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1 TM cells were more prone to ER stress from ECM accumulat
2 TM has long been hypothesized to play a role in aging, c
3 TMs have been associated with the capacity of glioma cel
4 r) was observed, from 37.2% (TM-2) to 18.1% (TM-3).This study shows that tea consumed simultaneously
6 relative to water) was observed, from 37.2% (TM-2) to 18.1% (TM-3).This study shows that tea consumed
11 that the second TM domain in the proposed 4-TM model of VKOR does not function as an authentic TM he
13 on method.Iron absorption was 5.7% +/- 8.5% (TM-1), 3.6% +/- 4.2% (TM-2), and 5.7% +/- 5.4% (TM-3).
14 ogous copies of a six-transmembrane-helix (6-TM) domain, which has no sequence homology to the canoni
16 copies of a Shaker-like six-transmembrane (6-TM) domain in each subunit and are ubiquitously expresse
17 extra interactions in seven-transmembrane (7-TM) domain of Smo due to an additional 2-pyridylmethyl g
20 he finding that hydrogen bond strengths in a TM helix can vary widely has implications for membrane p
21 that being more than just membrane anchors, TM helices could play an important role in the clusterin
22 a-ray emission mappings and of the color and TM element speciation by optical absorption spectroscopy
23 e region at the interface between the EC and TM domains, near the interlobe groove of NCT, emerges as
24 endothelial resistance of SC endothelial and TM cell monolayers and reduced monolayer permeability wh
25 ver concordance of diagnoses between WSI and TM methods and interobserver variance from GTC, followin
27 dermatopathologists who diagnosed by WSI and TM with a minimum 30-day washout between methodologies.
29 rtant because the identification of TNTs and TMs fills the gap in our knowledge of how cancer cells c
30 el of VKOR does not function as an authentic TM helix; supporting VKOR is a 3-TM protein, which is di
35 26 experimental dimeric structures formed by TM alpha-helices of 21 single-pass membrane proteins (in
40 o the enhanced functionality of human CD8(+) TM and their prominent role in protection and auto-immun
44 e sequence of APP and possibly other cleaved TM helices may be designed, in part, to make their backb
45 d multivariate linear mixed models comparing TM height and glaucoma type were performed to assess the
47 ain of wild-type hCNT1 and the corresponding TMs of cysteine-less NupC(C-) yielded results that valid
48 s, only two, Abisco((R))-100 and CoVaccineHT(TM), enhanced vaccine efficacy and sterile protection fo
51 nlasered TM from eyes with ExGl demonstrated TM thinning with collapse of Schlemm's canal; and proteo
52 lar heterogeneity of the recently discovered TMs with potential implications for future TM-targeting
53 regarding formation and function of distinct TM subtypes, with multiple parallels to neuronal develop
54 nally mobile regions within transport-domain TMs, identified pore-lining residues of functional impor
55 alphaIIb transmembrane and cytosolic domain (TM/CT) with a tilted beta3 TM/CT that leads to activatio
56 2, hairpin 1, putative transmembrane domain (TM) 7, and TM8), as well as TM9 of the scaffold domain o
57 eric structure for the transmembrane domain (TM) also was modeled and supported by experimental data.
58 tion of the quantitative redox state of each TM in each color shows that the contents of Fe, Cu, and
63 as found, and analysis of the Hendra virus F TM domain revealed a heptad repeat leucine-isoleucine zi
64 cificity: protective (Influenza-induced, Flu-TM) and non-protective (peptide-induced, TIM) spleen mem
74 whereas mutations in transmembrane helices (TM), alphaTM2 and alphaTM4, abolish the stimulation of a
75 hanism, in particular transmembrane helices (TMs) 1a and 7 as well as extracellular loops (ELs) 2 and
77 s9-mediated genome editing in cultured human TM cells and in a MYOC mouse model of POAG to knock down
78 rticoid (GC)-induced glaucoma, primary human TM cells and human post-mortem TM tissues, we show that
83 tachment can cause small (<20%) increases in TM wavelength, and that viscous loss in the subtectorial
84 stress injury was confirmed by reduction in TM-induced cell death when CHOP was depleted in Parkin k
85 Herein, we report a novel finding that, in TM cells, TGF-beta-induced increase in collagen expressi
88 Primary and Preschool Scale of Intelligence(TM)-III (WPPSI-III) and two scales of the Behavior Ratin
89 increased network formation by intercellular TMs, suggesting a functional and molecular heterogeneity
90 mor cells, however, had more interconnecting TMs, which were associated with increased radioresistanc
91 ectively inhibited the formation of invasive TMs and glioma growth, but increased network formation b
93 on was utilized to demonstrate that isolated TM domains of Hendra virus F protein associate in a mono
94 lecular dynamics simulations of the isolated TM domain in explicit lipid bilayers coupled to thermody
95 two residues at the external end of the KCNE TM segments underlie differences in the effects of the d
96 as led to the dramatic acceleration of known TM-catalyzed reactions, as well as to the discovery of u
97 It has been well-established that the known TMs can be classified by the dimensionality of the topol
98 ltisensor radar and optical imagery (Landsat TM/PALSAR/RADARSAT-1/TPI image stack) for detecting peat
99 control can be maintained by replacing lost TM cells, we transplanted TM-like cells derived from ind
100 refractive indices the transverse magnetic (TM) and transverse electric (TE) polarized modes were ca
105 e cartridge was filled with transport media (TM) (sealed at its funnel and back entrance with a stopp
106 that wave motions of the tectorial membrane (TM) play a critical role in determining the frequency se
109 e previously shown that trabecular meshwork (TM) cells might detect aqueous humor fluid shear stress
110 cilin expression in the trabecular meshwork (TM) has been suggested to play an important role in GC-i
112 x (ECM) proteins in the trabecular meshwork (TM) is associated with TM dysfunction and intraocular pr
113 e unlasered portions of trabecular meshwork (TM) of laser-treated primate eyes are understudied.
118 l glasses arise from their transition metal (TM) impurities and capture information about ancient gla
119 coordination of first-row transition metals (TMs) to {P8W48} typically yields frameworks which extend
120 approach that combines Phenotype MicroArray(TM) and SSR genotyping appeared useful to assess the per
123 of glass slides from traditional microscopy (TM) in a large cohort of dermatopathology cases with att
125 related extensions called tumor microtubes (TMs) reported in gliomas in vivo, has propelled this fie
128 s metastasis [POM]; or treatment monitoring [TM]) and type of cancer (prostate, lung, breast, or othe
130 primary human TM cells and human post-mortem TM tissues, we show that increased ECM accumulation lead
133 of the novel form of band crossing, the new TM cannot be described by the established results that c
134 confirmed to be a potent regulator of normal TM morphology and of TM-mediated tumor-cell invasion and
139 ates actin dynamics and the contractility of TM cells, consistent with its regulation of actin-relate
144 Recombinant APC and soluble fragments of TM (sTM) have been tested in settings associated with in
147 onally generated three-dimensional models of TM alpha-helices positioned in membranes; (iv) amino aci
148 cal motions and slower collective motions of TM helices and of structured loops, and used the simple
150 We previously designed a fusion protein of TM [single-chain variable fragment antibody (scFv)/TM] t
151 In this study, we examined the stability of TM during storage and when applied into a model food sys
152 approximation method that calculates TFEs of TM residues in TMBs accurately, with which depth-depende
154 rsity of such compounds, the coordination of TMs to the {P8W48} ring is poorly understood, and theref
156 highest in tests related to the outgrowth of TMs was tweety-homolog 1 (TTYH1), which was highly expre
157 The single mutants had a small effect on TM domain separation and cell death, whereas the double
158 t hair bundle stiffness has little effect on TM traveling waves calculated with physiological paramet
160 o probe the importance of the closed-to-open TM domain transition in the overall energetics of recept
163 ts indicated that a peptide representing p75 TM increases TrkB phosphorylation in a dose- and time-de
164 emical fractionation data suggested that p75 TM stimulates TrkB phosphorylation at the cell membrane.
167 .2%) when tea was administered 1 h postmeal (TM-3) than when tea was administered simultaneously with
170 be a promising target to specifically reduce TM-associated brain colonization by glioma cells in pati
172 r ring resonators, but to date NRPS requires TM-modes, so the TE-modes normally produced by integrate
176 ngle-chain variable fragment antibody (scFv)/TM] targeted to red blood cells (RBCs) to improve pharma
179 concomitantly with or before endotoxin, scFv/TM provided more potent protection against liver injury
184 hese results indicate that RBC-targeted scFv/TM exerts multifaceted cytoprotective effects and may fi
185 arable to Modeller in terms of GDT-TS score, TM-score, and GDT-HA score, while the average RMSD was i
186 mbrane (TM) regions revealed that the second TM domain in the proposed 4-TM model of VKOR does not fu
189 combined assessment of a panel of six serum TMs is a more accurate marker for LC presence than these
190 nthetic methods used for the formation of Si-TM complexes, Section 3 provides an extended discussion
191 le of finding 93+/-2% of all highly similar (TM-score>0.7) structures in the PDB for each query struc
192 TM-1), with tea administered simultaneously (TM-2), and with tea administered 1 h postmeal (TM-3).
194 hase microextraction-transmission mode (SPME-TM) device made of poly(etheretherketone) (PEEK) mesh th
195 ase Micro Extraction-Transmission Mode (SPME-TM) is a technology conceived as an effective synergy be
199 tes according to the scheme (SU-TM)3 --> (SU-TM)2TM --> (SU-TM)TM2 --> TM3 This was the case both whe
200 o the scheme (SU-TM)3 --> (SU-TM)2TM --> (SU-TM)TM2 --> TM3 This was the case both when activation wa
201 er intermediates according to the scheme (SU-TM)3 --> (SU-TM)2TM --> (SU-TM)TM2 --> TM3 This was the
202 We followed the isomerization of the SU-TM disulfide and subsequent SU release from Env with bio
203 event in the transformation via a substrate-TM interaction, an aspect that is uncommon for conventio
205 such as aerobic glycolysis, while memory T (TM) cells engage catabolic pathways, like fatty acid oxi
206 by at least a factor of 60, confirming that TM helix motions are linked to the citrate-binding event
207 (15)N NMR relaxation data and RDCs show that TM is highly ordered and uninterrupted for a total lengt
211 mposed of only a fluorescent protein and the TM helices of Tar to demonstrate that interactions betwe
215 Beyond the glass chemical composition, the TM redox is also a key factor in the glass color, but it
216 trength might be necessary to facilitate the TM helix breaking and bending that is often needed to sa
217 in transmembrane (TM) domains implicated the TM domain in the fusion process, but the structural and
218 that equivalent F, D, and T residues in the TM domain of FcepsilonR1alpha markedly influence the bio
219 nerally, the tocotrienols were stable in the TM form and showed highest stability when these TM were
225 he double mutant significantly increased the TM domain separation and more than doubled the sensitivi
227 ive ECM remodeling can cause fibrosis of the TM as in primary open-angle glaucoma (POAG) patients, an
228 ion at i, i+4 positions at the center of the TM domain dimer eliminates the barrier and stabilizes th
232 de of motions on the cytoplasmic side of the TM helices correlates with the ability of ASR to undergo
233 ter depends on the sequence or length of the TM helices, implying that certain conformations of these
235 ionally, the N- and C-terminal halves of the TM helix form trimeric cores of opposite nature (hydroph
238 ttle effect on the wave, suggesting that the TM is just thick enough to maximize the spatial extent o
239 imal external region (MPER) connected to the TM domain: i.e., the missing parts of the EBOV GP2 struc
240 e photoexcitation/catalytic cycle, where the TM complex plays a "double duty" role by harvesting ligh
241 tion of the P1 domain dipole moment with the TM electrical field considerably lowers the free-energy
242 bilized by hydrophobic interactions with the TM helix and polar and aromatic interactions with neighb
243 g between native E. coli receptors, with the TM sequence of better-clustering high-abundance receptor
244 relies on a conformational change within the TM domain of PhoQ induced by a perturbation in cell memb
245 otrienols were incorporated into yogurt, the TM and bulk oil forms showed a loss of 23.5% and 81.0%,
247 sment of dimerization heterogeneity of these TM domains demonstrated that 7 of them have a unique dim
252 e approximately 3 kcal/mol energy barrier to TM domain opening and the approximately 2 kcal/mol energ
254 st that the heptad repeat LIZ contributed to TM-TM association and is important for F protein functio
257 mation, in vitro assay data (including Tox21(TM)/ToxCast high-throughput screening data), and in sili
261 between the lipid bilayer and transmembrane (TM) helices of Escherichia coli chemoreceptors alone are
262 ling of single-pass (bitopic) transmembrane (TM) proteins and their complexes by providing structural
264 acid residues in the disputed transmembrane (TM) regions revealed that the second TM domain in the pr
265 l dynamics of a seven-helical transmembrane (TM) protein, Anabaena Sensory Rhodopsin (ASR) reconstitu
266 gh backbone hydrogen bonds in transmembrane (TM) helices have the potential to be very strong due to
272 lesterol binds the C-terminal transmembrane (TM) residues, near an amphipathic helix, without requiri
273 ough current models place the transmembrane (TM) and FL domains of GP2 in close proximity at critical
277 the membrane, maintaining the transmembrane (TM) potential, and facilitating the ATP-independent stag
278 ies (TFEs) of residues in the transmembrane (TM) region provides fundamental quantifications of therm
279 mutation in the middle of the transmembrane (TM) segment of KCNE3 introduces KCNE1-like effects on th
280 pressive domain (ISD), in the transmembrane (TM) subunit of the envelope glycoprotein and identified
281 partic acid residues in their transmembrane (TM) domains that mediate assembly, via interaction with
282 by replacing lost TM cells, we transplanted TM-like cells derived from induced pluripotent stem cell
285 dia from both thapsigargin- and tunicamycin (TM)-treated HuH7 cells, mouse primary hepatocytes, and i
286 load or in response to systemic tunicamycin (TM) developed adverse ventricular remodeling with excess
288 rthermore, microscopic analysis of unlasered TM from eyes with ExGl demonstrated TM thinning with col
292 ivalent to diagnosis from glass slides using TM in this statistically powerful study of 499 dermatopa
293 rimental structures of bitopic proteins; (v) TM topology and intracellular localization, (vi) physica
297 trabecular meshwork (TM) is associated with TM dysfunction and intraocular pressure (IOP) elevation
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