ライフサイエンスコーパス: TLR10

1 tion was seen to require TLR2 in addition to TLR10.

2 s a source of ligand for the orphan receptor TLR10.

3 n in chemokine output following silencing of TLR10.

4 and IL-8 were reduced following knockdown of TLR10.

5 om an ancestral gene also shared by TLR6 and TLR10.

6 T cell lines, we dissected the regulation of TLR10, a TLR highly expressed in human Treg cells.

7 man mononuclear cells with a monoclonal anti-TLR10 Ab suppressed proinflammatory cytokines released b

8 transfection in human cell lines showed that TLR10 acts as an inhibitory receptor when forming hetero

9 Blocking TLR10 after stimulation of peripheral blood mononuclear

10 The presence of the TLR10 alleles 775L, 369L, or 241H increased interleukin

11 However, TLR10, alone or in cooperation with TLR2, fails to activ

12 ning the extracellular recognition domain of TLR10 and the intracellular signaling domain of TLR1, re

13 ynonymous single-nucleotide polymorphisms in TLR10, and functional consequences of the TLR10 SNPs wer

14 esults suggest that human Treg cells express TLR10, and this expression is regulated through a cooper

15 nuclear cells (PBMCs) preincubated with anti-TLR10 antibody and HEK-293 cells overexpressing TLRs wer

16 After cross-linking anti-TLR10 antibody, no production of IL-1beta and other proi

17 I-related pathogens, and genetic variants in TLR10 are associated with protection against cSSSIs.

18 The modulatory effects of TLR10 are complex, involving at least several mechanisms

19 4p14, the specific ligands and functions of TLR10 are currently unknown, although it is expressed in

20 everal immune pathways, among them TLR1/TLR6/TLR10, as being shaped by convergent evolution in two hu

21 and skin structure infections (cSSSIs), with TLR10 being the first family member known to have an inh

22 Blocking TLR10 by antagonistic antibodies enhanced proinflammator

23 Transcriptional control of TLR10 by FOXP3 was determined through luciferase reporte

24 t Neandertal ancestry, we find the TLR6-TLR1-TLR10 cluster, which also contains functional adaptive v

25 Overexpression of TLR10 completely abrogated TLR2-induced interleukin 8 se

26 We conclude that human TLR10 cooperates with TLR2 in the sensing of microbes an

27 These results demonstrate that TLR10 functions as a broad negative regulator of TLR sig

28 or example, Toll-like receptor 1 (TLR1)/TLR6/TLR10 gene cluster showed a strong signal of adaptive se

29 Relevance of FOXP3 to TLR10 gene transcription in primary T cells was establis

30 ediate phenotype provides strong support for TLR10 genetic variation contributing to asthma risk.

31 Our results demonstrate that TLR10 has a functional role within the B cell lineage th

32 regulator of TLR signaling and suggests that TLR10 has a role in controlling immune responses in vivo

33 Three polymorphisms in TLR10, I775L, I369L, and N241H, were associated with red

34 ort for strong purifying selection acting on TLR10 in B. t. taurus cattle.

35 se a role for TIRAP-dependent TLRs, possibly TLR10 in particular, in the development and/or maintenan

36 This study assessed the role of TLR10 in recognition of cSSSI-related pathogens and whet

37 ogether, these data indicate novel roles for TLR10 in sensing pathogenic infection in both the epithe

38 d pathogens and whether genetic variation in TLR10 influences susceptibility to cSSSIs.

39 Murine TLR10 is a disrupted pseudogene, which precludes investi

40 ledge we demonstrate for the first time that TLR10 is a modulatory pattern-recognition receptor with

41 TLR10 is a modulatory receptor of innate immune response

42 We demonstrate that TLR10 is a modulatory receptor with mainly inhibitory ef

43 TLR10 is a potential asthma candidate gene because early

44 Phylogenetic analysis reveals that TLR10 is most related to TLR1 and TLR6, both of which me

45 Among human TLRs, TLR10 is the only family member without a defined agonis

46 Among the 10-member human TLR family, TLR10 is the only remaining orphan receptor without a kn

47 TOLL-like receptor 10 (TLR10) is the most recently identified human homolog of

48 ctor, which resulted in prompt production of TLR10 mRNA.

49 tion with cSSSI pathogens in the presence of TLR10 neutralizing antibody significantly increased inte

50 by UEC was demonstrated by RT-PCR, with only TLR10 not expressed.

51 We have found that Ab-mediated engagement of TLR10 on primary human B cells suppresses B cell prolife

52 mechanisms mediate the modulatory effects of TLR10: on the one hand, cotransfection in human cell lin

53 SNPs in 11 bovine innate immune genes (TLR1-TLR10, PGLYRP1) for 37 cattle breeds.

54 Furthermore, individuals bearing TLR10 polymorphisms displayed an increased capacity to p

55 Finally, transgenic mice expressing human TLR10 produced fewer cytokines when challenged with a TL

56 Enhanced expression of TLR10 protein in primary Treg cells was induced in a cal

57 nds of publications on TLRs, the function of TLR10 remains unknown.

58 heterodimers (with TLR1, TLR6, and possibly TLR10) require in addition the adaptor TIRAP, whereas UN

59 TLR10 requires TLR2 for innate immune recognition, and t

60 Silencing of TLR10 resulted in increased viability of L. monocytogene

61 asthma, as well as 4p14 near TLR1, TLR6 and TLR10 (rs2101521, P=5.3x10(-21)); 6p21.33 near HLA-C and

62 ular signaling domain of TLR1, revealed that TLR10 senses triacylated lipopeptides and a wide variety

63 tational modeling and mutational analysis of TLR10 showed preservation of the essential TLR2 dimer in

64 genetic analysis showed that TLR1, TLR6, and TLR10 single-nucleotide polymorphisms modulate Y. pestis

65 in TLR10, and functional consequences of the TLR10 SNPs were assessed via in vitro stimulation assays

66 We report here that TLR10 suppressed the production of an array of cytokines

67 ased on the crystal structure of the dimeric TLR10 TIR domain, the first binding site mediates TLR4-T

68 and type 1 IFN were measured in the serum of TLR10 transgenic mice compared to nontransgenic mice, bu

69 th either a T independent or T dependent Ag, TLR10 transgenic mice exhibit diminished Ab responses.

70 transgenic littermate controls, monocytes of TLR10 transgenic mice exhibited blunted IL-6 production

71 3, bditTLR4, TLR5, bditTLR7, TLR8, TLR9, and TLR10 upon Abeta stimulation is severely depressed in mo

72 proximity to the transcription start site of TLR10 was established through EMSA and chromatin immunop

73 We determined that TLR10 was expressed in human Treg cells through quantita

74 Interestingly, TLR10 was found to be expressed at greater levels in IgM

75 TLR10 was found to be predominantly expressed intracellu

76 xtended to TLR3, TLR6, TLR7, TLR8, TLR9, and TLR10, whereas the cellular level of TLR1, TLR2, and TLR

77 esembles closest to the Toll/IL-1R domain of TLR10 with low sequence homology, substantial difference