ライフサイエンスコーパス: TRP channel

1 lammation in-vivo that involve more than one TRP channel.

2 which is reminiscent of other heat-activated TRP channels.

3 aled as pivotal for allosteric activation in TRP channels.

4 ies that are important for the activation of TRP channels.

5 tion of cysteine residues on multiple Ca(2+) TRP channels.

6 ical modulation exhibited by TRPV1 and other TRP channels.

7 families of sensory proteins--rhodopsins and TRP channels.

8 ne lipids modulate other "receptor-operated" TRP channels.

9 lgesic properties, at least in part, via the TRP channels.

10 rations sufficient for activation of sensory TRP channels.

11 indeed forms the main intracellular gate in TRP channels.

12 f TRPV2 and may play a similar role in other TRP channels.

13 mental evidence supporting this mechanism in TRP channels.

14 sease (ADPKD), belongs to the superfamily of TRP channels.

15 B), a synthetic chemical that modulates many TRP channels.

16 29 ankyrin repeats, the largest number among TRP channels.

17 ar basis for the voltage-dependent gating of TRP channels.

18 C) is attenuated by antagonists of mGluR1 or TRP channels.

19 repertoire of sensory modalities mediated by TRP channels.

20 coded by norpA is critical for activation of TRP channels.

21 ylalanines found in all known subfamilies of TRP channels.

22 n that colocalizes to rhabdomeres along with TRP channels.

23 d gating of these and other thermo-sensitive TRP channels.

24 explain the large temperature sensitivity of TRP channels.

25 ared and unique features compared with other TRP channels.

26 sensitivity common to other thermosensitive TRP channels.

27 alling components, such as STIM proteins and TRP channels.

28 ividual cells expressing genetically encoded TRP channels.

29 crease in the calcium flow through activated TRP channels.

30 expression of transient receptor potential (TRP) channels.

31 the opening of transient receptor potential (TRP) channels.

32 ct upstream of transient receptor potential (TRP) channels.

33 bfamily of the transient receptor potential (TRP) channels.

34 tor of certain transient receptor potential (TRP) channels.

35 s that result from overactive or underactive TRP channels?

36 Here, we identified mucolipin TRP channel 1 (TRPML1) as the key lysosomal Ca2+ channel

37 This change is detected by mucolipin TRP channel 3 (TRPML3), a transient receptor potential c

38 Thermal transient receptor potential (TRP) channels, a group of ion channels from the transien

39 Transient receptor potential (TRP) channels, a superfamily of ion channels, can be div

40 Various TRP channels act as polymodal sensors of thermal and che

41 Transient receptor potential (TRP) channels act as sensors for a range of stimuli as d

42 Despite intensive study, the mechanisms of TRP channel activation by chemical or physical stimuli r

43 hannels, facilitates better understanding of TRP channel activation, and provides insights into the m

44 t a PLCbeta derivative that does not promote TRP channel activation, still contributes to signaling i

45 idence for a general role for this domain in TRP channel activation.

46 cuss the thermodynamic foundations of thermo-TRP channel activation.

47 fects of chloroform or the VGA isoflurane on TRP channel activation.

48 ells and measured ATP release in response to TRP channel activation.

49 of 5,6-EET to transient receptor potential (TRP) channel activation in nociceptor neurons and its co

50 TRP channel agonists anandamide and (-)menthol were foun

51 nd response to transient receptor potential (TRP) channel agonists.

52 s is regulated by a thermosensitive membrane TRP channel and the DAF-16/FOXO transcription factor, bu

53 ral architecture for this major subfamily of TRP channels and a well-defined calcium-binding site wit

54 coveries were made, few would have suspected TRP channels and astrocytes could contribute significant

55 Recent findings, however, put TRP channels and astrocytes in the spotlight, describe t

56 Here I discuss the recent developments on TRP channels and astrocytes that have made us aware of t

57 ce in the Drosophila larva involves distinct TRP channels and circuits.

58 provides six perspectives on the subject of TRP channels and disease.

59 st distinct roles of resolvins in regulating TRP channels and identify RvD2 as a potent endogenous in

60 suggest that most structural elements within TRP channels and Kv channels are not sufficiently relate

61 diovascular system, and interactions between TRP channels and other proteins involved in mechanoelect

62 mer 1 functions as an important scaffold for TRP channels and regulates mechanotransduction in skelet

63 erone and provide a mechanistic link between TRP channels and their GPCRs during biosynthesis and tra

64 ficity for TRPM3 compared with other sensory TRP channels, and blocked PregS-induced intracellular fr

65 ture analysis unveiled the modular design of TRP channels, and electrophysiological experiments condu

66 Macrophages express at least 3 different TRP channels, and the properly balanced activation of al

67 a drug that targets two functionally-related TRP channels, and thus can be used to combat isoforms of

68 mediated by a transient receptor potential (TRP) channel, and RT-PCR was used to confirm expression

69 bited by PIP2; where does PIP2 interact with TRP channels; and is the mechanism of modulation conserv

70 e is a transition from AP to CP, after which TRP channel antagonism is ineffective, and thus (3) that

71 s, which was attenuated by the non-selective TRP channel antagonist ruthenium red (10 microM).

72 TRP channel antagonists acted synergistically to reverse

73 e, and thus (3) that early intervention with TRP channel antagonists may attenuate the transition to

74 ine and were antagonized by the nonselective TRP channel antagonists Ruthenium Red and gadolinium, bu

75 ium that was abolished by preincubation with TRP channel antagonists.

76 that provide a basis for testable models of TRP channel architecture.

77 oform of phospholipase C, but TRPA1 or other TRP channel are not required.

78 TRP channels are activated by a variety of stimuli, incl

79 poral resolution of neuronal activation when TRP channels are activated by ambient temperature variat

80 tion with and without Ca(2+) bound, although TRP channels are believed to be tetramers.

81 thesis that in low extracellular calcium the TRP channels are dilating, and as a consequence open cha

82 Furthermore, several TRP channels are expressed on immune cells.

83 Mammalian TRP channels are grouped into six subfamilies (TRPC, TRP

84 Thermal TRP channels are important for thermal sensation and noc

85 of the core functional features of metazoan TRP channels are present in Cr-TRP1, suggesting that bas

86 Multiple TRP channels are regulated by phosphoinositides (PIs).

87 A recent study has shown that TRP channels are required for hygrosensation in Drosophi

88 the driving force for Ca(2+) entry, and some TRP channels are required for proliferation and migratio

89 Functional TRP channels are tetrameric complexes consisting of 4 po

90 The Transient Receptor Potential (TRP) channels are a family of cationic ion channels wide

91 hether sensory transient receptor potential (TRP) channels are a molecular target for apomorphine.

92 Transient receptor potential (TRP) channels are a superfamily of broadly expressed ion

93 Transient receptor potential (TRP) channels are abundant in the brain where they regul

94 Transient receptor potential (TRP) channels are activated by environmental particulate

95 Transient Receptor Potential (TRP) channels are emerging as essential cellular switche

96 Transient receptor potential (TRP) channels are important in many neuronal and non-neu

97 cts to humans, transient receptor potential (TRP) channels are key transducers of thermal, chemical a

98 ts to mammals, transient receptor potential (TRP) channels are known mediators for cellular sensing.

99 Transient receptor potential (TRP) channels are nonselective cation channels, several

100 Transient receptor potential (TRP) channels are polymodal cell sensors responding to d

101 Transient receptor potential (TRP) channels are polymodal signal detectors that respon

102 Transient receptor potential (TRP) channels are polymodal signal detectors that respon

103 Most transient receptor potential (TRP) channels are regulated by phosphatidylinositol-4,5-

104 Transient receptor potential (TRP) channels are sensors for a wide range of cellular a

105 Transient receptor potential (TRP) channels are the key sensory transducers that confe

106 The transient receptor potential (TRP) channels are unique cellular sensors that are widel

107 licate certain transient receptor potential (TRP) channels as a therapeutic target along with metabot

108 nary tuning of transient receptor potential (TRP) channels as thermosensors in the vertebrate nervous

109 el sharing key features present in mammalian TRP channels associated with sensory transduction.

110 ously unknown proteins, which we have named "TRP channel-associated factors" (TCAFs), as new TRPM8 pa

111 e opportunity to explore ionic conduction in TRP channels at atomic detail.

112 receptors as well as calcium influx through TRP channels, axon repulsion is mediated by TRP channels

113 bilateria and transient receptor potential (TRP) channels before the origin of animals.

114 of TRPA1, TRPV1, TRPC3 or TRPC6, nor by the TRP channel blocker Ruthenium Red.

115 Moreover, ruthenium red (a general TRP channel blocker), BTP2 (a general TRPC channel inhib

116 calcium and was blocked by the nonselective TRP channel blocker, ruthenium red.

117 m (Ca(2+)) and transient receptor potential (Trp) channels, but not sodium (Na(+)) channels or ligand

118 ight-sensitive transient receptor potential (TRP) channel by modulating the levels of dihydrosphingos

119 neuron excitability via actions on multiple TRP channels can contribute to the anti-inflammatory eff

120 Na(+) /Ca(2+) exchanger, but not TRP channels, can also facilitate STOC production.

121 We identified the first heteromeric TRP channels composed of subunits from 3 different TRP s

122 Transient receptor potential (TRP) channels comprise a large family of tetrameric cati

123 How do normally functioning TRP channels contribute to cell death pathways?

124 ties and set the stage for understanding how TRP channels contribute to mechanosensation.

125 Furthermore, recent evidence shows that TRP channels contribute to the progression and survival

126 nnels, such as transient receptor potential (TRP) channels, contribute to changes in Ca(2+) by modula

127 This suggests that cross-sensitization of TRP channels contributes to enhanced pain sensitivity in

128 Transient receptor potential (TRP) channels couple various environmental factors to ch

129 in freshly isolated mouse tissues and led to TRP channel-dependent release of proinflammatory neurope

130 Together, this study indicates that TRP channel dephosphorylation is a regulatory process th

131 hysiology that transient receptor potential (TRP) channel dephosphorylation at a specific site is a f

132 We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment

133 The TRP channel dilation mechanism may play important roles

134 mational changes in the outer pore region of TRP channels during activation.

135 is known about the folding and transport of TRP channels during biosynthesis.

136 Here, we review the emerging evidence that TRP channels, especially TRPCs, are critical regulators

137 so robustly activated by CFA1, whereas other TRP channels expressed by airway sensory neurons and lun

138 and excitation-contraction coupling; hence, TRP channels expressed in the heart most likely coordina

139 he extent of inflammation, pancreatic neuron TRP channel expression and function and excitability, an

140 In this study, we investigated functional TRP channel expression in human odontoblast-like cells a

141 hat the zinc-finger protein ZBTB20 regulates TRP channels expression in nociceptors.

142 nociception and pain sensation by modulating TRP channels expression in nociceptors.

143 TRPV5 is unique within the large TRP channel family for displaying a high Ca(2+) selectiv

144 key step in vision, expands the role of the TRP channel family in sensory perception, and presents i

145 opposing effects chloroform has on different TRP channel family members, the findings of this study p

146 ere, we found that a member of the canonical TRP channel family, TRPC3, is highly expressed in MRGPRD

147 eature of this transient receptor potential (TRP) channel family member.

148 ed the role of transient receptor potential (TRP) channel family members in mediating chloroform acti

149 associate with transient receptor potential (TRP) channel family proteins to form functionally import

150 ovided high-resolution structural details of TRP channel fragments although it fails to explain how t

151 ist-binding site from that found in TRPV1, a TRP channel from a different subfamily.

152 we examine the effect of several ligands on TRP channel function and the evidence regarding their me

153 excessively cool temperatures also requires TRP channel function, and whether warm and cool avoidanc

154 lueprint for understanding unique aspects of TRP channel function.

155 imuli is necessary for understanding overall TRP channel function.

156 r, and recent discoveries are revealing that Trp channels function as transducers for both.

157 ducing thermosensitivity can be critical for TRP channel functional diversification, facilitating the

158 hniques to elucidate molecular mechanisms of TRP channel gating and regulation.

159 echanisms whereby chemical ligands impact on TRP channel gating are poorly understood.

160 re present in Cr-TRP1, suggesting that basic TRP channel gating characteristics evolved early in the

161 We suggest that TRP channel gating is accompanied by large changes in mo

162 To identify amino acid residues crucial for TRP channel gating, we developed an unbiased, high-throu

163 First, we screened mutants for 18 TRP channel genes (including all TRPV orthologs) and fou

164 and cool avoidance use the same or distinct TRP channels has been unknown.

165 nnel; and (ii) electron microscopy of entire TRP channels has yielded low-resolution images that prov

166 ubunit of most transient receptor potential (TRP) channels has an additional TRP-domain helix with an

167 TRP channels have been associated with cell proliferatio

168 Several TRP channels have been implicated in Drosophila auditory

169 The TRP channels have been implicated in varied biologic fun

170 Although these TRP channels have been intensively studied, little is kn

171 TRP channels have emerged as key biological sensors in v

172 Gain-of-function mutations in TRP channels have not been previously implicated in dopa

173 Transient receptor potential (TRP) channels have been implicated as sensors of diverse

174 al properties and the mechanism of action in TRP channels, high-resolution three-dimensional structur

175 only very small numbers of K(+), Ca(2+) and Trp channel homologues.

176 s from mice lacking TRPM1 receptors, another TRP channel implicated in retinal function, revealed the

177 ing evidence demonstrates important roles of TRP channel in controlling vascular function including e

178 This review focuses on the role of TRP channels in a few surgically important disease proce

179 TRP channels in brown and white adipogenesis from human

180 The expression of TRP channels in CHO cells demonstrates that both WIN and

181 IFT) components, sensory receptors, or other TRP channels in different cell types.

182 expressed wild-type or specifically mutated TRP channels in human embryonic kidney cells and used ca

183 tability and messenger RNA expression of the TRP channels in NG and DRG pancreatic neurons.

184 tional and non-transcriptional regulation of TRP channels in odontoblasts.

185 AP (AP), we studied the involvement of these TRP channels in pancreatic inflammation and pain-related

186 hat chemosensing of this dietary molecule by TRP channels in the endothelium promotes arterial relaxa

187 However, developmental roles for TRP channels in the establishment of neuronal connectivi

188 by microOR activation, much more than other TRP channels in the same compartment, like TRPV1 and TRP

189 ral functional transient receptor potential (TRP) channels in live cells and in real time.

190 is the role of transient receptor potential (TRP) channels in pain perception?

191 f transient receptor potential ion channels (TRP channels) in health and disease.

192 1), one member of the vanilloid subfamily of TRP channels, in the pathophysiology of asthma.

193 sis that some GAs, through direct actions at TRP channels, increase postsurgical pain and inflammatio

194 To date, it is not known how TRP channels integrate the action of such disparate stim

195 d to cilia and further investigated ENKUR, a TRP channel-interacting protein identified in the cilia

196 m of temperature-dependent gating of thermal TRP channels involving an intracellular region assembled

197 Activation of TRP channels is verified by using genetically encoded fl

198 TRPV subset of transient receptor potential (TRP) channels is heat activated and proposed to be respo

199 id 4 (TRPV4), a Ca(2+)-permeable osmomechano-TRP channel, is highly expressed in articular chondrocyt

200 nction of NompC, a putative mechanosensitive TRP channel, is not only required for fly locomotion, bu

201 an homologue of the Drosophila photoreceptor TRP channel, is predominantly expressed within the outer

202 tage-dependent manner but, unlike many other TRP channels, is permeable to monovalent cations only.

203 ed that diverse types of channels, including TRP channels, K(2P) channels, MscS-like proteins, and DE

204 ions in TRPML1, a lysosomal Ca(2+)-permeable TRP channel, lead to mucolipidosis type IV, a neurodegen

205 the de-orphanization of natural products as TRP channel ligands may leverage their exploration as vi

206 or understanding the differential actions of TRP channel ligands, with important ramifications for TR

207 eveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and,

208 These neurons received TRP channel M8 (TRPM8)-positive DRG inputs as well as no

209 Finally, we foresee that TRP channels may be explored for the selective pharmacod

210 These TRP channels may be of particular relevance to respirato

211 suggests that loss of Homer 1 scaffolding of TRP channels may contribute to the increased stretch-act

212 r findings indicate that temperature-sensing TRP channels may not contain a specialized heat-sensor d

213 Pharmacologic activation or blockade of TRP channels may offer new treatment options in surgical

214 Thermal TRP channels mediate temperature transduction and pain s

215 that distinct transient receptor potential (TRP) channels mediate allodynia and hyperalgesia downstr

216 Our findings suggest that suppression of TRP channel-mediated neural excitation by the conserved

217 Tiotropium failed to modulate other TRP channel-mediated responses.

218 oints for designing natural product-inspired TRP channel modulators.

219 cs dictate that opening of these specialized TRP channels must involve an unusually large conformatio

220 ession or cellular localization of TRPA-1, a TRP channel needed in OLQ and IL1 neurons for touch beha

221 The transient receptor potential (TRP) channel NOMPC is important for mechanosensation-rel

222 implicates the transient receptor potential (TRP) channels NOMPC, NANCHUNG, and INACTIVE, but not the

223 ontribution of transient receptor potential (TRP) channels, notably TRPV4, in volume regulation after

224 els of known structure and Na(V), Ca(V), and TRP channels of unknown structure.

225 Transient receptor potential (TRP) channels of multiple subclasses are expressed in th

226 R(2) activates transient receptor potential (TRP) channels of nociceptive neurons to induce neurogeni

227 Because several of these TRP channels on macrophages are temperature sensitive, t

228 chemotaxis that link receptor activation to TRP channel opening and Ca2+ signaling.

229 al roles in PVD function (e.g., DEG/ENaC and Trp channels) or development (e.g., UNC-5 and LIN-17/fri

230 trimeric G protein, phospholipase Cbeta, the TRP channel, or the Na(+)/Ca(2+) exchanger did not influ

231 iated by TMC-1 and to a lesser extent by the TRP channel OSM-9.

232 The mechanism by which TRP channels participate in pruritogen-induced scratchin

233 Although TRP channels permeate many different cations, they are m

234 The transient receptor potential (TRPs) channels persist scarcely explored as targets, des

235 ciliary ultrastructure, localization of the TRP channel PKD-2 and the kinesin-3 KLP-6, and velocity

236 lcium compartment regulated by a heteromeric TRP channel, PKD1L1-PKD2L1, in mice and humans.

237 by a subset of taste cells that express the TRP channel PKD2L1 and its partner PKD1L3, however the m

238 Our results show that a TRP channel plays a role in regulating growth factor sig

239 bsequently interferes with expression of the TRP channel polycystin-2 (PKD2).

240 omeric complex formed by PKD1L3 and TRPP3, a TRP channel protein.

241 rward genetic screen of the TrpY1, the yeast TRP channel, recovered gain-of-function (GOF) mutations

242 How are TRP channels regulated by signal transduction cascades?

243 lding protein Homer 1 has been implicated in TRP channel regulation, we hypothesized that Homer prote

244 trafficking of transient receptor potential (TRP) channels remain poorly understood, and identifying

245 Transient receptor potential (TRP) channels represent interesting molecular target str

246 Here we identify two TRP channels required for cool avoidance, TRPL and TRP.

247 Although transient receptor potential (TRP) channel research has vastly increased our understan

248 the global genetic disruption of individual TRP channels result in phenotypes associated with impair

249 Yvc1p channel, a homologue of the mammalian TRP channels, revealed that the channel is activated by

250 Although TRP channels seem to be absent in plants, C. reinhardtii

251 cterization of a C. reinhardtii version of a TRP channel sharing key features present in mammalian TR

252 rovide a preview of what the future holds in TRP channel structural biology.

253 el ligands, with important ramifications for TRP channel structure-function analysis and pharmacology

254 ng that nyctalopin is acting as an accessory TRP channel subunit critical for proper channel localiza

255 recently that mutant mice lacking a specific TRP channel subunit, TRPC5, exhibited decreased innate f

256 ltiple genes encoding homologues of K(+) and Trp channel subunits, and genes encoding novel homologue

257 Although other TRP channels, such as TRPV4, are expressed in primary af

258 se the possibility that other members of the TRP channel superfamily are also regulated by caspase-me

259 sion of both TRPC6 and TRPC7, members of the TRP channel superfamily, also essentially eliminated the

260 ubfamily M member 3 (TRPM3), a member of the TRP channel superfamily, was recently identified as a no

261 ubgroup of the transient receptor potential (TRP) channel superfamily whose members have important ro

262 ur knowledge, this is the first example of a Trp channel that must undergo de novo expression for man

263 First, we identify TRP channels that function in the fly antenna to mediate

264 nilins and the transient receptor potential (TRP) channels that are distributed across ER/SR membrane

265 nilins and the transient receptor potential (TRP) channels that are distributed across ER/SR membrane

266 humans, which express many K(+), Ca(2+) and Trp channels, the genomes of pathogenic fungi encode onl

267 l activation, allowing temperature-sensitive TRP channels to function as polymodal nociceptors.

268 a Mini-Symposium entitled "Contributions to TRP Channels to Neurological Disease" included talks fro

269 rties by using transient receptor potential (TRP) channels to activate or ablate specific neuronal po

270 (+), Na(+), or transient receptor potential (TRP) channels to cross-react with intracellular Ca(2)(+)

271 use vanilloid transient receptor potential (TRP) channels to integrate light-evoked signals with amb

272 The ability of transient receptor potential (TRP) channels to sense and respond to environmental and

273 canonical (C) transient receptor potential (TRP) channel TRPC3 were present in both popliteal and fi

274 utation in the transient receptor potential (TRP) channel TRPC3.

275 Transient receptor potential (TRP) channels TRPC3 and homologous TRPC6 are expressed o

276 netically, the transient receptor potential (TRP) channels Trpm, NompC, and Polycystic kidney disease

277 An exception is the genetic ablation of the TRP channel TRPM7, which results in early embryonic leth

278 Recently, the transient receptor potential (TRP) channels TRPM8 and TRPA1 have been identified as mo

279 s of Kv2.1 with corresponding regions of two TRP channels, TRPM8 and TRPV1.

280 he regulation of gastric acid secretion by a TRP channel; TRPML1 is an important protein in parietal

281 All members of the vanilloid family of TRP channels (TRPV) possess an N-terminal ankyrin repeat

282 nts expressing transient receptor potential (TRP) channels TRPV1 and TRPA1 are thought to be required

283 The transient receptor potential (TRP) channels TRPV1 and TRPA1 have each been associated

284 py to determine the structure of a mammalian TRP channel, TRPV1, at 3.4 A resolution, breaking the si

285 vanilloid (V) transient receptor potential (TRP) channel TRPV4 can be rapidly recorded and character

286 (2+)-selective transient receptor potential (TRP) channels TRPV5 and TRPV6 play vital roles in calciu

287 cently modeled transient receptor potential (TRP) channels using the Gestalt Domain Detection Algorit

288 or inputs from transient receptor potential (TRP) channel V1 (TRPV1)-positive dorsal root ganglion (D

289 Functional expression of TRP channels was determined with reverse transcription p

290 -TyrR) and the transient receptor potential (TRP) channel Water witch (Wtrw), and astrocytes in turn

291 Antagonists of the two TRP channels were administered at different times to blo

292 Effects of nitro-oleic acid (OA-NO2) on TRP channels were examined in guinea-pig dissociated dor

293 TRP channels were first identified as membrane proteins

294 the archetypal Transient Receptor Potential (TRP) channel, which is essential for Drosophila phototra

295 TRPV4 ion channels represent osmo-mechano-TRP channels with pleiotropic function and wide-spread e

296 As TRP channels with specific subunit compositions may have

297 In contrast, replacement of portions of TRP channels with those of Kv2.1 consistently yielded no

298 be replaced by the analogous regions of both TRP channels without abolishing voltage-activation.

299 TRP channels, axon repulsion is mediated by TRP channels without involvement of IP3 receptors.

300 TRP channels work as sensors for a wide range of cellula