ライフサイエンスコーパス: TR

1 TR </=mild at baseline is strongly associated with reint

2 TR assembles with TERT and species-specific proteins, an

3 TR Doppler envelopes were assessed for quality.

4 TR jet velocity was inversely correlated with FMD.

5 TR severity was determined by the averaged vena contract

6 TR-FRET resolved the weakly bound (W) and strongly bound

7 TR/GR-null livers cannot reduce oxidized glutathione dis

8 TRs have been implicated in tumorigenesis, although it i

9 We identified >100 TRs associated with expression/methylation levels of adj

10 y of gene expression (noncanonical or type 3 TR signaling).

11 For grade A TR signals, echocardiographic measures of systolic pulmo

12 In patients with grade A TR signals, mean pulmonary arterial pressure-to-workload

13 ilability and shown to cause regression of a TR, endocrine-independent ER+ xenograft superior to that

14 ediated DNA replication and persistence of a TR-containing plasmid.

15 These compounds enabled the development of a TR-FRET based assay for OTR, readily amenable to high th

16 High-quality (grade A) TR Doppler was present in 68% at rest and 34% at peak ex

17 AF-TR is not rare and is associated with advanced age and r

18 n of functional TR because of chronic AF (AF-TR) remains undetermined.

19 ith right heart remodeling differ between AF-TR and left-sided heart disease-TR.

20 right ventricular end-systolic volume in AF-TR (P<0.001).

21 0.001) was associated with TR severity in AF-TR.

22 Clinical features of AF-TR included advanced age, female sex, greater right atri

23 The prevalence of AF-TR was 9.2%, whereas that of functional TR because of le

24 HODS AND To investigate the prevalence of AF-TR, 437 patients with moderate to severe TR underwent 3-

25 In 3D TV assessment, patients with AF-TR had a larger TV annular area with weaker annular cont

26 hormone administration to mice, whereas aged TR knockout mice spontaneously accumulate collagen.

27 led NY-ESO-1(pos) targets; however, although TR cells proved highly alloreactive, SE cells showed a f

28 Molecular docking and TR-FRET GR competitive binding experiments demonstrated

29 Both Ig and TR rearrangements showed a significant decrease in the n

30 thereby on the total diversity of the Ig and TR repertoire.

31 We demonstrate an increase of TH-levels and TR-expressions in pelagic-larvae, followed by a decrease

32 solved (TR) small-angle X-ray scattering and TR-FRET to correlate changes in the DNA conformations wi

33 s in the essential telomerase genes TERT and TR cause familial pulmonary fibrosis; however, in telome

34 development, thus demonstrating tissue- and TR isoform-specific canonical signaling.

35 d from human APOE-targeted-replacement (APOE-TR) and APOE-knock-out (KO) mice, with neuroinflammation

36 using human apoE-targeted replacement (apoE-TR) mice, which do not show amyloid pathology.

37 In animal studies, aged apoE2-TR mice also exhibited preserved memory function in wate

38 Moreover, apoE2-TR mice exhibited the lowest levels of cholesterol in th

39 Regardless, apoE2-TR mice showed similar or greater age-related changes in

40 erformance across apoE isoforms, where apoE2-TR mice had higher apoE levels.

41 tion, and oxidative stress compared to apoE3-TR or apoE4-TR mice.

42 iet (HFD) accelerates these effects in apoE4-TR mice at middle age.

43 idative stress compared to apoE3-TR or apoE4-TR mice.

44 us versus liver-identity factors, as well as TR grouping into functional families.

45 ect of variation at 4849 promoter-associated TRs, genotyped in 120 individuals, on neighboring gene e

46 Degree of baseline TR may be an important marker of long-term outcomes in t

47 Moderate or severe baseline TR was associated with shorter freedom from RVOT reinter

48 In patients with significant baseline TR, TPVR resulted in clinically relevant acute reduction

49 on of PHDs increased the interaction between TR-alpha and nuclear receptor corepressor 2 (NCOR2) and

50 o The upstream essential domain of T. brucei TR, termed the template core, constitutes three short he

51 for a cofactor, Dot1L, in gene activation by TR during vertebrate development.

52 ression of Dot1L enhances gene activation by TR in the presence of T3.

53 nt or targeting DIOs were likely mediated by TRs and that suppressing TR protects cones.

54 cer cells, tumor-recognizing CD4(+) T cells (TR-CD4) potently induced IFN-gamma-dependent growth arre

55 TRMs, such as one comprising core circadian TRs, are further recruited to selective subsets of CRMs

56 By computing TR-SWAXS patterns from the simulations, we could interpr

57 en in the setting of significant concomitant TR.

58 We now report that the same conformational TR-FRET based immunoassay detects polyglutamine- and tem

59 preferentially and coordinately corecruited TRs, assemble into hierarchical combinations at hepatic

60 ing rapid implementation of inducible CRISPR-TRs in mammalian cells.

61 RISPR-based transcription regulators (CRISPR-TRs) have transformed the current synthetic biology land

62 ed here in both a conventional fMRI dataset (TR = 2000 ms) as well as in information of meta-analyses

63 Eighty-five of 771 infants (11.0%) developed TR-ROP.

64 Our results suggest that the developed TR-LRET nanoparticle assay can be exploited for screenin

65 The developed TR-LRET nanoparticle assay gave corresponding results wi

66 We thus identified 278 candidate direct TR target genes.

67 ssure compared with left-sided heart disease-TR with sinus rhythm (all P<0.05).

68 with patients with left-sided heart disease-TR with sinus rhythm.

69 r between AF-TR and left-sided heart disease-TR.

70 eration retinas, suggesting locally elevated TR signaling.

71 Two genes, THRA and THRB, encode TRs; THRB2 has been associated with cone viability.

72 s while transgenic Dot1L enhances endogenous TR function in premetamorphic tadpoles in the presence o

73 ical for T3-induced activation of endogenous TR target genes while transgenic Dot1L enhances endogeno

74 using DNase-seq provides little evidence for TR footprints both in the absence and presence of hormon

75 of a sample efficient viscous medium jet for TR-SFX.

76 ltivariate model, significant predictors for TR-ROP were gestational age (GA) (odds ratio [OR], 5.7;

77 nfants in need of increased surveillance for TR-ROP.

78 ere we demonstrate a flexible, antibody-free TR-LRET kinase assay strategy that is enabled by the com

79 Propagation of viruses derived from TR-BAC, TB40-BAC4, and FIX-BAC in either fibroblast or e

80 Functional TR was present in 88%; in addition, 22 patients were als

81 oping transcatheter solutions for functional TR has gained greater momentum.

82 ass >/=II and moderate or greater functional TR were enrolled.

83 Ps) markers, indicating that many functional TR variants are not effectively assayed by SNP-based app

84 Therefore, characterization of functional TR because of chronic AF (AF-TR) remains undetermined.

85 f AF-TR was 9.2%, whereas that of functional TR because of left-sided heart disease was 45.3%.

86 The presence of functional TR, either isolated or in combination with left heart di

87 development for the treatment of functional TR.

88 ographic differences according to functional TR subtypes are unclear.

89 Fe3O4 NPs-GA-TR retained 92% of its initial activity after 120days of

90 at targeted studies that focus on genotyping TR variants are required to fully ascertain functional v

91 nificantly different from that found in GNRA TR interactions.

92 e angle of insertion found in a typical GNRA TR interaction.

93 lved in regulatory activities of the hepatic TR, NR1H4 (FXR; farnesoid X receptor), as our model syst

94 lack both TrxR1 and GR in all hepatocytes ('TR/GR-null livers') remain long-term viable.

95 s provided a framework for understanding how TR, TERT, and other proteins from ciliate as well as ver

96 We found identical TR effects in both the original thermo-tactile condition

97 which impacts on all main applications of IG/TR immunogenetic analysis.

98 dize, and validate the entire workflow of IG/TR NGS assays for 1) clonality assessment, 2) minimal re

99 ically discuss pitfalls and challenges of IG/TR NGS methodology and its applications in hemato-oncolo

100 gies, a deeper analysis of Ig and/or TCR (IG/TR) gene rearrangements is now within reach, which impac

101 e zebrafish shows a remarkable complexity in TR gene expression.

102 d in clinically relevant acute reductions in TR that persisted over at least 5 years of follow-up.

103 phage DGR is primed by an adenine residue in TR RNA and is dependent on the DGR-encoded reverse trans

104 ***Cl in KRs (2.8-3.0 kcal/mol) and S***N in TRs (4.6-5.3 kcal/mol).

105 ther purely thermal stimulation might induce TR, without any tactile object to which temperature can

106 espectively, to T cells expressing invariant TR-alpha (iTRA) chains.

107 TC) and tetramethylrhodamine isothiocyanate (TR-ITC).

108 sorders, 4th Edition, Text Revision (DSM -IV-TR), along with assessment of severity of illness using

109 ange, 7-50 years) diagnosed as having DSM-IV-TR autism or Asperger syndrome and 193 typical developin

110 udy 1, n=383; study 2, n=390) meeting DSM-IV-TR BED criteria were randomized (1:1) to placebo or LDX

111 this study, adult outpatients meeting DSM-IV-TR criteria for ADHD were randomized to 4 weeks of doubl

112 Patients meeting DSM-IV-TR criteria for major depressive disorder who presented

113 h an acute manic or mixed episode per DSM-IV-TR criteria were enrolled in this randomized, placebo-co

114 mood or psychotic episode fulfilling DSM-IV-TR criteria.

115 lations were based on considering the DSM-IV-TR criterion as the reference standard.

116 ects organized by Biotype and then by DSM-IV-TR diagnosis (n = 1409) using voxel-based morphometry wi

117 al trial of 333 adult patients with a DSM-IV-TR diagnosis of MDD across 59 research clinics globally,

118 ature on cancer-related PTSD has used DSM-IV-TR diagnostic criteria; the revised DSM-5 PTSD criteria

119 ual of Mental Disorders, 4th Edition (DSM-IV-TR) criteria and ID (n = 181), as well as general popula

120 the ubiquitous pseudoknot found in all known TRs, suggesting later evolution of this critical structu

121 n humans and primates by using 30,275 larger TRs (repeat unit length, 2-50 bp).

122 vestigated the structures of the full-length TR pseudoknot and isolated subdomains in Oryzias latipes

123 , and more than one-half had mild TR or less TR at discharge.

124 A major TR binding site in the immunoglobulin repeat 21 (Ig21) o

125 sion of P2a, P2a.1, is specific to mammalian TR.

126 se patients, and more than one-half had mild TR or less TR at discharge.

127 .07; 95% CI, 1.00-1.15; P=0.057) and </=mild TR (HR, 3.50; 95% CI, 1.75-7.0; P<0.001).

128 rculation status was associated with </=mild TR (odds ratio, 18.6; 95% CI, 5.3-65.2; P<0.001) and low

129 reinterventions was associated with </=mild TR (rate ratio, 1.87; 95% CI, 1.23-2.87; P=0.0037).

130 Freedom from moderate TR at 7 years was not significantly different in the 2 g

131 y associated with freedom from late moderate TR (p=0.04), and was an independent predictor of recover

132 ery (class I) or those with mild to moderate TR with a dilated annulus (>/=40 or >/=21 mm(2), Class I

133 In patients with moderate TR or tricuspid annular dilation who were undergoing deg

134 Moreover, we showed that most TR variants are poorly tagged by nearby single nucleotid

135 hyltransferase inhibition also increases Mpl-TR levels, suggesting that Ott1 uses an underlying epige

136 These potential eQTL/mQTL TRs were enriched for overlaps with transcription factor

137 erted transcriptional regulation by multiple TRs at CRMs.

138 Nevertheless, TRs also rapidly activate intracellular second-messenger

139 all of which were regulated by noncanonical TR signaling.

140 the physiological relevance of noncanonical TR signaling, we generated knockin mice with a mutation

141 s provide in vivo evidence that noncanonical TR signaling exerts physiologically important cardiometa

142 anuscript, we describe the design of a novel TR-FS device, along with preliminary data on detection a

143 rypanosoma brucei, revealing the ancestry of TR comprising two distinct structural core domains that

144 miological and pathophysiological aspects of TR, and the current and future directions of therapy.

145 ps, we determined the genome-wide binding of TR in the control and T3-treated tadpole intestine.

146 essential role in site-specific cleavage of TR RNA for cDNA priming.

147 The degree of TR was severe or massive in 88% of patients before the p

148 e past two decades, structures of domains of TR and TERT as well as other telomerase- and telomere-in

149 entified the essential functional domains of TR from the basal eukaryotic species Trypanosoma brucei,

150 d Thrb2 deletion, we examined the effects of TR inhibition.

151 and suggests that a significant fraction of TR variations exert functional effects via alterations o

152 tropicalis for genome wide identification of TR binding sites.

153 findings support the view that inhibition of TR locally in the retina is a therapeutic strategy for r

154 Moreover, the expression levels of TR were significantly higher in the cone-degeneration re

155 1 or more MitraClip devices and reduction of TR by at least 1 grade, were evaluated before discharge

156 acy analysis showed encouraging reduction of TR, which may potentially result in improved clinical ou

157 Based on results of TR gradings, a computerized algorithm determined whether

158 The risk of TR-ROP steadily increased with higher risk score and pre

159 ons express overlapping but distinct sets of TR genes suggesting regional differences in the neurogen

160 However, genome-wide surveys of TR variation in humans and closely related species have

161 Transcatheter treatment of TR with the MitraClip system seems to be safe and feasib

162 te structural domains is a common feature of TRs and emerged early in telomerase evolution.

163 However, how recruitment of a myriad of TRs is orchestrated at cis-regulatory modules (CRMs) to

164 examined the potential evolutionary role of TRs in gene expression differences between humans and pr

165 o three biomarker-specific oligonucleotides (TRs) via their 5'-end regions and to a capture probe-mag

166 oad by TPVR will have a beneficial effect on TR, as is often seen with surgical pulmonary valve repla

167 Treatments with TH or TR-antagonist, as well as relocation to the open-ocean,

168 s two different fMRI acquisition parameters (TR = 0.645 and 1.4 s).

169 In 13% of patients, TR remained severe after the procedure.

170 ve patients with RVOT obstruction and/or PR, TR was common.

171 4 PMA weeks or earlier independently predict TR-ROP.

172 creased with higher risk score and predicted TR-ROP well (AUC = 0.88; 95% CI, 0.85-0.92).

173 Image findings predicted TR-ROP better than GA (area under receiver operating cha

174 Risk score >/=3 points for predicting TR-ROP had a sensitivity of 98.8%, specificity of 40.1%,

175 Risk score points for predicting TR-ROP were derived from the regression coefficients of

176 However, in case of the primary TR, surgical options is limited by a relatively high ris

177 After the procedure, TR was reduced by at least 1 grade in 91% of the patient

178 Polymorphic promoter TRs were associated with increased variance in local gen

179 ong the subset of patients with high-quality TR Doppler signal.

180 Lower quality TR signals (grade B and C) correlated poorly with invasi

181 7, P = 0.035) or capecitabine and radiation (TR = 1.25, 95% CI: 1.04-1.51, P = 0.018).

182 gemcitabine and nab-paclitaxel [time ratio (TR) = 1.26, 95% CI: 1.02-1.57, P = 0.035) or capecitabin

183 Nonphysician trained readers (TRs) evaluated all image sets from eyes that ever had IO

184 tification for nonphysician trained readers (TRs) have not yet been described.

185 In addition, new questions arose from recent TR-SWAXS data that were interpreted as underdamped oscil

186 the bare protein, thereby reconciling recent TR-SWAXS experiments with the notion of overdamped globa

187 of immunoglobulin (Ig) and T-cell receptor (TR) rearrangements, using next-generation sequencing in

188 T cells displaying a large T-cell receptor (TR) repertoire, MH1Like proteins, such as CD1D and MR1,

189 ent actions of the thyroid hormone receptor (TR) during development and in hypothyroidism.

190 regulation by the thyroid hormone receptor (TR).

191 nd Dot1L in turn functions as a T3 receptor (TR) coactivator to promote vertebrate development.

192 These tetraloop-receptor (TR) interactions have a conserved geometry in which the

193 ectiveness of inhibition of the TH receptor (TR).

194 r thyroid-hormones (TH) and their receptors (TR) coordinate the larval recruitment of the coral-reef-

195 ed linkages between transmembrane receptors (TR) and the actin cytoskeleton are crucial for regulatin

196 ), through binding to its nuclear receptors (TRs), is able to antagonize transcriptional activation b

197 its high affinity for TH nuclear receptors (TRs), new data suggest that 3,5-diiodothyronine (T2) can

198 get gene transcription through T3 receptors (TRs).

199 Thyroid hormone (TH) and TH receptors (TRs) alpha and beta act by binding to TH response elemen

200 Single Texas red (TR) dye was specifically attached in the junction of the

201 This illusion is known as thermal referral (TR).

202 of more than 1200 transcription regulators (TR) in the adult telencephalon.

203 tion by multiple transcriptional regulators (TRs).

204 Tricuspid regurgitant (TR) jet velocity and its relationship to pulmonary hyper

205 tion between severe tricuspid regurgitation (TR) and mortality.

206 options for severe tricuspid regurgitation (TR) are limited, and additional interventional approache

207 e exercise testing, tricuspid regurgitation (TR) Doppler estimates and invasive measurement of pulmon

208 Tricuspid regurgitation (TR) is a common and important comorbidity in patients wi

209 tional or secondary tricuspid regurgitation (TR) is the most common cause of severe TR in the Western

210 owever, significant tricuspid regurgitation (TR) often accompanies left-side heart valve pathology an

211 Functional tricuspid regurgitation (TR) with a structurally normal tricuspid valve (TV) may

212 lus (TA) and reduce tricuspid regurgitation (TR).

213 0.027), and </=mild tricuspid regurgitation (TR; HR, 3.58; 95% CI, 2.04-6.30; P<0.001).

214 ransposition process from a template repeat (TR) to a variable repeat (VR) that results in adenine-to

215 ed to a position within the terminal repeat (TR) and its deletion resulted in lower ORF50 expression

216 rus (KSHV) initiates at the terminal repeat (TR) element and requires trans-acting elements, both vir

217 binds cooperatively to the terminal repeat (TR) region of the viral episome via adjacent LANA bindin

218 ecruitment of NAP1L1 at the terminal repeat (TR) region of the viral genome.

219 (LANA), which binds in the terminal repeat (TR) region of the viral genome.

220 source of genetic variation, tandem repeats (TRs) remain poorly studied due to technical difficulties

221 murine microglia from targeted replacement (TR) APOE3/3 and APOE4/4 mice.

222 ignaling in human apoE-targeted replacement (TR) mice in an age-dependent manner.

223 Treatment-resistant (TR) ER+ cell lines (MCF-7:5C and MCF-7:TAM1) were used f

224 We combine time-resolved (TR) small-angle X-ray scattering and TR-FRET to correlat

225 iboelectrification with torsional resonance (TR) mode atomic force microscopy (AFM).

226 R region, implicating the role of the G-rich TR in the perturbation of episomal DNA replication.

227 at the commercial harvest (CH) or tree-ripe (TR) stages were immediately exposed to cold treatment (4

228 hromosomes using an integral telomerase RNA (TR) template.

229 rse transcriptase (TERT) and telomerase RNA (TR) that provides the template for telomeric DNA synthes

230 e (TERT) and template in the telomerase RNA (TR), thereby helping to maintain genome integrity.

231 lved small- and wide-angle X-ray scattering (TR-SWAXS) is capable of tracking such ultrafast protein

232 ients with heart failure symptoms and severe TR on optimal medical treatment were treated with the Mi

233 ty of transcatheter repair of chronic severe TR with the MitraClip system were evaluated.

234 went MitraClip treatment for chronic, severe TR for compassionate use.

235 e transcatheter treatment options for severe TR implanted at different levels: the junction between v

236 evere TR pre-implantation, only 1 had severe TR at 1-year follow-up and beyond.

237 tion (TR) is the most common cause of severe TR in the Western world.

238 s studied, 77 (25.6%) had moderate or severe TR at baseline.

239 prevent the inevitable progression to severe TR and the need for a second surgical intervention.

240 AF-TR, 437 patients with moderate to severe TR underwent 3-dimensional (3D) transesophageal echocard

241 developed for treating patients with severe TR and right heart failure with prohibitive surgical ris

242 Patients with severe TR are often managed medically for years before TV repai

243 Of 13 patients with severe TR pre-implantation, only 1 had severe TR at 1-year foll

244 consensus to operate on patients with severe TR undergoing left-sided valve surgery (class I) or thos

245 Time-resolved SFX (TR-SFX) with a pump-probe delay of 1 ms yields differenc

246 e of and factors associated with significant TR in patients undergoing TPVR for RVOT obstruction or P

247 The SERS enhancement factors of single TR dye molecules located in the conjunction region in di

248 The Time-resolved fluorescence spectroscopy (TR-FS) has the potential to differentiate tumor and norm

249 from BACs containing the genomes of strains TR, TB40, FIX, and Merlin, as well as from Merlin-BAC re

250 Strong TR peptide ligands from platelet GP1balpha and G-protein

251 of the thyroid hormone receptors and suggest TR ligands could have beneficial effects to block the pr

252 likely mediated by TRs and that suppressing TR protects cones.

253 TERT protein is well-conserved across taxa, TR is highly divergent amongst distinct groups of specie

254 We also show that TR-FS is able to quantify the relative concentration of

255 ur purely thermoceptive results suggest that TR could reflect low-level organization of the thermocep

256 We hypothesized that TRs can operate as expression (eQTLs) and methylation (m

257 The TR binding to this site triggers the relief of Ig20 and

258 The TR secondary structure is believed to play a role in CAG

259 many of the genomic changes mediated by the TR in hypothyroidism are independent of NCoR1, suggestin

260 enerated knockin mice with a mutation in the TR DNA-binding domain that abrogates binding to DNA and

261 Abeta42 to the nanoparticles increasing the TR-LRET signal.

262 reverse the ligand-independent action of the TR on many gene targets and did not fully rescue the hig

263 sing of replications forks moving out of the TR region, implicating the role of the G-rich TR in the

264 Sequence analysis of the TR, a GC-rich DNA element, identified several potential

265 lar mechanism by which LANA assembles on the TR remains elusive.

266 Ser-2152, thereby dynamically regulating the TR-actin linkages.

267 We show that the TR-FS prototype is able to identify in near-real time th

268 Systemic and ocular treatment with the TR antagonists NH-3 and 1-850 increased cone density by

269 CoR1DeltaID), which cannot interact with the TR, in Pax8-KO mice, which make no thyroid hormone.

270 ting the complex, 3' overhang regions of the TRs were labeled with three distinct monolayer double-st

271 and kinetically (KRs) or thermodynamically (TRs) controlled regioisomers were obtained at room tempe

272 ctures of six complexes (three KRs and three TRs) were elucidated by single-crystal X-ray diffraction

273 coded lines within a single repetition time (TR) using two bipolar read-out trains.

274 uggesting functional consequences related to TR variation.

275 Our study assigns biological significance to TR variations in the human genome, and suggests that a s

276 After TPVR, TR severity was improved in 65% of those patients, and m

277 TRMs transcend TR classification into ubiquitous versus liver-identity

278 lved fluorescence resonance energy transfer (TR-FRET) and double electron-electron resonance (DEER),

279 lved fluorescence resonance energy transfer (TR-FRET) assay was 9.6 ng/mL, and the limit of detection

280 lved Fluorescence Resonance Energy Transfer (TR-FRET) assay, we demonstrate that Munc13-4 binds to Ra

281 lved fluorescence resonance energy transfer (TR-FRET) technology, to identify reversible inhibitors.

282 lved luminescence resonance energy transfer (TR-LRET) was developed for the detection of beta-amyloid

283 ected by TCR gene transfer (TCR transferred [TR]), SE T cells efficiently killed NY-ESO-1(pos) target

284 Our functional study of trypanosome TR core domains suggests that the functional requirement

285 Immobilized trypsin (TR) was more stable than the free one and demonstrated h

286 sence of hormone, suggesting that unliganded TR engagement with repressive complexes on chromatin is,

287 NCoR1's role in repression by the unliganded TR, we deleted NCoR1 in the livers of euthyroid and hypo

288 If left untreated, TR can progress and result in progressive right ventricu

289 Using TR antagonists and Thrb2 deletion, we examined the effec

290 rder in the protein's flexible regions using TR-FRET and DEER.

291 eriments on rubbing the sample surface using TR mode for the generation of triboelectric charges and

292 We further validated TR binding in vivo and analyzed the regulation of select

293 Vertebrate TR contains the template/pseudoknot (t/PK) and CR4/5 dom

294 aka fish), which has the smallest vertebrate TR identified to date.

295 technique included 1-mm heavily T2-weighted [TR 2000 ms; TE-200 ms] fast spin echo study in coronal a

296 per 100 mm(2); P<0.001) was associated with TR severity in AF-TR.

297 Our results suggest that in patients with TR secondary to AF, TV annuloplasty should be effective

298 ival than that observed in mice treated with TR cells.

299 Alterations in the arrangement of LBS within TR or at the tetramer assembly interface have a drastic

300 o R-loop-mediated BRCA1 binding sites within TRs.