ライフサイエンスコーパス: TNFR-II

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1 way common to two surface receptors CD40 and TNFR II.

2 ient in TNFR I (p55(-/-)) or both TNFR I and TNFR II (double knockout [DKO]) exhibited impaired viral

3 R I) and/or TNFR II, we show that TNFR I and TNFR II play redundant roles in down regulating the expa

4 pleens of mice deficient for both TNFR I and TNFR II.

5 While wild-type (+/+) and TNFR II-deficient (p75(-/-)) mice cleared LCMV from the

6 ermined that the production of TNF-alpha and TNFR-II in response to AQARSAASKVKVSMKF preceded the pro

7 ay data, the protein levels of TNF-alpha and TNFR-II were increased following stimulation of RAW264.7

8 Using neutralizing anti-TNFR-I and TNFR-II mAbs, we have now obtained evidence that TNF-alp

9 liquid and soft agar cultures, whereas anti-TNFR-II (p75) Ab had only a marginal effect.

10 n are mediated exclusively by TNFR-I, not by TNFR-II.

11 sion by Mphis through a pathway triggered by TNFR-II.

12 In contrast, TNFR-II (p75) function appears to be associated with enh

13 primary Mphis from mice deficient in TNFR-I, TNFR-II, or both TNF-alpha receptors (TNFRs), we determi

14 55-/-), TNFR-II (p75-/-), or combined TNFR-I/TNFR-II deficiency (p55-/-p75-/-) and their wild-type co

15 ceptor I (IL-1RI), IL-1RII, TNF receptor II (TNFR II), and IL-6 receptor as well as the level of proi

16 r-I (TNFR-I: p55) and TNF-alpha receptor-II (TNFR-II: p75).

17 deficient for TNF receptor I (TNFR I) and/or TNFR II, we show that TNFR I and TNFR II play redundant

18 We propose that ligand binding to CD40 or TNFR II leads to the formation of a TRAF2/TANK complex,

19 r tumor necrosis factor receptor (TNFR)-I or TNFR-II have normal numbers of NK and NK/T cells, implyi

20 gene-targeted deficiency in TNFR-I (p55-/-), TNFR-II (p75-/-), or combined TNFR-I/TNFR-II deficiency

21 locking TNF in vivo by administering soluble TNFR II fusion protein (TNFRII:Fc) significantly reduced

22 We propose that TNFR-II and the VLA-1 synergize to protect effector CD8

23 the region of chromosome 1 that contains the TNFR-II, 4-1BB, OX40 and CD30 gene cluster at 1p36.

24 lpha and one of its receptors, the p75 TNFR (TNFR-II), increasing 3.5- and 5.7-fold, respectively.

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