ライフサイエンスコーパス: TRAP

1 TRAP can be used to study the cell type-specific mRNA pr

2 TRAP forms undecameric rings, and AT assembles into tris

3 TRAP is delivered using adenovirus- and vaccinia virus-b

4 TRAP proteins are thought to play an integral role in pa

5 TRAP staining showed that osteoclast numbers were reduce

6 TRAP VWA domains adopt closed and open conformations, an

7 TRAP+ osteoclast numbers were the highest in the STZ+L g

8 TRAP-positive osteoclast-covered trabecular bone surface

9 TRAP-staining revealed no osteoclast differentiation in

10 TRAP-Ts typically employ a periplasmic substrate-binding

11 crosis factor receptor-associated protein-1 (TRAP-1), dampen the activation of the nutrient-sensing A

12 , and tartrate-resistant acid phosphatase 5 (TRAP) with receptor activator of NF-kappaB ligand-evoked

13 and tartrate-resistant acid phosphatase 5b (TRAP-5b), and calcium and alveolar bone levels in rats w

14 Here we characterize a TRAP allele (Rosa26(fsTRAP)) that makes this approach mo

15 of the malaria parasite Plasmodium express a TRAP family protein called merozoite-TRAP (MTRAP) that h

16 orms trimers, and multiple trimers bind to a TRAP 11mer.

17 rotein is the SBP of VcSiaPQM, a sialic acid TRAP transporter from Vibrio cholerae.

18 s tryptophan production by binding activated TRAP and preventing RNA binding.

19 ntagonist that binds to tryptophan-activated TRAP and prevents TRAP from binding to RNA, thereby upre

20 Tryptophan-activated TRAP binds to 11 (G/U)AG repeats in the 5' leader region

21 -binding surface on the tryptophan-activated TRAP ring and its high affinity for RNA.

22 the chemokine ligand 5 (CCL5, RANTES); after TRAP activation, platelets release over 25 ng/mL CCL5.

23 The protective effects of ANP against TRAP/HTV-induced lung injury were linked to the increase

24 All TRAP recipients who previously tested LCA(+) were HLA an

25 8, the animals were sacrificed, serum B-ALP, TRAP-5b, and calcium levels were measured, gingiva speci

26 1321N1 and C6 glioma cells without altering TRAP-6 and carbachol Ca(2+) responses.

27 l traversal and hepatocyte invasion [3]; and TRAP, which is necessary for gliding motility and invasi

28 gingival IL-1beta and IL-10, serum B-ALP and TRAP-5b levels, or alveolar bone compared with conventio

29 gingival IL-1beta and IL-10, serum B-ALP and TRAP-5b, and calcium and alveolar bone levels between th

30 vity are associated with COPD and asthma and TRAP is involved in regulating macrophage migration.

31 odium berghei homologues of antigens CSP and TRAP are combined.

32 ific to sporozoite surface-expressed CSP and TRAP proteins, but not intracellular glideosome-associat

33 This suggests that a combination of CSP and TRAP subunit vaccines could enhance protection against m

34 ell-known pre-erythrocytic antigens, CSP and TRAP, yet thousands of genes are expressed in the liver-

35 brogates the expression of NFATc1, Cstk, and TRAP during OC differentiation.

36 essed RANKL-induced osteoclast formation and TRAP activity dose-dependently.

37 acterial RNAs, activate PKR in TRAP-free and TRAP/l-Trp-bound forms.

38 ALP activity in osteoblasts and TRAP activity in RAW264.7 cells co-cultured with MC3T3-E

39 eated wounds at day 1 (P = 0.03), and P2 and TRAP induced a similar effect at days 3 (P = 0.002 and P

40 1beta; immunostaining increase for RANKL and TRAP; reduction of OPG and leukocytosis, which were sign

41 tion of Runx2, and up-regulation of Spp1 and TRAP.

42 used by excessive mechanical ventilation and TRAP peptide (TRAP/HTV), which was further exacerbated i

43 Anti-TRAP (AT) is an antagonist that binds to tryptophan-acti

44 rp RNA-binding attenuation protein) and anti-TRAP (AT).

45 [tetratricopeptide repeat-protein associated TRAP transporters (TPATs)] has four components.

46 w subfamily of TPATs (TPR-protein-associated TRAP-Ts) that require the action of a TPR-containing acc

47 Surface-associated TRAP (thrombospondin-related anonymous protein) family p

48 is-enoxacin; V-ATPase, vacuolar H(+)-ATPase; TRAP, tartrate-resistant acid phosphatase; alphaMEM D10,

49 ing WASp function with wiskostatin augmented TRAP-induced TGF-beta1 release in human platelets.

50 nannotated junctions with publicly available TRAP-seq data.

51 Only children with high average TRAP exposure from birth through age 7 years were at sig

52 We developed an axon-TRAP-RiboTag approach in mouse that allows deep-sequenci

53 Associations between TRAP exposure and allergic sensitization, lung function,

54 We examined the relationship between TRAP exposure and longitudinal wheezing phenotypes and a

55 The relationship between TRAP exposure and wheezing phenotypes and asthma was exa

56 This indicates that motor-binding TRAP family members function not just in parasite motili

57 excessive number of osteoclasts, detected by TRAP staining and histomorphometric quantification.

58 nockout (KO)/control bones was determined by TRAP staining, micro-computed tomography, and electron m

59 enesis from RAW264.7 cells were evaluated by TRAP stain assay.

60 h MM in a dose-dependent manner, as shown by TRAP staining (IC50: 10 and approximately 10 nM, respect

61 On the basis of the (68)Ga chelators TRAP (triazacyclononane-triphosphinate) and NODAGA, we s

62 ethods: On the basis of the (68)Ga chelators TRAP (triazacyclononane-triphosphinate) and NODAGA, we s

63 tand the association between early childhood TRAP exposure, and subsequent asthma, allergies and sens

64 We refer to this new method as PRV-Circuit-TRAP (PRV circuit-directed TRAP).

65 In contrast, TRAP exposure at participants' current homes significant

66 Osteoclastogenesis was assessed by counting TRAP-positive multinucleated cells in PB CD14+ monocytes

67 During development, TRAP-positive osteoclasts are found to line the TBI as b

68 rovide several examples of a droplet digital TRAP (ddTRAP) assay for telomerase activity, including q

69 od as PRV-Circuit-TRAP (PRV circuit-directed TRAP).

70 the affinity of TRAP for RNA and eliminates TRAP-mediated transcription termination in vitro.

71 Reduced RANKL immunolabeling and fewer TRAP-positive multinucleated cells were observed in the

72 Also, EP-TIL1 showed significantly fewer TRAP-positive multinucleated osteoclasts than EP and EP-

73 There were fewer TRAP-positive cells in the SRP/SA group than in the NT g

74 traffic exposure zones (TEZs) as a proxy for TRAP.

75 f several solute binding proteins (SBPs) for TRAP (tripartite ATP-independent permease) transporters

76 Typical substrates for TRAP transporters are organic acids including the sialic

77 icantly attenuated the cells ability to form TRAP positive, multinucleated giant cells.

78 eader RNA but cannot dissociate a pre-formed TRAP-RNA complex.

79 We assign positions to the four TRAP subunits within the complex, providing insights int

80 ipt is most susceptible to dissociation from TRAP.

81 Furthermore, TRAP captured known IRI-associated markers, validating t

82 High TRAP exposure at birth was significantly associated with

83 In conclusion, higher TRAP expression/activity are associated with COPD and as

84 We found higher TRAP activity/expression in lungs of patients with chron

85 However, higher TRAP(+) MNC numbers were observed in tibiae versus MB un

86 However, TRAP assay is susceptible to PCR-derived artifacts and r

87 irmed a TP53 gene-PML NB association, immuno-TRAP allowed us to uncover novel locus-PML NB associatio

88 with microarrays or deep sequencing, immuno-TRAP provides powerful opportunities for identifying gen

89 Our new technique, immuno-TRAP, overcomes these limitations.

90 bodies (PML NBs) as a model, we used immuno-TRAP to determine if specific genes localize within mole

91 d or produced locally by leukocytes, impairs TRAP-mediated PGA formation to the same level as specifi

92 Osteoclasts were counted in TRAP-stained sections.

93 ly, expression of CathepsinK was detected in TRAP-negative cells of the inner periosteal layer also e

94 e typical of bacterial RNAs, activate PKR in TRAP-free and TRAP/l-Trp-bound forms.

95 stent with the open and closed forms seen in TRAP SBP crystal structures.

96 ter for carboxylate-containing substrates in TRAP transporters by engineering the SBP to recognize a

97 at mitochondrial HSP90 chaperones, including TRAP-1, overcome metabolic stress and promote tumor cell

98 on, increased cartilage thickness, increased TRAP activity, and mineralization.

99 identified is a tripartite ATP-independent (TRAP) transporter, not previously associated with sugar

100 OPD were tested for their capacity to induce TRAP.

101 use macrophages, but only RANKL also induced TRAP activity in mouse lung slices.

102 tor of activated T cells c1 (NFATc1)-induced TRAP gene expression.

103 RANKL) and Xanthine/Xanthine Oxidase induced TRAP mRNA expression in mouse macrophages, but only RANK

104 nds were tested for their ability to inhibit TRAP activity and [Au(4,4'-dimethoxy-2,2'-bipyridine)Cl2

105 AubipyOMe also inhibited TRAP activity in murine macrophage and human lung tissue

106 n of AT trimers can condense multiple intact TRAP rings into large heterocomplexes, effectively reduc

107 levels of immature platelet fraction (IPF), TRAP-stimulated platelet surface CD42b, unstimulated pla

108 Studies of isolated TRAP and AT showed that AT can prevent TRAP from binding

109 N-gamma exhibited low levels of Cathepsin K, TRAP, RANK, and tumor necrosis factor receptor-associate

110 phocytotoxicity assay (LCA)(-) and 20 LCA(+) TRAP participants.

111 arily divergent organisms and disease-linked TRAP mutant fibroblasts from human patients.

112 Even relatively low TRAP exposures confer an increased risk of adverse respi

113 age Plasmodium falciparum malaria antigen ME-TRAP.

114 CS and 2 of 15 (13%) receiving ChAd63-MVA ME-TRAP achieved sterile protection after CHMI.

115 CS and 5 of 15 (33%) receiving ChAd63-MVA ME-TRAP demonstrated a delay in time to treatment, compared

116 the liver parasite burden, but ChAd63-MVA ME-TRAP remains the most promising antigenic insert for a v

117 79%, compared with 79%-84% for ChAd63-MVA ME-TRAP.

118 efficacy of ChAd63-MVA CS with ChAd63-MVA ME-TRAP.

119 -thrombospondin-related adhesion protein (ME-TRAP).

120 press a TRAP family protein called merozoite-TRAP (MTRAP) that has been implicated in erythrocyte inv

121 en cells both in vitro and in vivo Using miR-TRAP affinity purification technology, we identified the

122 Interestingly, mononucleated TRAP positive cells within PDL vasculature were observed

123 le marrow was cultured with PTH+1,25D3, more TRAP(+) MNCs were seen in LB versus MB cultures.

124 PD) and asthma compared to controls and more TRAP activity in lungs of mice with experimental COPD or

125 hage colony-stimulating factor produced more TRAP(+) MNCs and greater resorptive area.

126 se in the formation of giant, multinucleated TRAP(+) cells capable of F-actin ring formation.

127 sors that differentiated into multinucleated TRAP-positive cells in the presence of EPAC-selective st

128 d reduced the total number of multinucleated TRAP+ cells in mice that received ligature attachment.

129 racing, recording, and manipulating neurons, TRAP offers a powerful approach for understanding how th

130 Numerous TRAP-positive osteoclasts were found in the PDSG and PDC

131 bound to TRAP 11mer reduces the affinity of TRAP for RNA and eliminates TRAP-mediated transcription

132 of transcription by inducing dissociation of TRAP from the nascent RNA when it has bound to fewer tha

133 The generally null effect of TRAP on allergic rhinitis and aeroallergen sensitization

134 Different members of the DctP family of TRAP SBPs have binding sites that recognize a diverse ra

135 R-29a, -29b, or -29c diminished formation of TRAP (tartrate-resistant acid phosphatase-positive) mult

136 The impact of TRAP exposure on childhood behavior is not fully underst

137 ain were essential for PSTPIP2 inhibition of TRAP expression and osteoclast precursor fusion, whereas

138 s unclear and potent selective inhibitors of TRAP are required to assess functional aspects of the pr

139 ut only long-term exposure to high levels of TRAP throughout childhood was associated with asthma dev

140 zones assumed to have the highest levels of TRAP, was positively associated with high-density lipopr

141 ty and traffic exposure zones, as markers of TRAP exposure, and metabolic biomarkers for cardiovascul

142 Proxy measures of TRAP exposure were associated with intermediate metaboli

143 s is consistent with the known mechanisms of TRAP transporters and consider how the role of sugar oxi

144 ine/OVX groups presented a greater number of TRAP(+) cells around unligated teeth than the control gr

145 t BL and the OVX group the highest number of TRAP-positive (TRAP(+)) cells around ligated teeth (P <0

146 In PDCimG, the number of TRAP-positive osteoclasts and IL-6, MMP-1, and MMP-9-imm

147 The number of TRAP-positive osteoclasts was significantly higher in EM

148 bone loss and revealed increased numbers of TRAP+ osteoclastic cells lining the alveolar bone surfac

149 Ank KI/KI mice revealed decreased numbers of TRAP+ osteoclasts on the bone surface of pressure sides.

150 Quantification of TRAP-positive cells in the apical ends of Ank (KI/KI) in

151 4 [1.01, 1.53], respectively), regardless of TRAP exposure.

152 in biogenesis and sheds light on the role of TRAP in human congenital disorders of glycosylation.

153 The substrate binding proteins (SBP) of TRAP transporters are the best studied component and are

154 ity, and that PKG regulates the secretion of TRAP, an adhesin that is essential for motility.

155 A newly discovered subfamily of TRAP-Ts [tetratricopeptide repeat-protein associated TRA

156 hatases was only required for suppression of TRAP expression.

157 ng densely-packed DNA, comparable to that of TRAP.

158 some affinity purification (TRAP) from Olig2-TRAP transgenic mice.

159 nces in the number of either OCN-positive or TRAP-positive cells were observed between groups at 10 o

160 anslating ribosome affinity purification, or TRAP, combines cell type-specific transgene expression w

161 and rowanberry via different methods (ORAC, TRAP, HORAC and inhibition of lipid peroxidation).

162 d the highest antioxidant activity via ORAC, TRAP and HORAC assays, whereas blueberry extract was the

163 ereas higher-order complexes containing OST, TRAP, and TRAM were stabilized following substrate trans

164 in SSR4 and also reduces expression of other TRAP complex proteins.

165 otal radical trapping antioxidant parameter (TRAP) methods.

166 P) and thrombin receptor activating peptide (TRAP) concentrations.

167 d with thrombin receptor-activating peptide (TRAP) using ex vivo flow cytometry assays.

168 els of thrombin receptor activating peptide (TRAP)-stimulated percent P-selectin- and activated glyco

169 ive (EMD), tyrosine-rich amelogenin peptide (TRAP), and a synthetic proline-rich peptide (P2) on acut

170 ive mechanical ventilation and TRAP peptide (TRAP/HTV), which was further exacerbated in ANP(-/-) mic

171 s not exceeding a ratio of one AT trimer per TRAP 11-mer, restores tryptophan production by binding a

172 The tripartite ATP-independent periplasmic (TRAP) transporters are a widespread class of membrane tr

173 Tripartite ATP-independent periplasmic (TRAP) transporters are secondary transporters that have

174 ressing tartrate-resistant acid phosphatase (TRAP) activity produced by RANK-L-stimulated osteoclast

175 d femur tartrate resistant acid phosphatase (TRAP) activity, suggesting potential reduction of osteoc

176 FATc1), tartrate-resistant acid phosphatase (TRAP) and cathepsin K in vitro.

177 mal region of the tartrate acid phosphatase (TRAP) gene promoter and suppresses nuclear factor of act

178 N), and tartrate-resistant acid phosphatase (TRAP) immunohistochemical staining were performed.

179 to the tartrate-resistant acid phosphatase (TRAP) method.

180 Tartrate-resistant acid phosphatase (TRAP) staining, resorption pit assays, and real-time pol

181 tion of tartrate-resistant acid phosphatase (TRAP) were also performed.

182 G), and tartrate-resistant acid phosphatase (TRAP) were assessed.

183 nuclear tartrate-resistant acid phosphatase (TRAP)(+) osteoclasts, associated with reduced expression

184 (OPG), tartrate-resistant acid phosphatase (TRAP), and activated caspase-3 were performed at the fur

185 RANKL), tartrate-resistant acid phosphatase (TRAP), and osteoclast-associated receptor increased sign

186 13) and tartrate-resistant acid phosphatase (TRAP), leading to an acceleration in periodontal breakdo

187 lls for tartrate-resistant acid phosphatase (TRAP), receptor activator of nuclear factor-kappaB ligan

188 nd less tartrate-resistant acid phosphatase (TRAP)-positive cell induction than M0 or M2 macrophage t

189 creased tartrate-resistant acid phosphatase (TRAP)-positive cell number, and enhanced osteoclast acti

190 cleated tartrate-resistant acid phosphatase (TRAP)-positive cells from primary murine bone marrow-der

191 h fewer tartrate-resistant acid phosphatase (TRAP)-positive cells in alveolar bone.

192 Tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts in the alveolar process surfa

193 G), and tartrate-resistant acid phosphatase (TRAP).

194 enzyme tartrate resistant acid phosphatase (TRAP, two isoforms 5a and 5b) is highly expressed in alv

195 In a functional assay with physiological TRAP substrate osteopontin, AubipyOMe inhibited mouse ma

196 ial to Reduce Alloimmunization to Platelets (TRAP) study, 101 of 530 participants became refractory t

197 tions between traffic-related air pollution (TRAP) and allergic rhinitis remain inconsistent, possibl

198 nship between traffic-related air pollution (TRAP) and risk factors for cardiovascular disease needs

199 Traffic-related air pollution (TRAP) exposure is associated with allergic airway diseas

200 rly childhood traffic-related air pollution (TRAP) exposure on development of asthma and allergies re

201 m exposure to traffic-related air pollution (TRAP) in relation to progression in physical disability.

202 al effects of traffic-related air pollution (TRAP) on the developing brain.

203 stribution of traffic-related air pollution (TRAP), specifically nitrogen dioxide (NO(2)) and particu

204 th asthma and traffic-related air pollution (TRAP).

205 argeted recombination in active populations (TRAP), to obtain genetic access to neurons that were act

206 artrate-resistant acid phosphatase-positive (TRAP+) OCs and alveolar bone loss.

207 artrate-resistant acid phosphatase-positive (TRAP+) osteoclast numbers were also evaluated.

208 X group the highest number of TRAP-positive (TRAP(+)) cells around ligated teeth (P <0.05).

209 lated TRAP and AT showed that AT can prevent TRAP from binding to the trp leader RNA but cannot disso

210 Here, we show that AT can prevent TRAP-mediated termination of transcription by inducing d

211 ds to tryptophan-activated TRAP and prevents TRAP from binding to RNA, thereby upregulating expressio

212 ell-permeable thiol-reactive affinity probe (TRAP) consisting of a monosubstituted cyanine dye deriva

213 5-, thrombospondin-related adhesion protein (TRAP) 130-138-, or circumsporozoite protein (CSP) 252-26

214 to thrombospondin-related adhesion protein (TRAP) by using a viral vector.

215 red thrombospondin-related adhesive protein (TRAP), provide only intermediate to low levels of protec

216 um thrombospondin-related anonymous protein (TRAP) in clinical trials.

217 ), thrombospondin-related anonymous protein (TRAP), and cell-traversal protein for ookinetes and spor

218 by thrombospondin repeat anonymous protein (TRAP).

219 The translocon-associated protein (TRAP) complex is an integral component of the translocon

220 erotetrameric translocon-associated protein (TRAP) complex.

221 called trp RNA binding Attenuation Protein (TRAP) controls attenuation of the tryptophan biosyntheti

222 tryptophan RNA-binding attenuation protein (TRAP), which binds its target RNA sequence close to the

223 dditionally, the trp 5'-UTR binds a protein, TRAP (tryptophan RNA-binding attenuation protein), which

224 l mechanism are the homo-oligomeric proteins TRAP (trp RNA-binding attenuation protein) and anti-TRAP

225 the telomeric repeat amplification protocol (TRAP) based on polymerase chain reaction (PCR) amplifica

226 The telomere repeat amplification protocol (TRAP) for the human reverse transcriptase, telomerase, i

227 rom Telomeric Repeat Amplification Protocol (TRAP-LIG) assay demonstrated efficient telomerase inhibi

228 Translating Ribosome Affinity Purification (TRAP) and CREB-target gene repositories.

229 Translating ribosome affinity purification (TRAP) and in vitro luciferase reporter assay indicate th

230 translating ribosome affinity purification (TRAP) and RNA-seq to identify mistranslating mRNAs in CA

231 translating ribosome affinity purification (TRAP) from Olig2-TRAP transgenic mice.

232 Translating Ribosome Affinity Purification (TRAP) methodology to purify ribosome-associated mRNAs an

233 ranslational ribosome affinity purification (TRAP) mice (both sexes).

234 translating ribosome affinity purification (TRAP) of mRNA populations in CRE-expressing cells.

235 translating ribosome affinity purification (TRAP) profiling, electrophysiology, and behavior, we dem

236 ranslational ribosome affinity purification (TRAP) to isolate and profile mRNA from myofibroblasts an

237 translating ribosome affinity purification (TRAP).

238 r Translating Ribosome Affinity Purification(TRAP).

239 (translating ribosome affinity purification; TRAP) is an effective means to isolate ribosome-bound RN

240 nstrate that the genes encoding the putative TRAP-T components from T. pallidum, tp0957 (the SBP), an

241 Expression of RANK, TRAP, cathepsin K, calcitonin receptor, matrix metallopr

242 -gamma reduced the mRNAs encoding for RANKL, TRAP, and Cathepsin K.

243 tivated receptor 1 (PAR1) thrombin receptor (TRAP-stimulated P-selectin, activated GPIIb-IIIa, and CD

244 anscripts, and that cardiomyocyte-restricted TRAP is a useful means to identify genes that are differ

245 Retro-TRAP (translating ribosome affinity purification) techno

246 Retro-TRAP uses an anti-GFP ribosomal tag (expressed virally o

247 Using these viruses and Retro-TRAP (translating ribosome affinity purification), a pre

248 aser-capture microdissection and FACS, Retro-TRAP is a high-throughput methodology that requires mini

249 mophilus influenzae virulence-related SiaPQM TRAP transporter.

250 nchronously developing granule neurons (Sync-TRAP) showed that conditional knockout of the core NuRD

251 merase inhibitory activity in the telomerase TRAP-LIG assay.

252 There was some evidence that TRAP was associated with eczema and hay fever.

253 We show that TRAP can provide selective access to neurons activated b

254 Furthermore, we show that TRAP is an effective means for studying translational re

255 n a growing body of evidence suggesting that TRAP exposures may accelerate aging-related declines in

256 vide biochemical and structural support that TRAP transporters function predominantly as high affinit

257 The TRAP assay can only reproducibly detect approximately 2-

258 The TRAP+ cell population initially followed the stress grad

259 ed the ~17-kDa ameloblastin (Ambn-N) and the TRAP (tyrosine-rich amelogenin peptide) fragments.

260 al root resorption (OERR), necrosis, and the TRAP+ cell population.

261 hain-breaking activity, as determined by the TRAP method.

262 ovides a step-by-step guide to implement the TRAP methodology, which takes 2 d to complete once all m

263 50 values in the sub-micromolar range in the TRAP-LIG assay, which are the best among the benzimidazo

264 Adaptation of the TRAP assay to digital format allows accurate and reprodu

265 The 5'-most region of the TRAP binding site in the nascent transcript is most susc

266 f the marker and of the other members of the TRAP complex.

267 dissecting the molecular organization of the TRAP complex.

268 tributes to Pax6-mediated suppression of the TRAP gene expression induced by NFATc1.

269 y tryptophan, the outer circumference of the TRAP ring binds specifically to a series of tandem seque

270 d SBPs as well as permease components of the TRAP transporters, members of the DUF1537 family, and a

271 issection, cell panning or cell sorting, the TRAP methodology bypasses the need for tissue fixation o

272 This is the first evidence that the TRAP complex, which binds to the oligosaccharyltransfera

273 Together, these data show that the TRAP strategy and the Rosa26(fsTRAP) allele will be usef

274 ent tumor delineation-were obtained with the TRAP-based monomer (68)Ga-avebehexin.

275 ent tumor delineation-were obtained with the TRAP-based monomer (68)Ga-avebehexin.

276 ivity, increases PGA formation when added to TRAP-stimulated blood.

277 t is not known how many trimers must bind to TRAP in order to interfere with RNA binding.

278 We also show that one AT trimer bound to TRAP 11mer reduces the affinity of TRAP for RNA and elim

279 f asthma and allergic outcomes if exposed to TRAP.

280 We sought to determine whether exposure to TRAP in middle age is associated with allergic sensitiza

281 Exposure to TRAP in participants' early life and at current home add

282 Early-life exposure to TRAP is associated with increased risk for persistent wh

283 e association between early-life exposure to TRAP using a surrogate, elemental carbon attributed to t

284 Also, early childhood exposure to TRAP was associated with development of asthma across ch

285 In summary, exposure to TRAP was related to asthma and allergic diseases.

286 Participants' time-weighted exposure to TRAP, from birth through age 7 years, was estimated usin

287 We measured participants' exposures to TRAP using two surrogates: residential proximity to majo

288 ne expressing a multiepitope string fused to TRAP and 3 doses of RTS,S/AS01B (group 1; n = 20) or 3 d

289 a slight increase in platelet reactivity to TRAP only in responders to eltrombopag but not to levels

290 lation in asthmatic patients and response to TRAP.

291 te ATP-independent periplasmic transporters (TRAP-Ts) are bacterial transport systems that have been

292 ide on the triazacyclononane-triphosphinate (TRAP) chelator, followed by automated (68)Ga labeling.

293 mpared to no protection using virus-vectored TRAP alone and 40% protection using adenovirus-CSP prime

294 es is seen when combined with virus-vectored TRAP, and the combination is no more protective than eit

295 maintained when combined with virus-vectored TRAP.

296 t ChAd63 and MVA vectors expressing P. vivax TRAP (PvTRAP) and show their ability to induce high anti

297 smodium berghei parasite expressing P. vivax TRAP to allow studies of vaccine efficacy and protective

298 horts (Ntotal = 15,299), we examined whether TRAP and genetic polymorphisms related to inflammation a

299 n conclusion, these data are consistent with TRAP SBPs undergoing a simple two-state transition from

300 nses was also achieved by combining R21 with TRAP-based viral vectors and protective efficacy was sig