ライフサイエンスコーパス: TMEM16

1 mber), and increased sodium tolerance (yeast TMEM16).

2 lso expressed in these cells, while TMEM16B, TMEM16D and TMEM16E were all at least 50 times less abun

3 ther family members, such as TMEM16C (ANO3), TMEM16D (ANO4), TMEM16F (ANO6), TMEM16G (ANO7) and TMEM1

4 The recently identified TMEM16/anoctamin protein family includes Ca(2+)-activate

5 Several chloride channels including TMEM16, bestrophin, CFTR, CLCN2 and CLCA1, are also expr

6 We conclude that TMEM16 CaCCs have intrinsic Vm - and Cl(-) -sensitive du

7 he structural basis of anion conduction in a TMEM16 channel and it defines the foundation for the div

8 Two other purified TMEM16-channel homologues do not mediate scrambling, sug

9 TMEM16 channels consist of eight putative transmembrane

10 The role of the putative pore-loop of TMEM16 channels was investigated using a chimeric approa

11 Given the physiological importance of TMEM16 channels, it is important to study how incoming s

12 ng and validated the idea that ions permeate TMEM16 Cl(-) channels via a structurally homologous path

13 ts, the anoctamin family (ANO, also known as TMEM16) exhibits characteristics most similar to those e

14 Whether distant relatives of the vertebrate TMEM16 families also form CaCCs is an intriguing open qu

15 elated calcium-activated ion channels in the TMEM16 family and conducting systematic mutagenesis of a

16 The TMEM16 family comprises Ca(2+)-activated Cl(-) channels

17 and SCN2A (rs3769955: P = 3.1 x 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 x 10(-20)

18 Here we report that a TMEM16 family member from Drosophila melanogaster, Subdu

19 EM16E), aberrant X segregation (a Drosophila TMEM16 family member), and increased sodium tolerance (y

20 s mutant, the first knockout of a vertebrate TMEM16 family member, provides a mouse model of tracheom

21 less abundantly expressed and the remaining TMEM16 family members were absent.

22 scramblase or an ion channel like other ANO/TMEM16 family members.

23 Thus, the TMEM16 family might have diverged in two or three differ

24 The TMEM16 family of "transmembrane proteins with unknown fu

25 Recently, members of the TMEM16 family of Ca(2+)-gated channels have been shown t

26 The TMEM16 family of membrane proteins, also known as anocta

27 We find that these channels in the TMEM16 family share a homodimeric architecture facilitat

28 TMEM16F of the TMEM16 family that includes TMEM16A/B Ca(2+)-activated C

29 underlies the evolutionary divergence of the TMEM16 family, and that other homologues, such as TMEM16

30 chemistry facilitate lipid permeation in the TMEM16 family, and we hypothesize that membrane interact

31 TMEM16C belongs to the TMEM16 family, which includes the Ca(2+)-activated Cl(-)

32 n for the diverse functional behavior in the TMEM16 family.

33 rily conserved biophysical properties in the TMEM16 family.

34 The transmembrane protein 16 (TMEM16) family of membrane proteins includes both lipid

35 emain to be elucidated and the links between TMEM16 functions and human physiology and pathologies ne

36 Other members of the Tmem16 gene family, including Tmem16f and Tmem16k, were

37 The recent identification of an ancestral TMEM16 homologue with intrinsic channel and scramblase a

38 gated channel, with characteristics of other TMEM16 homologues, and a Ca(2+)-dependent scramblase, wi

39 roteins in yeast: Ist2 (related to mammalian TMEM16 ion channels), the tricalbins (Tcb1/2/3, ortholog

40 structure of the fungal Nectria haematococca TMEM16 (nhTMEM16) scramblase suggested a putative mechan

41 ctamin 1), a member of the transmembrane 16 (TMEM16) protein family, forms CaCCs in pulmonary artery

42 Anoctamin (ANO)/TMEM16 proteins exhibit diverse functions in cells throu

43 sults suggest cooperative roles for CLCA and TMEM16 proteins in influencing the physiology of multipl

44 tions that alter ion channel activity of the TMEM16 proteins localize around the groove, it was sugge

45 blases including bovine rhodopsin and fungal TMEM16 proteins.

46 ly to be a general functional feature of the TMEM16 scramblases and therefore of general importance i

47 ANO5 is a member of the Anoctamin/TMEM16 superfamily that encodes both ion channels and re

48 y members of the anoctamin (Ano, also called Tmem16) superfamily, but the mechanisms of Ano1 gating b