ライフサイエンスコーパス: TMJ

1 TMJ arthritis was present in the majority of patients wi

2 TMJ clicking was the most common clinical symptom.

3 TMJ disk displacement was less prevalent and was of a di

4 TMJ intra-articular status was determined by 3 blinded,

5 TMJ reconstruction with standard alloplastic prosthesis

6 TMJ tissues were removed, and expression of TNF-alpha an

7 There was involvement of 23 TMJs in the 14 patients who had followup MRI studies; re

8 extracellular matrix that may function in a TMJ disc replacement.

9 the FCSC pool and regenerates cartilage in a TMJ injury model.

10 that mice deficient in Gli2 display aberrant TMJ development such that the condyle loses its growth-p

11 Acute TMJ arthritis was diagnosed in 75% of the children by MR

12 Of those with acute TMJ arthritis, 71% were asymptomatic, and 63% had normal

13 JD, representing the subject's most advanced TMJ diagnosis.

14 To assess if estrogens act rapidly to affect TMJ-responsive neurons, we applied 17beta-estradiol (E2)

15 d cartilage thickness significantly affected TMJ disc tractional forces.

16 the prognosis of using standard alloplastic TMJ prostheses for the treatment of TMJ ankylosis in Chi

17 In conclusion, progesterone ameliorated TMJ inflammation through inhibition of NF-kappaB pathway

18 ble working to balancing muscle activity and TMJ reaction ratios during biting to those observed in v

19 es for muscle weight, cranial dimension, and TMJ dimension data.

20 sociation between MRI-depicted effusions and TMJ arthralgia, and (2) a PPT of 1 pound does not discri

21 om Severity Index (SSI) for jaw function and TMJ pain respectively.

22 HS sulfation is critical for mandibular and TMJ development and allows HS-PGs to exert their roles v

23 , but their possible roles in mandibular and TMJ formation are largely unclear.

24 in the underlying pathology of migraine and TMJ disorders.

25 beneficial in the treatment of migraine and TMJ disorders.

26 perienced significant improvement in MIO and TMJ effusion.

27 ermal fibroblasts, a mixture of the two, and TMJ disc cells in a scaffoldless tissue-engineering appr

28 ndent OA-like changes in the knee joints and TMJs.

29 ge-dependent OA-like changes in the knee and TMJs of Col9a1-/- mice starting at the age of 3 months.

30 d in the articular cartilage of the knee and TMJs of the mutant mice.

31 ciceptive response of rats with an arthritic TMJ and reduced the amount of the proinflammatory cytoki

32 Arthritic TMJs showed marked enhancement of the synovial and subsy

33 We found that P4 replacement attenuated TMJ inflammation and the nociceptive responses in a dose

34 Longitudinally, 76% of baseline TMJ soft tissue diagnoses and 71% of the baseline hard t

35 o consider the potential association between TMJ remodeling and mandibular repositioning under orthop

36 The correlations between TMJ intra-articular status and TMD impact were 0.05 (95%

37 Bilateral TMJ MR imaging and clinical examination were performed a

38 Bilateral TMJ PPTs and MRIs were obtained.

39 men with compared to women without bilateral TMJ DD.

40 in women with (+) and without (-) bilateral TMJ disc displacement (DD).

41 between sham-treated and antigen-challenged TMJs.

42 Findings of both acute and chronic TMJ disease were detected by MRI in 53% of the patients.

43 Average ED for contralateral TMJs was significantly larger ( P = 0.012) by 1.4-fold i

44 he condyle and in the disk of the developing TMJ.

45 d 800 times more glycosaminoglycans than did TMJ constructs.

46 ular joint (TMJ) intra-articular disorders ("TMJ intra-articular status"), representing a transition

47 he activating FgfR3(P244R) mutation disturbs TMJ developmental processes, likely by reducing hedgehog

48 importance of regulated RTK signaling during TMJ development and suggest multiple skeletal origins fo

49 clinical symptoms were used to classify each TMJ data sample as healthy control ( n = 124) or TMJOA (

50 Tissue engineering TMJ discs has emerged as an alternative approach to over

51 stages of the disease, using an established TMJ OA genetic mouse model deficient in 2 extracellular

52 However, evaluating TMJ pathology in mice using standard histologic methods

53 nificant shear loads onto the fibrocartilage TMJ disc during jaw motion.

54 nd tissue defects in young bgn(-/0)fmod(-/-) TMJ subchondral bone are likely attributed to increased

55 reduced type I collagen in bgn(-/0)fmod(-/-) TMJ subchondral bone.

56 were three-fold higher in bgn(-/0)fmod(-/-) TMJs than in WT.

57 ted from 3-week-old WT and bgn(-/0)fmod(-/-) TMJs with an intact cartilage/subchondral bone interface

58 ifferentially expressed in bgn(-/0)fmod(-/-) TMJs, including 5 genes involved in osteoclast activity/

59 ease in RANKL/OPG ratio in bgn(-/0)fmod(-/-) TMJs.

60 t biglycan and fibromodulin are critical for TMJ subchondral bone integrity and reveal a potential ro

61 agnosed JIA were prospectively evaluated for TMJ arthritis.

62 t the pig may be a suitable animal model for TMJ bioengineering efforts.

63 Our data indicate that Prg4 is needed for TMJ disc integrity and function and that its absence lea

64 ne integrity and reveal a potential role for TMJ subchondral bone turnover during the initial early s

65 examination are not sufficient to screen for TMJ disease.

66 res greater than 1 pound is a valid test for TMJ arthralgia.

67 od can serve as a primary screening tool for TMJ pathology, before proceeding to complicated, time co

68 coming limitations of current treatments for TMJ disorders.

69 s in tissue stiffness and ultrastructure for TMJ components is critical to understanding joint functi

70 nges in the tissue engineering of functional TMJ discs.

71 dence of TMJ inflammation received CT-guided TMJ injections of corticosteroid (triamcinolone acetonid

72 However, TMJ effusions lack adequate specificity for identifying

73 with a chamber in the exact shape of a human TMJ was designed for controllable perfusion throughout t

74 oromandibular joint (TMJ) and to model human TMJ disease.

75 ile and compressive) properties of the human TMJ disc, and also discs from the cow, goat, pig, and ra

76 ns lack adequate specificity for identifying TMJ arthralgia and were not associated with pain.

77 tion and for the long-term goal of improving TMJ disorder treatment strategies.

78 In TMJ- but not in PO-inflamed rats, Fos-like immunoreactiv

79 number, and enhanced osteoclast activity in TMJ subchondral trabecular bone of UAC-treated rats.

80 f TNF-alpha and its receptors was altered in TMJ tissues during inflammation.

81 electrical and solute transport behaviors in TMJ discs under mechanical loading and aids in the under

82 leviating oxidative stress-related damage in TMJ chondrocytes.

83 To assess the requirement for Ddr2 in TMJ development, studies were undertaken to compare wild

84 hat a reduction in FcgammaRIII expression in TMJ tissues would reduce the nociceptive and inflammator

85 inhibition of ectopic cartilage formation in TMJ disease.

86 the crucial role of sprouty (Spry) genes in TMJ development.

87 ll death and severe functional impairment in TMJ chondrocytes, and warrant in vivo testing to explore

88 Fos expression suggests that an increase in TMJ C-fiber input after inflammation and robust central

89 -AR signal-mediated subchondral bone loss in TMJ osteoarthritisis associated with increased RANKL sec

90 f the temporal bone, with important roles in TMJ functions.

91 upport the idea that Wnt5a/Ror2 signaling in TMJ subchondral BMSCs enhanced by UAC promoted BMSCs to

92 At study inception, TMJ disk displacement was observed in 31% of asymptomati

93 Inceptive TMJ status was maintained after 15 years in 91% (43 of 4

94 or crossbite (UAC) was established to induce TMJ degeneration in rats.

95 an be used as indicators of adjuvant-induced TMJ inflammation.

96 indicators for sequelae of adjuvant-induced TMJ inflammation.

97 on in nociception was comparable to an intra-TMJ injection of 15d-PGJ2.

98 However, intra-TMJ injections are painful.

99 poro-mandibular or temporomandi-bular joint (TMJ), a highly specialized synovial joint that permits m

100 tive remodelling of temporomandibular joint (TMJ) and to determine associated mechanisms.

101 thritis (OA) of the temporomandibular joint (TMJ) and to explore the role of stromal cell-derived fac

102 y used to study the temporomandibular joint (TMJ) and to model human TMJ disease.

103 Temporomandibular joint (TMJ) ankylosis is a refractory disease that is difficult

104 s, but its roles in temporomandibular joint (TMJ) are unclear.

105 Inflammation of the temporomandibular joint (TMJ) can alter behavioral responses such as food intake

106 We selected the temporomandibular joint (TMJ) condylar bone as our tissue model, because of its c

107 l zone niche in the temporomandibular joint (TMJ) condyle.

108 he mutation affects temporomandibular joint (TMJ) development and growth.

109 but their roles in temporomandibular joint (TMJ) development are unknown.

110 -engineering of the temporomandibular joint (TMJ) disc aims to provide patients with TMJ disorders an

111 gitudinal course of temporomandibular joint (TMJ) disc displacement (DD) and degenerative joint disea

112 nt of patients with temporomandibular joint (TMJ) disc displacement without reduction (DDwoR), but th

113 or individuals with temporomandibular joint (TMJ) disc displacement without reduction with limited mo

114 The temporomandibular joint (TMJ) disc is a heterogeneous fibrocartilaginous tissue p

115 degeneration of the temporomandibular joint (TMJ) disc may be promoted by tractional forces.

116 The temporomandibular joint (TMJ) disc plays a critical role in normal function of th

117 ional forces on the temporomandibular joint (TMJ) disc predispose tissue fatigue.

118 ransport in porcine temporomandibular joint (TMJ) discs using the electrical conductivity method.

119 Temporomandibular joint (TMJ) disorders are often associated with development of

120 uency and impact of temporomandibular joint (TMJ) disorders necessitate research in characterizing th

121 ogy of migraine and temporomandibular joint (TMJ) disorders.

122 the hypothesis that temporomandibular joint (TMJ) eminence shapes develop ideally to minimize joint l

123 the consequences on temporomandibular joint (TMJ) growth and organization over age.

124 Temporomandibular joint (TMJ) inflammation is closely associated with oxidative s

125 advanced stages of temporomandibular joint (TMJ) intra-articular disorders ("TMJ intra-articular sta

126 The temporomandibular joint (TMJ) is a complex hinge and gliding joint that induces s

127 The temporomandibular joint (TMJ) is a specialized synovial joint essential for the f

128 ee that the primate temporomandibular joint (TMJ) is loaded compressively during function and that co

129 s) derived from the temporomandibular joint (TMJ) mandibular condyle that generates cartilage anlagen

130 usly shown in a rat temporomandibular joint (TMJ) model that injection of 15d-PGJ2 into the rat TMJ c

131 erally into the rat temporomandibular joint (TMJ) or perioral (PO) skin to produce inflammation in de

132 gy and treatment of temporomandibular joint (TMJ) osteoarthritis (TMJOA) remain complex and unclear.

133 bone remodeling in temporomandibular joint (TMJ) osteoarthritis.

134 seek treatment for temporomandibular joint (TMJ) symptoms, typically occurring with anterior disc di

135 ive response of the temporomandibular joint (TMJ) to mandibular advancement, while others have report

136 affecting the human temporomandibular joint (TMJ), but the underlying molecular mechanisms remain obs

137 The causes of temporomandibular joint (TMJ)-related signs and symptoms are largely unknown.

138 ulations in the rat temporomandibular joint (TMJ).

139 nd in the arthritic temporomandibular joint (TMJ).

140 tive changes in the temporomandibular joint (TMJ).

141 e, we use the human temporomandibular joint (TMJ).

142 oints including the temporomandibular joint (TMJ).

143 erived from bovine temporomandibular joints (TMJ), were examined for matrix loss and the expression o

144 Knee joints and temporomandibular joints (TMJs) from Col9a1-/- mice and their wild-type (Col9a1+/+

145 ke lesions in mice temporomandibular joints (TMJs), displaying as subchondral trabecular bone loss.

146 the right and left temporomandibular joints (TMJs), or in the cisterna magna, respectively, to induce

147 In temporomandibular joints (TMJs), the disc and condylar cartilage function as load-

148 milar for soft tissue diagnoses and the left TMJ.

149 pontaneously in proteoglycan 4 (Prg4) mutant TMJ discs without further invasive procedure.

150 ion is required for completion of post-natal TMJ growth and organization.

151 iant fibrocartilaginous matrix in the native TMJ disc.

152 intermediate zone, reminiscent of the native TMJ disc.

153 emonstrate that DDR2 is necessary for normal TMJ condyle development and homeostasis and that these D

154 sing movements of the mandible, the "normal" TMJ was silent for all age groups.

155 equation model estimated the association of TMJ intra-articular status with the latent measure TMD i

156 Analysis of primary cultures of TMJ articular chondrocytes from wild-type and Ddr2(slie/

157 a) characterized individual-specific data of TMJ stress-field mechanics to determine ED (ED = W/ Q mJ

158 that MRI is preferable for the detection of TMJ disease in new-onset JIA.

159 conductivity, as well as ion diffusivity, of TMJ discs was determined under confined compression with

160 ages 4-16 years with JIA and MRI evidence of TMJ inflammation received CT-guided TMJ injections of co

161 Exposure of TMJ fibrochondrocytes to rHuIL-1beta resulted in the ind

162 d (PPT) of 1 pound for the identification of TMJ arthralgia.

163 nificant implications for the improvement of TMJ therapeutics.

164 l brainstem site for synaptic integration of TMJ sensory signals, while recording single neuron activ

165 complex to influence sensory integration of TMJ-related information.

166 ng pathways is critical for the integrity of TMJ development and for the maintenance of cellular orga

167 ay led to a dramatic and progressive loss of TMJ articular integrity and osteoarthritis-like changes.

168 e technique, previously validated markers of TMJ pain or nociception (specifically, meal duration and

169 dependent manner in the synovial membrane of TMJ.

170 acial skeleton in a juvenile animal model of TMJ arthritis.

171 Models of TMJ intra-articular status other than ours (normal struc

172 ed to determine differences in prevalence of TMJ symptoms among the three examination times.

173 Prevalence of TMJ symptoms did not change significantly between examin

174 tive data on the biomechanical properties of TMJ condylar cartilage.

175 ults showed that the transport properties of TMJ discs were region-dependent.

176 he presence or absence of the self-report of TMJ pain.

177 Histologic specimens of TMJ were assessed quantitatively for arthritis.

178 turnover during the initial early stages of TMJ OA disease in this model.

179 ole in joint function may guide our study of TMJ pathologies, including disc displacement.

180 d no previous history or present symptoms of TMJ pain or dysfunction.

181 ly, the osteoblast activity in the tissue of TMJ subchondral trabecular bone of these UAC-treated rat

182 oplastic TMJ prostheses for the treatment of TMJ ankylosis in Chinese patients with severe mandibular

183 HA(oligos) treatment of TMJ chondrocytes resulted in enhanced MMP-3 expression,

184 cal loading and aids in the understanding of TMJ pathophysiology related to tissue nutrition.

185 Conceptualizing worsening of TMJ intra-articular disorders as 4 stages and characteri

186 Analysis of TMJs from newborn Ddr2(slie/slie) mice revealed a develo

187 essed and activated in the articular zone of TMJs but not knee joints.

188 rogated the catabolic effects of IL-1beta on TMJ chondrocytes by inhibiting iNOS, COX-2, and MMP-1 mR

189 ntially diminishing its catabolic actions on TMJ fibrochondrocytes.

190 The effects of continuous passive motion on TMJ were simulated by exposing primary cultures of rabbi

191 sive loading and stress-field translation on TMJ disc-surface tractional forces and stresses.

192 Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease that affects both cart

193 Two primary outcomes (TMJ pain intensity and maximum mouth opening) and a numb

194 increased osteoclast activity and an overall TMJ subchondral trabecular bone loss in the UAC-treated

195 Porcine TMJ discs (n = 187) received a 10-N vertical static load

196 Porcine TMJ discs were compressed between an axially translating

197 tation creep tests were performed on porcine TMJ condylar cartilage at 5 different regions-anterior,

198 ntact area were performed on 8 adult porcine TMJs at 5 different regions (anterior, posterior, centra

199 ential direct and indirect roles to preserve TMJ structural and cellular integrity over post-natal li

200 Primary TMJ synoviocytes were treated with TNF-alpha or IL-1beta

201 A-adrenergic signal in chondrocytes promotes TMJ degenerative remodelling by chondrocyte-mediated pro

202 Previous quantitative TMJ characterization studies examined either the human o

203 lated by exposing primary cultures of rabbit TMJ fibrochondrocyte monolayers to cyclic tensile strain

204 The impact of PLGA MP concentration on rat TMJ function was quantified via computerized meal patter

205 odel that injection of 15d-PGJ2 into the rat TMJ can provide antinociceptive relief against a subsequ

206 15d-PGJ2 cream for 15min directly on the rat TMJ skin did not induce any significant antinociceptive

207 able for intra-articular delivery to the rat TMJ, a finding that has significant implications for the

208 y (within 10 minutes) and reversibly reduced TMJ-evoked neural activity at the Vc/C(1-2) region.

209 ical evidence and various theories regarding TMJ growth modification are discussed.

210 ession of hard tissue diagnoses in the right TMJ occurred in 15.2% of subjects (95% CI, 10.5% to 20.8

211 llenge from formalin injection into the same TMJ.

212 H rats also demonstrated larger implant-side TMJ discs and mandibular fossae in comparison with the o

213 hate-buffered physiological saline solution, TMJ = temporomandibular joint, mu(T) =tractional coeffic

214 he fact that a reliable animal model of such TMJ diseases is not available.

215 represent a compensatory response to sustain TMJ movement and function.

216 The majority of children with symptomatic TMJ arthritis improved after intraarticular corticostero

217 advancement, while others have reported that TMJ adaptive responses are non-existent and negligible.

218 The TMJ and PO inflammation-induced Fos expression parallele

219 Although the TMJ disc has been well-characterized under tension and c

220 their mandibular ramus was elongated by the TMJ prosthesis and 2 patients were combined with Le Fort

221 Thus, we characterized the TMJ phenotype in wild-type and Prg4 -/- mouse littermate

222 ent an efficient approach to engineering the TMJ disc graft with anisotropic scaffold microstructure,

223 oparticle-based drug delivery system for the TMJ.

224 region, to modulate sensory signals from the TMJ region.

225 to dynamic behavior, perhaps implicating the TMJ disc as a structure primarily exposed to predominant

226 entified in this screen were examined in the TMJ and compared with those of other synovial joints, in

227 ated by type I and III collagen found in the TMJ and other fibrocartilages, has been associated with

228 icking anisotropic collagen alignment in the TMJ disc and corresponding mechanical properties.

229 ssive strain impeded solute transport in the TMJ disc.

230 ify changes in gene expression levels in the TMJ during early stages of the disease, using an establi

231 ine measures; follow-up was performed in the TMJ Impact Project.

232 n of an osteoarthritis-like condition in the TMJ in the Col1-IL-1betaXAT mouse model resulted in up-r

233 L-1beta) and IgG content was measured in the TMJ tissue by enzyme-linked immunosorbent assay.

234 FcgammaRIII expression in the TMJ tissue was assayed by immunocytochemistry or Western

235 RNA reduced the amount of FcgammaRIII in the TMJ tissues, and the transcript was cleaved in a manner

236 s behind the various tissues involved in the TMJ's normal growth and maturation.

237 the articular eminence/glenoid fossa in the TMJ, and fusion of the articular disc.

238 in conjunction with arthritic changes in the TMJ, assessed by histopathologic and immunohistochemical

239 s or agonists were injected locally into the TMJ area of UAC rats.

240 th complete Freund's adjuvant (CFA) into the TMJ or served as uninjected controls and were killed two

241 CFA injection, the injection of CFA into the TMJ produced a significantly stronger inflammation assoc

242 Cs (GFP-BMSCs) were weekly injected into the TMJ region for 4, 8, and 12 wk.

243 tructs were expected to appear most like the TMJ disc constructs.

244 ed to guide bony mass removal and locate the TMJ prosthesis (Biomet, USA).

245 een patients had followup MRI studies of the TMJ 6-12 months after injection.

246 tion of the joint, and many disorders of the TMJ are a result of disc dysfunction.

247 The main components of the TMJ are the mandibular condyle, the glenoid fossa of the

248 t the fibrous and cartilaginous zones of the TMJ condyle.

249 The ultrastructure of the TMJ disc and cartilage is different from that of hyaline

250 t than the corresponding contact area of the TMJ disc.

251 ional forces following static loading of the TMJ disc: (1) increase with compressive strain at the st

252 The OA cartilage of the TMJ displays a synchronous increase in SDF-1 and RANTES

253 for cellular and molecular evaluation of the TMJ during its adaptive response to biomechanical forces

254 s adaptive remodeling or degeneration of the TMJ following discectomy.

255 Individuals with JRA of the TMJ frequently show aberrations in mandibulofacial devel

256 njected into the superior joint space of the TMJ in rats.

257 The etiology of degenerative disease of the TMJ may involve fatigue produced by surface tractional f

258 e genetic program for the development of the TMJ remains poorly understood.

259 ions in experimental JRA-like disease of the TMJ that are similar to those observed in humans with th

260 Fundamentally, OA of the TMJ was induced by unilateral anterior crossbite in mice

261 the synovial and subsynovial tissues of the TMJ, and plasma volume (PV) and permeability surface are

262 resulting from inflammatory arthritis of the TMJ, and siRNA has the potential to be an effective trea

263 tered craniofacial development in JRA of the TMJ, we characterized the gross morphologic adaptations

264 olecular framework for future studies of the TMJ.

265 iated with adjuvant-induced arthritis of the TMJ.

266 rol related to inflammatory disorders of the TMJ.

267 subchondral bone loss in mice with OA of the TMJ.

268 towards degraded cartilage in mice OA of the TMJ.

269 we performed micro-tribometry testing on the TMJ disc and condylar cartilage to obtain their region-

270 ut the effect of orthopedic treatment on the TMJ, it is necessary that we understand the biologic bas

271 As in primates, the TMJ was found to be load-bearing during mastication, wit

272 During stimulation, the TMJ reaction strains were significantly lower with the c

273 bly, our work provides the evidence that the TMJ condyle and disc develop independently of the mandib

274 differences were noted, indicating that the TMJ forms via a distinct molecular program.

275 ologically and biochemically superior to the TMJ disc and dermal fibroblast constructs, and their com

276 structs would produce matrix relevant to the TMJ disc, but the mixture constructs were expected to ap

277 highly expressed in muscles attached to the TMJ, including the lateral pterygoid and temporalis musc

278 The TMJs of all patients were imaged with MRI and US within

279 valbumin was used to induce arthritis in the TMJs of 10 previously sensitized adult white rabbits.

280 ficantly greater degenerative changes in the TMJs of 3- and 10-mo-old Ddr2(slie/slie) mice as compare

281 ighted magnetic resonance (MR) images of the TMJs in 58 patients with pain and dysfunction were analy

282 of effusions was observed in 11 (48%) of the TMJs.

283 ic as well as asymptomatic, maintained their TMJ status during 15 years.

284 Common to TMJ and PO inflammation, Fos-LI was induced in the trige

285 by the addition of hydrogen peroxide (HO) to TMJ-derived chondrocyte cultures.

286 that these DDR2 functions are restricted to TMJ fibrocartilage and not seen in the hyaline cartilage

287 a transition from normal joint structure to TMJ disc displacement with and without reduction (DDwR a

288 , were significantly elevated in CFA-treated TMJ tissues.

289 e all significantly increased in CFA-treated TMJ tissues.

290 ) in antigen-challenged than in sham-treated TMJs.

291 number of posterior functional tooth units, TMJ disorder, and dentition status) on overall diet qual

292 stimated potential for cartilage fatigue via TMJ energy densities (ED) and jaw muscle duty factors (D

293 and treatment of morbidities associated with TMJ arthritis in JIA.

294 er fibrocartilages, has been associated with TMJ degeneration, but its role in normal joint developme

295 Thirty females with TMJ disc displacement with reduction were divided into t

296 that primary treatment for individuals with TMJ closed lock should consist of medical management or

297 n a single-blind trial, 106 individuals with TMJ closed lock were randomized among medical management

298 RI-depicted effusions identify patients with TMJ arthralgia.

299 int (TMJ) disc aims to provide patients with TMJ disorders an option to replace diseased tissue with

300 ales in each of two groups, with and without TMJ disc displacement.