ライフサイエンスコーパス: TRA

1 TRA 2 degrees P-TIMI 50 (Trial to Assess the Effects of

2 TRA has become the dominant percutaneous coronary interv

3 TRA use increased from 14.0% to 58.6% in 417 038 PCI pat

4 TRA was a predictor for reduced bleeding (odds ratio=0.2

5 TRA was associated with a reduction in bleeding and tran

6 TRA was independently associated with a 35% reduction in

7 TRA was independently associated with a decreased risk o

8 TRA was independently associated with reduced 30-day mor

9 TRA-1 activity inhibits male development and allows fema

10 TRA-1 binds to sites adjacent to a number of heterochron

11 TRA-1 export requires TRA-1 binding to the tra-2 3' untr

12 TRA-1 patterns rely on nuclear export since treatment wi

13 TRA-1, a member of the Ci/Gli family of transcriptional

14 TRA-1, a member of the GLI family of transcription facto

15 TRA-1/GLI is best known as a master regulator of sex det

16 TRA-3, an ortholog of CAPN5, has been shown to be involv

17 TRA-F stimulation of Sxl seems to be direct at some poin

18 atode global sexual regulator Transformer 1 (TRA-1), a transcription factor acting at the interface b

19 list of transcription factors includes WT-1, TRA-1, bicoid, the bacterial sigma(70) subunit, STAT1 an

20 The conservation of the TRA-1- TRA-2 interaction underscores its importance in sex dete

21 The functional importance of the TRA-1-TRA-2 physical interaction is supported by genetic inter

22 In patients with an MMRS <10, TRA was used in 71,771 (43.2%) of 166,083 PCI procedures

23 We identified 184 TRA-1-binding sites in Caenorhabditis elegans, many with

24 Between 2005 and 2007, TRA did not appear to reduce mortality at 1 year (HR=0.8

25 28; P=0.376), whereas between 2008 and 2011, TRA conferred survival benefit at 1 year (HR=0.65; 95% C

26 fficient (ADC) in tumor regions for group 3 (TRA-8) and group 4 (TRA-8/Gem) were 21 +/- 9% (mean +/-

27 mor regions for group 3 (TRA-8) and group 4 (TRA-8/Gem) were 21 +/- 9% (mean +/- SE) and 27 +/- 3%, r

28 uripotency, including Oct-4, SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, nanog and alkaline phosphatase.

29 ts-Thrombolysis in Myocardial Infarction 50 (TRA 2 degrees P-TIMI 50) was a randomized, double-blind,

30 TRA-1-60(+)), with variable yield (6 to >500 TRA-1-60(+) iPSC colonies per 10 mL blood; n = 6).

31 en 4 (SSEA-4), tumor rejection antigen 1-60 (TRA 1-60), and tumor rejection antigen 1-81 (TRA 1-81) (

32 SSEA-4, tumour-rejection antigen (TRA)-1-60, TRA-1-81, and alkaline phosphatase.

33 SEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9

34 , including Oct-4, SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, nanog and alkaline phosphatase.

35 We also identified 78 TRA-1-binding sites in the related nematode Caenorhabdit

36 h Sendai were variably reprogrammed (10%-80% TRA-1-60(+)), with variable yield (6 to >500 TRA-1-60(+)

37 TRA 1-60), and tumor rejection antigen 1-81 (TRA 1-81) (traditional markers of human embryonic stem c

38 sults indicate that MIDA1 is an effective 9L TRA and will be useful for the investigation of specific

39 that resides among normal hESC colonies as a TRA-1-60(-)/SSEA4(-)/SOX1(+) cell and developed a method

40 essing the masculinizing protein FEM-3, is a TRA-3 substrate.

41 Our data are consistent with coexport of a TRA-1/tra-2 mRNA complex reducing TRA-1 nuclear activity

42 omes this retention resulting in export of a TRA-1/tra-2 mRNA complex.

43 d a transgenic mouse expressing the TCR of a TRA-specific T cell that had escaped negative selection.

44 emporal trends in use of transradial access (TRA) for percutaneous coronary intervention (PCI) in ST-

45 ith transfemoral access, transradial access (TRA) for percutaneous coronary intervention is associate

46 Transradial access (TRA) has been associated with reduced access site-relate

47 emic complications after transradial access (TRA) is controversial.

48 The transradial access (TRA) site has become the default access site for percuta

49 ementation of the Theory of Reasoned Action (TRA) using artificial-neural networks.

50 stal germline, where MPK-1 is not activated, TRA-1 represses the male fate as NOS-3 functions in tran

51 The transmission-reducing activity (TRA) of these agents is currently determined in the stan

52 Age-adjusted TRA reduction did not significantly affect either the ti

53 , in patients with abnormal AT results after TRA.

54 is that expression of tissue-restricted Ag (TRA) is a unique feature of thymic epithelium.

55 multidrug resistance (MDR) reversal agents (TRAs) has been designed and synthesized.

56 iscuous expression of tissue-restricted Ags (TRA) by thymic epithelial cells (TEC).

57 sion of a plethora of tissue-restricted Ags (TRAs) by medullary thymic epithelial cells (mTECs) plays

58 e range of peripheral tissue-restricted Ags (TRAs) by mTECs remain poorly defined.

59 tes the expression of tissue-restricted Ags (TRAs) in thymic epithelial cells.

60 ve four T cell receptor (TCR) chains: alpha (TRA), beta (TRB), gamma (TRG) and delta (TRD).

61 ng analysis of TCR-beta (TRB) and TCR-alpha (TRA) rearrangements of CD3(-)CD4(+)CD8(-) immature singl

62 Although TRAs as short as 100 bp seeded new telomeres, these trac

63 In propensity-matched analyses, TRA remained a predictor for survival at 1 year (HR=0.60

64 -2 physically associates with both FEM-1 and TRA-1 in vivo, and cul-2 mutant males share feminization

65 ty to disrupt interactions between HER-1 and TRA-2A-expressing cells, and a localized region on the H

66 tency markers OCT4, SOX2, NANOG, SSEA-4, and TRA-1-60, give rise to derivatives of the three germ lay

67 -4, Nanog, Sox-2, SSEA-4, TERT, TRA-1-60 and TRA-1-81 up to 65h after exposure to ionizing radiation

68 Thus, principles of BLM and TRA frameworks are confounded by the feeding behavior of

69 ressor, FEM-CUL-2 (E3 ubiquitin ligase), and TRA-1 (Gli transcriptional repressor), which acts both i

70 cells were immunopositive for the RPE65 and TRA-1-85.

71 Combining CD30 to SSEA4 and TRA-1-81 in FACS greatly enhanced specificity and effici

72 nd skewed length distribution of the TRB and TRA complementary determining region 3 sequences from SC

73 We investigated the expression of AIRE and TRAs in DS and control thymic tissue using quantitative

74 Anti-TRA-1 antibodies that recognize human pluripotent stem c

75 dies: anti-RPE65 (RPE-specific marker), anti-TRA-1-85 (human cell marker), anti-Ki67 (proliferation m

76 The anti-human DR5 antibody TRA-8 was efficacious in reducing the severity of arthri

77 efficacy of anti-death receptor 5 antibody (TRA-8) combined with gemcitabine was measured using diff

78 hen treated with an anti-human DR5 antibody, TRA-8.

79 (SSEA)-3, SSEA-4, tumour-rejection antigen (TRA)-1-60, TRA-1-81, and alkaline phosphatase.

80 t react weakly to tissue-restricted antigen (TRA).

81 SEA3 and SSEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein an

82 tissue-restricted peripheral self-antigens (TRA) from the total thymic ectopic TRA repertoire, weake

83 tissue-restricted peripheral self-antigens (TRA), which is in mature medullary thymic epithelial cel

84 ot express potent tumour rejection antigens (TRAs).

85 gens (TAAs) and/or tumor rejection antigens (TRAs).

86 onal deletion to tissue-restricted antigens (TRAs) requires positive selection and CCR7-mediated migr

87 nce induction to tissue-restricted antigens (TRAs), the outcome of which depends on the context in wh

88 pression of tissue-restricted self antigens (TRAs) in medullary thymic epithelial cells (mTECs) is es

89 of numerous tissue-restricted self-antigens (TRAs) in medullary thymic epithelial cells (mTECs) is es

90 pectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central

91 and model (BLM) and tissue residue approach (TRA)) are based on the established link between uptake,

92 Transradial approach (TRA), when compared with transfemoral, improves the safe

93 by the insertion of a telomere repeat array (TRA) into the host genome, which seeds the formation of

94 Age-adjusted telomere repeat array (TRA) reduction was found to significantly correlate with

95 3 promoter contains multiple sites that bind TRA-1A in gel shift assays, and mutations in these sites

96 Cleavage of TRA-2A by TRA-3 generates a peptide predicted to have feminizing a

97 NAs are likely to be regulated indirectly by TRA-1.

98 on is directly regulated in the intestine by TRA-1A, providing a molecular link between the global re

99 Depletion of pathogenic macrophages by TRA-8 led to significantly reduced clinical scores for a

100 Alternative splicing of fru is regulated by TRA and TRA2 and depends on an exonic splicing enhancer

101 male-specific FRU(M) protein is regulated by TRA, we hypothesized that a fru-derived transgene encodi

102 own targets of transcriptional regulation by TRA-1A.

103 is permissive for repression of splicing by TRA-2 while allowing efficient splicing in the absence o

104 ependent interaction between Cb-TRA-1 and Cb-TRA-2, but intriguingly, no cross-species interactions a

105 find an MX-dependent interaction between Cb-TRA-1 and Cb-TRA-2, but intriguingly, no cross-species i

106 Our findings characterize TRA expression in mTECs as a coordinated process that mi

107 -wide significant signals for PCT1 (CLEC19A, TRA, GGTA2P, TM9SF2, IFI16, RBMS3), PCT4 (HPVC1) and PCT

108 an oocyst intensity and generates comparable TRA estimates.

109 Some DNA segments containing TRA-1-binding sites drive male-specific expression patte

110 The regulatory hierarchy that controls TRA-1 is well established, but the downstream effectors

111 Fe(VI) leading predominantly to N-desmethyl-TRA (ca. 40%), whereas the proposed oxygen transfer prev

112 The measurement of diagnostic TRA may prove to be clinically important in the selectio

113 used, and an agonistic antibody against DR5 (TRA-8) and human recombinant TRAIL were used to ligate D

114 The temperature-dependent function of the Ds-TRA-2(ts2) protein was also evident by the up- and down-

115 lerance and prevents autoimmunity, with each TRA being expressed in only a few mTECs.

116 antigens (TRA) from the total thymic ectopic TRA repertoire, weakens the platform for central toleran

117 Thus, recirculating RTEs encounter TRAs during a transitional developmental stage that faci

118 vention of Atherothrombotic Ischemic Events (TRA 2 degrees P)-TIMI 50 trial.

119 entification of potent and broadly expressed TRAs and effective adjuvants to stimulate a robust and d

120 elegans, the Gli-family transcription factor TRA-1 is the terminal effector of the sex-determination

121 The Gli-like transcription factor TRA-1 of C. elegans promotes female development by repre

122 n binding sites for the transcription factor TRA-1A and are capable of driving expression of fog-3 in

123 encodes a zinc finger transcription factor, TRA-1A, that regulates, directly or indirectly, all gene

124 by studying genetically sensitized females: TRA-F from either maternal or zygotic tra expression sti

125 We also found evidence for TRA-1 feedback regulation of the global sex-determinatio

126 nd sera from malaria-exposed individuals for TRA.

127 with the fog-3 promoter and is required for TRA-1 to bind to fog-3 promoter.

128 We searched for TRA-1 consensus DNA binding sites near genes with sex-en

129 tion is below that of negative selection for TRA.

130 cent cis-elements that are binding sites for TRA-1A and a POU-type homeodomain protein UNC-86 and act

131 Consistent with its SGP function, TRA-1 protein is present in SGPs during embryogenesis an

132 Expression of functional TRA-2 protein in the male germline of Drosophila is regu

133 ggestive of a relationship between a greater TRA-reduction and a shorter time to acceleration (P =.05

134 report that despite the absence of EF hands, TRA-3 has calcium-dependent proteolytic activity and its

135 rval=153-399) lives would have been saved if TRA adoption were uniform nationally.

136 pool of Aire(+)mTEC(high), with an improved TRA transcriptome despite aGVHD.

137 In TRA 2 degrees P-TIMI 50--a randomised, placebo-controlle

138 ntify lives saved and lost by differences in TRA adoption.

139 ous MI followed up for 2.5 years (median) in TRA 2 degrees P-TIMI 50 [Thrombin Receptor Antagonist in

140 e site with a strong splice site resulted in TRA-2 independent splicing, while substitution with an u

141 e-specific TGE-binding factor GLD-1 increase TRA-2 protein expression and inhibit sperm production in

142 lative to AIRE-induced TRA, AIRE-independent TRA are more numerous and show greater splicing complexi

143 o found that AIRE-dependent and -independent TRA present several distinctive features.

144 port that AIRE-dependent versus -independent TRA project nonredundant representations of peripheral t

145 and preferentially included AIRE-independent TRAs.

146 equency of mTECs that express any individual TRA is quite low (>0.4-2%).

147 ntral tolerance induction because individual TRAs are purged from the total repertoire secondary to a

148 In particular, relative to AIRE-induced TRA, AIRE-independent TRA are more numerous and show gre

149 -ST-segment-elevation myocardial infarction, TRA appears to be a predictor for survival.

150 es arising with STEMCCA-loxP were invariably TRA-1-60(+), yielding 5.3 +/- 2.8 iPSC colonies per 20 m

151 Transformation of a 2.6-kb TRA into tetraploid plants resulted in a DNTF efficiency

152 h saline (control), gemcitabine (120 mg/kg), TRA-8 (200 mug), or TRA-8 combined with gemcitabine, res

153 celeration, such that patients with a larger TRA reduction entered the accelerated phase more rapidly

154 uman Merlin-deficient mesothelioma cell line TRA and in human Merlin-deficient meningiomas.

155 on of the human pluripotent stem cell marker TRA-1-60 with CD151 and CD166.

156 of cells expressing the pluripotency marker TRA-1-81.

157 effective mechanism to noninvasively monitor TRA-8 efficacy.

158 Nevertheless, TRA-F stimulation of Sxl autoregulation in the gonadal s

159 Finally, no TRA/delta excision circles (TRECs), a marker of TRA/delt

160 dullary TEC, AIRE-driven pGE upregulates non-TRA coding genes that enhance cell-cell interactions (e.

161 wdr-5.2 are redundantly required for normal TRA-1 dependent repression, and this function is indepen

162 with its role in female development: nuclear TRA-1 is higher in hermaphrodite intestines and in speci

163 , as disruption of binding increases nuclear TRA-1 and female development.

164 0.100 mg (group 3), or 0.200 mg (group 4) of TRA-8 on days 0 and 3.

165 In the absence of TRA-1, the TRE retains tra-2 mRNA in the nucleus.

166 ein TRA-2, and we find that the abundance of TRA-2 is modestly elevated in laf-1/+ females.

167 ans hermaphrodites by the combined action of TRA-1/Gli, a complex composed of TRA-4/PLZF-like, NASP,

168 gained the greatest benefit from adoption of TRA during PCI.

169 Analysis of TRA expression in individual and small pools of sorted m

170 The binding of TRA-1 to the 3'UTR overcomes this retention resulting in

171 Cleavage of TRA-2A by TRA-3 generates a peptide predicted to have fe

172 d action of TRA-1/Gli, a complex composed of TRA-4/PLZF-like, NASP, and HDA-1/HDAC, and synMuv B prot

173 of NOS-3, FEM-CUL-2-mediated degradation of TRA-1 and the promotion of membrane organization during

174 duce the proteasome-dependent degradation of TRA-1.

175 ed sequences for the FEM-3-binding domain of TRA-2 for 9 of the same strains.

176 enorhabditis and the FEM-3 binding domain of TRA-2 is itself hypervariable, a key protein-protein int

177 The FEM-3-binding domain of TRA-2 is less polymorphic than FEM-3.

178 ymorphism allowed in FEM-3 and the domain of TRA-2 that binds it, we have examined intraspecific vari

179 egression was used to quantify the effect of TRA on 30-day mortality and quantify lives saved and los

180 However, there are few data on the effect of TRA on mortality, specifically, in patients with non-ST-

181 Proviral silencing and expression of TRA-1-60, DNMT3B and REX1 can be used to distinguish the

182 on, suggesting the safety and feasibility of TRA across the whole spectrum of AT results.

183 ment exists on the safety and feasibility of TRA across the whole spectrum of AT results.

184 The frequency of TRA compared with transfemoral access for patients under

185 HER-1 inhibits the function of TRA-2A, a multipass integral membrane protein thought to

186 ependent pGE is not limited to generation of TRA.

187 base, we investigated outcomes for growth of TRA in different regions in England and Wales in 448 853

188 This complex controls the level of TRA-1A, a Ci/Gli homolog and master regulator of sex det

189 /delta excision circles (TRECs), a marker of TRA/delta locus rearrangements, were detected in SCID an

190 e speciation of the tertiary amine moiety of TRA, with apparent second-order rate constants of 7.4 (+

191 In total, six OPs of TRA were identified for both oxidants using Qq-LIT-MS, L

192 One, the MX region of TRA-2, is as well conserved in C. remanei as it is in C.

193 ching was used to assess the relationship of TRA with in-hospital clinical end points of major bleedi

194 ent may be an evolutionarily ancient role of TRA-1/GLI in nematode development.

195 valuate the thymic expression of a subset of TRA, parathyroid hormone, calcitonin, and thyroglobulin,

196 opic expression of fog-3, a direct target of TRA-1 repression.

197 me sperm rather than oocytes, is a target of TRA-1A.

198 Other direct targets of TRA-1 are similarly derepressed in the double mutant.

199 d C. elegans large C-terminal truncations of TRA-1 that retain the DNA-binding domain affect sex dete

200 he predicted risk of bleeding and the use of TRA (P<0.001).

201 The use of TRA for PCI in STEMI was associated with a lower rate of

202 The use of TRA has been associated with less bleeding and improved

203 predicted risk of bleeding and actual use of TRA in STEMI.

204 The use of TRA increased over the study period although the growth

205 an effective strategy for identification of TRAs for in animal-glioma models of cytokine gene therap

206 ividual mTEC expresses a limited spectrum of TRAs, and the frequency of mTECs that express any indivi

207 The ADC increase at day 3 was dependent on TRA-8 dose level, averaging 6% +/- 3 (standard error of

208 gemcitabine (120 mg/kg), TRA-8 (200 mug), or TRA-8 combined with gemcitabine, respectively, on day 0.

209 nstrate that DR5 ligation by either TRAIL or TRA-8 induces two functional outcomes, apoptosis and exp

210 t humoral immune response against 9L TAAs or TRAs in rats immunized s.c. with 9L-IL4 could be demonst

211 revails for O(3) attack resulting in N-oxide-TRA as the main OP (ca. 90%).

212 chanism can explain the formation of N-oxide-TRA, while a one-electron transfer may result in the for

213 bsets of human mTECs expressing a particular TRA coexpress distinct sets of genes.

214 ion of the global sex-determination pathway: TRA-1 binds its own locus and those of multiple upstream

215 Pluripotency (TRA-1-81, SSEA3, OCT4, NANOG, SOX2) remained unaffected,

216 since Sxl harbors highly conserved predicted TRA-F binding sites.

217 in 71,771 (43.2%) of 166,083 PCI procedures; TRA was used in 8,655 (40.1%) of 21,559 PCI procedures i

218 former (tra) to make its feminizing product, TRA-F.

219 d that GLD-1 activity is required for proper TRA-1 protein expression in hermaphrodites.

220 ity of the Ca(2+)-regulated calpain protease TRA-3, and the aspartyl protease ASP-4.

221 expression of the sex determination protein TRA-2, and we find that the abundance of TRA-2 is modest

222 In C. elegans, the zinc-finger protein TRA-1A is thought to be the final arbiter of somatic sex

223 We show that the membrane protein TRA-2A, which promotes XX female development by repressi

224 in complexes with the transmembrane receptor TRA-2 and the phosphatase FEM-2 in these species.

225 sing an in vitro system in which recombinant TRA/TRA2 could activate the female-specific 5'-splice si

226 and obtained evidence of numerous recurring TRA-co-expression patterns, each present in only a subse

227 xport of a TRA-1/tra-2 mRNA complex reducing TRA-1 nuclear activity, and identify an interesting RNA-

228 L-2 and the FEM proteins negatively regulate TRA-1 protein levels in C. elegans.

229 cell patterns add up to faithfully represent TRAs, is poorly understood.

230 TRA-1 export requires TRA-1 binding to the tra-2 3' untranslated region (3' UT

231 relationship between baseline bleeding risk, TRA utilization, and procedure-related outcomes in patie

232 rug-resistance (MDR) reversal agents (C-seco-TRAs) are noncytotoxic at the upper limit of solubility

233 t tissue-restricted peripheral selfantigens (TRAs) required for effective negative thymic selection.

234 that integrates the sex determination signal TRA-1 and the cell fate determination and survival signa

235 Single TRA-1-60(-)/SSEA4(-)/SOX1(+) cells grown in serum-free m

236 Six TRAs exhibit ability to modulate a wide range of ATP-bin

237 thelial lineages and that expression of some TRAs by mTECs may reflect this activity.

238 Thus, expression of some TRAs by mTECs may represent coordinated gene expression

239 ative feedback mechanism in which a specific TRA-2 isoform represses splicing of the M1 intron in the

240 , many with temporal- and/or tissue-specific TRA-1 association.

241 m using ovalbumin (OVA) as a model surrogate TRA that the de novo production of OVA-specific CD4(+) T

242 ty of recipient Aire(+)mTEC(high) to sustain TRA diversity.

243 ke in Patients With Acute Coronary Syndrome [TRA.CER] [Study P04736AM3]; NCT00527943).

244 , such as Oct-4, Nanog, Sox-2, SSEA-4, TERT, TRA-1-60 and TRA-1-81 up to 65h after exposure to ionizi

245 Here, we present data that TRA-1 is regulated by degradation mediated by a CUL-2-ba

246 rumental variable analysis demonstrated that TRA conferred mortality benefit at 1-year with an absolu

247 ctivity and TUNEL staining demonstrated that TRA-8 rapidly induced apoptosis of macrophages in inflam

248 Our data provide preclinical evidence that TRA-8 is a potential novel biologic agent for rheumatoid

249 We find that TRA-1 has a sex-specific distribution consistent with it

250 tients with an MMRS >/=20, illustrating that TRA was used less in those at highest risk from bleeding

251 Genetic studies have indicated that TRA-1 is negatively regulated by the fem-1, fem-2, and f

252 We propose that TRA-1/GLI and EHN-3 have overlapping roles in regulation

253 In this paper, we show that TRA-1/GLI controls development of the two somatic gonada

254 Our results show that TRA-2-dependent repression of M1 splicing depends on the

255 Studies suggest that TRA may reduce mortality in patients with ST-segment-ele

256 These results suggest that TRA-1 controls sexual dimorphism through a small number

257 ve male-specific expression, suggesting that TRA-1 imposes sex specificity on developmental timing.

258 A new study suggests that TRA expression is a specialized property of terminally d

259 The TRA cohort of patients was stratified into deciles based

260 The TRA subsets aligned along progressive differentiation st

261 ceh-30 is transcriptionally repressed by the TRA-1 transcription factor, the terminal regulator of se

262 rmination in C. elegans is controlled by the TRA-1 zinc finger protein, a Ci/GLI homolog that promote

263 In this context, the TRA-4 protein functions with NASP-1, a C. elegans homolo

264 olled by a 28-nucleotide repeat element, the TRA-2/GLI element (TGE), located in its 3' untranslated

265 n of the conventional TCR loci, encoding the TRA, TRB, TRG and TRD chains, in the opossum Monodelphis

266 m represses splicing of the M1 intron in the TRA-2 pre-mRNA.

267 between narcolepsy and polymorphisms in the TRA@ (T-cell receptor alpha) locus, with highest signifi

268 The conservation of the TRA-1- TRA-2 interaction underscores its importance in s

269 The fate of the TRA-1-60(-)/SSEA4(-)/SOX1(+) neural precursor becomes sp

270 The functional importance of the TRA-1-TRA-2 physical interaction is supported by genetic

271 on the MX regulatory domain, a region of the TRA-2 intracellular domain shown previously to be critic

272 factor binds the intracellular domain of the TRA-2 membrane protein.

273 show that SUP-26 regulates the level of the TRA-2 protein through TGE in vivo and binds directly to

274 first documented genetic involvement of the TRA@ locus, encoding the major receptor for HLA-peptide

275 NOT1 represses the TRA genes necessary for the development of female traits

276 ere we report the surprising result that the TRA-1 transcription factor binds the intracellular domai

277 stained brightly for L-selectin and with the TRA-1-81 antibody, which recognizes carbohydrate epitope

278 loping transgenic cells are exposed to their TRA in the thymus, only a fraction of them are eliminate

279 ullary thymic epithelial cells express these TRAs, as do extrathymic epithelial tissues that are not

280 etermination pathway, perhaps acting through TRA-1A, allow spermatogenesis in C. elegans and C. brigg

281 Thus, TRA-1 coordinates sexual development by reinforcing the

282 and RNAi depletion of some genes adjacent to TRA-1-binding sites results in defects in male sexual de

283 We found that clonal deletion to TRA was completely abrogated in the absence of Bim and l

284 study the role of Bim in clonal deletion to TRA, we constructed bone marrow (BM) chimeras using OT-I

285 e existence of a level of self-reactivity to TRA to which the thymus confers no protection and illust

286 easurement of early breast tumor response to TRA-8 treatment, prior to detectable tumor shrinkage, pr

287 cs and oxidation products (OPs) of tramadol (TRA), an opioid, were investigated for its oxidation wit

288 Transfectol (TRA) -SPIO incubation resulted in the highest frequency

289 une 2009, a total of 942 patients undergoing TRA were screened, and 203 were recruited, of whom 83, 6

290 rotein pool and also a larger pool of unique TRAs compared with control exosomes.

291 ptor (TCR) for clonal deletion to UbA versus TRA and highlight the profound ability of other toleranc

292 es, 8.3% of the PCI cases were performed via TRA.

293 ,728 PCI procedures, 17,912 (14.6%) were via TRA.

294 discussed here, an alternative model-whereby TRA expression is regulated by conserved developmental p

295 wing reductions in mortality associated with TRA use.

296 The mortality benefit with TRA at 1 year was not seen at the low-volume centers (HR

297 Treatment of MTB cells with TRA 3aa and 10a at the MIC caused filamentation and prol

298 ing to the prognostic benefit conferred with TRA.

299 with this, the FEM-3 protein interacts with TRA-2 in each species, but in a strictly species-specifi

300 After encounter with TRAs in the absence of inflammation, RTEs exhibited defe