR9, and TNFR-associated factor

120 of the concept that astrocyte and microglial TLR1, -2, and -5 are involved in the in vivo response of

121 d Pam3Cys, specific for heterodimer molecule TLR1/TLR2.

122 ment for cooperation with other TLRs, namely TLR1 and TLR6, to mediate cell signaling.

123 associated with asthma, as well as 4p14 near TLR1, TLR6 and TLR10 (rs2101521, P=5.3x10(-21)); 6p21.33

124 TLR2 as well as its coreceptor CD14, but not TLR1 or TLR4.

125 Blockade of TLR6 but not TLR1 prevented hIAPP-induced TLR2 activation, consistent

126 chimeras with TLR1+TLR2 or TLR2+TLR6 but not TLR1+TLR6) resulted in LPS responsiveness, indicating fu

127 Here we show that TLR2/6 but not TLR1/2 heterodimers sense Junin virus glycoprotein and i

128 electively blocked TLR4 stimulation, but not TLR1/2, TLR2/6, or TLR3 activation.

129 TLR6, not TLR1, was shown to be involved in mediating the inflamma

130 ensity >1) also exhibited the highest 25% of TLR1 expression levels (P = .01 by chi2 test).

131 We found that DFE-induced activation of TLR1 and TLR6 may cause polarization toward a T helper t

132 D2.F4 inhibits agonist-induced activation of TLR1, supporting a crucial role for the loop of LRR11 in

133 synthetic lipopeptide Pam3Cys, an agonist of TLR1/2, reduced Treg function and induced Th17 skewing i

134 demonstrated to have enhanced association of TLR1 with the endoplasmic reticulum chaperone gp96.

135 Unravelling the molecular basis of TLR1 and TLR6-driven heterodimerization upon LPA binding

136 TLR5, TLR2, a combination of TLR1 and TLR2, or a combination of TLR2 and TLR6 respond

137 repeat motifs 9-12 in the central domain of TLR1 were found to be critical for cooperative TLR2-indu

138 10 and the intracellular signaling domain of TLR1, revealed that TLR10 senses triacylated lipopeptide

139 ion between soluble extracellular domains of TLR1 and TLR2 and a synthetic triacylated lipopeptide ag

140 Furthermore, transient expression of TLR1 and TLR2 in human embryonic kidney 293 cells result

141 ajor-infected macrophages, the expression of TLR1 and TLR2, but not TLR6, increased; TLR2-TLR2 associ

142 rphisms in TLR1 modify surface expression of TLR1 on T lymphocytes and confer enhanced Teff resistanc

143 icroglia enhances not only the expression of TLR1, -2, and -5, but also that of TLR4.

144 R4, and TLR9, and the baseline expression of TLR1, TLR2, and TLR4, but not TLR9 was significantly low

145 dysregulation, we examined the expression of TLR1, TLR2, TLR4, and TLR9 on B cells and monocytes of f

146 d upregulated mRNA and protein expression of TLR1, TLR6, IL-25, and IL-33 in human atopic dermatitis

147 DFE activated the expression of TLR1, TLR6, IL-25, and IL-33 in human primary keratinocy

148 n a comprehensive study of the expression of TLR1-10 mRNAs and protein in primary human dermal (HD) a

149 The expression of TLR1-9 by UEC was demonstrated by RT-PCR, with only TLR1

150 otif and prevents cell surface expression of TLR1.

151 EDN activates TLR2 independently of TLR1 or TLR6.

152 IL-6 secretion in vitro, the involvement of TLR1 as a TLR2 coreceptor, and the activation of both NF

153 Knockdown of TLR1 resulted in less activation by miRNAs.

154 R9, and TLR10, whereas the cellular level of TLR1, TLR2, and TLR4 is not affected by TRIF overexpress

155 rs with the SNP had higher surface levels of TLR1 and were demonstrated to have enhanced association

156 ication model, combined expression levels of TLR1, TICAM2 and CD14 on day of vaccination and CTLA4 an

157 ter silencing AC7, changes in mRNA levels of TLR1, TNFR-associated factor 6, and ST2 were seen and un

158 Ligation of TLR1/2 caused an increased recruitment of IL-1R-associat

159 tions between DD loop of TLR2 and BB loop of TLR1, Gly-676 in TLR1 was rationally mutated to Ala and

160 signaling pathways, and that the BB loops of TLR1/6 and TLR2 play distinct roles in formation of rece

161 eceptor/resistance (TIR) deletion mutants of TLR1, TLR2, and TLR6.

162 es LRR 9-17 in the extra-cellular portion of TLR1 mediates response to Francisella lipoproteins and t

163 lymorphisms (SNPs) located in this region of TLR1 by generating these variants and examining receptor

164 although the central extracellular region of TLR1 is required for stimulation, there are subtle diffe

165 s for PRAT4A and PRAT4B in the regulation of TLR1 surface expression.

166 , act as positive and negative regulators of TLR1 surface trafficking, respectively.

167 a induction, suggesting an important role of TLR1/2 heterodimer in regulating proinflammatory respons

168 Silencing of TLR1 inhibited PPE17-triggered cytoplasmic export of IRA

169 MyD88-dependent stimulation of TLR1/2 and TLR5 also upregulated PD-L1 expression on CMF

170 Stimulation of TLR1/2 or TLR2/6 dramatically down-regulated FcepsilonRI

171 In addition, the suppression of TLR1 inhibited the release of IL-33.

172 echanism for the differential trafficking of TLR1 I602S variants, and highlight the distinct roles fo

173 We have found that a variant of TLR1 based upon the SNP P315L, located in the loop of LR

174 munity during oral infection is dependent on TLR1 and results from the combinatorial effect of TLR2/T

175 Among the 3 TLR genes at 4p14, only TLR1 was differentially expressed per copy number of the

176 73E, S74D) were defective in binding TLR2 or TLR1 and could not activate APCs, despite retaining full

177 h palmitoyl-3-cysteine-serine-lysine-4 (P3C; TLR1/2 ligand) but not poly(I:C) (TLR3 ligand) or LPS (T

178 Corroboratively, Pam3CSK4 (TLR1-TLR2 ligand) and peptidoglycan (TLR2 ligand) increa

179 40L, Pam2CSK4 (TLR2/6 agonist), or Pam3CSK4 (TLR1/2 agonist).

180 rgic patients were stimulated with Pam3CSK4 (TLR1/2 ligand), FSL-1 (TLR2/6 ligand), monophosphoryl li

181 An analysis of a partial TLR1 cDNA from Sf9 cells indicates that residues that li

182 overlaps those of TLR2 dimerization partners TLR1 and TLR6 extensively.

183 FcepsilonRI and TLR2 as well as its partners TLR1 and TLR6.

184 ands activating Toll-like receptor pathways (TLR1/2, TLR4, and TLR7/8) and influenza virus-and mapped

185 50 activates human and mouse TLR2, TLR2 plus TLR1, and TLR4 in transiently transfected HEK 293 cells

186 to the control sensors fabricated using pure TLR1 or -2 standalone.

187 As a pattern recognition receptor, TLR1 mediates innate immune responses to a variety of mi

188 madelta T cells, express Toll-like receptors TLR1 and TLR2, as well as dectin-1, but not TLR4 and cou

189 gagement of a subset of Toll-like receptors (TLR1, TLR2 and TLR4) results in the recruitment of mitoc

190 e QTLs map to pattern recognition receptors (TLR1-6-10 cluster), cytokine and complement inhibitors,

191 ved from homozygous 602S individuals rescues TLR1 cell surface trafficking and cellular responses to

192 In this role, TLR1 enables host responses to a variety of bacteria, in

193 1519309 [TLR3], rs740044 [ILIR2], rs4543123 [TLR1], rs5741812 [LBP], rs917998 [IL18RAP], and rs313664

194 that line the substrate-binding cleft of Sf9 TLR1 and human BMP1 are nearly perfectly conserved, offe

195 ze that because of their PAMP specificities, TLR1, -2, -5, and -9 may be involved in the pathogenesis

196 ns mediating adaptive immunity (IFNG, STAT1, TLR1) are deficient, whereas those mediating auto-inflam

197 terial lipopeptides, including the synthetic TLR1/2 lipopeptide Pam3CSK4.

198 In contrast, agonists targeting TLR1/2 cause mMDSC to mature into immunosuppressive M2-l

199 of these data, we tested the hypothesis that TLR1/2 stimulation on CTLs would enhance antitumor activ

200 Our results support the idea that TLR1 and TLR6 diverged during evolution to differentiall

201 Immunogenetic analysis showed that TLR1, TLR6, and TLR10 single-nucleotide polymorphisms mo

202 Furthermore the phylogeny shows that TLR1-like genes arose independently in fish, birds and m

203 Our results suggest that TLR1 248S is associated with an increased risk for lepro

204 These findings suggest that TLR1 polymorphisms could influence immune-related diseas

205 The TLR1 rs5743618TT genotype was also associated with C. tr

206 The TLR1 variant (rs4543123) was associated with both multip

207 The TLR1-1805GG polymorphism in B burgdorferi RST1-infected

208 The TLR1/6-BBP failed to inhibit NF-kappaB or MAPK activatio

209 The TLR1/TLR2 heterodimer and NOD2 are important recognition

210 Although the TLR1/LT-IIb-B(5) interface is relatively smaller, the le

211 the causative agent of Lyme disease, and the TLR1/TLR2-specific agonist PAM(3)CSK(4).

212 functional analysis, individuals bearing the TLR1 248N or 80T allele showed lower IL-6 secretion upon

213 whole-blood assays, individuals carrying the TLR1 80R-allele showed increased interleukin 10 producti

214 ses compared with individuals who harbor the TLR1 602I variant.

215 can American women with PID, variants in the TLR1 and TLR4 genes, which may increase signaling, were

216 volved in close contacts with Gly-676 in the TLR1 BB loop.

217 systems, the TLR1 602S variant, but not the TLR1 602I variant, exhibits the expected deficiencies in

218 RAT4B rescues cell surface expression of the TLR1 602S variant.

219 rence further revealed that silencing of the TLR1 and TLR2 genes alone or combined, but not the TLR5

220 We revealed that the C/C genotype of the TLR1 rs5743551 polymorphism was significantly associated

221 Specific silencing of the TLR1, TLR2, or TLR5 gene by RNA interference further rev

222 The frequency of the TLR1-1805GG polymorphism was greater in patients with an

223 We report that the ligation of the TLR1/2 heterodimer on OT-1 cytotoxic T-lymphocytes (CTL)

224 When expressed in heterologous systems, the TLR1 602S variant, but not the TLR1 602I variant, exhibi

225 ken together, these results suggest that the TLR1 602S variant protects against mycobacterial disease

226 tor cells that is, at least in part, via the TLR1-NF-kappaB signaling pathway.

227 induce the same responses compared with the TLR1+TLR2 pair.

228 entified several immune pathways, among them TLR1/TLR6/TLR10, as being shaped by convergent evolution

229 Furthermore, these TLR1 polymorphisms displayed impaired cytokine release b

230 We conclude that this TLR1 SNP leads to excessive PMN priming in response to c

231 astrocytes respond to B. burgdorferi through TLR1/2 and TLR5.

232 al cells through TLR6 and -2 but not through TLR1 and -2.

233 activate TLR2 in vivo (specifically through TLR1/2 heterodimers) could shift the Treg/Th17 balance t

234 ecognized by the Toll-like receptor 2 (TLR2)/TLR1 heterodimer complex.

235 The Toll-like receptor 2 (TLR2)/TLR1 receptor complex responds to amyloid fibrils, a com

236 monstrate that human platelets express TLR2, TLR1, and TLR6.

237 xpression vectors containing genes for TLR2, TLR1, and CD14, membrane-bound CD14 enhanced NF-kappaB a

238 TLR4 stimulation had no effect on TLR2, TLR1, and TLR5 expression.

239 g assays demonstrated that recombinant TLR2, TLR1, and CD14 bound purified curli fibers.

240 cognize diacylated liporoteins, whereas TLR2-TLR1 heterodimers recognize triacylated lipopeptides.

241 ibited cytokine production induced by a TLR2/TLR1 agonist, S-(2,3-bis(palmitoyloxy)-(2R,2S)-propyl)-N

242 nduced cell activation is mediated by a TLR2/TLR1 complex.

243 directly interact with TLR2 and that a TLR2/TLR1 heterodimer is a functional sensor for HCMV.

244 CAM-1 or E-selectin was observed with a TLR2/TLR1 ligand.

245 Instead, activation of TLR2 and TLR2/TLR1 by LPS is in large part due to copurifying molecule

246 former are preferentially recognized by TLR2/TLR1, whereas the latter are favored by TLR2/TLR6.

247 using 293 cells expressing the chimeric TLR2/TLR1 and TLR2/TLR6 complexes, we report the selectivity

248 PorB with TLR2 is essential for driving TLR2/TLR1-dependent cellular responses and is thought to occu

249 Interestingly, TLR2/TLR1 was not involved in T(H)1 immune responses during s

250 ivation by CAP-PEs includes assembly of TLR2/TLR1 receptor complex, induction of downstream signaling

251 esults from the combinatorial effect of TLR2/TLR1-induced IL-6 and IL-23 and the presence of TGF-beta

252 platelets with Pam(3)CSK4, a synthetic TLR2/TLR1 agonist, directly induced platelet aggregation and

253 eritoneal administration of a synthetic TLR2/TLR1 agonist, Pam3CSK4, disease burden was dramatically

254 multaneously treated with the synthetic TLR2/TLR1 ligand Pam(3)CSK(4) or with purified curli fibrils

255 hanced NF-kappaB activation through the TLR2/TLR1 complex stimulated with curli fibers or recombinant

256 enterotoxigenic E. coli, activates the TLR2/TLR1 heterodimer (TLR2/1).

257 the selectivity of PorB binding to the TLR2/TLR1 heterodimer, which is required for initiating signa

258 4 and FTT1103 stimulate exclusively the TLR2/TLR1 heterodimer.

259 Similarly, soluble CD14 augmented the TLR2/TLR1 response to curli fibers in the absence of membrane

260 Activation of the TLR2/TLR1/CD14 trimolecular complex by amyloids provides nove

261 To determine whether this TLR2/TLR1 ligand stimulates inflammatory responses when bacte

262 Thus, TLR2/TLR1 engagement alone by M. tuberculosis lipoprotein tri

263 ating that human CD4(+) T cells can use TLR2/TLR1 heterodimers to directly respond to M. tuberculosis

264 meras but not in macrophages expressing TLR4/TLR1, TLR4/TLR2, or TLR4/TLR6 chimeras.

265 Two of the four loci (TLR6-TLR1 and HLA-DQA1-HLA-DQB1) identified in all three orig

266 Three SNPs located in the TLR6-TLR1 locus had the lowest P-values and Q-values < 0.1 wh

267 The TLR6-TLR1 locus is likely to have a central role in the devel

268 ighest Neandertal ancestry, we find the TLR6-TLR1-TLR10 cluster, which also contains functional adapt

269 The TLRLs TLR1/2L:Pam3CSK4, TLR5L:flagellin, TLR4L:LPS, and TLR8/7

270 Individual murine TLRs (TLR1 to TLR9) and dual combinations of these TLRs that a

271 Toll-like receptors (TLRs) TLR1, TLR2, TLR4, and TLR6 are evolutionarily conserved,

272 RNA for all of the recently identified TLRs, TLR1-9, used for recognition of bacterial and viral mole

273 tory responses to bacterial endotoxin and to TLR1/2, TLR7, and TLR9 ligands, Wnt5A, but not Wnt3A, in

274 e trafficking, confers hyporesponsiveness to TLR1 agonists, and protects against the mycobacterial di

275 alysis reveals that TLR10 is most related to TLR1 and TLR6, both of which mediate immune responses to

276 ndergo maturation exclusively in response to TLR1/2 ligand stimulation and that the immunological sta

277 onstrate that JNK1 regulates the response to TLR1/2 ligands and suggest a positive feedback loop that

278 IFN-alpha production in pDCs in response to TLR1/2, TLR2/6, TLR3, TLR5, and TLR8 engagement in mDCs

279 or to the cell surface, loss of responses to TLR1 agonists, and differential susceptibility to diseas

280 and phosphorylation of MAPK Erk and p38 upon TLR1/2 triggering, compared with predominant activation

281 novel TLR2-dependent activators that utilize TLR1, TLR6, or both as co-receptors.

282 ith TLR1 or TLR6 in 293T cells, but not when TLR1, 2, 3, 5, 6, or 9 was transfected individually.

283 spA is involved in activation of TLR2, while TLR1 serves as a signaling partner.

284 rihydrochloride was strongly associated with TLR1 surface expression.

285 chimeras in some combinations (chimeras with TLR1+TLR2 or TLR2+TLR6 but not TLR1+TLR6) resulted in LP

286 rough activation of TLR2 in cooperation with TLR1.

287 colonic epithelial cells cotransfected with TLR1 and -2 preferentially respond to a synthetic tripal

288 rystal structure of a TLR2 heterodimer (with TLR1) with Pam3CysSK4.

289 nocytes, by inducing heterodimerization with TLR1 in an NADPH oxidase-dependent manner.

290 Although TLR2 forms heterodimers with TLR1 or TLR6, recognizing different ligands, differences

291 TLR4 and the TLR2 heterodimers (with TLR1, TLR6, and possibly TLR10) require in addition the

292 MyD88(-/-) mice, followed by injection with TLR1/2 ligand, resulted in a synergistic antitumor effec

293 48Ser)) (rs4833095), a coding SNP in LD with TLR1-7202G, was also associated with mortality in gram-p

294 In addition, stimulation with TLR1/2 ligand (Pam(3)Cys) or TLR4 ligand (lipopolysaccha

295 Dimerization of TLR2 with TLR1 was inhibited by the n-3 fatty acid docosahexaenoic

296 TLR2, with TLR1 and TLR6, recognizes structurally diverse bacterial

297 TLR2, together with TLR1 and TLR6, is essential for detecting lipopeptides a

298 s is mediated by TLR4 and TLR2 together with TLR1 or TLR6 in mice and TLR1 but not TLR6 in humans.

299 activation when TLR2 was co-transfected with TLR1 or TLR6 in 293T cells, but not when TLR1, 2, 3, 5,

300 common single nucleotide polymorphism within TLR1, is associated with aberrant trafficking of the rec