ライフサイエンスコーパス: TRAF1

1 TRAF1 (TNFR-associated factor 1), TRAF2, and the inhibit

2 TRAF1 and TRAF2 form an oligomeric complex that associat

3 TRAF1 and TRAF2 preferentially form the TRAF1: (TRAF2)(2

4 TRAF1 cleavage was markedly reduced in cells that contai

5 TRAF1 expression negatively correlates with programmed d

6 TRAF1 is a member of the TRAF family, which plays import

7 TRAF1 is a member of the TRAF protein family, which regu

8 TRAF1 protein levels were also elevated in circulating B

9 TRAF1 was also highly inducible by CD40 ligand in cultur

10 TRAF1(-/-) dendritic cells show attenuated responses to

11 TRAF1(-/-) mice are viable and have normal lymphocyte de

12 TRAF1(-/-) T cells exhibit stronger than wild-type (WT)

13 TRAF1, a prosurvival signaling adaptor required for 4-1B

14 TRAF1, TRAF2, and TRAF3 appear to associate independentl

15 TRAF1, TRAF2, and TRAF3 bind to a single site in the LMP

16 TRAF1, TRAF2, and TRAF3 interacted with the same region.

17 TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5,

18 TRAF1/2 and cIAP1/2 are members of the TNF receptor-asso

19 TRAF1/C5 rs3761847 GG homozygote status was associated w

20 TRAF1/C5 rs3761847 was identified using real-time polyme

21 ecrosis factor receptor associated factor 1 (TRAF1) and defender-against cell death (DAD-1) is regula

22 factor receptor (TNFR) associated factor 1 (TRAF1) and TRAF3.

23 ecrosis factor receptor-associated factor 1 (TRAF1) has been implicated in the regulation of antiapop

24 s factor (TNF) receptor-associated factor 1 (TRAF1) is a member of the recently defined TRAF family.

25 TNF receptor-associated factor 1 (TRAF1) is a unique TRAF protein because it lacks a RING

26 signaling adaptor TNFR-associated factor 1 (TRAF1) is specifically lost from virus-specific CD8 T ce

27 TNFR-associated factor 1 (TRAF1) is unique among the TRAF family, lacking most zin

28 proteins, TNF receptor-associated factor 1 (TRAF1), is highly regulated in pulmonary cells.

29 Bfl-1/A1, TNF receptor-associated factor-1 (TRAF1), and Fas-associated death domain protein-like int

30 mbers, and TNF receptor-associated factor-1 (TRAF1).

31 crosis factor receptor-associated protein 1 (TRAF1), interleukin-1alpha (IL-1alpha), MCP-2, N-cadheri

32 factor receptor-associated factors 1 and 2 (TRAF1 and TRAF2).

33 r interacts with FADD, caspase-8, caspase-3, TRAF1, and TRAF2 through distinct domains.

34 genes such as those encoding interleukin-8, TRAF1, and c-IAP2.

35 expands T cells and reduces viral load in a TRAF1-dependent manner.

36 iapoptosis (IAP1, Bcl-2, Bcl-X(L), Bfl-1/A1, TRAF1 and cFLIP), and invasion (MMP-9) were also downreg

37 , IAP1, IAP2, XIAP, Bcl-2, Bcl-xL, Bfl-1/A1, TRAF1 and FLIP, were all downregulated by zerumbone.

38 survivin, IAP 1, IAP 2, Bcl-x(L), Bfl-1/A1, TRAF1, and FLIP in wild-type mouse embryonic fibroblasts

39 survivin, IAP1, IAP2, XIAP, Bcl-2, Bfl-1/A1, TRAF1, and FLIP were all down-regulated by SCH 66336, wh

40 IAP2, Bcl-xL, Bcl-2, cFLIP, XIAP, Bfl-1/A1, TRAF1, and Survivin), proliferation (cyclin D1, COX2, an

41 Although aberrant TRAF1 expression in tumors has been reported, the role o

42 Activated TRAF1(-/-) T cells, but not TRAF1(+/+) T cells, responde

43 nds the TRAF1 promoter in vivo and activates TRAF1 transcription.

44 rmal tissues and provide evidence of altered TRAF1 expression in lymphoid malignancies.

45 Although TRAF1 can displace TRAF2 and CD40 from raft fractions, i

46 n blot analysis confirmed that IL-1alpha and TRAF1 mRNA levels resulted in increased protein expressi

47 apoptosis (IAP1, Bfl-1/A1, Bcl-2, cFLIP, and TRAF1), proliferation (cyclin D1 and c-Myc), and angioge

48 ic upregulation of IL-1alpha (21.5-fold) and TRAF1 (27.5-fold) gene expression in tissues of Johne's

49 n of the antiapoptotic genes A1, c-IAP2, and TRAF1; inhibition of caspase 3; and protection from apop

50 optosis (IAP1 and IAP2, Bcl-2, Bcl-x(L), and TRAF1), proliferation (cyclin D1 and c-Myc), invasion (C

51 ates the antiapoptotic activity of p80HT and TRAF1 deficiency reestablishes B cell homeostasis in p80

52 was to delineate the signaling pathways and TRAF1 promoter elements responsible for phorbol ester-me

53 Increased expression of STAT1 and TRAF1 in MLBCL was confirmed by immunohistochemistry.

54 he evidence for association of the STAT4 and TRAF1/C5 loci with RA using imputed data from the Wellco

55 Bcl-2, Bcl-xL, IAP1,(2) MCl-1, survivin, and TRAF1), apoptosis (Bax, Bid), inflammation (COX-2), prol

56 cIAP-1/2, Bcl-2, Bcl-xL, XIAP, Survivin, and TRAF1), proliferation (cyclin D1, c-Myc, COX-2), invasio

57 TNFR1 and TRAF1 were polyubiquitinated in lipid rafts after TBI.

58 Although c-IAP1 bound TRAF2 and TRAF1 in vitro, it ubiquitinated only TRAF2.

59 While 4-1BB bound TRAF2 and TRAF1, Ox40 interacted with TRAF3 and TRAF2.

60 ntiapoptosis (IAP1, IAP2, Bcl-2, Bcl-xL, and TRAF1), proliferation (cyclin D1 and c-Myc), and invasio

61 31)-mediated NF-kappaB activation as well as TRAF1 coactivation, and 30% of TRAF2 is associated with

62 Because TRAF1 is a transcriptional target gene of NF-kappaB, I3C

63 Because TRAF1 is upregulated by many stimuli, it may modulate th

64 We also show that while both TRAF1 and cIAP1 have non-redundant roles in suppressing

65 n by LMP1(1-231) is likely to be mediated by TRAF1/TRAF2 heteroaggregates since TRAF1 is unique among

66 o to the upregulation of genes such as CD40, TRAF1, and IRF5, which encode proteins that promote B ce

67 thritis susceptibility genes including CD40, TRAF1, TNFAIP3 and PRKCQ.

68 siRNA we show that in activated CD8 T cells TRAF1 is also involved in this process and that constitu

69 hway downstream of 4-1BB in primary T cells, TRAF1 also restricts the constitutive activation of NIK

70 c-Myc), cell survival (Bcl-2, Bcl-xL, cFLIP, TRAF1, IAP1, IAP2, and survivin), invasion (matrix metal

71 r newly defined CD40-responsive genes cIAP2, TRAF1, TRAF4/CART and DR3 were unaffected.

72 In contrast, there was a high and consistent TRAF1 overexpression in EBV-induced lymphoproliferations

73 In contrast, TRAF1 alone interacts very weakly with cIAP2.

74 In contrast, TRAF1 is maintained at higher levels in virus-specific T

75 tified proapoptotic fragments Cys-RIPK1, Cys-TRAF1, Asp-BRCA1, Leu-LIMK1, Tyr-NEDD9, Arg-BID, Asp-BCL

76 ffect of reduced pulmonary TRAF1 expression, TRAF1-null (-/-) and control, BALB/c (wild-type), mice w

77 in associating with TNFR-associated factors TRAF1 and TRAF2, and the second site is similar to TNFRI

78 is factor receptor (TNFR)-associated factors TRAF1, TRAF2, TRAF3, and TRAF5 and the TNFR-associated d

79 n NF-kappaB-regulated antiapoptotic factors, TRAF1, TRAF2, c-IAP1, and c-IAP2, is most pronounced in

80 f endogenous NF-kappaB target genes (c-FLIP, TRAF1), and resistance to apoptosis.

81 TRAF proteins (except for TRAF1) contain an N-terminal RING finger domain that is

82 in vivo and suggest a molecular pathway for TRAF1 activation in the pathogenesis of lymphomas.

83 the strongest predictors of death in RA (for TRAF1/C5 GG versus AA, hazard ratio 3.85 [95% confidence

84 s used by LMP1 and identify a novel role for TRAF1 as a modulator of oncogenic signals.

85 naling and identify a physiological role for TRAF1 as a regulator of the subcellular localization of

86 The core binding site for TRAF1, TRAF2, and TRAF3 in CD40 could be minimally subst

87 TRADD is specific for TRAF1 and TRAF2, which ensures the recruitment of clAPs

88 uction but also NIK stabilization by forming TRAF1.NIK complex.

89 Furthermore, skin from TRAF1(-/-) mice was hypersensitive to TNF-induced necros

90 lucidate the function of TRAF1, we generated TRAF1-deficient mice.

91 imeric CD40 was found to be TRAF2 > TRAF3 >> TRAF1 and TRAF6.

92 ge B-cell lymphoma showed a moderate to high TRAF1 signal.

93 However, TRAF1 is absent in many established epithelial cell line

94 However, TRAF1/2-binding mutants of c-IAP2.MALT1 still oligomeriz

95 resent study, we demonstrated that the human TRAF1 mRNA has an unusually long 5'-UTR that contains in

96 1 can also self-associate and binds to human TRAF1, TRAF2, and TRAF4.

97 s of TNF-induced TRAF1 expression identified TRAF1.NIK as a central complex linking canonical and non

98 ome-wide association studies have identified TRAF1/C5 as a rheumatoid arthritis (RA) susceptibility l

99 These data identify TRAF1 as a specific target of caspases activated during

100 These findings identify TRAF1 as a potential biomarker of HIV-specific CD8 T cel

101 Variants in IL2RA, TRAF1/C5, and RSBN1 were not associated with JIA.

102 Mice deficient in TRAF1 (TRAF1(-/-)) and wild-type (WT) control animals we

103 Thus, expression of this LMP1 domain in TRAF1-positive lymphoma cells promotes significant JNK a

104 TNF-alpha levels were strikingly elevated in TRAF1-/- mice.

105 omoter activity indicating a role for ERK in TRAF1 induction.

106 The risk of death in RA is increased in TRAF1/C5 rs3761847 GG homozygotes and appears to be inde

107 liferation and excess cytokine production in TRAF1-deficient CD8 T cells compared with WT CD8 T cells

108 ms (e.g., PKCalpha and betaI) play a role in TRAF1 regulation.

109 e 13-acetate (PMA) and bryostatin I, induced TRAF1 mRNA expression; pretreatment with actinomycin D b

110 tational-experimental studies of TNF-induced TRAF1 expression identified TRAF1.NIK as a central compl

111 two genes relevant to chronic inflammation: TRAF1 (encoding tumor necrosis factor receptor-associate

112 t and dependent on the presence of an intact TRAF1/2/3 binding site.

113 e- dependent manner that critically involves TRAF1 and TRAF2.

114 re Toll-like receptor 1 (TLR1), TLR2, IRAK3, TRAF1, IRG1, PTGS2, MMP9, IFI44, IFIT1, and CD40.

115 the endoplasmic reticulum stress-induced JNK/TRAF1 axis as well as the APAF-1/caspase-9 axis, activat

116 2, X chromosome-linked IAP, Bcl-2, Bcl-x(L), TRAF1, FLIP, and survivin), proliferative (cyclin D1, cy

117 T cells lacking TRAF1 hyperproliferate in response to T cell receptor si

118 otein 1 (LMP1) in mouse B cell lines lacking TRAF1, TRAF2, or both TRAFs.

119 1) were for CREB1, FGG, MAP3K5, RIPK3, LSP1, TRAF1, DUSP2, and ITGB3.

120 ments responsible for phorbol ester-mediated TRAF1 induction in human colon cancers.

121 ment with actinomycin D blocked PMA-mediated TRAF1 expression suggesting induction at the transcripti

122 rm-selective inhibitors blocked PMA-mediated TRAF1 mRNA and promoter stimulation; rottlerin, a select

123 In contrast to WT mice, TRAF1(-/-) recipients failed to display goblet cell hype

124 inus of the molecule (TRAF2DN), which mimics TRAF1, developed lymphadenopathy and splenomegaly due to

125 ptides with progressive deletions, a minimal TRAF1, TRAF2, and TRAF3 binding region was mapped to the

126 2/p100 processing, we mathematically modeled TRAF1.NIK as a coupling signaling complex and validated

127 Moreover, TRAF1 knockdown abrogates the antiapoptotic activity of

128 Cs, including CD71, FSCN1, IRF4, NMES1, MX1, TRAF1.

129 Although purified myeloid TRAF1(-/-) dendritic cells (DCs) exhibited normal Ag-pre

130 TNFR-associated factor (TRAF) family, namely TRAF1, TRAF2, TRAF3, and TRAF5, but not to TRAF6.

131 Along with other associations near TRAF1 and TNFAIP3, this implies a central role for the C

132 ly all non-Hodgkin's lymphoma show low or no TRAF1 expression.

133 Activated TRAF1(-/-) T cells, but not TRAF1(+/+) T cells, responded to TNF by proliferation an

134 Moreover, transfer of TRAF1(+) but not TRAF1(-) memory T cells at the chronic stage of infectio

135 Transient overexpression of TRAF2, but not TRAF1, induced NF-kappaB activation and HIV-1-long termi

136 The ability of TRAF1, TRAF2, and CRAF1 to associate with CD30 was confi

137 In the absence of TRAF1, an increased amount of TRAF2 was recruited to lip

138 ruitment and DC activation in the airways of TRAF1(-/-) mice, suggesting that the expression of TRAF1

139 n vivo, CD11c(+)CD11b(+) DCs from airways of TRAF1(-/-) recipients were not activated, and purified d

140 erved, as well as heterotypic association of TRAF1-TRAF2 and TRAF3-TRAF5.

141 The association of TRAF1/C5 rs3761847 alleles with the risk of death was as

142 ntrast to TRAF2 and TRAF3, direct binding of TRAF1, TRAF4, TRAF5, or TRAF6 to CD40 was not detected.

143 UV irradiation did not result in cleavage of TRAF1, and overexpression of the C-terminal TRAF1 fragme

144 carcinogenesis study showed that deletion of TRAF1 in mice results in a significant inhibition of ski

145 ive mutants consisting of the TRAF domain of TRAF1 and TRAF2 inhibited CD30 induction of NF-kappaB ac

146 with the conserved C-terminal TRAF domain of TRAF1 and TRAF2.

147 l analyses demonstrated that TRAF domains of TRAF1, TRAF2, TRAF3, and TRAF6 formed homo-trimers in so

148 -/-) mice, suggesting that the expression of TRAF1 in resident lung cells is required for the develop

149 For example, expression of TRAF1 was highly restricted, with B cell lymphomas consi

150 l-length TRAF3 or dominant negative forms of TRAF1 or TRAF2.

151 , we also observed an increased frequency of TRAF1(+) HIV-specific CD8 T cells 10 wk after completion

152 To elucidate the function of TRAF1, we generated TRAF1-deficient mice.

153 or a clear understanding of the functions of TRAF1.

154 Here we investigated the importance of TRAF1 and TRAF2 for c-IAP2.MALT1-stimulated NF-kappaB ac

155 LMP1 signal on the JNK axis independently of TRAF1 status.

156 r results demonstrate selective induction of TRAF1 in human colon cancer cells through a Ca(2+)-depen

157 To further examine the interactions of TRAF1 and NIK with NF-kappaB2/p100 processing, we mathem

158 h 1 expression and HIV load and knockdown of TRAF1 in CD8 T cells from viral controllers results in d

159 In addition, enhanced levels of TRAF1 could result in cells within the lesions of Johne'

160 ignaling and suggest that cellular levels of TRAF1 may play an important role in modulating the degra

161 cells from p80HT mice express high levels of TRAF1, an antiapoptotic protein also implicated in lymph

162 rked increases in the steady-state levels of TRAF1, TRAF2, TRAF5, and TRAF6.

163 The in vivo locations of TRAF1, TRAF2, TRAF5, and TRAF6 were determined in human

164 GFbeta induces the posttranslational loss of TRAF1, whereas IL-7 restores TRAF1 levels.

165 IL-5, IL-13, or TNF occurred in the lungs of TRAF1(-/-) mice.

166 hat in EBV-transformed B lymphocytes most of TRAF1 or TRAF3 and 5% of TRAF2 are associated with LMP1

167 ain of LMP1 depends on the reconstitution of TRAF1 expression.

168 region appears to inhibit the recruitment of TRAF1 and TRAF2 to membrane rafts by the CTAR1 region.

169 ing to OX40 likely results in recruitment of TRAF1 for downstream signalling.

170 tion of TRAF2 or combined down-regulation of TRAF1 and TRAF2 did not affect c-IAP2.MALT1-stimulated s

171 In this study, we investigated the role of TRAF1 in an adoptive transfer model of allergic lung inf

172 The critical role of TRAF1 in the regulation of TRAF2-dependent JNK signaling

173 ion in tumors has been reported, the role of TRAF1 remains elusive.

174 cIAP1/2, which explains regulatory roles of TRAF1 in TNF signaling.

175 Moreover, transfer of TRAF1(+) but not TRAF1(-) memory T cells at the chronic

176 tribute to the IRES-dependent translation of TRAF1 during vincristine treatment.

177 ulation of the IRES-dependent translation of TRAF1 may be involved in effecting the cancer cell respo

178 h Ras inhibitors had minimal to no effect on TRAF1 induction suggesting dependence on Raf, but not Ra

179 pathway activation is dependent not only on TRAF1 induction but also NIK stabilization by forming TR

180 Moreover, transfer of WT or TRAF1(-/-) DCs failed to restore T cell recruitment and

181 an chronic lymphocytic leukemias overexpress TRAF1 and Bcl-2, our findings suggest that cooperation b

182 epletion of TRAF2 and the associated protein TRAF1 by proteolysis.

183 r kinase RIP (receptor-interacting protein), TRAF1, and cIAP-1 (cellular inhibitor of apoptosis prote

184 actor (TRAF) family of six adaptor proteins (TRAF1-6) links the TNFR superfamily to the nuclear facto

185 RT-1, RIP), TRAF domain containing proteins (TRAF1-6) as well as new members and adaptor proteins suc

186 previously identified TRAF family proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, and TRAF6), whereas t

187 associated factor (TRAF) family of proteins, TRAF1 and TRAF2, independently bind to the intracellular

188 were genotyped for 5 variants in the PTPN22, TRAF1/C5, STAT4, and TNFAIP3 loci.

189 To determine the effect of reduced pulmonary TRAF1 expression, TRAF1-null (-/-) and control, BALB/c (

190 -kappaB pathway downstream of 4-1BB requires TRAF1, whereas cIAP1 plays a redundant role with cIAP2.

191 on in genes associated with immune response (TRAF1, RIPK3, BAT2, and TLR6), mitogen-activated protein

192 revious results showed that IL-7 can restore TRAF1 expression in virus-specific CD8 T cells in mice,

193 ational loss of TRAF1, whereas IL-7 restores TRAF1 levels.

194 alysis of 232 non-Hodgkin lymphomas revealed TRAF1 overexpression in 112 (48%) cases.

195 diated by TRAF1/TRAF2 heteroaggregates since TRAF1 is unique among the TRAFs in coactivating NF-kappa

196 ssociated factor (TRAF) family, specifically TRAF1, TRAF5, and TRAF6, but not with TRAF2, TRAF3, or T

197 PD98059 and UO126, suppressed PMA-stimulated TRAF1 promoter activity indicating a role for ERK in TRA

198 Raf-C4) significantly reduced PMA-stimulated TRAF1 promoter activity whereas transfection of dominant

199 in which TRAF1 is active in vivo, we studied TRAF1 transcripts in normal lymphoid tissue, in Epstein-

200 his finding is replicated in future studies, TRAF1/C5 genotyping could identify patients at increased

201 Surprisingly, TRAF1 and one chain of TRAF2 in the TRAF1: (TRAF2)(2): c

202 Surprisingly, TRAF1, -2, or -3 does not interact with the terminal LMP

203 Targeting TRAF1 function might lead to strategies for preventing a

204 TRAF1, and overexpression of the C-terminal TRAF1 fragment did not enhance cell death in these cases

205 observed when overexpressing the C-terminal TRAF1 fragment in HEK293T and HT1080 cells.

206 These data confirm that TRAF1 is an inducible molecule and indicates its deregul

207 Collectively these results demonstrate that TRAF1 plays a critical role in regulating T cell activat

208 Taken together, our findings indicate that TRAF1 and TRAF2 cooperate in CD40 but not LMP1 signaling

209 These results indicate that TRAF1 and/or TRAF2 play an important role in cell death

210 These results indicate that TRAF1 translation is initiated via the IRES and regulate

211 In vivo studies indicated that TRAF1 expression levels in mouse skin are induced by sho

212 It is known that TRAF1 transcription is inducible by various cytokines, b

213 Here, we report that TRAF1 is required for solar UV-induced skin carcinogenes

214 However, the biological roles that TRAF1 plays in immune cell signaling have been elusive,

215 Here we show that TRAF1 (but not TRAF2-6) is cleaved by certain caspases i

216 Here we show that TRAF1 and TRAF2 interact with A20, a zinc finger protein

217 We show that TRAF1 depletion prevents TNF-induced NIK stabilization a

218 Moreover, we show that TRAF1 is required for solar UV-induced extracellular sig

219 Mechanistic studies showed that TRAF1 expression enhances the ubiquitination of ERK5 on

220 Immunohistochemical analysis showed that TRAF1 expression is up-regulated in human actinic kerato

221 These findings suggest that TRAF1 is a negative regulator of TNF signaling.

222 Overall, our results suggest that TRAF1 mediates ERK5 activity by regulating the upstream

223 These studies suggest that TRAF1 provides negative feedback for TNF-alpha synthesis

224 apping TRAF binding regions and suggest that TRAF1, TRAF2, and TRAF3 could bind competitively to one

225 We confirm association of the STAT4 and the TRAF1/C5 loci with RA bringing to 5 the number of confir

226 B1, PTPN22, STAT4, a region in 6q23, and the TRAF1/C5 locus.

227 ystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes.

228 A common genetic variant at the TRAF1-C5 locus on chromosome 9 is associated with an inc

229 p80HT binds the TRAF1 promoter in vivo and activates TRAF1 transcription

230 TRAF1 and TRAF2 preferentially form the TRAF1: (TRAF2)(2) heterotrimer, which interacts with cIA

231 Given the TRAF1 expression and known link to nuclear factor-kappa

232 (particularly the most proximal site) in the TRAF1 promoter significantly decreased PMA-mediated prom

233 6736 in the C12orf30 locus, rs3761847 in the TRAF1/C5 locus, rs2104286 in the IL2RA locus, rs7574865

234 isingly, TRAF1 and one chain of TRAF2 in the TRAF1: (TRAF2)(2): cIAP2 ternary complex mediate interac

235 tor-associated factors (TRAF), including the TRAF1/TRAF2 positive regulators and TRAF3 negative regul

236 Consistent with the desensitization of the TRAF1-binding co-stimulatory receptor 4-1BB, 4-1BBL-defi

237 Given the association of the TRAF1/C5 locus in two previous large case-control series

238 study was to examine the association of the TRAF1/C5 locus with death in patients with RA.

239 ing peptide-based mutational analyses of the TRAF1/TRAF2/TRAF3 and TRAF6 binding sequences in CD40 to

240 Interestingly, we found that the TRAF1 expression is induced in cancer cells by chemother

241 e for association of variants mapping to the TRAF1/C5 gene was detected in the 1860 RA cases and 2930

242 ruited to the LMP1 signaling complex via the TRAF1/2/3/5 binding site within the cytoplasmic domain o

243 In normal lymphoid tissue, TRAF1 message proved to be absent from all resting B and

244 L), ice, TNF-alpha, TNF-beta, TNFR1, TNFR2, TRAF1, TRAF2, TRAF3, cIAP2, and tradd at the level of mR

245 of TNF depends on the activity of the TNFR2/TRAF1 pathway that is regulated by MAVS signaling.

246 interaction and established that binding to TRAF1 and TRAF2 is not required for c-IAP2.MALT1-stimula

247 any reports assigning contradictory roles to TRAF1.

248 Mice deficient in TRAF1 (TRAF1(-/-)) and wild-type (WT) control animals were adop

249 inding domain that recruits A20 to the TRAF2-TRAF1 complex and a C-terminal domain that mediates inhi

250 e TNF receptor associated factors 2/1 (TRAF2/TRAF1) heterocomplex, which mediates the recruitment of

251 nally, we demonstrate that T cell-transfused TRAF1(-/-) recipient mice demonstrated impaired up-regul

252 lung injury, intratracheal TNF-alpha-treated TRAF1-/- mice exhibited marked liver injury with an appr

253 alveolar lavage from intratracheally treated TRAF1-/- mice produced more TNF-alpha than cells from tr

254 cell line transduces signals that upregulate TRAF1 levels but does not alter JAK3 levels or activatio

255 which contained the sequence PEQET, whereas TRAF1 and TRAF2 were capable of binding to either the PE

256 To identify the cells in which TRAF1 is active in vivo, we studied TRAF1 transcripts in

257 e resolve this paradox by showing that while TRAF1 is required for maximal activation of the classica

258 ivation, and 30% of TRAF2 is associated with TRAF1 in EBV-transformed B cells.

259 MP1 and that most of LMP1 is associated with TRAF1 or TRAF3.

260 AITR associates with TRAF1 (TNF receptor-associated factor 1), TRAF2, and TRA

261 c-IAP2.MALT1 fusion protein associates with TRAF1 and TRAF2 using the same binding site.

262 etail a region of LMP-1 that associates with TRAF1, TRAF2, and TRAF3.

263 milar in their constitutive association with TRAF1, TRAF2, TRAF3, TRADD, and RIP.

264 Coexpression of CD30 with TRAF1 or TRAF2 but not TRAF3 augmented NF-kappaB activat

265 proach those of TRAF2 upon coexpression with TRAF1 and/or TRAF2, indicating that TRAF2A stability is

266 the EGFR either alone or in combination with TRAF1 and TRAF3.

267 with LMP-1 most avidly and can compete with TRAF1 and TRAF2 for binding to LMP-1.

268 crucial for their physical interaction with TRAF1 and TRAF2.

269 of EGFR expression requires interaction with TRAF1, -2, and -3.

270 AF3 were stronger than the interactions with TRAF1 and TRAF6.

271 etween the cytoplasmic tail of TRANCE-R with TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6.

272 whereas the TD of SPOP interacts weakly with TRAF1 and TRAF6 only.

273 entified as the caspase cleavage site within TRAF1, generating two distinct fragments.