ライフサイエンスコーパス: TNF receptor-associated factor

1 ivation, and increased polyubiquitination of TNF receptor-associated factors.

2 TNF receptor-associated factor 1 (TRAF1) is a unique TRA

3 One of these proteins, TNF receptor-associated factor 1 (TRAF1), is highly regu

4 AITR associates with TRAF1 (TNF receptor-associated factor 1), TRAF2, and TRAF3, and

5 osome-linked IAP, Bcl-2, Bcl-x(L), Bfl-1/A1, TNF receptor-associated factor 1, and cellular Fas-assoc

6 The tumor necrosis factor (TNF) receptor-associated factor 1 (TRAF1) is a member of

7 bitor of apoptosis protein (c-IAP1), c-IAP2, TNF receptor-associated factor-1 (TRAF-1), TRAF-2, B-cel

8 romosome-linked IAP (XIAP), Bcl-2, Bfl-1/A1, TNF receptor-associated factor-1 (TRAF1), and Fas-associ

9 or necrosis factor (TNF) family members, and TNF receptor-associated factor-1 (TRAF1).

10 s (SAPKs, Jun NH2-terminal kinases) requires TNF receptor associated factor 2 (TRAF2).

11 B-inducing kinase-IKK was interrupted at the TNF receptor associated factor 2 and NF-kappa B-inducing

12 eptor 1-TNF receptor associated death domain-TNF receptor associated factor 2 NF-kappa B-inducing kin

13 , TNF receptor 2 (TNF-R2) interacts with the TNF receptor associated factors 2/1 (TRAF2/TRAF1) hetero

14 ding of CD154 (gp39, CD40L) to CD40 recruits TNF receptor- associated factor 2 (TRAF2) and TRAF3 to t

15 am of receptor-interacting protein (RIP) and TNF receptor- associated factor 2.

16 induces IRAK1 sumoylation in the presence of TNF receptor-associated factor 2 (TRAF2) and intracellul

17 B and JNK activity associated with increased TNF receptor-associated factor 2 (TRAF2) and NF-kappaB e

18 We examined the contributions of TNF receptor-associated factor 2 (TRAF2) and TRAF3 to CD

19 The death domain kinase RIP and the TNF receptor-associated factor 2 (TRAF2) are essential e

20 of the Fn14-TRAF domain site or depletion of TNF receptor-associated factor 2 (TRAF2) expression by s

21 TNF receptor-associated factor 2 (TRAF2) is a signal-tra

22 In addition, we also demonstrated that the TNF receptor-associated factor 2 (TRAF2) plays little ro

23 Furthermore, we found that TNF receptor-associated factor 2 (TRAF2) recruitment is

24 Both CD40 and CD120b bind TNF receptor-associated factor 2 (TRAF2) upon ligand sti

25 TNF receptor-associated factor 2 (TRAF2) was identified

26 we discovered that GAPDH interacts with the TNF receptor-associated factor 2 (TRAF2), a protein requ

27 and CD160 engagement induced recruitment of TNF receptor-associated factor 2 (TRAF2), but not TRAF3,

28 ptosis signal-regulating kinase 1 (ASK1) and TNF receptor-associated factor 2 (TRAF2), regulation of

29 aling by TRANCE-R appears to be dependent on TNF receptor-associated factor 2 (TRAF2), since JNK indu

30 aprolin (TTP) is Lys-63-polyubiquitinated by TNF receptor-associated factor 2 (TRAF2), suggesting a r

31 wn to be important for CD40 association with TNF receptor-associated factor 2 (TRAF2), TRAF3, and TRA

32 One gene in particular, TNF receptor-associated factor 2 (TRAF2)-inhibiting prot

33 s and c-Jun NH(2)-terminal kinases) requires TNF receptor-associated factor 2 (TRAF2).

34 d to the TNF receptor 1 (TNF-R1) complex via TNF receptor-associated factor 2 (TRAF2).

35 K) is the recruitment to the TNF receptor of TNF receptor-associated factor 2 (TRAF2).

36 c-jun N-terminal kinase (JNK/SAPK) requires TNF receptor-associated factor 2 (TRAF2).

37 cells, along with the selective reduction of TNF receptor-associated factor 2 and impairment in the a

38 e/IkappaBalpha kinase was interrupted at the TNF receptor-associated factor 2 and NF-kappaB-inducing

39 Overexpression of a dominant negative TNF receptor-associated factor 2 construct, lacking the

40 d IL-6, and the cytoplasmic adaptor molecule TNF receptor-associated factor 2 is involved in both R-8

41 Tumor necrosis factor alpha (TNF-alpha) and TNF receptor-associated factor 2 protein were moderately

42 40 ligation, and inhibits the recruitment of TNF receptor-associated factor 2 to the CD40.

43 e essential for GAPDH-mediated activation of TNF receptor-associated factor 2 ubiquitination.

44 Cbl-b associates with TNF receptor-associated factor 2 upon CD40 ligation, and

45 at beta-arrestin-1 is associated with TRAF2 (TNF receptor-associated factor 2), an adaptor protein of

46 osis protein 1, Bcl-2, Bcl-xL, survivin, and TNF receptor-associated factor 2), proliferation (cyclin

47 F-alpha induced the ubiquitination of TRAF2 (TNF receptor-associated factor 2), which interacts with

48 ter gene expression activated by TNF, TNFR1, TNF receptor-associated factor 2, and NF-kappaB-inducing

49 eptor, TNF receptor-associated death domain, TNF receptor-associated factor 2, NF-kappa B-inducing ki

50 e activated by receptor-interacting protein, TNF receptor-associated factor 2, NF-kappaB-inducing kin

51 IKK-beta, TNF receptor-associated factor 6, TNF receptor-associated factor 2, receptor-interacting p

52 ulin were related to increased expression of TNF receptor-associated factor 2, the product of an NF-k

53 These data suggest that TNFR1, through a TNF receptor-associated factor 2-NF-kappaB signaling pat

54 rs or dominant-negative forms of p38 MAPK or TNF receptor-associated factor 2.

55 level of cIAP1 and, in some cases, cIAP2 and TNF receptor-associated factor 2.

56 eptor 1/TNF receptor-associated death domain/TNF receptor-associated factor 2/NF-kappaB-inducing kina

57 cytoplasmic domain of CD40, while binding of TNF receptor-associated factors 2 and 3 is dispensable,

58 microscopy revealed that JAB1 interacts with TNF receptor-associated-factor 2 (TRAF2).

59 Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and receptor-i

60 Tumour-necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is a key compo

61 Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is a key media

62 Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is an adaptor

63 Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is an intracel

64 molecules, including tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2).

65 h the adapter protein tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2).

66 paB regulator, TRAF2 (tumor necrosis factor (TNF) receptor-associated factor 2), as an oncogene that

67 (E2) Ubc13 for binding to the RING domain of TNF-receptor associated factor 2 (TRAF2), thereby inhibi

68 TNF-receptor-associated factor 2 (TRAF2), an E3 ubiquiti

69 RADD (TNF receptor-associated death domain), TNF receptor-associated factor-2 (TRAF-2), the Ser/Thr k

70 ptor proteins, including the docking protein TNF receptor-associated factor-2 (TRAF-2), which is beli

71 The subcellular localization of the TNF receptor-associated factor-2 (TRAF2) adaptor protein

72 In particular, Bcl-2, TNF receptor-associated factor-2 (TRAF2), and TRAF4 were

73 Because hCG also blocked TNF receptor-associated factor-2 and NF-kappaB-inducing

74 both knockdowns reduce expression of TRAF2 (TNF receptor-associated factor-2) protein, and small int

75 IP (receptor-interacting protein), or TRAF2 (TNF receptor-associated factor-2) were caused by apoptog

76 hibitor of apoptosis-1), cIAP-2, and TRAF-2 (TNF receptor-associated factor-2)) in an NF-kappaB-depen

77 tor 1, TNF receptor-associated death domain, TNF receptor-associated factor-2, NF-kappaB-inducing kin

78 tor 1, TNF receptor-associated death domain, TNF receptor-associated factor-2, NF-kappaB-inducing kin

79 by TNF receptor-associated death domain and TNF receptor-associated factor-2.

80 In this study, we show that TNF receptor associated factor 3 (TRAF3) plays a critica

81 as used to explore the in vivo expression of TNF receptor-associated factor 3 (TRAF-3), a putative si

82 PTPN22 directly associated with TNF receptor-associated factor 3 (TRAF3) and promotes TR

83 D88 as a prototypical adaptor, we identified TNF receptor-associated factor 3 (TRAF3) as a new compon

84 Here we identified TNF receptor-associated factor 3 (TRAF3) as a regulator

85 vely regulated by the full-length isoform of TNF receptor-associated factor 3 (Traf3) as formation of

86 The adaptor protein TNF receptor-associated factor 3 (TRAF3) is a critical r

87 The adaptor protein TNF receptor-associated factor 3 (TRAF3) regulates signa

88 athway signaling by promoting degradation of TNF receptor-associated factor 3 (Traf3), a potent inhib

89 , but not RANKL, increased OCP expression of TNF receptor-associated factor 3 (TRAF3), an adapter pro

90 d the effect of selective deletion in TEC of TNF receptor-associated factor 3 (TRAF3), an inhibitor o

91 volves degradation of an inhibitory protein, TNF receptor-associated factor 3 (TRAF3), but how this s

92 inhibiting Lys(63)-linked ubiquitination of TNF receptor-associated factor 3 (TRAF3).

93 ine kinase RICK, which was then able to bind TNF receptor-associated factor 3 (TRAF3).

94 Tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) regulates both

95 onstrate that loss of tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) results in con

96 in and failed to bind tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3), a TBK1 comple

97 uniparental disomy in tumor necrosis factor (TNF) receptor-associated factor 3 and TNFalpha-induced p

98 LTbetaR, not HveA, recruits TNF receptor-associated factor-3 (TRAF3), and LIGHT-indu

99 induces IDO and involves the recruitment of TNF receptor-associated factor-3 to the Toll-like recept

100 uous degradation by a tumor necrosis factor (TNF) receptor-associated factor-3 (TRAF3)-dependent E3 u

101 We identify TNF receptor associated factor 4 (TRAF4) as a novel Drap

102 f p47(phox) and recovered the orphan adapter TNF receptor-associated factor 4 (TRAF4).

103 ownstream gene-TRAF4 (tumor necrosis factor [TNF] receptor associated-factor 4)-that functions in cel

104 Here, we identify tumor necrosis factor (TNF)-receptor-associated factor-4 (TRAF4) as a new targe

105 The cytoplasmic signaling protein TNF receptor-associated factor 5 (TRAF5) has been implic

106 is inhibited by dominant negative mutants of TNF receptor-associated factor 5 (TRAF5), TRAF6, NF-kapp

107 p62 interacts with TNF receptor associated factor 6 (TRAF6) and is required

108 found to activate NF-kappaB in concert with TNF receptor associated factor 6 (TRAF6), we propose tha

109 l analyses revealed that DAB2 interacts with TNF receptor-associated factor 6 (TRAF6) and attenuates

110 TNF receptor-associated factor 6 (TRAF6) associates with

111 NKL-induced NF-kappaB activation and delayed TNF receptor-associated factor 6 (TRAF6) deubiquitinatio

112 completely understood, but ubiquitination of TNF receptor-associated factor 6 (TRAF6) has recently be

113 TNF receptor-associated factor 6 (TRAF6) is an adaptor p

114 TNF receptor-associated factor 6 (TRAF6) is an adaptor p

115 TNF receptor-associated factor 6 (TRAF6) is identified a

116 TNF receptor-associated factor 6 (TRAF6), a verified tar

117 Upon LPS challenge, CREBH interacts with TNF receptor-associated factor 6 (TRAF6), an E3 ubiquiti

118 This study demonstrates that, TNF receptor-associated factor 6 (TRAF6), an E3 ubiquiti

119 This activation requires TNF receptor-associated factor 6 (TRAF6), and U(L)37 con

120 urthermore, NOSTRIN interacted directly with TNF receptor-associated factor 6 (TRAF6), leading to the

121 1 receptor-associated protein kinase (IRAK), TNF receptor-associated factor 6 (TRAF6), phosphatidylin

122 rectly interacting with the TRAF-C domain of TNF receptor-associated factor 6 (TRAF6), resulting in i

123 thin a recently identified binding motif for TNF receptor-associated factor 6 (TRAF6).

124 se 1, IL-1 receptor-associated kinase 4, and TNF receptor-associated factor 6 (TRAF6).

125 1 receptor-associated kinase 1 (IRAK-1), and TNF receptor-associated factor 6 (TRAF6).

126 -1 receptor-associated kinase 1 (IRAK-1) and TNF receptor-associated factor 6 (TRAF6).

127 Lys-34 and required the E3 ubiquitin ligase TNF receptor-associated factor 6 after stimulation of ce

128 se-pair with sequences in the 3' UTRs of the TNF receptor-associated factor 6 and IL-1 receptor-assoc

129 ys-63-linked polyubiquitination at Lys-34 by TNF receptor-associated factor 6 and is thereby activate

130 nd prevents the dissociation of, IRAK-IRAK-4-TNF receptor-associated factor 6 from the TLR signaling

131 ion of IL-1 receptor-associated kinase 1 and TNF receptor-associated factor 6 protein levels.

132 ependent upon binding of the adapter protein TNF receptor-associated factor 6 to the cytoplasmic doma

133 ase) and subsequently integrates with TRAF6 (TNF receptor-associated factor 6) and/or c-fos signaling

134 ukin-1 receptor-associated kinase)1/4-TRAF6 (TNF receptor-associated factor 6), leading to integrin a

135 d expression of the signal transducer TRAF6 (TNF receptor-associated factor 6), leading us to conside

136 e system of IKK complex activation by TRAF6 (TNF receptor-associated factor 6), we show that these pe

137 AK1, TAB1 (TAK1 binding protein), and TRAF6 (TNF receptor-associated factor 6).

138 involving MyD88, IL-1R-associated kinase 1, TNF receptor-associated factor 6, and IkappaB kinase and

139 ts of myeloid differentiation protein, IRAK, TNF receptor-associated factor 6, and NF-kappaB-inducing

140 otein interactions with IKK-alpha, IKK-beta, TNF receptor-associated factor 6, TNF receptor-associate

141 leukin (IL)-1 receptor-associated kinase and TNF receptor-associated factor 6, two key adaptor/scaffo

142 luding MyD88, IL-1R-associated kinase 4, and TNF receptor-associated factor 6, while it inhibited the

143 terleukin-1 receptor-activated kinase-1, and TNF receptor-associated factor 6.

144 isolated NASPs act either via or upstream of TNF receptor-associated factor 6.

145 t signaling by disrupting the recruitment of TNF receptor-associated factor 6/c-Src complex to lipid

146 the molecular adaptor tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) exhibit a spec

147 Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is a key media

148 Tumour-necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is the only TR

149 es demonstrated that tumour necrosis factor (TNF) receptor-associated factor 6 (TRAF6) plays a key ro

150 estigated the role of tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6), an adaptor pr

151 Here we show that tumour necrosis factor (TNF) receptor-associated factor 6 (TRAF6), an adaptor pr

152 d kinase (IRAK-1) and tumor-necrosis factor (TNF) receptor-associated factor 6 (TRAF6), which are kno

153 We also found that tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6), which mediate

154 luding IL-1 receptor-associated kinase 4 and TNF-receptor associated factor 6.

155 he CINC promoter by IL-17 in IEC-6 cells was TNF receptor-associated factor-6 (TRAF6), but not TRAF2,

156 r gene activity was 16-fold higher following TNF receptor-associated factor-6 transfection after IL-1

157 ly interacts with IL-1R-associated kinase-1, TNF receptor-associated factor-6, TGF-beta-activated kin

158 cells, is dependent upon a MyD88-dependent, TNF receptor-associated factor-6-independent signaling p

159 l survival by hindering interactions between TNF-receptor-associated factors, blocking their negative

160 We have identified a Drosophila TNF-receptor-associated factor, DTRAF1, by screening for

161 te that cells lacking TRAF3, a member of the TNF receptor-associated factor family, are defective in

162 Here we identified mutations in TRAF3IP1 (TNF Receptor-Associated Factor Interacting Protein 1) in

163 mary gland identified tumor necrosis factor (TNF) receptor-associated factor-interacting protein (TRI

164 eptor, TNF receptor-associated death domain, TNF receptor-associated factor, NF-kappaB-inducing kinas

165 paB activation pathways, including the TRAF (TNF receptor-associated factor) proteins, IKK, NF-kappaB

166 The adaptor protein TNF receptor associated factor (TRAF) 3 is required for

167 NOPO is the Drosophila homolog of human TNF receptor associated factor (TRAF)-interacting protei

168 aling (SOCS) 3, B-cell CLL/lymphoma (BCL) 3, TNF receptor-associated factor (TRAF) 1, and TNFAIP3-int

169 ation and proteasome-mediated degradation of TNF receptor-associated factor (TRAF) 2 and TRAF6, which

170 of c-IAP1 is blocked upon coexpression with TNF receptor-associated factor (TRAF) 2, and this is ach

171 receptor-associated kinase (IRAK) 4, IRAK1, TNF receptor-associated factor (TRAF) 6, TGF-beta-activa

172 TRAF1/2 and cIAP1/2 are members of the TNF receptor-associated factor (TRAF) and the inhibitor

173 The TNF receptor-associated factor (TRAF) family of molecule

174 In this report we identify the TNF receptor-associated factor (TRAF) family of signal t

175 act directly with signaling molecules of the TNF receptor-associated factor (TRAF) family to activate

176 Through their interaction with the TNF receptor-associated factor (TRAF) family, members of

177 ng association with adaptor molecules of the TNF receptor-associated factor (TRAF) family.

178 TNF receptor-associated factor (TRAF) proteins associate

179 is: inhibitor of apoptosis(IAP)-1 and X-IAP, TNF receptor-associated factor (TRAF)-2, and factors OX4

180 rm prolactin receptors (PRLR-S), constrained TNF receptor-associated factor (TRAF)-dependent innate i

181 n-canonical K63-linked polyubiquitination of TNF receptor-associated factor (TRAF)-family adapter pro

182 sponsible for noncanonical ubiquitination of TNF receptor-associated factor (TRAF)-family adapter pro

183 HVEM activates NF-kappaB and AP-1 through a TNF receptor-associated factor (TRAF)-mediated mechanism

184 antiapoptotic factors Bcl-xL, A1/Bfl-1, and TNF receptor-associated factor (TRAF)1, all of which are

185 xpressing in B lymphocytes either Bcl-2 or a TNF receptor-associated factor (TRAF)2 mutant lacking th

186 receptor-associated death domain (TRADD), DN-TNF receptor-associated factor (TRAF)2, DN-receptor-inte

187 ein caused a shift in CD40 signaling through TNF receptor-associated factors (TRAF), including the TR

188 ransformation, binds tumour necrosis factor (TNF) receptor associated factor (TRAF) 1 and TRAF3 and t

189 e that IHPK2 binds to tumor necrosis factor (TNF) receptor-associated factor (TRAF) 2 and interferes

190 Tumor necrosis factor (TNF) receptor-associated factor (TRAF) 2 is an intracell

191 g by deubiquitinating tumor necrosis factor (TNF) receptor-associated factor (TRAF) 2, TRAF6, and NEM

192 ction is initiated by tumor necrosis factor (TNF) receptor-associated factor (TRAF) adapter proteins,

193 Intracellular tumor necrosis factor (TNF) receptor-associated factor (TRAF) adapter proteins,

194 nd is a member of the tumor necrosis factor (TNF) receptor-associated factor (TRAF) family of putativ

195 A member of the tumor necrosis factor (TNF) receptor-associated factor (TRAF) family was identi

196 Tumor necrosis factor (TNF) receptor-associated factor (TRAF) proteins associat

197 -kappaB, and binds to tumor necrosis factor (TNF)-receptor-associated factor (TRAF) proteins, but the

198 s on the ubiquitin-conjugating enzyme Ubc13, TNF receptor-associated factor TRAF2, the protein kinase

199 Furthermore, recruitment of the TNF-receptor-associated factor TRAF6 and activation of t

200 A family of proteins called TNF receptor associated factors (TRAFs) plays key roles

201 gnal transducers for TNFRs are the family of TNF receptor associated factors (TRAFs).

202 JNK) pathways through their interaction with TNF receptor-associated factors (TRAFs) and NF-kappaB-in

203 F) family receptor in its ability to recruit TNF receptor-associated factors (TRAFs) and TNF receptor

204 TNF receptor-associated factors (TRAFs) are recruited to

205 , the most recently identified member of the TNF receptor-associated factors (TRAFs) family of protei

206 mily members, including CD40, is mediated by TNF receptor-associated factors (TRAFs) that interact wi

207 its ligand initiates signaling by recruiting TNF receptor-associated factors (TRAFs) to the CD40 cyto

208 are believed to be mediated in part through TNF receptor-associated factors (TRAFs), a family of cyt

209 lecule CD40 and its signaling intermediates, TNF receptor-associated factors (TRAFs), in diet-induced

210 The CD30 cytoplasmic tail interacts with TNF receptor-associated factors (TRAFs), which have been

211 d to be delivered through mediators known as TNF receptor-associated factors (TRAFs).

212 Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are critical si

213 Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are cytoplasmic

214 Intracellular tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are key element

215 Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are mediators o

216 in part, by engaging tumor necrosis factor (TNF) receptor-associated factors (TRAFs), which also med

217 Tumour necrosis factor (TNF)-receptor-associated factors (TRAFs) form a family o

218 membrane to the nucleus through cytoplasmic TNF-receptor-associated factors (TRAFs).

219 these bacteria resulted in the activation of TNF receptor associated factors, two recently described