ライフサイエンスコーパス: TMP

1 TMP reached maximal levels on day 3 after drug administr

2 TMP residues were measured above LOD (0.3 mug kg(-)(1))

3 TMP-AcBOPDIPY rapidly labeled engineered eDHFR tags via

4 TMP-SMX administration significantly reduced liver stage

5 TMP-SMX inhibited development of rodent and P. falciparu

6 TMP-SMX is not gametocytocidal, but at prophylactic leve

7 TMP-SMZ may be used safely for prophylaxis of recurrent

8 unteers were randomly assigned to Group 1 (1 TMP-SMZ tablet every 2 days for 311 days) or Group 2 (1

9 gated and compared to previously reported (1-TMP-2-BH2-C6H4)2 (1; TMP = tetramethylpiperidyl) and (1-

10 previously reported (1-TMP-2-BH2-C6H4)2 (1; TMP = tetramethylpiperidyl) and (1-NMe2-2-BH2-C6H4)2 (4;

11 m alkylmagnesium amide [Na4Mg2(TMP)6(nBu)2] (TMP=2,2,6,6-tetramethylpiperidide), a template base as i

12 olones (35%), followed by carbapenems (20%), TMP-SMX (18.5%), and ceftazidime (11%).

13 class 1 integron was found in 25 (93%) of 27 TMP-SMX-resistant CgA isolates but in only 43 (63%) of 6

14 n-CgA isolates (P < 0.001) and in none of 44 TMP-SMX-susceptible E. coli isolates (P < 0.0001).

15 mploying [5',5"-D,D]-5'-dThd, [5',5"-D,D]-5'-TMP, [CD(3)]-dThd and [CD(3),6D]-dThd, we find unequivoc

16 nM, respectively) when assayed with p-Nph-5'-TMP as a substrate.

17 ophenyl 5'-thymidine monophosphate (p-Nph-5'-TMP) as an artificial substrate.

18 se substrate p-nitrophenyl 5'-dTMP (p-Nph-5'-TMP).

19 confirmed by employing (15)N substituted 5'-TMP.

20 up 9 hydrazido(2-) complex, Cp*IrN(TMP) (6) (TMP=2,2,6,6-tetramethylpiperidine) is reported.

21 tant CgA isolates but in only 43 (63%) of 68 TMP-SMX-resistant non-CgA isolates (P < 0.001) and in no

22 ) clindamycin-treated and 182 of 198 (91.9%) TMP-SMX-treated subjects (difference, 0.2%; 95% confiden

23 Among 95 TMP-SMX-resistant isolates, 68 and 27 isolates carried c

24 ICLs generated by trioxsalen/ultraviolet A (TMP/UVA) during development and aging.

25 with A-TMP-fluorescein, A-TMP-Dapoxyl, and A-TMP-Atto655.

26 ar protein targets with A-TMP-fluorescein, A-TMP-Dapoxyl, and A-TMP-Atto655.

27 ed an acrylamide-trimethoprim-fluorophore (A-TMP-fluorophore v2.0) electrophile with an optimized lin

28 sis for routine production of a variety of A-TMP-probe v2.0 labels.

29 ct the covalent trimethoprim chemical tag (A-TMP-tag) has on the SM imaging performance of the fluoro

30 cell environment and demonstrate that the A-TMP-tag complements the advantageous SM imaging properti

31 es for SM imaging and demonstrate that the A-TMP-tag with Atto655 and Alexa647 are promising reagents

32 properties of these fluorophores and their A-TMP-tag conjugates.

33 aving an 8-min half-life for reaction with A-TMP-biotin v2.0 in vitro.

34 g of various cellular protein targets with A-TMP-fluorescein, A-TMP-Dapoxyl, and A-TMP-Atto655.

35 e was 39% against ciprofloxacin, 44% against TMP-SMX, and 25% against cefuroxime.

36 anometallic reagents (Mg(CH2 SiMe3 )2 and Al(TMP)iBu2 ), key intermediates in this process have been

37 y studies of zincates 4 and 7 with the amine TMP(H) supply experimental evidence that these heterobim

38 solate, and 5% were resistant to ampicillin, TMP-SMX, and chloramphenicol.

39 Mixing of KOtBu, BuLi, and TMP(H) in heptane gave a solution of the base mixture wh

40 ngs where MRSA is prevalent, clindamycin and TMP-SMX produce similar cure and adverse event rates amo

41 gnificant difference between clindamycin and TMP-SMX, with respect to either efficacy or side-effect

42 kis(pentafluorophenyl)porphyrin dianion) and TMP (tetramesitylporphyrin dianion), with and without im

43 y is required to rearrange the disulfide and TMP to its most effective orientation for the SMe group

44 iocakes, indicating that membrane fluxes and TMP evolution levels had significant effects on the abun

45 with the mononucleotides AMP, CMP, GMP, and TMP.

46 encoded chemical tags CLIP, SNAP, Halo, and TMP for tissue labeling; this resulted in >100-fold incr

47 fragments were cloned upstream of mDHFR and TMP resistant clones expressing soluble protein were ide

48 We characterized NNRTI and TMP-SMX effects on Plasmodium liver stages in vivo using

49 -effects and poor adherence by patients, and TMP-SMX alone is recommended in Australia.

50 iL (AaThiL) with nonhydrolyzable AMP-PCP and TMP, and also with the products of the reaction, ADP and

51 Significant differences in the SMM and TMP concentrations between yolk and white in post treatm

52 complexes (TMP)Co-CH(OAc)CH3 (4, Co-R2) and (TMP)Co-CH(OAc)CH2C(CH3)2CN (3, Co-R1), respectively.

53 ase inhibitor nevirapine, and the antibiotic TMP-SMX were assessed for activity against Plasmodium fa

54 f the iodonium moiety and unsymmetrical aryl(TMP)iodonium salts are primarily employed.

55 lts, we conducted in vitro studies assessing TMP-SMX effects on the rodent parasites P. yoelii and Pl

56 alations with sterically hindered TMP bases (TMP = 2,2,6,6-tetramethylpiperide) of magnesium and zinc

57 n of substituted toluenes using BuLi/KO-t-Bu/TMP(H) (LiNK metalation conditions) with subsequent in s

58 wo-step deprotonation reaction of anisole by TMP-dialkyl zincates and show the relevance of the alkyl

59 ction of feed constituents was influenced by TMP and RSF.

60 , the next dNTP is added slowly to a D-carba TMP at the primer terminus.

61 ditional dNTPs, which should protect D-carba TMP from excision.

62 form the six-coordinate 18-electron complex (TMP)Rh-OCH(3)(CH(3)OH).

63 A luminescent terbium complex, TMP-Lumi4, was introduced into cultured cells using two

64 proceed on to form organo-cobalt complexes (TMP)Co-CH(OAc)CH3 (4, Co-R2) and (TMP)Co-CH(OAc)CH2C(CH3

65 robustness, this second-generation covalent TMP-tag adds to the limited number of chemical tags that

66 here we report a second-generation covalent TMP-tag that has a fast labeling half-life and can readi

67 ed, placebo-controlled trial comparing daily TMP-SMX plus monthly dihydroartemisinin-piperaquine (DP)

68 the daily TMP-SMX plus DP arm and the daily TMP-SMX alone arm (6.1% vs. 3.1%; relative risk, 1.96; 9

69 acental malarial infection between the daily TMP-SMX plus DP arm and the daily TMP-SMX alone arm (6.1

70 dihydroartemisinin-piperaquine (DP) to daily TMP-SMX alone in HIV-infected pregnant women in an area

71 g of insecticide, adding monthly DP to daily TMP-SMX did not reduce the risk of placental or maternal

72 ing conformations may contribute to decrease TMP binding and thus may be responsible for TMP resistan

73 ection effects in the ternary complexes DHFR.TMP.NADPH (large positive binding co-operativity) and DH

74 he increase in protein stability in the DHFR.TMP.NADPH complex involves increased ordering in the pro

75 For the DHFR.TMP.NADPH complex, the ligand-induced protection factors

76 peated exposures to malaria parasites during TMP-SMX administration induces stage-specific and long-l

77 richia coli dihydrofolate reductase (eDHFR), TMP-decorated iron oxide nanoparticles bind to eDHFR wit

78 ormation of the binary complexes with either TMP or NADPH and that the binary structures are approach

79 Emerging CC1292 expressed TMP-SMX resistance and decreased susceptibility to penic

80 integrons harboring resistance cassettes for TMP-SMX (dfr) was examined.

81 R(TMP) on [O(2)] provided rate constants for TMP reaction, O(2) quenching, and lifetimes compatible w

82 s own mRNA depending on cellular demands for TMP.

83 r labile solid phase pools were observed for TMP than for SAs.

84 TMP binding and thus may be responsible for TMP resistance.

85 hydrofolate reductase (DHFR), the target for TMP.

86 The order of reactivity was OEP > TPP > TMP.

87 ating that synthesis of [(3)H]TTP from [(3)H]TMP arose solely from the dephosphorysynthase pathway th

88 d the metabolism of [(3)H]thymidine or [(3)H]TMP as precursors of [(3)H]TTP in isolated intact or bro

89 The equivalent addition of [(3)H]TMP produced far less [(3)H]TTP than the amount observed

90 des deoxyuridine triphosphatelation of [(3)H]TMP to [(3)H]thymidine.

91 t TK2, the synthesis of [(3)H]TTP from [(3)H]TMP was effectively blocked, demonstrating that synthesi

92 3)H]thymidine was readily converted to [(3)H]TMP, but further phosphorylation was prevented even thou

93 on of long-lived CD62L(hi)Bcl-2(hi)Eomes(hi) TMPs.

94 However, the biocake (S2 and S4) at a high TMP level (i.e., after the TMP jump) had many more prote

95 irected metalations with sterically hindered TMP bases (TMP = 2,2,6,6-tetramethylpiperide) of magnesi

96 However, TMP-resistant strains have arisen with point mutations i

97 duces clinical episodes of malaria; however, TMP-SMX effect on Plasmodium liver stages requires furth

98 This work suggests that hybrid TMPs constitute an interesting class of materials for fu

99 zene and react to produce transient hydride (TMP)Co-H and radicals (*CH(OAc)CH2C(CH3)2CN (R1*)) that

100 MP)Rh-OCH(3)(CH(3)OH)) and rhodium hydride ((TMP)Rh-H) complexes.

101 There were no significant differences in TMP blush scores or ST-segment resolution.

102 To determine the role of the membrane in TMP metabolism, mitochondrial membranes were disrupted b

103 with three FO membranes and with increasing TMP up to a maximum of 50 psi (3.45 bar).

104 anes might slightly increase with increasing TMP, and RSF substantially declines with increasing TMP.

105 d RSF substantially declines with increasing TMP.

106 rminal Group 9 hydrazido(2-) complex, Cp*IrN(TMP) (6) (TMP=2,2,6,6-tetramethylpiperidine) is reported

107 rt and 0 degrees C using a mixed-metal Li/K-TMP amide comprised of KOtBu, BuLi, and 2,2,6,6,-tetrame

108 Resistance to at least TMP-SMX and ampicillin was present in 25% of isolate, an

109 tuted tetraphenylporphyrin type macrocycles (TMP or To-F(2)PP) with covalently attached N-donor ligan

110 e prefers TMP synthesized by TK2 over medium TMP and that this is disrupted in broken mitochondria.

111 ervable equilibrium with rhodium methoxide ((TMP)Rh-OCH(3)(CH(3)OH)) and rhodium hydride ((TMP)Rh-H)

112 as achieved by using a hindered catalyst, Mn(TMP)Cl, 2.

113 measurements of thymidine 5'-monophosphate (TMP) and acid-digested plasmid and genomic DNA preparati

114 for most of the thymidine 5'-monophosphate (TMP), calf thymus DNA (CTDNA), and plasmid DNA (PLDNA) a

115 nt phosphorylation of thiamin monophosphate (TMP) to form thiamin pyrophosphate (TPP), the active for

116 rein the sodium alkylmagnesium amide [Na4Mg2(TMP)6(nBu)2] (TMP=2,2,6,6-tetramethylpiperidide), a temp

117 corresponding to oxidants such as [Fe(IV)(O)(TMP)] (TMP = tetramesitylporphinate), [Ru(IV)(O)(bpy)(2)

118 teria grayi We found that the acquisition of TMP resistance via decreased drug affinity is limited by

119 We wished to determine if the acquisition of TMP-SMX resistance by CgA occurred before or after the C

120 pargyl-linked inhibitors reveal the basis of TMP resistance and illuminate the influence of Tyr 102 o

121 s to a postulate for the structural basis of TMP resistance in DHFR and also suggests design strategi

122 fusive, most likely caused by confinement of TMP mobility by the submembranous MreB network.

123 FR, the biocompatibility of the conjugate of TMP-iron oxide nanoparticles renders a convenient and ve

124 osensitized transformation rate constants of TMP decreased with increasing DOM preoxidation and were

125 alth clinic and analyzed for determinants of TMP-SMX resistance.

126 inical rationale for clinical development of TMP in WM alone or in combination with inhibitors of MYD

127 aimed at determining the optimum duration of TMP-SMX prophylaxis in HIV-infected or HIV-exposed child

128 potential anti-infection immunity effect of TMP-SMX prophylaxis.

129 We compared the efficacy and side-effects of TMP-SMX with TMP-SMX plus doxycycline for the oral phase

130 are commonly prescribed, but the efficacy of TMP-SMX has been questioned.

131 nce of the alkyl groups in the efficiency of TMP-dialkyl zincate bases.

132 mples after accounting for the inhibition of TMP photodegradation by DOM.

133 ween peak current intensity and logarithm of TMP concentration between 1.0 x 10(-6) and 1.0 x 10(-4)M

134 iously noted for the photosensitized loss of TMP, the incomplete inhibition of the enhanced RH2O2 fol

135 and 4a as catalysts gave in the presence of TMP TOFs of up to 7.5 h(-1), producing [TMPH][formate] (

136 embrane fouling both in terms of the rate of TMP development and the properties of the membrane cake

137 The knockdown of Rpn6 upon removal of TMP revealed that this protein is essential for ubiquiti

138 2.1.1.45), which catalyzes the synthesis of TMP and is the sole de novo source of TTP for DNA replic

139 All volunteers were treated with 1 tablet of TMP-SMZ (160 mg/800 mg) twice daily for 45 days, and all

140 A randomized controlled trial of TMP-SMZ prophylaxis in patients receiving biologics is n

141 The combined use of TMP with Bruton's tyrosine kinase or interleukin-1 recep

142 esistance to ceftazidime, and limited use of TMP-SMX.

143 R signaling actively blocks the formation of TMPs responding to weak TCR agonists, thereby promoting

144 B cytoskeleton and regulates the mobility of TMPs.

145 led formation of an unsymmetrical adduct of (TMP)Co-CH(OAc)CH3 (4) with *CH(OAc)CH3 (R2*) and support

146 ction is made for the reactivity and KIE of (TMP)Fe(IV) horizontal lineO complex, and a comparison is

147 d LRV remained stable at different operating TMPs.

148 incision and drainage alone, clindamycin or TMP-SMX in conjunction with incision and drainage improv

149 ved oral clindamycin 300 mg 4 times daily or TMP-SMX 320 mg/1600 mg twice daily, each for 7 days.

150 patients to receive TMP-SMX plus placebo or TMP-SMX plus doxycycline for 20 weeks (1:1; block size o

151 Recently, we successfully rendered our TMP-tag covalent with a proximity-induced reaction betwe

152 MI) flow grade, tissue myocardial perfusion (TMP) blush, ST-segment resolution, and major adverse car

153 osed of layered transition metal phosphates (TMPs) covalently bound to organic absorber molecules to

154 muM inhibited (66-99%) the hydrolysis of pnp-TMP by both recombinant NPP1 and cell surface NPP1 activ

155 ne with tetramesityl rhodium(II) porphyrin ((TMP)Rh(II*)) produces a (1)H NMR-observable equilibrium

156 tions of cobalt(II) tetramesityl porphyrin ((TMP)Co(II)*, 1) and vinyl acetate (VAc) in benzene and r

157 es for studying the transmembrane potential (TMP) induced during the treatment of biological cells wi

158 a small number of memory T cell precursors (TMPs) survive to form a pool of long-lived memory T cell

159 The preelectroporation TMP induced in tightly packed cells is analyzed for two

160 compartmentalized so that TMP kinase prefers TMP synthesized by TK2 over medium TMP and that this is

161 Among children prescribed TMP-SMX prophylaxis, there were no significant differenc

162 Among children not prescribed TMP-SMX prophylaxis, 4443 treatments for malaria were gi

163 The trans-membrane pressure (TMP) increase was similar in the early stages of the mem

164 iocake (S3) at a low transmembrane pressure (TMP) level (i.e., before the TMP jump) had larger gray i

165 rated that hydraulic transmembrane pressure (TMP), common in industrial operation of FO membrane elem

166 ncreasing operating transmembrane pressures (TMPs).

167 and membrane affects trans-membrane protein (TMP) diffusion and reveal that the mobility of the TMPs

168 sensor was successfully applied to quantify TMP in urine samples.

169 strong acceptor tetracyano-p-quinodimethane (TMP/HMP-TCNQ) were grown by vapor diffusion.

170 R(TMP) was inversely proportional to dioxygen concentratio

171 rate of 2,4,6-trimethylphenol (TMP) loss (R(TMP)) on dioxygen concentration was examined both for a

172 tion, as well as the inverse dependence of R(TMP) on [O(2)] for these samples, suggests that there re

173 Modeling the dependence of R(TMP) on [O(2)] provided rate constants for TMP reaction,

174 We show that DD-Cre triggers rapid TMP-dependent recombination of loxP-flanked ('floxed') a

175 ce, we randomly assigned patients to receive TMP-SMX plus placebo or TMP-SMX plus doxycycline for 20

176 One participant who received TMP-SMX had a hypersensitivity reaction.

177 ria after DP treatment in children receiving TMP-SMX prophylaxis.

178 However, for children receiving TMP-SMX, associations were strong and evident for all sa

179 In children not receiving TMP-SMX, low piperaquine concentrations were only modest

180 Borohydride reduction significantly reduced TMP loss, supporting the role of aromatic ketone triplet

181 MOM group replaced TMP C ring and generated a potent analogue 15, which sho

182 The soils could resupply TMP so rapidly that in one soil, where Tc = 2 min, suppl

183 rim-sulfamethoxazole (TMP-SMX) and rifampin, TMP-SMX alone, rifampin alone, or tetracycline alone.

184 the isolated Ru(T-pMe-PP)((t)BuSH)(2) and Ru(TMP)(MeSSMe)(2), were characterized in situ.

185 mation of the bis(disulfide) complex from Ru(TMP)(MeCN)(2) in solution occurs with a cooperativity ef

186 disulfide in the solid state structure of Ru(TMP)(MeSSMe)(2) is eta(1)(end-on) coordinated, the first

187 quaternary substituted products (see scheme; TMP = 2,2,6,6-tetramethylpiperidine).

188 red during and after administration of a SMM/TMP combination in laying hens in doses of 8 g l(-)(1) a

189 ulfamethoxazole-trimethoprim 800/160 mg (SMZ/TMP) daily for 30 days followed by Monday, Wednesday, Fr

190 c gram-negative antibiotic resistance to SMZ/TMP (75% vs. 80%; P=1.00) and ciprofloxacin (16.7% vs. 3

191 an additional 5 months (Group 1) versus SMZ/TMP Monday, Wednesday, Friday for 6 months plus ciproflo

192 d 1H-perfluoroalkane reagents, DMPU solvent, TMP(2)Zn base, and a copper chloride/phenanthroline cata

193 The compatibility of the strong TMP-bases with BF3.OEt2 (formation of frustrated Lewis p

194 l evidence is trimethoprim-sulfamethoxaxole (TMP-SMX) plus doxycycline.

195 omycin (23%), trimethoprim-sulfamethoxazole (TMP-SMX) (9%), and cefuroxime (7%).

196 Trimethoprim-sulfamethoxazole (TMP-SMX) and fluoroquinolones were active against 94% an

197 Daily trimethoprim-sulfamethoxazole (TMP-SMX) and insecticide-treated nets remain the main in

198 included oral trimethoprim-sulfamethoxazole (TMP-SMX) and rifampin, TMP-SMX alone, rifampin alone, or

199 indamycin and trimethoprim-sulfamethoxazole (TMP-SMX) are commonly prescribed, but the efficacy of TM

200 lindamycin or trimethoprim-sulfamethoxazole (TMP-SMX) for 10 days.

201 ors (PIs) and trimethoprim-sulfamethoxazole (TMP-SMX) have known activity against parasites during li

202 Trimethoprim-sulfamethoxazole (TMP-SMX) is widely used in malaria-endemic areas in huma

203 nd prescribed trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis.

204 ose receiving trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis.

205 402 (36%) to trimethoprim-sulfamethoxazole (TMP-SMX), 355 (32%) to sulfamethoxazole-sulfisoxazole, 3

206 usceptible to trimethoprim-sulfamethoxazole (TMP-SMX), and all isolates were clindamycin susceptible.

207 clindamycin, trimethoprim-sulfamethoxazole (TMP-SMX), or placebo for 10 days.

208 Additionally, trimethoprim-sulfamethoxazole (TMP-SMX), used for opportunistic infection prophylaxis i

209 TI) caused by trimethoprim-sulfamethoxazole (TMP-SMX)-resistant Escherichia coli is increasing and va

210 Trimethoprim-sulfamethoxazole (TMP-SMZ) is an alternative treatment for methicillin-res

211 usceptible to trimethoprim-sulfamethoxazole (TMP-SMZ), and this therefore represents a potentially at

212 h as Bactrim (trimethoprim-sulfamethoxazole; TMP-SMX) continue to play an important role in treating

213 terruption, and 5 patients were still taking TMP-SMX.

214 of a small molecule inhibitor, terameprocol (TMP), targeting Sp1 activity in WM.

215 rin (TPP), 5,10,15,20-tetramesitylporphyrin (TMP), and 2,3,7,8,12,13,17,18-octaethylporphyrin (OEP).

216 = the dianion of meso-tetramesitylporphyrin (TMP) or meso-tetrakis(4-methylphenyl)porphyrin (H(2)T-pM

217 perature reactions of tetramesitylporphyrin (TMP) and Hangman iron complexes containing acid (HPX-CO2

218 u, BuLi, and 2,2,6,6,-tetramethylpiperidine (TMP(H)).

219 tic amount of 2,2,6,6-tetramethylpiperidine (TMP) allows for a convenient (1 g-7.5 kg) synthesis of b

220 hindered base 2,2,6,6-tetramethylpiperidine (TMP) furnished H2 ligand deprotonation.

221 2,2,6,6-Tetramethylpiperidine (TMP)-catalyzed (1-10%) chlorinations of phenols by SO2Cl

222 chloride and 2,2,6,6-tetramethylpiperidine (TMP).

223 gainst these mutant enzymes and strains than TMP.

224 This work demonstrates that TMP is an effective probe for the determination of Rf,T

225 Despite the known effects that TMP-SMX has in reducing clinical malaria, its impact on

226 We next investigated and observed that TMP treatment induced further inhibition of WM cells in

227 Results revealed that TMP minimally affected water flux, reverse salt flux (RS

228 nt malaria models, we previously showed that TMP-SMX, at prophylactic doses, can arrest liver stage d

229 salvage pathway is compartmentalized so that TMP kinase prefers TMP synthesized by TK2 over medium TM

230 ent of malaria parasites and speculated that TMP-SMX prophylaxis during repeated malaria exposures wo

231 Our findings suggest that TMP-SMX is not inferior to TMP-SMX plus doxycycline for

232 The TMP-injected Tlr9(-/-) mice, and not the wild-type mice,

233 and S4) at a high TMP level (i.e., after the TMP jump) had many more proteins in the pH range of 4.0-

234 brane pressure (TMP) level (i.e., before the TMP jump) had larger gray intensities in the pH 5.5-7.0

235 Our results indicate that both the TMP and the foulant layer synergistically affected ARB r

236 ith the two platforms was comparable for the TMP.

237 clindamycin group was similar to that in the TMP-SMX group (221 of 266 participants [83.1%] and 215 o

238 ndamycin group (15 of 221, 6.8%) than in the TMP-SMX group (29 of 215 [13.5%], P=0.03) or the placebo

239 (264 in the clindamycin group and 260 in the TMP-SMX group), including 155 children (29.6%).

240 5% in the clindamycin group and 88.2% in the TMP-SMX group; difference, -1.2 percentage points; 95% C

241 3% in the clindamycin group and 77.7% in the TMP-SMX group; difference, -2.6 percentage points; 95% c

242 n the TMP-SMX plus placebo group than in the TMP-SMX plus doxycycline group (122 [39%] vs 167 [53%]).

243 us placebo group and 21 patients (7%) in the TMP-SMX plus doxycycline group developed culture-confirm

244 16 patients (5%) in the TMP-SMX plus placebo group and 21 patients (7%) in the T

245 verse drug reactions were less common in the TMP-SMX plus placebo group than in the TMP-SMX plus doxy

246 9) in the placebo group and 0% (0/72) in the TMP-SMZ group (P < .001, log-rank test).

247 Cys) nucleophile engineered just outside the TMP-binding pocket of Escherichia coli dihydrofolate red

248 are better, and more homogeneously raise the TMP of tightly packed cells to a simulated electroporati

249 iffusion and reveal that the mobility of the TMPs tested is subdiffusive, most likely caused by confi

250 -H bond energetics are used to evaluate the (TMP)Rh-OCH(3) bond dissociation free energy (Rh-OCH(3) B

251 O-Arylations with these TMP salts were demonstrated to be highly chemoselective.

252 ble for de novo biosynthesis of thymidylate (TMP) and is essential for cell proliferation and surviva

253 onding to oxidants such as [Fe(IV)(O)(TMP)] (TMP = tetramesitylporphinate), [Ru(IV)(O)(bpy)(2)(py)](2

254 d and randomly assigned 626 patients: 311 to TMP-SMX plus placebo and 315 to TMP-SMX plus doxycycline

255 ents: 311 to TMP-SMX plus placebo and 315 to TMP-SMX plus doxycycline.

256 ne transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

257 Crystal structures of the enzymes bound to TMP and propargyl-linked inhibitors reveal the basis of

258 ings suggest that TMP-SMX is not inferior to TMP-SMX plus doxycycline for the oral phase of melioidos

259 tion of Shigella isolates with resistance to TMP-SMX was 40% among white persons, 58% among Hispanic

260 to confer the majority of this resistance to TMP.

261 llege community was found to be resistant to TMP-SMX.

262 1 and XPF-1) imparted extreme sensitivity to TMP/UVA relative to wild-type animals, manifested as dev

263 vinyl acetate and hydrogen atom transfer to (TMP)Co(II)* are reported through kinetic studies for the

264 ed a high selectivity and sensitivity toward TMP.

265 Trimethoprim (TMP) that specifically binds to eDHFR was linked to the

266 ed by the simple folate analog trimethoprim (TMP).

267 f sulfamonomethoxine (SMM) and trimethoprim (TMP) in egg yolk and white was measured during and after

268 and sulfadimethoxine, SDM) and trimethoprim (TMP).

269 s controlled by the antibiotic trimethoprim (TMP).

270 the small-molecule antibiotic trimethoprim (TMP).

271 ydrofolate reductase (DHFR) by trimethoprim (TMP) prevents growth, but this can be relieved by murine

272 Several antifolates, including trimethoprim (TMP) and a series of propargyl-linked analogues, bind di

273 cDHFR with methotrexate (MTX), trimethoprim (TMP), and its potent analogue, PY957.

274 voltammetry in the presence of Trimethoprim (TMP) as template molecules.

275 (coop) = -2.9 kcal mol(-1)) of trimethoprim (TMP) binding to a bacterial dihydrofolate reductase (DHF

276 ics-based fitness landscape of trimethoprim (TMP) resistance for Escherichia coli dihydrofolate reduc

277 f the high affinity binding of trimethoprim (TMP) to Escherichia coli dihydrofolate reductase (eDHFR)

278 s the critical element for the trimethoprim (TMP) resistance.

279 DHFR has natural resistance to trimethoprim (TMP; 2).

280 ary and ternary complexes with trimethoprim (TMP), folinic acid and coenzymes (NADPH/NADP(+)).

281 ryliodonium salts with the trimethoxyphenyl (TMP) moiety as dummy group.

282 diated degradation of 2,4,6-trimethylphenol (TMP) by (3)NOM* was significantly slowed at higher IS.

283 f the initial rate of 2,4,6-trimethylphenol (TMP) loss (R(TMP)) on dioxygen concentration was examine

284 f approximately 3 for 2,4,6-trimethylphenol (TMP) to a high of approximately 15 for 3,4-dimethoxyphen

285 of the probe compound 2,4,6-trimethylphenol (TMP), which is unaffected by DOM inhibition effects.

286 a phosphorus nucleophile, trimethylphospine (TMP).

287 nstrate that use of 2,4,6-trimethylpyridine (TMP) as the base in peptide couplings produces glycopept

288 Here we have developed a novel and versatile TMP-AcBOPDIPY probe for selective and turn-on labeling o

289 ct liver stage Plasmodium parasites, whereas TMP-SMX prevents patent parasitemia.

290 FR and its binary and ternary complexes with TMP and NADPH and made complementary thermodynamic measu

291 splayed markedly increased growth rates with TMP compared to strains expressing insoluble EphB2 (TK d

292 he efficacy and side-effects of TMP-SMX with TMP-SMX plus doxycycline for the oral phase of melioidos

293 th clindamycin (58 of 265 [21.9%]) than with TMP-SMX (29 of 261 [11.1%]) or placebo (32 of 255 [12.5%

294 Nine patients were treated with TMP-SMX and rifampin.

295 e relapsed and was successfully treated with TMP-SMX.

296 Treatment with TMP inhibited the growth and survival and impaired nucle

297 quilibrium measurements in conjunction with (TMP)Rh-H and CH(3)O-H bond energetics are used to evalua

298 al mol(-1) for association of methanol with (TMP)Rh-OCH(3) to form the six-coordinate 18-electron com

299 Reactions of peroxyacids with (TMP)FeIII(OH) and methyl ester Hangman (HPX-CO2Me)FeIII(

300 ooth dehydrogenation when generated using Zn(TMP)2 2 LiCl as a base in the presence of excess ZnCl2 ,