ライフサイエンスコーパス: TNF receptor

1 nt and maintenance of recruited TRAF2 at the TNF receptor.

2 s recruitment of IKKalpha and IKKbeta to the TNF receptor.

3 sion and promigration activity downstream of TNF receptors.

4 pathophysiological responses after engaging TNF receptors.

5 nses, can be regulated by binding to soluble TNF receptors.

6 liver injury depends on hepatocyte-intrinsic TNF receptor 1 (p55, TNFR1).

7 TNF-alpha] and other immune markers [soluble TNF receptor 1 (sTNF-R1), sTNF-R2, C-reactive protein, a

8 Pretreatment with recombinant human soluble TNF receptor 1 (sTNFR1) in the intrathecal space at the

9 Activation of TNF receptor 1 (TNF-R1) can generate signals that promot

10 TNF receptor 1 (TNFR1) antagonist-neutralizing antibody

11 NF-induced Gal-9 expression was dependent on TNF receptor 1 (TNFR1) as TNF failed to induce Gal-9 in

12 Cs was blocked by neutralizing antibodies to TNF receptor 1 (TNFR1) but not to TNFR2 and was abolishe

13 n previous reports, simultaneous deletion of TNF receptor 1 (TNFR1) failed to rescue this severe phen

14 or-alpha (TNF-alpha) signaling and show that TNF receptor 1 (TNFR1) is necessary for the illness-indu

15 ably, crossing this strain with mice lacking TNF receptor 1 (TNFR1) leads to a complete rescue of the

16 disease and cancer that were independent of TNF receptor 1 (TNFR1) signaling.

17 -alpha/beta receptor (IFN-alpha/betaR1), and TNF receptor 1 (TNFR1), indicating that each of these ef

18 Here we show that TNF receptor 1 (TNFR1)-associated death domain (TRADD)-d

19 tatin-1, or simultaneous genetic deletion of TNF receptor 1 (TNFR1).

20 their target tissues, which in turn express TNF receptor 1 (TNFR1).

21 ha-mediated NF-kappaB activation through the TNF receptor 1 (TNFR1)/IkappaB kinase (IKK) pathway.

22 trolled and progressive in absence of TNF or TNF receptor 1 (TNFR1)/TNFR2 (TNFR1R2) with increased in

23 stemic treatment of DKO animals with soluble TNF receptor 1 (TNFRI) prevented upregulation of Rho A s

24 ivation of T cells, were markedly reduced in TNF receptor 1 and 2 gene knockout mice.

25 dant surface protein of S. aureus, activates TNF receptor 1 and EGF receptor (EGFR) signaling cascade

26 TNFalpha is mediated by neuronally expressed TNF receptor 1 and requires activation of p38 MAPK, phos

27 EC/D3 expresses the receptors for TNF-alpha, TNF receptor 1 and TNF receptor 2, and for IFN-gamma.

28 In cells, SPATA2 is recruited to the TNF receptor 1 signaling complex and is required for CYL

29 f hepatocytes involves the rapid shedding of TNF receptor 1 to limit TNFalpha signaling.

30 protein kinase 1 (RIPK1) is recruited to the TNF receptor 1 to mediate proinflammatory signaling and

31 f tumor necrosis factor (TNF)-alpha, soluble TNF receptor 1, interferon (IFN)-gamma, IFN-inducible pr

32 Rather, TWEAK induced TNFalpha secretion and TNF receptor 1-dependent assembly of a death-signaling c

33 however, the anti-Fn14s showed no effect on TNF receptor 1-induced cell death and P4A8 even blocked

34 omplexes by mediating RIP1 dissociation from TNF receptor 1.

35 th in the intestinal epithelium was mediated TNF receptor 1.

36 s attenuated by loss or inhibition of TNF or TNF receptor 1.

37 Of the examined markers, only TNF receptors 1 and 2 (TNFR1 and TNFR2) associated with

38 Elevated plasma concentrations of TNF receptors 1 and 2 (TNFR1 and TNFR2) predict developm

39 of tumor necrosis factor alpha (TNF-alpha), TNF receptors 1 and 2, active caspase 8, active caspase

40 , tumor necrosis factor (TNF) alpha, soluble TNF receptors 1 and 2, C-reactive protein, interleukin-6

41 We have identified tumor necrosis factor (TNF) receptor 1 (TNFR1) as a critical modifier of TrkA a

42 MYD88 deficiency or tumour-necrosis factor (TNF) receptor 1 deficiency, demonstrating the importance

43 rosis factor (TNF)-alpha (p = .010), soluble TNF receptor-1 (sTNFR1; p < .001), and IL-1 receptor ant

44 TNF receptor-1 (TNF-R1) signal transduction is mediated

45 tion obtained with baseline levels of plasma TNF receptor-1 (TNFR-1), TNFR-2, and kidney injury molec

46 o determine whether genetic variation in the TNF receptor-1 gene (TNFR1) contributes to aging-related

47 Studies in mice deficient in TNF-alpha, TNF receptor-1, or TNF receptor-2 revealed that although

48 8 virus in wild-type, tumor necrosis factor (TNF) receptor-1 knockout (TNFRKO), and interleukin-1 (IL

49 y etanercept, a soluble version of the human TNF receptor 2 (hTNFR2), is a well established strategy

50 ntrations of ICAM-1, E-selectin, and soluble TNF receptor 2 (sTNF-R2), a marker related to TNF-alpha,

51 as a transmembrane form tmTNF, signaling via TNF receptor 2 (TNFR2) and TNFR1, and a soluble form, so

52 Our study, using novel TNF receptor 2 (TNFR2) conditional KO mice with selectiv

53 genes encoding tumor necrosis factor (TNF), TNF receptor 2 (TNFR2), and the signaling proteins stres

54 -9 after vaccination; peak levels of soluble TNF receptor 2 and monokine induced by IFN-gamma (MIG) o

55 in T cells are specifically mediated through TNF receptor 2 signaling.

56 e senescence involves an abrogation of tmTNF/TNF receptor 2 signaling.

57 receptors for TNF-alpha, TNF receptor 1 and TNF receptor 2, and for IFN-gamma.

58 significantly correlated with IL-6, soluble TNF receptor 2, intercellular adhesion molecule 1, vascu

59 -alpha (tmTNF-alpha) is the prime ligand for TNF receptor 2, which has been shown to mediate angiogen

60 PCSK9 (P = 0.001), TNF receptor-2 (P < 0.01), and IL-1 receptor antagonist

61 e deficient in TNF-alpha, TNF receptor-1, or TNF receptor-2 revealed that although TNF-alpha was not

62 Soluble tumor necrosis factor (TNF) receptor-2 (TNFR2) and interleukin-1 receptor antag

63 f target genes in response to Toll-like- and TNF-receptor activation.

64 r receptor families, including the TNF-alpha/TNF receptor and ErbB ligand/EGFR pathways.

65 f MyD88-independent receptors, including the TNF receptor and TLR3.

66 TNFalpha) by ADAM17, which in turn activates TNF receptors and canonical NF-kappaB signaling.

67 lvulitis, we examined mice deficient in both TNF receptors and in TTP; four of five of these mice exh

68 action by binding to Tumor Necrosis Factor (TNF) receptors and antagonizing TNFalpha.

69 We found that Sam68 is recruited to the TNF receptor, and its deficiency dramatically reduces RI

70 a inflammatory markers (IL-6, IL-10, soluble TNF-receptors, and C-reactive protein) in patients with

71 we show that monocytes deficient for TNF or TNF receptors are outcompeted by their wild-type counter

72 and MAPK signaling pathways mediated by the TNF receptor, as well as multiple pattern recognition re

73 chanistically, Pellino3 negatively regulated TNF receptor associated 6 (TRAF6)-mediated ubiquitinatio

74 The adaptor protein TNF receptor associated factor (TRAF) 3 is required for

75 NOPO is the Drosophila homolog of human TNF receptor associated factor (TRAF)-interacting protei

76 In this study, we show that TNF receptor associated factor 3 (TRAF3) plays a critica

77 We identify TNF receptor associated factor 4 (TRAF4) as a novel Drap

78 p62 interacts with TNF receptor associated factor 6 (TRAF6) and is required

79 A family of proteins called TNF receptor associated factors (TRAFs) plays key roles

80 (E2) Ubc13 for binding to the RING domain of TNF-receptor associated factor 2 (TRAF2), thereby inhibi

81 ownstream gene-TRAF4 (tumor necrosis factor [TNF] receptor associated-factor 4)-that functions in cel

82 TNF receptor-associated death domain (TRADD) is an essen

83 receptor-associated kinase (IRAK) 4, IRAK1, TNF receptor-associated factor (TRAF) 6, TGF-beta-activa

84 TRAF1/2 and cIAP1/2 are members of the TNF receptor-associated factor (TRAF) and the inhibitor

85 rm prolactin receptors (PRLR-S), constrained TNF receptor-associated factor (TRAF)-dependent innate i

86 n-canonical K63-linked polyubiquitination of TNF receptor-associated factor (TRAF)-family adapter pro

87 induces IRAK1 sumoylation in the presence of TNF receptor-associated factor 2 (TRAF2) and intracellul

88 of the Fn14-TRAF domain site or depletion of TNF receptor-associated factor 2 (TRAF2) expression by s

89 Furthermore, we found that TNF receptor-associated factor 2 (TRAF2) recruitment is

90 we discovered that GAPDH interacts with the TNF receptor-associated factor 2 (TRAF2), a protein requ

91 aprolin (TTP) is Lys-63-polyubiquitinated by TNF receptor-associated factor 2 (TRAF2), suggesting a r

92 e essential for GAPDH-mediated activation of TNF receptor-associated factor 2 ubiquitination.

93 F-alpha induced the ubiquitination of TRAF2 (TNF receptor-associated factor 2), which interacts with

94 IKK-beta, TNF receptor-associated factor 6, TNF receptor-associated factor 2, receptor-interacting p

95 PTPN22 directly associated with TNF receptor-associated factor 3 (TRAF3) and promotes TR

96 Here we identified TNF receptor-associated factor 3 (TRAF3) as a regulator

97 vely regulated by the full-length isoform of TNF receptor-associated factor 3 (Traf3) as formation of

98 The adaptor protein TNF receptor-associated factor 3 (TRAF3) is a critical r

99 The adaptor protein TNF receptor-associated factor 3 (TRAF3) regulates signa

100 athway signaling by promoting degradation of TNF receptor-associated factor 3 (Traf3), a potent inhib

101 d the effect of selective deletion in TEC of TNF receptor-associated factor 3 (TRAF3), an inhibitor o

102 volves degradation of an inhibitory protein, TNF receptor-associated factor 3 (TRAF3), but how this s

103 ine kinase RICK, which was then able to bind TNF receptor-associated factor 3 (TRAF3).

104 inhibiting Lys(63)-linked ubiquitination of TNF receptor-associated factor 3 (TRAF3).

105 l analyses revealed that DAB2 interacts with TNF receptor-associated factor 6 (TRAF6) and attenuates

106 NKL-induced NF-kappaB activation and delayed TNF receptor-associated factor 6 (TRAF6) deubiquitinatio

107 TNF receptor-associated factor 6 (TRAF6) is an adaptor p

108 TNF receptor-associated factor 6 (TRAF6) is an adaptor p

109 TNF receptor-associated factor 6 (TRAF6) is identified a

110 TNF receptor-associated factor 6 (TRAF6), a verified tar

111 Upon LPS challenge, CREBH interacts with TNF receptor-associated factor 6 (TRAF6), an E3 ubiquiti

112 This study demonstrates that, TNF receptor-associated factor 6 (TRAF6), an E3 ubiquiti

113 urthermore, NOSTRIN interacted directly with TNF receptor-associated factor 6 (TRAF6), leading to the

114 1 receptor-associated protein kinase (IRAK), TNF receptor-associated factor 6 (TRAF6), phosphatidylin

115 rectly interacting with the TRAF-C domain of TNF receptor-associated factor 6 (TRAF6), resulting in i

116 se 1, IL-1 receptor-associated kinase 4, and TNF receptor-associated factor 6 (TRAF6).

117 1 receptor-associated kinase 1 (IRAK-1), and TNF receptor-associated factor 6 (TRAF6).

118 -1 receptor-associated kinase 1 (IRAK-1) and TNF receptor-associated factor 6 (TRAF6).

119 thin a recently identified binding motif for TNF receptor-associated factor 6 (TRAF6).

120 Lys-34 and required the E3 ubiquitin ligase TNF receptor-associated factor 6 after stimulation of ce

121 ys-63-linked polyubiquitination at Lys-34 by TNF receptor-associated factor 6 and is thereby activate

122 ase) and subsequently integrates with TRAF6 (TNF receptor-associated factor 6) and/or c-fos signaling

123 ukin-1 receptor-associated kinase)1/4-TRAF6 (TNF receptor-associated factor 6), leading to integrin a

124 e system of IKK complex activation by TRAF6 (TNF receptor-associated factor 6), we show that these pe

125 AK1, TAB1 (TAK1 binding protein), and TRAF6 (TNF receptor-associated factor 6).

126 otein interactions with IKK-alpha, IKK-beta, TNF receptor-associated factor 6, TNF receptor-associate

127 isolated NASPs act either via or upstream of TNF receptor-associated factor 6.

128 Here we identified mutations in TRAF3IP1 (TNF Receptor-Associated Factor Interacting Protein 1) in

129 s on the ubiquitin-conjugating enzyme Ubc13, TNF receptor-associated factor TRAF2, the protein kinase

130 paB activation pathways, including the TRAF (TNF receptor-associated factor) proteins, IKK, NF-kappaB

131 both knockdowns reduce expression of TRAF2 (TNF receptor-associated factor-2) protein, and small int

132 induces IDO and involves the recruitment of TNF receptor-associated factor-3 to the Toll-like recept

133 ein caused a shift in CD40 signaling through TNF receptor-associated factors (TRAF), including the TR

134 , the most recently identified member of the TNF receptor-associated factors (TRAFs) family of protei

135 lecule CD40 and its signaling intermediates, TNF receptor-associated factors (TRAFs), in diet-induced

136 ivation, and increased polyubiquitination of TNF receptor-associated factors.

137 ver syndromes (familial Mediterranean fever, TNF receptor-associated periodic syndrome, and hyperimmu

138 its role in signal transduction as TRAF and TNF receptor-associated protein (TTRAP) and ETS1-associa

139 lin and three mitochondrial proteins, TRAP1 (TNF receptor-associated protein 1), citrate synthase, an

140 TRAP1 (TNF receptor-associated protein), a member of the HSP90

141 kappaB p100, which acts as an inhibitor, and TNF receptor-associated receptor 3 (TRAF3); however, a r

142 Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and receptor-i

143 Tumour-necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is a key compo

144 paB regulator, TRAF2 (tumor necrosis factor (TNF) receptor-associated factor 2), as an oncogene that

145 in and failed to bind tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3), a TBK1 comple

146 uniparental disomy in tumor necrosis factor (TNF) receptor-associated factor 3 and TNFalpha-induced p

147 the molecular adaptor tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) exhibit a spec

148 es demonstrated that tumour necrosis factor (TNF) receptor-associated factor 6 (TRAF6) plays a key ro

149 estigated the role of tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6), an adaptor pr

150 d kinase (IRAK-1) and tumor-necrosis factor (TNF) receptor-associated factor 6 (TRAF6), which are kno

151 uous degradation by a tumor necrosis factor (TNF) receptor-associated factor-3 (TRAF3)-dependent E3 u

152 The functions of adaptor proteins, including TNF-receptor-associated death domain protein (TRADD) and

153 TNF-receptor-associated factor 2 (TRAF2), an E3 ubiquiti

154 Furthermore, recruitment of the TNF-receptor-associated factor TRAF6 and activation of t

155 New knock in animal models for TNF-receptor-associated periodic syndrome, and familial

156 APRIL binds two different TNF receptors, B cell maturation antigen (BCMA) and tran

157 ut rather, indirectly via IL-1 receptors and TNF receptors being expressed on glial cells in superfic

158 taining structures colocalize with activated TNF receptors but not with activated IL-1 receptors.

159 vation of ATF-2 by separately inhibiting the TNF receptor complex and JNK pathway through a negative

160 However, blocking both Fas and TNF receptor death pathways inhibited their apoptosis an

161 tions of anti-TNF Abs, or interbreeding with TNF receptor-deficient mice.

162 ave proposed an alternate model in which the TNF-receptor dimer-sitting at the vertices of a large su

163 f a TB granuloma formation that includes TNF/TNF receptor dynamics to elucidate these mechanisms.

164 TNF antibody adalimumab, but not the soluble TNF receptor etanercept, paradoxically promoted the inte

165 Glucocorticoid-induced TNF receptor expression was evaluated in cytokine-treate

166 We report that the TNF receptor family member CD137 (TNFRSF9) is expressed

167 dy, we investigated the possibility that the TNF receptor family member CD27 is present on leukemia s

168 ed in patients with progressing disease, the TNF receptor family member CD30/TNFRSF8 was confirmed in

169 and TIE2, the glycoprotein TROP2, the small TNF receptor family member FN14, and the G protein-coupl

170 utely required for costimulation through the TNF receptor family member OX40 (also known as CD134).

171 We identified FN14 (TNFRSF12A), a TNF receptor family member, as a factor that promotes pr

172 y with the costimulatory pathways induced by TNF receptor family members (i.e., CD27, OX40, and 4-1BB

173 tream of NF-kappaB-inducing kinase (NIK) and TNF receptor family members including lymphotoxin-beta r

174 t NF-kappaB activation downstream of several TNF receptor family members mediates lymphoid organ deve

175 Tregs express several costimulatory TNF receptor family members that activate non-canonical

176 of T cell checkpoints, agonists of selected TNF receptor family members, and inhibitors of undesirab

177 CD40, a member of the TNF receptor family, is expressed on all mature B cells

178 Glucocorticoid-induced TNF receptor family-related protein (GITR) regulates the

179 BCMA, members of the tumor necrosis factor (TNF) receptor family involved in B-CLL.

180 The tumor necrosis factor (TNF) receptor family member CD40 plays an essential role

181 HVEM is a tumor necrosis factor (TNF) receptor family member with four natural ligands th

182 ing to treatment with etanercept, a modified TNF receptor-Fc fusion protein.

183 2 results in the release of pro-TNFalpha and TNF receptors from the cell surface, and pharmacological

184 ed mice administered with a TNF-neutralizing TNF receptor fusion molecule preserved their structure,

185 r treatment of wild-type mice with a soluble TNF receptor fusion protein (Enbrel), revealed that radi

186 -TNF Abs (e.g., infliximab) as compared with TNF receptor fusion protein (etanercept).

187 on gene 3 [LAG3], and glucocorticoid-induced TNF receptor [GITR]) were assessed at the mRNA level.

188 x protein P3 [FOXP3], glucocorticoid-induced TNF receptor [GITR], lymphocyte activation gene 3 [LAG3]

189 ble TNF, recombinant methionyl human soluble TNF receptor I (p55-TNFRI), or adalimumab.

190 ptor interacting protein kinase (RIPK1) from TNF receptor I (TNFR1) to form a caspase-8 activating co

191 ncentrations of tumor necrosis factor (TNF), TNF receptors I and II (TNF-RI and TNF-RII), interleukin

192 TNF-receptor I (TNFRI) mutant mice were protected from i

193 , PKCepsilon facilitates the assembly of the TNF receptor-I signaling complex to trigger NF-kappaB ac

194 also essential for NF-kappaB activation via TNF receptor, IL-1 receptor and toll-like receptor 4.

195 ion-promoting signals requires Myd88 but not TNF receptor, implicating host innate immune pathways bu

196 experiments and genetic ablation of IL-1 and TNF receptor in vivo.

197 Little is known about specific TNF receptors in regulating TNF-induced RBR in bone marr

198 factor (TNF) necessary for signaling via the TNF receptors in stromal cells.

199 Herein, we investigate the roles of TNF and TNF receptors in the control of Mycobacterium bovis baci

200 was observed only for tumor necrosis factor (TNF) receptors in the metabolic cluster (geometric mean

201 concentrations is restricted by noise at the TNF receptor level, whereas discernibility of high TNF c

202 uria is strongly associated with circulating TNF receptor levels but not TNFalpha levels (free or tot

203 The TNF receptor-ligand superfamilies (TNFRSF/TNFSF) are cen

204 d with futile inhibition of AP-1 and SP-1 in TNF receptor muted cells.

205 i-albumin Nb to generate Nb Alb-70-96 named "TNF Receptor-One Silencer" (TROS).

206 ranslational NFkappaB nuclear import, muting TNF receptor, overexpression, and physiological inductio

207 lammatory effects of TNF are mediated by the TNF receptor p55 (p55TNFR) (encoded by the Tnfrsf1a gene

208 Interestingly, using mice deficient in both TNF receptors p55 and p75, chimeric animals and anti-TNF

209 hway shows significant similarities with the TNF receptor pathway.

210 tenin signalling for the control of PD-1 and TNF receptor proteins.

211 This process involves activation of type-1 TNF receptors, recruitment of Src family kinases (SFK) a

212 lucocorticoid-induced tumor necrosis factor (TNF) receptor related gene (GITR), a member of TNF recep

213 Glucocorticoid-induced TNF receptor-related protein ligand (GITRL), a ligand fo

214 t LPS-induced iNOS expression leads to rapid TNF receptor shedding from the surface of hepatocytes vi

215 t showed that genetic inhibition of TNFalpha/TNF receptor signal transduction down-regulates beta amy

216 The TNF receptors signaled through interferon regulatory fac

217 naling and tumor necrosis factor-alpha (TNF)/TNF receptor signaling are known to contribute to these

218 ur results demonstrate that globally ablated TNF receptor signaling exacerbates pathogenesis and argu

219 eneralized to enable the inhibition of other TNF receptor signaling mechanisms that are associated in

220 h domain (TRADD) is an essential mediator of TNF receptor signaling, and serves as an adaptor to recr

221 directly on RIP1 and promote necroptosis in TNF receptor signaling, as the gene conferring the trait

222 r of NF-kappaB during Toll-like receptor and TNF receptor signaling.

223 Dysregulation of tumor necrosis factor (TNF) receptor signaling is a key feature of various infl

224 hat by enabling linear ubiquitination in the TNF receptor signalling complex, SHARPIN interferes with

225 assembly complex, recruited to the CD40 and TNF receptor signalling complexes together with its othe

226 regulated through the production of soluble TNF receptors (sTNFRI and sTNFRII).

227 Our results indicate that TNF receptor subtype 1 but not 2 plays a critical role i

228 Here, we report that TNF receptor subtypes (TNFR1 and TNFR2) differentially m

229 The tumor necrosis factor (TNF) and TNF receptor superfamilies (TNFSF and TNFRSF) consist of

230 focused on RANKL/OPG signalling, the TNF and TNF receptor superfamilies and the NF-kB pathway.

231 Members of the TNF receptor superfamily (TNFRSF) are key costimulators

232 4-1BB (CD137) is a TNF receptor superfamily (TNFRSF) member that is thought

233 rfamily (TNFSF) interact with members of the TNF receptor superfamily (TNFRSF).

234 Members of the TNF receptor superfamily activate diverse cellular funct

235 ully colonize in the brain, we reasoned that TNF receptor superfamily member 10A/10B apoptosis-induci

236 lial cells, led to upregulated expression of TNF receptor superfamily member 12a, also known as fibro

237 Heterozygous C104R or A181E TNF receptor superfamily member 13b (TNFRSF13B) mutation

238 WT) mice with a deficiency in genes encoding TNF receptor superfamily member 1a (TNFR1; TNFR1 knockou

239 member 1a (TNFR1; TNFR1 knockout [KO] mice), TNF receptor superfamily member 1b (TNFR2; TNFR2 KO mice

240 TNF receptor superfamily member 25 (TNFRSF25; also known

241 he IFN-gamma-activated, nonapoptotic form of TNF receptor superfamily member 6 (Fas) in BMMSCs to a c

242 Also, TNF receptor superfamily member 6 (FAS) protein was over

243 Signaling of the TNF receptor superfamily member CD27 activates costimula

244 e, we show that FGFR-1 can interact with the TNF receptor superfamily member fibroblast growth factor

245 ng reading frame UL144 is an ortholog of the TNF receptor superfamily member, herpesvirus entry media

246 is factor receptor II (TNFRII) is one of the TNF receptor superfamily members and our recent patholog

247 response to signals mediated by a subset of TNF receptor superfamily members, NIK becomes stabilized

248 Similar to other TNF receptor superfamily members, we found that TWEAK in

249 units of DR5 and the structurally homologous TNF receptor superfamily members.

250 luding the negative co-receptor PD-1 and the TNF receptor superfamily proteins GITR and OX40.

251 n of FGF-inducible 14 (Fn14, a member of the TNF receptor superfamily) gene.

252 F) receptor related gene (GITR), a member of TNF receptor superfamily, by agonist antibodies or natur

253 e Item et al. show that Fas, a member of the TNF receptor superfamily, contributes to mitochondrial d

254 Here we show that CD40, a member of the TNF receptor superfamily, is a major regulator of dendri

255 rin (OPG), an immunoregulatory member of the TNF receptor superfamily, is expressed in inflamed intes

256 rus entry mediator (HVEM), a molecule of the TNF receptor superfamily, promoted HIF-1alpha activity i

257 y mediator (HVEM; TNFRSF14), a member of the TNF receptor superfamily, provides key signals for MPEC

258 Alike other members of the TNF receptor superfamily, TRAIL receptors contain a pre-

259 xpress members of the tumor-necrosis factor (TNF) receptor superfamily (TNFRSF), but the role of thos

260 Members of the tumour necrosis factor (TNF) receptor superfamily have important functions in im

261 as the importance of tumour necrosis factor (TNF) receptor superfamily members in thymus medulla deve

262 vel markers from the tumour necrosis factor (TNF) receptor superfamily were also identified.

263 DR3), a member of the tumor necrosis factor (TNF) receptor superfamily, is up-regulated in human tubu

264 CD40, a member of the tumor necrosis factor (TNF) receptor superfamily.

265 The TNF-receptor superfamily member CD30 is expressed on nor

266 other structurally homologous members of the TNF-receptor superfamily, relies on ligand-stabilized tr

267 pe was attenuated by genetic ablation of the TNF receptor TNF-R1 in NEMO(Deltahepa)/p21(-/-) mice, de

268 /W-sh) mice engrafted with TNF-alpha(-/-) or TNF receptor (TNF-R)(-/-) MCs, we found that TNF-alpha a

269 For further analysis, antibodies to TNF receptor (TNFR) 1 or 2 were applied, or CSD was moni

270 Selective inhibition of TNF receptor (TNFR) 1 signaling holds the potential to g

271 ll memory because of the differential use of TNF receptor (TNFR) family costimulatory receptors.

272 Individual TNF receptor (TNFR) signaling in RBR was evaluated in BM

273 nal cell necroptosis, processes that involve TNF receptor (TNFR) signaling.

274 esponses, and costimulatory molecules in the TNF receptor (TNFR) superfamily are viewed as a major so

275 Agonistic anti-TNF receptor (TNFR) superfamily member antibodies are a

276 LMP1 functionally mimics TNF receptor (TNFR) superfamily member CD40, but LMP1 si

277 ligation of death receptors, a subset of the TNF receptor (TNFR) superfamily.

278 f TRIM28 strikingly suppressed expression of TNF receptor (TNFR)-1 and -2, decreased TNF-alpha-induce

279 s undertaken to investigate the influence of TNF receptor (TNFR)-costimulated lymphocytes on collagen

280 d revealed the antithetic effects of the two TNF receptors (TNFR) in the central nervous system, wher

281 ons of members of the tumor-necrosis factor (TNF) receptor (TNFR)-associated factor (TRAF) family in

282 itical regulators of tumour necrosis factor (TNF) receptor (TNFR)-mediated signalling.

283 ensitivity was associated with expression of TNF receptor TNFR1 and was abrogated by interfering with

284 r caused by missense mutations in the type 1 TNF receptor (TNFR1).

285 mice that are genetically deficient for the TNF receptor TNFR2.

286 host immune system is to encode homologs of TNF receptors (TNFRs) that block TNF-alpha function.

287 ockout mice that were also deficient in both TNF receptors ("triple knockout" mice) to remove the sec

288 VHD by Tregs was fully abolished by blocking TNF receptor type 2 (TNFR2) or by using TNF-deficient do

289 n of TNFalpha and RANKL by pegylated soluble TNF receptor type I (pegTNFRI) and osteoprotegerin (OPG)

290 Long-term global inhibition of TNF receptor type I (TNF-RI) and TNF-RII signaling witho

291 Genetic abrogation of TNF receptor type I (TNFRI) in Tak1DeltaHEP mice reduced

292 nduced lupus nephritis and treated mice with TNF receptor type II (TNFRII) Ig after TNFalpha expressi

293 It was reported that TNF receptor type II signaling, which has the capacity t

294 TNF receptor ubiquitous scaffolding and signaling protei

295 cytoprotective signaling downstream of both TNF receptors, via unclear mechanisms.

296 Tnfrsf1a, or Tnfrsf1b (Tnfrsf1a and b encode TNF receptors) were injected with TNF or saline (control

297 rting enzyme (TACE) results in an unattached TNF receptor, which participates in the scavenging of sT

298 alysis show that, upon the engagement of the TNF receptor with TNF-alpha on ECs, CD31 becomes activat

299 Because APRIL shares binding of the TNF receptors with B cell activation factor, separating

300 sy was uncontrolled in the absence of TNF or TNF receptors with exacerbated inflammatory response, im